TCM Prescription: Qing Re Zhen Ke Syrup



Prescription Description
Prescription IDTCMF78
Pinyin NameQing Re Zhen Ke Tang Jiang
Chinese Name清热镇咳糖浆
English NameQing Re Zhen Ke Syrup
Function Description咳嗽
IndicationsCough
Disease ICD-11 Category MD12 [Cough, 咳嗽 ];
Human Tissues Associated with IndicationTonsil, Lung
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2117 Lepidium apetalum 葶苈子 TCMH2117 ITSAB3973-14
TCMH6 Ardisiae japonicae 矮地茶 TCMH6
TCMH2545 Houttuynia cordata 鱼腥草 TCMH2545 ITSAJ4504-14
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1656 Angelica decursiva 前胡 TCMH1656 ITSAN4164-14
TCMH128 Castanea mollissima 板栗壳 TCMH128 GBVX1897-13
TCMH605 Pumex 浮海石 TCMH605
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, HSD17B1, HSD17B2, KIT, MET, MIF 7.57253
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.52612
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.20488
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MAOB, MMP9, SRC, TERT 7.20488
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PDE5A, PIM1, TYR, XDH 7.11016
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.9949
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 6.78388
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, SRC, TERT, XDH 6.63051
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, SRC, TERT, XDH 6.62755
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.54614
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, TYR, XDH 5.9455
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 5.93495
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.93495
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, TERT, XDH 5.93495
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF 5.66154
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, SRC, TERT, XDH 5.61696
[BP] GO:0010033 response to organic substance AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MAOB, MMP2, RORC, SRC, TYR 5.44072
[BP] GO:0042221 response to chemical AKR1B1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MAOB, MMP2, MMP9, RORC, SRC, TERT, TYR 5.42347
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, SRC, TERT 5.35837
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, MAOB, RORC, SRC, TYR 5.35837
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, KIT, MAOB, MET, MIF, SRC, TERT, XDH 5.29752
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, SRC, TERT, XDH 5.2333
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, XDH 5.17528
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MAOB, MMP2, MMP9, RORC, SRC, TYR 5.08502
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.04772
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, KIT, MET, MIF, MMP9, PIM1, SRC, TERT 4.98406
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, KIT, MET, MIF 4.9217
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF 4.9217
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP2, PDE5A, PIM1, RORC, SRC, TERT, TYR, XDH 4.88656
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, XDH 4.71794
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, MAOB, TYR, XDH 4.45213
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 4.3998
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PIM1, SRC, TERT, XDH 4.27194
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, MMP9, SRC, TERT 4.26782
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FLT3, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, SRC, TERT, XDH 4.25242
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.21015
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 4.1598
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 4.09741
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.08868
[BP] GO:0006805 xenobiotic metabolic process CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 4.05667
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.05614
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 4.05614
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 4.05614
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, MMP9, SRC, TERT 4.05614
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, SRC, TERT, XDH 4.04286
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, SRC, TERT, XDH 3.95169
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PIM1, SRC, TERT 3.89962
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.89962
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.89962
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP12, MMP9, SRC, TERT 3.83424
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, HSD17B2, KDR, KIT, MAOB, MET, MIF, MMP2, MMP9, PIM1, RORC, SRC, TERT, TYR 3.77547
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, FLT3, IGF1R, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, TERT 3.76965
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, MMP9, SRC, TERT 3.74596
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, MAOB, RORC, SRC, TYR 3.74596
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, FABP4, KIT, MAOB, MMP9, TERT 3.74596
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MIF, MMP9, SRC, TERT 3.74596
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.74258
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PDE5A, SRC, TERT, XDH 3.72502
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, RORC, SRC, TERT 3.7204
[BP] GO:0032787 None ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF 3.46626
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.44479
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, KDR, KIT, MET, MIF, PDE5A, SRC, XDH 3.38289
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, PDE5A, SRC, XDH 3.3785
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, RORC, SRC 3.37814
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, KIT, MAOB, MMP2, SRC 3.36542
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, KIT, MAOB, MIF, MMP12, MMP2, MMP9, RORC, SRC, TERT, TYR 3.36265
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 3.3546
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, KIT, SRC, TYR 3.33515
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, KIT, MET, MIF, PIM1, SRC, TYR 3.32866
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 3.30811
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, KIT, MAOB, SRC 3.30811
[BP] GO:0051716 cellular response to stimulus AKR1B1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MIF, MMP2, MMP9, RORC, SRC, TERT 3.27483
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.18525
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, TYR 3.14784
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.14463
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.12837
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP12, MMP9, PDE5A, PIM1, RORC, SRC, TERT, XDH 3.05707
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.99716
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.98064
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, HCAR2, KDR, KIT, MET, MIF, MMP12, MMP9, PDE5A, PIM1, SRC, TERT 2.90738
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, HCAR2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP12, MMP9, PDE5A, PIM1, RORC, SRC, TERT, XDH 2.78516
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, TYR 2.77681
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.77096
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, HSD17B2, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TYR 2.77096
[BP] GO:0006082 organic acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PIM1, TYR 2.71574
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, KIT, MAOB, MMP9, PIM1, RORC, SRC, TYR 2.66014
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.64328
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HCAR2, KDR, MIF, SRC 2.64328
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, KIT, MIF, PDE5A, SRC 2.63463
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, TYR, XDH 2.55293
[BP] GO:0071310 cellular response to organic substance AKR1B1, AXL, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, RORC, SRC 2.55293
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.55293
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55062
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, TYR, XDH 2.54788
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.5159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.45935
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, FLT3, KDR, KIT, MIF, PDE5A, SRC, XDH 2.45362
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.44758
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.40729
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.38686
[BP] GO:0002793 None ACHE, ADORA1, HCAR2, MIF, MMP12, SRC 2.36439
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, SRC 2.36439
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.32741
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.30818
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30021
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30021
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, KIT, MIF, PDE5A, SRC 2.29889
[BP] GO:0044248 cellular catabolic process ACHE, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MAOB, PDE5A, SRC, XDH 2.29773
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.2958
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.28602
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.28602
[BP] GO:0043408 regulation of MAPK cascade ADORA1, FLT3, IGF1R, KDR, KIT, MIF, PDE5A, SRC, XDH 2.27982
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.2692
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF 2.2692
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.2692
[BP] GO:1901575 None ACHE, ADORA1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MAOB, PDE5A, XDH 2.2692
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.2692
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.26398
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF 2.24875
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, MIF 2.24875
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, MAOB, SRC 2.22236
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.19052
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.19052
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC, TERT 2.18425
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.18425
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.18425
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, MIF, SRC 2.16689
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.1577
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.14595
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.12416
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, SRC 2.11884
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, HCAR2, MIF, MMP12, SRC, TERT 2.09996
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.09407
[BP] GO:0030335 positive regulation of cell migration IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 2.05842
[BP] GO:0030198 extracellular matrix organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.01168
[BP] GO:0043062 extracellular structure organization CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.00648
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.00081
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, MAOB, PDE5A, XDH 2.00081
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX5, AURKB, CA1, CA2, CA4, CA7, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, KDR, KIT, MAOB, MIF, MMP2, MMP9, PDE5A, PIM1, SRC, TERT, TYR, XDH 1.58284
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HCAR2, HSD17B2, IGF1R, KDR, KIT, MAOB, MET, MMP2, PIM1, SRC, TERT, TYR 1.48607
[CC] GO:0005615 None ACHE, AKR1B1, ALOX5, AXL, FABP3, KIT, MIF, MMP12, MMP2, MMP9, XDH 1.21848
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9 1.20895
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TERT 1.12671
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, SRC, TERT, TYR, XDH 10.9003
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.8022
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP12, MMP2, MMP9, PIM1, RORC, TYR, XDH 10.5776
[MF] GO:0043167 ion binding ACHE, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, SRC, TERT, TYR, XDH 8.67573
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.20488
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.07369
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.28735
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.75419
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.68798
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.58718
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.3538
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, MAOB, TYR, XDH 5.32917
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.9986
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.85341
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.83575
[MF] GO:0043169 cation binding ACHE, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, TERT, TYR, XDH 4.7924
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.54036
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.52565
[MF] GO:0046872 metal ion binding ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, RORC, TERT, TYR, XDH 4.33384
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, MAOB, SRC, XDH 4.27515
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.14725
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.10611
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.65658
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.52712
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, RORC 3.35263
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.33001
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.98064
[MF] GO:0008389 None CYP2A13, CYP2A6 2.96657
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.70703
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 2.55293
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MAOB, MET, PDE5A, PIM1, SRC, XDH 2.54757
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 2.42991
[MF] GO:0042802 identical protein binding ACHE, CSNK2A1, FLT3, IGF1R, KDR, KIT, MAOB, MET, MIF, MMP9, TERT, TYR, XDH 2.10864
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, SRC 2.01843
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00081


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.4204
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.0348
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.9
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.8649
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 4.5293
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.1345
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.6914
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.5293
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, MMP9, MET, IGF1R 3.5604
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.5941
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, MAOB, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1B1, TYR, CYP19A1, XDH 3.2177
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 3.0672
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.7286
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, MIF, TYR 3.2177
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.5311
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.7286
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2 2.9519
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.5756
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.5849
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.298
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2 2.5756
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.4658
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.1628
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.2126
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.5756
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.9348
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.7737
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, MET, IGF1R 1.6062
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.6341
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.6062
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5527
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.22
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4516
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2827
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.475
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.22
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3858
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2985
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5 1.1473
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9772
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1127
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1159
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0061
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8608
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1 0.8108
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6465
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5914
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5914
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6465
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5581
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5914
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3537
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6465
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5581
Platelet activation_Homo sapiens_hsa04611 SRC 0.5399
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.4234
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5914
Glioma_Homo sapiens_hsa05214 IGF1R 0.6465
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5914
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5914
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5914
Gap junction_Homo sapiens_hsa04540 SRC 0.5914
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5771
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4116
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.63
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5914
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4224
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5445
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4897
Alcoholism_Homo sapiens_hsa05034 MAOB 0.4533
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5914
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4533
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4462
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5233
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5399
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6251
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.516
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.516
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5271
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5399
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5151
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4897
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5445
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5914
Peroxisome_Homo sapiens_hsa04146 XDH 0.5914
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5914
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4462
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.534
Axon guidance_Homo sapiens_hsa04360 MET 0.5354
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6465
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6465
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5914
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6465
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6465
Bile secretion_Homo sapiens_hsa04976 CA2 0.63
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6465
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6465
Shigellosis_Homo sapiens_hsa05131 SRC 0.6465
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2679
Malaria_Homo sapiens_hsa05144 MET 0.691
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.691
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6902
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7592
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8468
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB, MIF 2.4782
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8468
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7953
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.828
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8468
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8608
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8959


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)