TCM Prescription: Wei Sheng Powder



Prescription Description
Prescription IDTCMFx5542
Pinyin NameWei Sheng San
Chinese Name卫生散
English NameWei Sheng Powder
Function Description中风, 急惊风, 霍乱, 疮疡
IndicationsAcute convulsion disorder, Severe vomiting and diarrhoea disorder, Cholera, Convulsions, Stroke
Disease ICD-11 Category SE33 [Acute convulsion disorder (TM1), 急惊风 (TM1) ];
SD92 [Severe vomiting and diarrhoea disorder (TM1), 霍乱 (TM1) ];
1A00 [Cholera, 霍乱 ];
8A68.Z [Type of seizure, unspecified, 癫痫发作类型，未特指的 ];
8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ];
Human Tissues Associated with IndicationBrain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH916 Succinus 琥珀 TCMH916
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH1451 Pleione yunnanensis rolfe 毛慈菇 TCMH1451
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH1060 Bombyx batryticatus 僵蚕 TCMH1060
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH1659 Semen euphorbiae pulveratum 千金子霜 TCMH1659 ITSAM343-14
TCMH2646 Rhizoma paridis 重楼 TCMH2646
TCMH1573 Bovis calculus 牛黄 TCMH1573
TCMH1139 Radix euphorbiae pekinensis 京大戟 TCMH1139
TCMH2175 Galla chinensis 五倍子 TCMH2175
TCMH2329 Realgar 雄黄 TCMH2329
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH2605 Margarita 珍珠 TCMH2605
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1346 Helicobacter pylori
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway