TCM Prescription: Qing Re Jie Du Ruan Capsules



Prescription Description
Prescription IDTCMF7053
Pinyin NameQing Re Jie Du Ruan Jiao Nang
Chinese Name清热解毒软胶囊
English NameQing Re Jie Du Ruan Capsules
Function Description清热解毒。用于热毒壅盛所致发热面赤, 烦燥口渴, 咽喉肿痛; 流感, 上呼吸道感染见上述证候者
IndicationsInfluenza, Upper respiratory infection(uri)
Disease ICD-11 Category 1E32 [Influenza, virus not identified, 季节性流行性感冒，病毒尚未鉴定 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung, blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH2083 Viola philippica 甜地丁 TCMH2083 ITSAJ4283-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MMP2, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 13.0201
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.9579
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 12.9579
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR 12.7942
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, INSR, MAOB, MMP2, MMP9, NR3C1, PPARA, PTGS2, RORC, SRC, TEK, TYR 12.4005
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PDE5A, PGR, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 11.4067
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.1702
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.1439
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.6264
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 10.6264
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, KIT, MAOB, MMP2, NR3C1, PPARA, PTGS2, SMAD3, SRC, TEK 10.5799
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP2, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 10.2621
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.0955
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 10.028
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.97637
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.93592
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MAOB, MMP9, PTGS2, SRC, TERT 9.87422
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOB, MET, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.58432
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, RORC, SMAD3, SRC, TERT 9.34133
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 9.27038
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.20047
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 8.83996
[BP] GO:0033993 response to lipid ALPL, AR, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MAOB, NR3C1, PTGS2, RORC, SRC, TYR 8.70448
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, FLT3, MAOB, NR3C1, PTGS2, RORC, SRC, TEK, TYR 8.66506
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, FABP4, FLT3, FUT7, GSK3B, HSD17B2, INSR, KDR, KIT, MAOB, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TYR 8.51191
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, MAOB, NR3C1, PPARA, PTGS2, SRC, TEK 8.44723
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.44723
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 8.42073
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.42073
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.4155
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.39893
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.36769
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 8.24745
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 8.24745
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PTGS2, RORC, SMAD3, SRC 8.09184
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DHFR, DUSP3, DYRK1A, EGFR, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 8.05873
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.01124
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.9993
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DYRK1A, EGFR, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.93984
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, NUAK1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT 7.92066
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 7.92059
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.57355
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, HSD17B2, INSR, KDR, KIT, MAOB, MMP9, PGR, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 7.57355
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.48771
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PPARA, PTGS2 7.43022
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.43016
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, HSPA1A, IDO1, PDE5A, PIM1, PPARA, PTGS2, TYR, XDH 7.41798
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 7.40529
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 7.30784
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.27739
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.21024
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.14535
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MAOB, MMP9, PTGS2, TERT 7.01735
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 7.00706
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR3C1, NUAK1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TYR 7.00706
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.9371
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.9371
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 6.68294
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.68071
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.49704
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.37299
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.27139
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.20201
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, DNMT1, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 6.20201
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IDO1, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 6.1866
[BP] GO:0048513 animal organ development ACHE, AR, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.12033
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.12033
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.0706
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.99297
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.93873
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.9322
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.93003
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.93003
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.91558
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.91396
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH 5.9061
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 5.87302
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.8712
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.83682
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.81878
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 5.8083
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, FLT3, INSR, KDR, KIT, PDE5A, PTPN1, SRC, TEK, XDH 5.69964
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.69334
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, GSK3B, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 5.66477
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 5.65406
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCL2, DUSP3, DYRK1A, EGFR, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.62124
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCL2, DUSP3, DYRK1A, EGFR, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 5.60195
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 5.60022
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, GSK3B, KIT, PGR, PPARA, RORC, SRC 5.58946
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, MAOB, NR3C1, PTGS2, SRC 5.58368
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PDE5A, PTPN1, SRC, TEK, XDH 5.58021
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, INSR, MAOB, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT 5.51201
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.49084
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.49084
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AR, AURKB, BCL2, CDC25B, DHFR, EGFR, FLT3, GSK3B, HSPA1A, INSR, KIT, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.37627
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.35901
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DUSP3, DYRK1A, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH 5.33098
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DNMT1, EGFR, GSK3B, IGF1R, INSR, MMP2, MMP9, NR3C1, PTGS2, RORC, SRC 5.3154
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DNMT1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 5.26726
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.25211
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, EGFR, PPARA, SMAD3 5.24456
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.23592
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.20741
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.15763
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, KIT, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR 5.15763
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, DNMT1, EGFR, FLT3, GSK3B, IGF1R, INSR, KIT, MMP2, NR3C1, PTGS2, SMAD3, SRC 5.08712
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, IDO1, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 5.07938
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 5.02431
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.01051
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.98802
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.98169
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.87098
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DNMT1, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 4.86548
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 4.86251
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.82564
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.81044
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.81044
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, INSR, KDR, KIT, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, TNKS2, XDH 4.81044
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TERT 4.80962
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, FLT3, NR3C1, PTGS2, RORC, SRC 4.78058
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.75671
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, KDR, MAOB, NR3C1, PTGS2, SRC 4.72034
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, GSK3B, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC, TERT 4.71623
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, KIT, MET, PPARA, PTGS2 4.71281
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PTGS2, RORC, SRC, TEK 4.65799
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, MAOB, NR3C1, PTGS2, SRC 4.64629
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.63879
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.58768
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, FLT3, KIT, MET, PIM1, SRC, TEK, TYR 4.56364
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 4.54511
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS 4.53937
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50439
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, KIT, PDE5A, PTPN1, SRC, TEK, TNKS 4.43295
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2 4.42716
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 4.4246
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.39967
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 4.39967
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 4.39967
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 4.3805
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, EGFR, FLT3, GSK3B, HSPA1A, INSR, KIT, PDE5A, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.3805
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.32366
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.31247
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, MAOB, NR3C1, SRC 4.24106
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 4.23078
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CYP1B1, FABP3, HSPA1A, IDO1, PDE5A, PTGS2, SMAD3, TERT, XDH 4.23078
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DUSP3, DYRK1A, EGFR, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH 4.22549
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.22231
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, KIT, PGR, PTGS2, SRC 4.22231
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.20995
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 4.2099
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 4.18692
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DHFR, MAOB, TYR 4.17039
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.16274
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.09691
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, IDO1, INSR, KIT, MMP2, MMP9, PGR, PTGS2, SRC 4.0639
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 4.0639
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PDE5A, PTPN1, SRC 4.04825
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, IDO1, KIT, MMP2, MMP9, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 4.04825
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS2, SRC 4.01825
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, HSPA1A, IDO1, MAOB 4.00825
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, GSK3B, KDR, KIT, MET, MMP2, MMP9, PGR, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT 3.96413
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.95927
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.93398
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.92782
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, BCL2, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, FABP4, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.91678
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, MAOB, NR3C1, PTGS2 3.89869
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.88794
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.88794
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 3.81914
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK, XDH 3.76355
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 3.76355
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 3.75534
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.74805
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.73931
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.73877
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.71335
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK 3.66962
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.66962
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT 3.6682
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.6682
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.6682
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 3.66248
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.62538
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.61087
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, KIT, PTGS2 3.61087
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.60714
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.60448
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2, TNKS, TNKS2 3.58566
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.58566
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, DNMT1, EGFR, FLT3, GPR35, GSK3B, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.58566
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 3.56663
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.55583
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, GSK3B, IDO1, INSR, KDR, KIT, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS2, XDH 3.55583
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, GSK3B, KDR, SMAD3, SRC, TEK 3.55333
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.53549
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC, TERT 3.49793
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 3.44702
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.44638
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.44638
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.41503
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, HCAR2, HSPA1A, IDO1, KIT, MMP12, MMP2, PDE5A, PTPN1, PTPRS, SMAD3, SRC 3.41468
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PDE5A, PTPN1, SRC, TEK 3.41298
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 3.39984
[BP] GO:0043412 macromolecule modification ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.38955
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.3805
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.37792
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.37511
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.36451
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.35618
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR3C1, PGR, PIM1, PPARA, RORC, SRC 3.34328
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.34256
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.34256
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CYP1B1, IDO1, INSR, KDR, KIT, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK, TERT 3.34123
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.30367
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, GPR35, GSK3B, HCAR2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.30237
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DNMT1, EGFR, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 3.28682
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, INSR, MAOB, PTGS2, SMAD3 3.26571
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.26139
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.26139
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.2083
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.2083
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.19226
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PDE5A, PTPN1, SRC 3.16909
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, GSK3B, KDR, SMAD3, SRC, TEK 3.16909
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TNKS 3.16471
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.1518
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.14703
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2 3.14703
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.14392
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.14392
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 3.14096
[BP] GO:0048608 reproductive structure development AR, AXL, BCL2, CYP19A1, HSD17B2, INSR, KIT, SRC 3.11198
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PDE5A, PTPN1, SRC 3.10873
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.10581
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.09897
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.09726
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 3.07791
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 3.06327
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 3.04664
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, PDE5A, PTPN1, SRC, TEK, TNKS 3.03311
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 3.01518
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 3.01034
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.00462
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.99936
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, PTGS2, SRC 2.99936
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, DHFR, EGFR, FLT3 2.96627
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94629
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2 2.94629
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.94629
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.92171
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.89747
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, GSK3B, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.89692
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, GPR35, MAOB, MMP9, PTGS2 2.89147
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, APP, AXL, BCL2, EGFR, GPR35, GSK3B, IDO1, PDE5A, PTGS2, PTPRS, SMAD3, TEK, TERT, XDH 2.87795
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 2.87795
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.87795
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.87795
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, PTGS2, SRC 2.87633
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, DYRK1A, GSK3B, TNKS 2.86254
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 2.85379
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MAOB, PDE5A, XDH 2.84018
[BP] GO:1903827 regulation of cellular protein localization APP, AR, BCL2, CSNK2A1, EGFR, GSK3B, PTGS2, PTPN1, SMAD3, SRC, TERT 2.83378
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.80829
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PDE5A, PTPN1, SRC 2.79513
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 2.79474
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 2.78713
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.78323
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, MAOB, SRC 2.77982
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.76091
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 2.7592
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CYP1B1, EGFR, GSK3B, IDO1, INSR, KDR, KIT, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH 2.75432
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CYP19A1, DUSP3, IDO1, MMP12, PDE5A, PTPRS 2.75137
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.74356
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, GSK3B, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.72244
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.70606
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.6888
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.65666
[BP] GO:0010906 None GSK3B, INSR, PPARA, RORC, SRC 2.64106
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.63201
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63201
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.63201
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CSNK2A1, EGFR, GSK3B, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.63201
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.62571
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.60837
[BP] GO:0050678 None AR, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.5883
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, PIM1, PTPRS, SMAD3, TNKS2 2.58427
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.57203
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.56995
[BP] GO:0060748 None AR, PGR 2.56742
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.56742
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.561
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.561
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.561
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.561
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.55854
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, TEK, TYR 2.55555
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, GSK3B, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.55555
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.55555
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PDE5A, PTPN1, SRC, TEK 2.53876
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.53876
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.53876
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, SRC, TERT 2.53201
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, EGFR, KIT, PGR, PTGS2, SRC 2.52814
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.52463
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.51925
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.51177
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.50954
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.50323
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.48535
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.48535
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, GSK3B, KDR, SMAD3, TEK 2.48502
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.46667
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, KDR, KIT, PTGS2, TEK, TERT 2.46508
[BP] GO:0035295 tube development AKR1B1, AR, CYP1A1, EGFR, KIT, SMAD3 2.46508
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT 2.45896
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.45301
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, KIT, PDE5A, PTPN1, SRC 2.44568
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.43952
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, GSK3B, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.4383
[BP] GO:2000243 None AR, INSR, PDE5A, SRC 2.43639
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 2.42532
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9, RORC 2.4219
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.41902
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.41326
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.41326
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.41326
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.41326
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.40763
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, RORC, SMAD3, SRC 2.38336
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DYRK1A, GSK3B, SRC, TNKS 2.36315
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.36015
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, TYR 2.35926
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.35726
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.34399
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.34372
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.33802
[BP] GO:0051248 None APP, CSNK2A1, DHFR, DNMT1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.33802
[BP] GO:0070213 None TNKS, TNKS2 2.33165
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33165
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.32436
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.31596
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CYP1A1, CYP1A2, GSK3B, IDO1, MAOB, MMP12, PTGS2, SMAD3, SRC 2.31159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.31039
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.28776
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, GSK3B, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.28776
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.27061
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.27061
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26081
[BP] GO:0010675 None GSK3B, INSR, PPARA, RORC, SRC 2.25924
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, EGFR, FABP3, FABP4, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.25616
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.24662
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.23006
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.22922
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, APP, BCL2, CA2, CA7, GPR35, MAOB, MMP9, PTGS2 2.22622
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.22534
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, KIT, PTGS2, TYR 2.22437
[BP] GO:0051129 negative regulation of cellular component organization APP, AR, DNMT1, GSK3B, HSPA1A, MET, PTPRS, SRC, TNKS, TNKS2 2.21757
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.21757
[BP] GO:0010629 None APP, AR, AURKB, DHFR, DNMT1, DYRK1A, FABP4, HSPA1A, KDR, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, XDH 2.20893
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.20611
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.20611
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, GPR35, GSK3B, HSPA1A, MAOB, MMP9, PTGS2 2.20611
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SMAD3, SRC, XDH 2.20611
[BP] GO:0051052 regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.19917
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.17342
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17342
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR3C1, NR3C2, PGR, PPARA, RORC 2.14864
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.14509
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.14101
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.14097
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.13217
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.13217
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, INSR, SRC 2.12393
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.12393
[BP] GO:1903829 positive regulation of cellular protein localization APP, BCL2, EGFR, GSK3B, PTGS2, SMAD3, SRC, TERT 2.12202
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, BCL2, EGFR, MET, SRC, TEK 2.11556
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, PDE5A, PTPN1, SRC 2.10718
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.0986
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET 2.0963
[BP] GO:0044057 None ADORA1, ADORA3, EGFR, GPR35, HCAR2, KIT, PDE5A, PTGS2, SMAD3 2.0786
[BP] GO:0010628 positive regulation of gene expression APP, AR, DNMT1, EGFR, GSK3B, HSPA1A, INSR, KIT, MET, MMP12, NR3C1, PGR, PPARA, RORC, SMAD3, SRC, TERT, TNKS 2.07218
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.05836
[BP] GO:0007623 circadian rhythm DYRK1A, EGFR, GSK3B, PPARA, RORC 2.05804
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.05627
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.05627
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.05207
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.05037
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.04907
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.0436
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, DNMT1, DYRK1A, EGFR, FABP4, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.02854
[BP] GO:0048638 regulation of developmental growth APP, AR, BCL2, INSR, PIM1, PTPRS, TNKS2 2.0283
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.02315
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1 2.01487
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.01487
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.01145
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PTPN1, SRC, TEK 2.00709
[BP] GO:0022602 ovulation cycle process BCL2, KIT, PGR, SRC 2.00639
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.00639
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.00449
[BP] GO:1990535 None APP, INSR 2.00449
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.00449
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GPR35, GSK3B, HCAR2, HSD17B2, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP2, NR3C2, PGR, PIM1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 2.96595
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.89692
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.87992
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT 2.85379
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, KIT, MAOB, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.831
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.6138
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, DHFR, DUSP3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, NR3C1, NR3C2, PDE5A, PGR, PIM1, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 2.55555
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, APP, AR, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FABP3, FABP4, FLT3, FUT7, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 2.46548
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.42532
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.34365
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PTGS2, PTPRS, SRC, TEK 2.14588
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00449
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 14.7628
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TNKS, TNKS2, TUBB3, TYR, XDH 14.7628
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 14.1463
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.0955
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.77086
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.9993
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, SMAD3, TNKS 7.97741
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.38937
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 6.75573
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 6.4481
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.27716
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 6.21424
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.04981
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK 6.04923
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.49084
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.30356
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NR3C1 5.15763
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.10977
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 5.10848
[MF] GO:0003707 steroid hormone receptor activity AR, NR3C1, NR3C2, PGR, PPARA, RORC 4.77883
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DHFR, DYRK1A, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NUAK1, PDE5A, PIM1, PTPRS, SRC, TEK, TUBB3, XDH 4.71623
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.65799
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 4.61891
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3, XDH 4.6178
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TERT 4.45436
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 4.10228
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.99473
[MF] GO:0005496 steroid binding AR, HSD17B1, NR3C1, NR3C2, PGR, RORC 3.93119
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS2, SRC 3.9166
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TUBB3, XDH 3.89869
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, PTPRS, SRC, TEK 3.78002
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.7337
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DNMT1, DYRK1A, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, KIT, MAOB, MET, MMP12, NR3C1, NR3C2, NUAK1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TUBB3, XDH 3.64782
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, MAOB, PTGS2, SRC, XDH 3.61024
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.55583
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.55583
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.55583
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.49496
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.44638
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, PTPRS, SRC, TEK, TUBB3 3.38955
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.35623
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, GSK3B, HSPA1A, KIT, MET, NR3C1, PGR, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2 3.34503
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.34328
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 3.31987
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.22044
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 3.16959
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.09897
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, KDR, KIT, MAOB, MET, MMP9, PGR, PTGS2, SMAD3, TERT, TYR, XDH 3.09726
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.09459
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.98097
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.96627
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.94791
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 2.88794
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 2.85813
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TUBB3 2.85206
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.74356
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.6996
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.66043
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, PGR, PPARA, RORC 2.6138
[MF] GO:0004879 nuclear receptor activity AR, PGR, PPARA, RORC 2.6138
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.58226
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.56742
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TUBB3 2.55854
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.50013
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC 2.48502
[MF] GO:0051425 None APP, INSR 2.33165
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.28776
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.26931
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.24541
[MF] GO:0043559 insulin binding IGF1R, INSR 2.14509
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.13737
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05207
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00449


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.8035
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8035
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, PTGS2, MMP9, EGFR, IGF1R, AR, KIT, BCL2, MET 6.9957
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.758
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, MAOB, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, DHFR, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.575
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 5.4435
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.6019
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1, IDO1 5.1166
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.7064
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.1125
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.1309
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.1247
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 3.9003
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, EGFR, IGF1R 3.9003
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.671
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, BCL2, EGFR, IGF1R 3.6796
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 3.5072
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 3.8251
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.4479
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5, ALOX15, PTGS2 3.3174
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2 3.3378
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 3.205
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.0925
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.4774
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0008
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0612
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, INSR, PPARA 2.3687
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1059
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.0092
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.8745
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.168
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.1059
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 1.8447
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0771
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, BCL2 2.1038
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.9846
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0141
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7607
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC, EGFR 1.7796
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7557
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2, HSPA1A 1.6596
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.704
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.7762
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT, TYR 1.6914
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.739
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.542
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.4011
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.5086
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.53
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, HSPA1A 1.414
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, EGFR 1.4325
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.5068
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, INSR 1.4011
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, NR3C1 1.3232
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, IGF1R 1.399
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.399
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, INSR, PPARA 1.3419
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.3896
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.3095
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, GSK3B, APP 1.2671
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.1121
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, TERT 0.8952
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.9255
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.9237
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2685
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2961
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.8894
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 0.8952
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8952
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3016
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3016
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8693
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8139
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7062
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7414
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0362
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOB 0.8492
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.8564
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.7602
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.6899
Influenza A_Homo sapiens_hsa05164 GSK3B, HSPA1A 0.6899
Phagosome_Homo sapiens_hsa04145 TUBB3 0.345
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.355
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6859
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3704
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0648
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3822
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.6631
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0771
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.0898
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6165
Platelet activation_Homo sapiens_hsa04611 SRC 0.4111
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2677
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.156
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.2142
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4639
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4686
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4686
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4639
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4706
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4757
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.475
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4686
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2671
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, EGFR 1.399
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4883
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2198
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2677
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2 1.2371
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4944
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2677
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5085
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4934
Peroxisome_Homo sapiens_hsa04146 XDH 0.5098
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3218
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5482
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5482
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5482
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5346
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5464
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5544
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5702
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.5678
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, NR3C2 1.5578
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5753
Shigellosis_Homo sapiens_hsa05131 SRC 0.5728
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5969
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6169
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6203
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7194
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6203
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6203
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6394
Malaria_Homo sapiens_hsa05144 MET 0.6444
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6436
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.6444
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6436
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6451
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.739
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.6326
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6582
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6914
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6645
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8665
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6171
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6631
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6899
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7328
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7328
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7657
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8139
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8164
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.1724
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7749
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8139
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.845
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8952
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9363
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0574


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)