TCM Prescription: Bai Le Mian Capsules



Prescription Description
Prescription IDTCMF7090
Pinyin NameBai Le Mian Jiao Nang
Chinese Name百乐眠胶囊
English NameBai Le Mian Capsules
Function Description滋阴清热, 养心安神。用于肝郁阴虚型失眠症, 症见入睡困难, 多梦易醒, 醒后不眠, 头晕乏力, 烦躁易怒, 心悸不安等。
IndicationsInsomnia
Disease ICD-11 Category 7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationBrain, Heart, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH62 Lilium brownii 百合 TCMH62 ITSAO2415-14
TCMH327 Eleutherococcus senticosus 刺五加 TCMH327 KR080437
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH815 Flos albiziae 合欢花 TCMH815
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH438 Juncus effusus 灯心草 TCMH438 ITSAD4376-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT334 EBP 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Isomerase Q15125
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT434 JAK2 Tyrosine-protein kinase JAK2 Kinase O60674
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT881 BBOX1 Gamma-butyrobetaine dioxygenase Oxidoreductase O75936
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B2, MET, MGLL, PPARA, TRPV1 11.4112
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, FABP3, FUT7, GLO1, HMGCR, MGLL, PIM1, PPARA, TYR, XDH 9.90661
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 9.77714
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, HMGCR, HSD11B1, HSD17B2 9.63884
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 9.36228
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, JAK2, KDR, MMP2, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 7.8005
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HMGCR, HSD17B2, IGF1R, JAK2, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A4, SRC, TRPV1, TYR 7.7895
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MGLL 7.31905
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 7.13743
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MGLL 7.09431
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, TYR, XDH 6.87552
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD17B2, JAK2, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 6.8315
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TERT, TRPV1 6.69251
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, JAK2, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 6.68737
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, MGLL, PPARA 6.68737
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP2, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TYR, XDH 6.65851
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, MGLL, PPARA 6.65851
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, JAK2, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 6.58406
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, NR3C1, PIM1, PPARA, RORC, SRC 6.58406
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, NR3C1, PPARA, RORC, SRC 6.4272
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MGLL 6.41427
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B2, TYR, XDH 6.41427
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 6.22098
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, TYR, XDH 6.17581
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, JAK2, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 6.08001
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, JAK2, NR3C1, RORC, SLC6A4, SRC, TYR 6.05888
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HMGCR, HSD17B2, IGF1R, JAK2, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 6.00465
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CYP1B1, ESR1, FLT3, GLO1, HMGCR, IGF1R, JAK2, KDR, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TRPV1, XDH 6.00465
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CDC25B, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, JAK2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TOP2A, TYR 6.00465
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MGLL 5.88761
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CES1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MGLL, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR 5.74761
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, EBP, HMGCR, TYR 5.73959
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, APEX1, CA2, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, SLC6A4, SRC, TRPV1 5.73131
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 5.73114
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, RORC 5.67379
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, JAK2, NR3C1, PPARA, RORC, SRC 5.66299
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MGLL, PPARA 5.57908
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, JAK2, KCNH2, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1 5.57339
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.49639
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, JAK2, KDR, SLC6A4, SRC 5.45242
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APEX1, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 5.44216
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, EBP, HMGCR, HSD11B1, HSD17B2 5.40835
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SLC6A4, SRC, TRPV1 5.38223
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, GLO1, HMGCR, IGF1R, JAK2, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 5.38223
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B2 5.37465
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EBP, HMGCR, TYR 5.37111
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B2, JAK2 5.37111
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, RORC, SLC6A4, SRC, TRPV1, TYR 5.32654
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APEX1, CA2, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SLC6A4, SRC, TRPV1 5.24197
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.22471
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, GLO1, HMGCR, IGF1R, JAK2, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 5.18494
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC, TRPV1 5.15205
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.13646
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP3A4, EBP, HMGCR, HSD11B1, HSD17B2, MGLL 5.03608
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 4.95036
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, MGLL 4.90631
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, MGLL, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.75477
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, JAK2, KCNH2, MET, SRC, TERT, TRPV1 4.75477
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B2 4.69104
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, GLO1, HMGCR, IGF1R, JAK2, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.50274
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, FABP3, HMGCR, KCNH2, KDR, NR3C1, SLC6A2, SLC6A4, SRC, TRPV1 4.48711
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MGLL, PIM1, PPARA, TYR 4.48711
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.47808
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CYP19A1, CYP1B1, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.47483
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, ESR1, FLT3, HMGCR, IGF1R, JAK2, KDR, MMP12, MMP2, MMP9, PIM1, TERT 4.33552
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR 4.29689
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, JAK2, MMP2, MMP9, TERT 4.29689
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, EBP, HMGCR, MGLL 4.28098
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 4.27677
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HMGCR, JAK2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.22534
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, EBP, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.21455
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CYP19A1, CYP1B1, FLT3, HMGCR, JAK2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.20487
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, MGLL 4.18534
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KCNH2, KDR, NR3C1, SRC, TRPV1 4.0486
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MGLL, PIM1, PPARA, TYR 4.02223
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 3.99091
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, GLO1, MGLL, PIM1, PPARA, TYR 3.93715
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.91457
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.86978
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.8448
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.8448
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, TRPV1, XDH 3.82471
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation JAK2, MMP2, MMP9, TERT 3.80338
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, JAK2, MET, MGLL, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 3.72192
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.68868
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TOP2A, TRPV1, XDH 3.68868
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TRPV1 3.68298
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 3.64355
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 3.62996
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.54363
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.52352
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 3.4737
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TOP2A, XDH 3.36595
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, JAK2, KDR, MET, SRC 3.29513
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, JAK2, KDR, MET, SRC 3.25586
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, PPARA, RORC, SRC 3.25452
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.2371
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, HMGCR, JAK2, KDR, MET, PTPN1, SRC, XDH 3.22492
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, IGF1R, JAK2, KDR, PIM1, SRC 3.16793
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, JAK2, MMP2, MMP9, TERT 3.141
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MGLL, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.12453
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.05544
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, JAK2, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.04726
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.04726
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.03504
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, CA2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EBP, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, JAK2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.01421
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway ESR1, ESR2, JAK2, NR3C1, SRC 3.01421
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, HMGCR, JAK2, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT, TRPV1 2.97056
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, HMGCR, JAK2, KDR, PTPN1, SRC, XDH 2.96035
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, HMGCR, JAK2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.96035
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.94438
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation JAK2, MMP2, MMP9, TERT 2.89987
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MGLL, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.88967
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, HMGCR, JAK2, KCNH2, KDR, MET, MGLL, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, TRPV1, XDH 2.87594
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, JAK2, KDR, MET, MGLL, MMP12, PPARA 2.84018
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 2.83883
[BP] GO:0009115 None AOX1, XDH 2.82695
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.82695
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.82695
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.82695
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, EBP, HMGCR 2.78906
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.77181
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, JAK2, KCNH2, MET, TRPV1 2.76017
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, HMGCR, JAK2, KDR, MMP9, PTPN1, SRC, XDH 2.73021
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, HMGCR, JAK2, KDR, MMP9, PTPN1, SRC, XDH 2.73021
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, NR3C1, SLC6A4, SRC, TRPV1 2.69403
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 2.68564
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, JAK2, KCNH2, MMP12, SLC6A4, SRC, TERT, TRPV1 2.68396
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HMGCR, IGF1R, JAK2, PTPN1, SRC 2.65002
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.64299
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 2.63861
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation IGF1R, JAK2, KDR, SRC 2.6386
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, ESRRA, FABP4, FLT3, HMGCR, JAK2, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 2.63691
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.63691
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, JAK2, KDR, MET, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TOP2A, TRPV1 2.62916
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.62916
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.62916
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CYP1B1, ESR1, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MMP9, PTPN1, SRC, XDH 2.60251
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 2.59768
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, HMGCR, JAK2, KDR, MMP9, PTPN1, SRC, XDH 2.59608
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, HMGCR, IGF1R, JAK2, KDR, PTPN1, SRC, XDH 2.53878
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, HMGCR, MMP2, PPARA, SLC6A4, SRC, TERT, TRPV1, TYR 2.53878
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, JAK2, PTPN1, SRC 2.53878
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.53181
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.52923
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 2.51825
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CDC25B, CES1, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, JAK2, KDR, MET, MMP2, MMP9, RORC, SRC, TERT, TOP2A 2.49526
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HMGCR, KDR, SRC, TRPV1 2.49526
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.49526
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, HMGCR, IGF1R, JAK2, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.49417
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, JAK2, PPARA 2.47338
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.46707
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.46707
[BP] GO:0046110 None AOX1, XDH 2.45665
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.45665
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, IGF1R, JAK2, KDR, MET, MMP9, SRC, TERT 2.43253
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESRRB, HMGCR, JAK2, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT, TRPV1 2.41743
[BP] GO:0006066 None AKR1B1, AKR1B10, CES1, CYP1B1, CYP3A4, EBP, HMGCR 2.39902
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, JAK2, MMP12, SLC6A4, SRC, TRPV1 2.37932
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC, TRPV1, TYR 2.36263
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, JAK2, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.34785
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4 2.33453
[BP] GO:0048511 rhythmic process AXL, ESR1, PPARA, RORC, SLC6A4, SRC, TOP2A 2.33453
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, HMGCR, SLC6A4, TRPV1, TYR 2.33415
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.3237
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.3237
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, HMGCR, IGF1R, JAK2, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.31568
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.29467
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.2919
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28775
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.28529
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, FLT3, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, PIM1, PTPN1, SRC, XDH 2.25806
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, JAK2, MGLL, MMP12, MMP2, PPARA, PTPN1, SRC 2.25332
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, JAK2, MET, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TOP2A, TRPV1 2.24436
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23786
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.22478
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 2.22478
[BP] GO:0006145 None AOX1, XDH 2.22478
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.22478
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.22478
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, HMGCR, JAK2, KDR, MMP9, PTPN1, SRC, XDH 2.22478
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.2202
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.20974
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.20974
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.20768
[BP] GO:0016125 None CES1, CYP19A1, CYP1B1, EBP, HMGCR 2.20713
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, JAK2, MGLL, MMP2, MMP9, PPARA, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1 2.19024
[BP] GO:0019433 None FABP3, FABP4, MGLL 2.16224
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, JAK2, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.15957
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 2.14559
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, SLC6A4, SRC, TRPV1, TYR 2.13444
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, HMGCR, IGF1R, JAK2, KDR, MET, MGLL, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.13444
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.12199
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, ESR1, ESR2, ESRRA, ESRRB, IGF1R, JAK2, KDR, MET, MMP12, NR3C1, PPARA, RORC, SRC, TERT, TOP2A 2.09493
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, TERT 2.09417
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CYP1A1, HMGCR, SLC6A4, SRC, TRPV1, TYR 2.09174
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, SLC6A4, SRC 2.07386
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, FLT3, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, PIM1, PTPN1, SRC, XDH 2.06265
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.05707
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.04896
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.04896
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.04505
[BP] GO:0032845 None ADORA1, ADRA2A, HMGCR, SRC, TRPV1 2.00382
[BP] GO:0050730 None ADORA1, ADRA2A, FLT3, JAK2, PTPN1, SRC 2.00064
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, JAK2, KCNH2, KDR, MGLL, MMP2, MMP9, NR3C1, PIM1, PTPN1, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 3.13751
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, FLT3, HMGCR, HSD11B1, HSD17B2, MGLL, PTPN1 2.62916
[CC] GO:0005783 None ADORA1, APEX1, CA4, CES1, CES2, CYP19A1, EBP, FLT3, HMGCR, KDR, PTPN1, XDH 2.22864
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, ESR1, FLT3, GLO1, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.12199
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, ESR1, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 2.05707
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 17.043
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CDC25B, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EBP, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TOP2A, TYR, XDH 10.7387
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, IGF1R, JAK2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TOP2A, TRPV1, TYR, XDH 10.1795
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, JAK2, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 9.4194
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GLO1, JAK2, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 9.04774
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH 7.99293
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.99293
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B2, TYR, XDH 7.56108
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC 6.89848
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.17581
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7 5.57908
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.45242
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, JAK2, SRC 5.37784
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.37111
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.31242
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.31242
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, NR3C1, RORC 5.29082
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, JAK2, SRC 5.19739
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.15205
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.05977
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 5.04429
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, GLO1 4.33473
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, ESR1, ESR2, FLT3, HMGCR, IGF1R, JAK2, KCNH2, KDR, MET, MGLL, MMP9, SLC6A4, TERT, TOP2A, TRPV1, TYR, XDH 4.29689
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 4.15878
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, NR3C1, PPARA, RORC, TRPV1 4.13632
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD17B2, XDH 4.09675
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, EBP, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 4.05902
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, IGF1R, JAK2, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TOP2A, TRPV1 3.94755
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, JAK2, SRC, XDH 3.93559
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, APEX1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.83793
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 3.77372
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.44182
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, EBP, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.38988
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, JAK2, KDR, MET, SRC 3.36681
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.29388
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, EBP, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 3.22492
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP3A4 3.10441
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.98992
[MF] GO:0052689 carboxylic ester hydrolase activity ACHE, CA1, CA2, CES1, CES2, MGLL 2.92673
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, EBP, ESR1, ESR2, ESRRA, ESRRB, FLT3, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 2.88272
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82695
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.82695
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, HMGCR, KCNH2, MGLL, SLC6A4, TERT, TOP2A, TYR, XDH 2.80676
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.73121
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, HMGCR, JAK2, KCNH2, MET, NR3C1, PPARA, PTPN1, SLC6A4, SRC, TOP2A 2.62627
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.46707
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.45665
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.45665
[MF] GO:0005330 None SLC6A2, SLC6A4 2.45665
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.45665
[MF] GO:0047374 None CES1, CES2 2.45665
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CES1, CES2, MGLL, PTPN1 2.39294
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.39055
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B2 2.31009
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, IGF1R, JAK2, KCNH2, KDR, MET, PIM1, SRC 2.23786
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, FLT3, HMGCR, KCNH2, MGLL, SLC6A4, TERT, TOP2A, TYR, XDH 2.23778
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.22478
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.22478
[MF] GO:0032795 None ADORA1, ADRA2A 2.22478
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.22478
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.12199
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.07856
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.04896
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04896
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, JAK2 2.00186


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP2C19, CYP19A1, HSD11B1, EBP, FUT7, AKR1B10, ALOX5, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, MGLL, CES1 8.0185
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.8719
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.5378
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4016
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 5.1906
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.1973
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1973
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3429
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9477
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.7565
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9477
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 3.5321
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.7873
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, CYP2C19 3.375
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, JAK2, ESR1, ESR2 3.2289
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.324
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4, CYP2C19 3.2765
Adherens junction_Homo sapiens_hsa04520 PTPN1, SRC, MET, IGF1R 3.2075
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2765
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0425
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, MGLL 2.3383
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, ADRA2A 2.0045
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1, MGLL 2.2923
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9205
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.0786
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.7873
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9205
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7873
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, JAK2 1.7873
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7592
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4876
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, JAK2, IGF1R 1.4551
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1, JAK2 1.3527
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.3107
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, JAK2, MET, IGF1R 1.2056
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0522
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3107
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3527
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0709
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0295
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9401
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2615
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, JAK2 0.9566
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2431
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.963
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2592
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, JAK2 1.2452
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1852
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9401
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, JAK2 0.9401
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9401
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8213
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9344
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.9165
Tuberculosis_Homo sapiens_hsa05152 SRC, JAK2 0.7151
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC, JAK2 0.6921
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.6542
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2437
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2437
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7873
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2906
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3
Herpes simplex infection_Homo sapiens_hsa05168 JAK2 0.3283
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3405
Influenza A_Homo sapiens_hsa05164 JAK2 0.3405
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3796
Platelet activation_Homo sapiens_hsa04611 SRC 0.4196
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3683
Measles_Homo sapiens_hsa05162 JAK2 0.404
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4073
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.404
Tight junction_Homo sapiens_hsa04530 SRC 0.404
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4196
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4073
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4843
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4499
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4196
Axon guidance_Homo sapiens_hsa04360 MET 0.4153
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4724
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4724
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4695
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4779
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4843
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4843
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4843
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 MGLL 0.4724
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4779
Gap junction_Homo sapiens_hsa04540 SRC 0.4843
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7033
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4843
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4843
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4779
Peroxisome_Homo sapiens_hsa04146 XDH 0.4852
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.524
Leishmaniasis_Homo sapiens_hsa05140 JAK2 0.5242
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5589
Glioma_Homo sapiens_hsa05214 IGF1R 0.5589
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9348
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5581
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5634
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5589
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5589
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7592
Shigellosis_Homo sapiens_hsa05131 SRC 0.5589
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6916
Malaria_Homo sapiens_hsa05144 MET 0.6383
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6436
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6407
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6921
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.777
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7577
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7918
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8213
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7844
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.815
Steroid biosynthesis_Homo sapiens_hsa00100 EBP 0.9133
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8804
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9961
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2075
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2677


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)