TCM Prescription: Shan Mai Jian Pi Oral Liquid



Prescription Description
Prescription IDTCMF6974
Pinyin NameShan Mai Jian Pi Kou Fu Ye
Chinese Name山麦健脾口服液
English NameShan Mai Jian Pi Oral Liquid
Function Description消食健脾, 行气和胃。
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH672 Alpinia officinarum 高良姜 TCMH672 ITSAK2176-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.5731
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.7879
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, IDO1, MPO, PIM1, PTGES, PTGS2, TYR, XDH 11.4662
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGES, PTGS2, RORC, SRC, TYR 11.1073
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IDO1, IGF1R, MPO, PTGES, PTGS2, RORC, SRC, TYR 9.44842
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, PTGES, PTGS2, RORC, SRC, TYR 9.04638
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 8.16732
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PTGES, PTGS2, RORC, SRC, TYR 7.88023
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 7.5058
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, PTGES, PTGS2, RORC, SRC, TYR 7.00462
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.8865
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PTGES, PTGS2 6.37505
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, PTGES, PTGS2, SRC 6.36908
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3 5.84135
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 5.84135
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 5.66819
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FLT3, IDO1, IGF1R, KDR, PIM1, PTGES, PTGS2, SRC, XDH 5.18983
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 5.18104
[BP] GO:0010647 positive regulation of cell communication AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, HCAR2, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 5.16293
[BP] GO:0023056 positive regulation of signaling AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, FLT3, HCAR2, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 5.14458
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SRC, XDH 5.02845
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 4.94053
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.87164
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PTGS2, SRC 4.76808
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3 4.73759
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.56136
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, APP, AXL, BCL2, CYP1B1, F2, F3, FLT3, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 4.5012
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, PTGS2, SRC 4.47107
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC 4.38999
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36496
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SRC 4.31373
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, SRC, TYR 4.25358
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD17B2, KDR, MET, MPO, PIM1, PTGS2, RORC, SRC, TYR 4.1979
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGES, PTGS2, SRC 4.1979
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, F3, FABP3, FABP4, FLT3, HSD17B2, IDO1, IGF1R, KDR, MPO, PTGES, PTGS2, PTPN1, RORC, SRC, TYR 4.1979
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 4.16259
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MET, PTGS2, SRC, XDH 3.93131
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F2, F3, FLT3, HTR6, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.92538
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SRC 3.92538
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.90472
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.78756
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MPO, PTGS2, SRC 3.75519
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 3.75519
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FLT3, HSD17B2, KDR, PIM1, PTGS2, RORC, SRC, TYR 3.71127
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 3.71127
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.71127
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.71127
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SRC 3.71127
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HCAR2, HTR6, IDO1, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, RORC, SRC, XDH 3.71127
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, RORC, SRC 3.71127
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, PTGS2, RORC, SRC 3.52742
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.41663
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.38426
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, KDR, SRC 3.3012
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, RORC, SRC 3.3012
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.3012
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F2, F3, FABP4, HSD17B2, IDO1, IGF1R, MET, MPO, PIM1, PTGS2, RORC, SRC, TYR 3.22027
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, F2, IDO1, MPO, PTGES, PTGS2, SRC 3.22027
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PTGES, PTGS2 3.21463
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, PTGS2, RORC, SRC 3.21463
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18415
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, F2, F3, FLT3, HTR6, KDR, MET, PTGS2, PTPN1, SRC, XDH 3.12592
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, PTGES, PTGS2 3.11899
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, F2, IDO1, MPO, PTGES, PTGS2, SRC 3.07573
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.97343
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, FLT3, HTR6, IDO1, KDR, MET, PTGS2, PTPN1, SRC, XDH 2.97134
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 2.93867
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, ESR1, F2, F3, FLT3, IGF1R, KDR, PIM1, PTGS2 2.88769
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, FABP3, KDR, PTGS2, SRC 2.87675
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.87074
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.85344
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.85037
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, F2, HCAR2, KDR, PTGS2, SRC 2.81947
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.79564
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, RORC, SRC 2.79564
[BP] GO:0009115 None AOX1, XDH 2.79452
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, F2, FABP3, FLT3, HCAR2, PTGS2, RORC, SRC 2.79415
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, SRC, XDH 2.77403
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS2 2.73233
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.70323
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.69801
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.64661
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2 2.63866
[BP] GO:0032103 positive regulation of response to external stimulus F2, F3, FABP4, IDO1, KDR, MET, PTGS2 2.59935
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIM1, SRC, TYR 2.59935
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.59935
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.58624
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.55039
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HTR6, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.53892
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO 2.53746
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, XDH 2.53205
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, ESRRB, F2, F3, HCAR2, IDO1, KDR, MET, PIM1, PTGS2, SRC 2.52561
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD17B2, IDO1, PTGS2, SRC 2.48082
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, PTGS2, PTPN1, RORC, SRC 2.48082
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGES, PTGS2 2.47753
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC 2.47753
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.47098
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.46397
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PTGES, PTGS2 2.41831
[BP] GO:0046110 None AOX1, XDH 2.41831
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.41831
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PTGS2, SRC 2.38349
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, F2, KDR, SRC 2.37029
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.37029
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.36385
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.36385
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, MPO, PTGS2, SRC, TYR 2.36178
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, IDO1, MPO, PTGES, PTGS2 2.31676
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.31321
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.30174
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, IDO1, MPO, SRC, XDH 2.29777
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, PTGES, PTGS2, SRC 2.29777
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, XDH 2.28631
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, PTGS2, SRC 2.27977
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.27099
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.21206
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, F2, HCAR2, PTGS2 2.21206
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.20291
[BP] GO:0006145 None AOX1, XDH 2.18044
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18044
[BP] GO:0010562 positive regulation of phosphorus metabolic process APP, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, KDR, PTGS2, PTPN1, SRC, XDH 2.15211
[BP] GO:0045937 positive regulation of phosphate metabolic process APP, BCL2, CDC25B, ESRRB, F2, FABP3, FLT3, KDR, PTGS2, PTPN1, SRC, XDH 2.15211
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.14648
[BP] GO:0030334 regulation of cell migration APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, MET, PTGS2, SRC 2.11295
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PTGES, PTGS2 2.10318
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, ESR1, F2, FABP3, FABP4, MET 2.09376
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGES, PTGS2, TYR 2.08249
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.07874
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, MET, PTGS2, SRC 2.06227
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.06109
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 2.04898
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PTGES, PTGS2, TYR 2.02863
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.02576
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.02576
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, IDO1, MPO, SRC, XDH 2.02481
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, PTGS2, SRC 2.01702
[BP] GO:0010641 None F3, SRC 2.01702
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.01702
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.45396
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.89568
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, KDR, MPO, PIM1, PTGES, PTGS2, PTPN1, SRC, TYR, XDH 1.88889
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, FLT3, HSD17B2, PTGES, PTGS2, PTPN1 1.66716
[CC] GO:0043226 organelle ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, HTR6, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, RORC, SRC, TYR, XDH 1.20991
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.9953
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PIM1, PTPN1, RORC, TYR, XDH 14.047
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.7879
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2731
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, RORC, SRC, TYR, XDH 11.1548
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, F3, FLT3, FUT7, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGES, PTGS2, PTPN1, SRC, TYR, XDH 9.04638
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.21886
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, IDO1, MPO, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 6.69457
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PTPN1, RORC 6.28962
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, IDO1, MPO, PIM1, PTGS2, PTPN1, RORC, TYR, XDH 6.28962
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TYR, XDH 5.97898
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 5.66266
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC 5.41883
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, PTGES, PTGS2, SRC, XDH 5.20349
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.16259
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, RORC 3.95601
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.95601
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.89283
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75519
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.71127
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, RORC 3.67316
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59543
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.57659
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD17B1, HSD17B2, XDH 3.21463
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, HSD17B1, RORC 3.17791
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.13174
[MF] GO:0038023 signaling receptor activity AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, RORC 2.97343
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TYR 2.93867
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.80934
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.80921
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79452
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.79442
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.63866
[MF] GO:0004872 receptor activity AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, RORC 2.47916
[MF] GO:0060089 molecular transducer activity AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, RORC 2.36178
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.18044
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.13472
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.09376
[MF] GO:0004871 signal transducer activity AXL, CHRM2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, HTR6, IGF1R, KDR, MET, RORC 2.09212
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.06194
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01702


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.4609
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.2431
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.3209
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES, IDO1 5.5109
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 5.6171
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4351
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MET, CDC25B 2.6664
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, IGF1R 2.5897
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.5897
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.9374
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, ALOX5, PTGS2 2.5897
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2415
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGES 2.2415
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1191
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2114
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, IGF1R 1.8642
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1191
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 1.9927
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.8642
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 BCL2, PIM1, F3 1.8642
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, ESR2 1.8642
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8871
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.7997
Pathways in cancer_Homo sapiens_hsa05200 FLT3, BCL2, PTGS2, MET, IGF1R 1.7284
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6615
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4493
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6 1.2992
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, F2 1.2465
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PTGS2 1.4187
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4169
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2011
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3184
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3184
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3154
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4009
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3184
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0634
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1328
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, F2 1.0359
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.2011
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2603
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.2103
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4 1.3184
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.1019
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9382
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.26
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8274
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 1.0359
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0359
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2 0.8945
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7445
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.908
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.8492
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9169
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6 0.8
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7335
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8016
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.9374
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7997
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7357
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2952
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3599
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4096
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3995
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3865
Platelet activation_Homo sapiens_hsa04611 SRC 0.48
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.48
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4563
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.4989
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4096
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4588
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.4989
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5382
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4443
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3865
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.48
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4563
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.48
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4628
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4551
Phagosome_Homo sapiens_hsa04145 MPO 0.4342
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.48
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5223
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5248
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.528
GnRH signaling pathway_Homo sapiens_hsa04912 SRC 0.5345
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.48
Axon guidance_Homo sapiens_hsa04360 MET 0.4755
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5382
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.528
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5223
Gap junction_Homo sapiens_hsa04540 SRC 0.5382
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5382
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.528
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5382
Peroxisome_Homo sapiens_hsa04146 XDH 0.5406
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5802
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5804
Glioma_Homo sapiens_hsa05214 IGF1R 0.6105
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6105
Bile secretion_Homo sapiens_hsa04976 CA2 0.5862
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6148
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6098
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6105
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6105
Shigellosis_Homo sapiens_hsa05131 SRC 0.6105
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6745
Malaria_Homo sapiens_hsa05144 MET 0.6849
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6899
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6872
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6925
Bladder cancer_Homo sapiens_hsa05219 SRC 0.7335
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7862
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.817
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8312
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8312
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8492
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8239
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8471
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0554
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3154


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)