GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
[BP] GO:0065008 |
regulation of biological quality
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SLCO1B1, SMAD3, SRC, TEK, TRPV1, XDH |
10.8135 |
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.7235 |
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
10.7235 |
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
10.0469 |
[BP] GO:0010033 |
response to organic substance
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR |
10.0049 |
[BP] GO:1901700 |
response to oxygen-containing compound
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
9.83962 |
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
9.7501 |
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1, TRPV1 |
9.72484 |
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F2, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
9.6757 |
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
9.66082 |
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
9.59144 |
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
9.02672 |
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
8.85061 |
[BP] GO:0042221 |
response to chemical
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR |
8.85061 |
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
8.85061 |
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH |
8.60794 |
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK |
8.16977 |
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F2, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.81677 |
[BP] GO:0009719 |
response to endogenous stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 |
7.81677 |
[BP] GO:0009725 |
response to hormone
|
AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK, TRPV1 |
7.71636 |
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.67235 |
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, ADRB2, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F2, GPR35, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 |
7.53686 |
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.37913 |
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.24601 |
[BP] GO:0070887 |
cellular response to chemical stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 |
7.20368 |
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, SLCO1B1, SLCO1B3, TRPV1 |
7.20368 |
[BP] GO:0030168 |
platelet activation
|
AXL, F2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC |
7.20368 |
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
7.20182 |
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FDPS, FUT7, GLO1, HSPA1A, MIF, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH |
7.20182 |
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH |
7.16601 |
[BP] GO:0014070 |
response to organic cyclic compound
|
ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PRKCE, PRKCG, PTGS2, RORC, SRC, TEK, TRPV1, TYR |
7.1405 |
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, EGFR, F2, FABP3, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.05974 |
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, EGFR, F2, FABP3, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
7.05974 |
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH |
7.05974 |
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TYR, XDH |
7.0031 |
[BP] GO:0071310 |
cellular response to organic substance
|
ADRB2, AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SMAD3, SRC, TRPV1 |
6.97644 |
[BP] GO:0006468 |
protein phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
6.88224 |
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA6, CA7, CA9 |
6.86905 |
[BP] GO:0050896 |
response to stimulus
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F2, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR |
6.83777 |
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FDPS, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH |
6.78539 |
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
6.78539 |
[BP] GO:0042592 |
homeostatic process
|
ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TRPV1 |
6.75847 |
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FDPS, FUT7, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 |
6.70867 |
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A |
6.66887 |
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.55783 |
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 |
6.55003 |
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, ADRB1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, F2, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
6.49115 |
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
6.38659 |
[BP] GO:0006690 |
icosanoid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 |
6.31258 |
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
ADRB2, AKR1B1, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RORC, SRC, TRPV1 |
6.22127 |
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK |
6.17251 |
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
6.15957 |
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
6.15609 |
[BP] GO:0016310 |
phosphorylation
|
AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
6.10791 |
[BP] GO:0001775 |
cell activation
|
ALOX5, AXL, BCL2, EGFR, F2, FLT3, FUT7, HSPA1A, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 |
6.06346 |
[BP] GO:0051716 |
cellular response to stimulus
|
ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 |
6.02408 |
[BP] GO:0051049 |
regulation of transport
|
ACHE, ADORA1, ADRB2, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, F2, GPR35, HSPA1A, INSR, KCNA3, MIF, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TRPV1 |
5.98469 |
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC |
5.94321 |
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR |
5.94321 |
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.94321 |
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.88409 |
[BP] GO:0006820 |
anion transport
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, SLCO1B1, SLCO1B3, TRPV1 |
5.8798 |
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
5.87935 |
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MIF, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.87578 |
[BP] GO:0033993 |
response to lipid
|
ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PRKCE, PTGS2, RORC, SRC, TYR |
5.80107 |
[BP] GO:0019369 |
arachidonic acid metabolic process
|
CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 |
5.80107 |
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
F2, FABP3, FLT3, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK |
5.77526 |
[BP] GO:2000377 |
regulation of reactive oxygen species metabolic process
|
BCL2, CYP1B1, EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH |
5.74773 |
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F2, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RORC, SLC5A1, SMAD3, SRC, TEK, TOP1, TRPV1, TYR |
5.72694 |
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, CYP19A1, DUSP3, EGFR, ESR1, F2, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.6246 |
[BP] GO:2000379 |
positive regulation of reactive oxygen species metabolic process
|
EGFR, F2, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH |
5.6246 |
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK |
5.5823 |
[BP] GO:0065009 |
regulation of molecular function
|
ADORA1, ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH |
5.55719 |
[BP] GO:0010243 |
response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR |
5.50251 |
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
5.494 |
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1, SLCO1B1 |
5.49027 |
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, CYP1A1, F2, FABP3, FDPS, FLT3, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK |
5.48071 |
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
5.48071 |
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
5.42928 |
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK |
5.42928 |
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, F2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 |
5.42617 |
[BP] GO:0030335 |
positive regulation of cell migration
|
BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.41185 |
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK |
5.3796 |
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FDPS, HSD17B1, HSD17B2 |
5.33365 |
[BP] GO:0031399 |
regulation of protein modification process
|
ADORA1, ADRB2, BCL2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH |
5.31783 |
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, TEK |
5.31073 |
[BP] GO:0006811 |
None
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, KCNA3, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TRPV1 |
5.31073 |
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.27799 |
[BP] GO:2000147 |
positive regulation of cell motility
|
BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.24649 |
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH |
5.21311 |
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
5.20437 |
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, ADRB1, ADRB2, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR |
5.18989 |
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, ADRB2, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH |
5.16629 |
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.1608 |
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
5.15125 |
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK |
5.12697 |
[BP] GO:0051272 |
positive regulation of cellular component movement
|
BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.12697 |
[BP] GO:0009894 |
regulation of catabolic process
|
ADORA1, ADRB2, APEX1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 |
5.12697 |
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
5.12697 |
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC |
5.12697 |
[BP] GO:1901698 |
response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR |
5.10652 |
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, BCL2, CA2, CA7, EGFR, F2, KDR, MIF, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 |
5.09696 |
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGS1, PTGS2, TBXAS1 |
5.08025 |
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
5.06798 |
[BP] GO:0042493 |
response to drug
|
AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PRKCD, PRKCE, PRKCG, PTGS2, SRC, TOP1, TRPV1 |
5.05988 |
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A, TYR |
5.02861 |
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH |
5.02458 |
[BP] GO:0048585 |
negative regulation of response to stimulus
|
ADORA1, ADRB2, BCL2, CYP19A1, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.99321 |
[BP] GO:0040017 |
positive regulation of locomotion
|
BCL2, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK |
4.98506 |
[BP] GO:0048878 |
chemical homeostasis
|
AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
4.96078 |
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC |
4.94591 |
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.94193 |
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH |
4.93578 |
[BP] GO:0018105 |
peptidyl-serine phosphorylation
|
AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 |
4.90034 |
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
4.89392 |
[BP] GO:1901652 |
response to peptide
|
ADRB2, AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 |
4.88519 |
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PRKCD, PRKCE, PTGS2, SRC, TRPV1 |
4.88322 |
[BP] GO:0010648 |
negative regulation of cell communication
|
ACHE, ADORA1, ADRB2, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH |
4.87535 |
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK |
4.86705 |
[BP] GO:0048511 |
rhythmic process
|
AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, PRKCG, RORC, SRC, TOP1, TOP2A |
4.86375 |
[BP] GO:0023057 |
negative regulation of signaling
|
ACHE, ADORA1, ADRB2, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH |
4.86325 |
[BP] GO:0007166 |
cell surface receptor signaling pathway
|
ADORA1, ADORA3, ADRB2, AXL, BCL2, CA1, CSNK2A1, EGFR, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, TRPV1 |
4.83586 |
[BP] GO:0032270 |
positive regulation of cellular protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
4.8132 |
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, ADRB2, EGFR, FLT3, INSR, KDR, MIF, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH |
4.80149 |
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, BCL2, CYP1A1, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK |
4.7738 |
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
4.76813 |
[BP] GO:0032101 |
regulation of response to external stimulus
|
ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, KDR, MET, MIF, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK |
4.75632 |
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC |
4.75081 |
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK |
4.75009 |
[BP] GO:0031347 |
regulation of defense response
|
ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK |
4.7329 |
[BP] GO:0006631 |
fatty acid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGS1, PTGS2, TBXAS1 |
4.71812 |
[BP] GO:0019371 |
None
|
CBR1, PTGS1, PTGS2, TBXAS1 |
4.71099 |
[BP] GO:0031401 |
positive regulation of protein modification process
|
ADORA1, ADRB2, BCL2, CDC25B, EGFR, F2, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH |
4.70193 |
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
4.66702 |
[BP] GO:0018209 |
peptidyl-serine modification
|
AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 |
4.57001 |
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 |
4.55254 |
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TYR, XDH |
4.50503 |
[BP] GO:0033674 |
positive regulation of kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, F2, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
4.48162 |
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, FDPS, HSD17B1, HSD17B2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 |
4.43642 |
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, ADRB2, AKR1B1, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH |
4.40996 |
[BP] GO:2001243 |
negative regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
4.40996 |
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC |
4.39744 |
[BP] GO:0008283 |
cell proliferation
|
ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR |
4.33715 |
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, ADRB2, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC |
4.32788 |
[BP] GO:0032847 |
regulation of cellular pH reduction
|
BCL2, CA2, CA7 |
4.32643 |
[BP] GO:0043549 |
regulation of kinase activity
|
ADORA1, ADRB2, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
4.32643 |
[BP] GO:0035556 |
intracellular signal transduction
|
ADRB1, ADRB2, AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK |
4.29286 |
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 |
4.28075 |
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, F2, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1 |
4.26252 |
[BP] GO:0051050 |
positive regulation of transport
|
ACHE, ADORA1, ADRB2, AXL, BCL2, CA2, CYP19A1, EGFR, F2, INSR, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 |
4.25885 |
[BP] GO:0048513 |
animal organ development
|
ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR |
4.23214 |
[BP] GO:0043085 |
positive regulation of catalytic activity
|
ADORA1, ADRB1, ADRB2, AURKB, BCL2, CDC25B, EGFR, ESR1, F2, FLT3, HSPA1A, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH |
4.22645 |
[BP] GO:0043405 |
regulation of MAP kinase activity
|
ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC |
4.19108 |
[BP] GO:2000021 |
regulation of ion homeostasis
|
ADORA1, BCL2, CA2, CA7, F2, KDR, PRKCE, SRC, TRPV1 |
4.17739 |
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, ADRB2, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH |
4.13837 |
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
ADRB2, AKR1B1, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 |
4.1359 |
[BP] GO:0044236 |
multicellular organism metabolic process
|
ADRB1, ADRB2, MMP1, MMP12, MMP2, MMP9, TRPV1 |
4.13041 |
[BP] GO:0051347 |
positive regulation of transferase activity
|
ADORA1, ADRB2, AURKB, CDC25B, EGFR, F2, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
4.12431 |
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS |
4.107 |
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC |
4.0817 |
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 |
4.07461 |
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
4.0431 |
[BP] GO:1902532 |
negative regulation of intracellular signal transduction
|
BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH |
4.02968 |
[BP] GO:0051338 |
regulation of transferase activity
|
ADORA1, ADRB2, AURKB, CDC25B, DUSP3, EGFR, F2, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK |
3.96635 |
[BP] GO:0006805 |
xenobiotic metabolic process
|
CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1, RORC |
3.94147 |
[BP] GO:0050728 |
negative regulation of inflammatory response
|
ADORA1, CYP19A1, F2, PPARA, PRKCD, SMAD3, TEK |
3.91789 |
[BP] GO:0045787 |
positive regulation of cell cycle
|
APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, PRKCA, PRKCE, SRC |
3.86454 |
[BP] GO:1904407 |
positive regulation of nitric oxide metabolic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.86454 |
[BP] GO:0045429 |
positive regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.86454 |
[BP] GO:0048871 |
multicellular organismal homeostasis
|
ADORA1, ADRB1, ADRB2, AKR1B1, MET, PIK3CA, TRPV1 |
3.85254 |
[BP] GO:0031348 |
negative regulation of defense response
|
ADORA1, CYP19A1, F2, MMP12, PPARA, PRKCD, SMAD3, TEK |
3.84294 |
[BP] GO:0097237 |
cellular response to toxic substance
|
AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE |
3.81131 |
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, ADRB2, CA2, CA7, EGFR, PRKCE, PTGS2 |
3.78938 |
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, PRKCD, SRC, TEK |
3.77475 |
[BP] GO:0009611 |
response to wounding
|
ACHE, ADORA3, BCL2, CYP1A1, EGFR, F2, PPARA, SMAD3 |
3.70764 |
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FDPS |
3.70581 |
[BP] GO:0050727 |
regulation of inflammatory response
|
ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PRKCD, PTGS2, SMAD3, TEK |
3.70287 |
[BP] GO:0009968 |
negative regulation of signal transduction
|
ADRB2, BCL2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH |
3.68714 |
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
ADRB2, AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 |
3.63733 |
[BP] GO:0032787 |
None
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2, TBXAS1 |
3.63358 |
[BP] GO:0038083 |
peptidyl-tyrosine autophosphorylation
|
EGFR, IGF1R, INSR, KDR, SRC |
3.6014 |
[BP] GO:0050801 |
ion homeostasis
|
BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, FABP3, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
3.58197 |
[BP] GO:0030155 |
regulation of cell adhesion
|
BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK |
3.58197 |
[BP] GO:0009636 |
response to toxic substance
|
AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, PRKCD, PRKCE, SRC |
3.57493 |
[BP] GO:0044267 |
cellular protein metabolic process
|
ADRB2, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
3.55876 |
[BP] GO:0001505 |
regulation of neurotransmitter levels
|
ACHE, CYP1B1, EGFR, INSR, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 |
3.54207 |
[BP] GO:0040016 |
embryonic cleavage
|
PIK3CB, TOP1, TOP2A |
3.50986 |
[BP] GO:0045859 |
regulation of protein kinase activity
|
ADORA1, ADRB2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
3.44962 |
[BP] GO:0051239 |
regulation of multicellular organismal process
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, F2, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TEK, TRPV1, XDH |
3.44443 |
[BP] GO:0071900 |
regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC |
3.43905 |
[BP] GO:0032268 |
regulation of cellular protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
3.43606 |
[BP] GO:1903428 |
positive regulation of reactive oxygen species biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.40711 |
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.4065 |
[BP] GO:0045860 |
positive regulation of protein kinase activity
|
ADORA1, ADRB2, CDC25B, EGFR, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
3.35198 |
[BP] GO:1901699 |
cellular response to nitrogen compound
|
ADRB2, AKR1B1, APEX1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 |
3.3413 |
[BP] GO:0051234 |
None
|
ACHE, ADORA1, ADRB2, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, EGFR, F10, F2, FABP3, HSPA1A, KCNA3, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TRPV1, XDH |
3.3413 |
[BP] GO:0043269 |
regulation of ion transport
|
ADORA1, ADRB2, BCL2, CA2, CA7, F2, GPR35, KCNA3, MIF, MMP9, PRKCD, PRKCE, PTGS2 |
3.3413 |
[BP] GO:0031649 |
None
|
ADRB1, ADRB2, TRPV1 |
3.32791 |
[BP] GO:0043393 |
regulation of protein binding
|
ADRB2, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC |
3.32614 |
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, APEX1, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH |
3.28912 |
[BP] GO:0043434 |
None
|
APEX1, FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 |
3.26511 |
[BP] GO:0008217 |
None
|
ADORA1, ADRB1, ADRB2, PPARA, PTGS1, PTGS2, SMAD3 |
3.25786 |
[BP] GO:0002682 |
regulation of immune system process
|
ADORA1, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, F2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC |
3.2575 |
[BP] GO:0032103 |
positive regulation of response to external stimulus
|
EGFR, F2, FABP4, KDR, MET, MIF, PRKCA, PTGS2, SMAD3 |
3.2575 |
[BP] GO:0045428 |
regulation of nitric oxide biosynthetic process
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
3.22989 |
[BP] GO:0051726 |
regulation of cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TOP2A |
3.22127 |
[BP] GO:0006810 |
None
|
ACHE, ADORA1, ADRB2, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, F10, F2, FABP3, HSPA1A, KCNA3, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TRPV1, XDH |
3.19814 |
[BP] GO:0016477 |
cell migration
|
AXL, CYP1B1, EGFR, F2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK |
3.19251 |
[BP] GO:0010632 |
regulation of epithelial cell migration
|
KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK |
3.19251 |
[BP] GO:0002024 |
None
|
ADRB1, ADRB2, TRPV1 |
3.18102 |
[BP] GO:0003018 |
None
|
ADORA1, ADRB1, ADRB2, EGFR, PTGS2, SRC, TEK |
3.16883 |
[BP] GO:0050873 |
None
|
ADRB1, ADRB2, FABP4, PTGS2 |
3.16883 |
[BP] GO:0016572 |
histone phosphorylation
|
AURKB, PRKCA, PRKCB, PRKCD |
3.16883 |
[BP] GO:0019538 |
protein metabolic process
|
ACHE, ADRB2, ALPL, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
3.16376 |
[BP] GO:0006464 |
cellular protein modification process
|
ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
3.1515 |
[BP] GO:0036211 |
protein modification process
|
ADRB2, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
3.1515 |
[BP] GO:0001952 |
regulation of cell-matrix adhesion
|
BCL2, KDR, PIK3CB, SMAD3, SRC, TEK |
3.1515 |
[BP] GO:0098771 |
inorganic ion homeostasis
|
BCL2, CA12, CA2, CA7, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
3.13136 |
[BP] GO:0051701 |
interaction with host
|
AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC |
3.1289 |
[BP] GO:2001242 |
regulation of intrinsic apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
3.1289 |
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1, PRKCD |
3.11993 |
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 |
3.11993 |
[BP] GO:0051179 |
None
|
ACHE, ADORA1, ADRB2, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, EGFR, ESR1, F10, F2, FABP3, HSPA1A, KCNA3, MIF, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TRPV1, XDH |
3.07299 |
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
3.05067 |
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 |
3.03708 |
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, ADRB2, BACE1, CA2, CA7, EGFR, PRKCE, PTGS2 |
3.03708 |
[BP] GO:0006855 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
3.02737 |
[BP] GO:0007346 |
regulation of mitotic cell cycle
|
APEX1, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TOP2A |
3.02737 |
[BP] GO:0001659 |
None
|
ADORA1, ADRB1, ADRB2, TRPV1 |
3.01562 |
[BP] GO:0050730 |
None
|
ADORA1, EGFR, FLT3, MIF, PRKCD, PRKCE, PTPN1, SRC |
3.00999 |
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7, PRKCE |
2.96356 |
[BP] GO:0001503 |
ossification
|
ALPL, BCL2, EGFR, MMP2, MMP9, TEK |
2.92699 |
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
F2, FLT3, SRC, TEK |
2.91333 |
[BP] GO:0032147 |
activation of protein kinase activity
|
ADORA1, ADRB2, EGFR, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC |
2.90875 |
[BP] GO:0031329 |
regulation of cellular catabolic process
|
ADRB2, APEX1, BCL2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 |
2.90572 |
[BP] GO:0050878 |
regulation of body fluid levels
|
ADORA1, AKR1B1, F10, F2, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH |
2.87847 |
[BP] GO:0048732 |
gland development
|
BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR |
2.87847 |
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FDPS, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
2.84404 |
[BP] GO:0043412 |
macromolecule modification
|
ADRB2, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A |
2.83387 |
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGS2, SRC |
2.83376 |
[BP] GO:0015872 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.82977 |
[BP] GO:0015697 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.82977 |
[BP] GO:0051246 |
regulation of protein metabolic process
|
ADORA1, ADRB2, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F2, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH |
2.82977 |
[BP] GO:0040011 |
locomotion
|
AXL, CYP1B1, EGFR, F2, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK |
2.82977 |
[BP] GO:0050776 |
regulation of immune response
|
BCL2, DUSP3, ESR1, F2, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, SMAD3, SRC |
2.82977 |
[BP] GO:0035408 |
None
|
PRKCA, PRKCB |
2.82977 |
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, PRKCD, SRC, TEK |
2.81879 |
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, KDR, PIK3CA, PIK3CB, SRC |
2.81879 |
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FDPS, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
2.81879 |
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
APEX1, AURKB, BCL2, CSNK2A1, DUSP3, ESR1, ESR2, F2, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH |
2.81209 |
[BP] GO:0048870 |
cell motility
|
AXL, CYP1B1, EGFR, F2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK |
2.7931 |
[BP] GO:0090087 |
None
|
ACHE, ADORA1, CA2, EGFR, F2, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
2.76284 |
[BP] GO:0007190 |
None
|
ADORA3, ADRB1, ADRB2, PRKCA |
2.75006 |
[BP] GO:0046456 |
icosanoid biosynthetic process
|
ALOX5, MIF, PTGS1, PTGS2 |
2.75006 |
[BP] GO:0072507 |
divalent inorganic cation homeostasis
|
BCL2, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.74754 |
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
2.74188 |
[BP] GO:0032230 |
positive regulation of synaptic transmission, GABAergic
|
CA2, CA7, PRKCE |
2.74188 |
[BP] GO:0001516 |
None
|
MIF, PTGS1, PTGS2 |
2.74188 |
[BP] GO:0046457 |
None
|
MIF, PTGS1, PTGS2 |
2.74188 |
[BP] GO:0001525 |
angiogenesis
|
CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK |
2.74119 |
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, CYP19A1, CYP3A4, FDPS, HSD17B1, HSD17B2 |
2.72911 |
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, EGFR, MMP2, MMP9, PTGS2 |
2.72273 |
[BP] GO:1904951 |
positive regulation of establishment of protein localization
|
ACHE, BCL2, EGFR, F2, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
2.71752 |
[BP] GO:0010810 |
regulation of cell-substrate adhesion
|
BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK |
2.71752 |
[BP] GO:0015695 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLC47A1 |
2.71752 |
[BP] GO:0051130 |
positive regulation of cellular component organization
|
ADRB2, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK |
2.71745 |
[BP] GO:0010638 |
positive regulation of organelle organization
|
ADRB2, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK |
2.70058 |
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
2.69004 |
[BP] GO:0038128 |
None
|
EGFR, PIK3CA, PRKCA, SRC |
2.67815 |
[BP] GO:0018107 |
peptidyl-threonine phosphorylation
|
BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD |
2.67815 |
[BP] GO:0009895 |
negative regulation of catabolic process
|
ADORA1, BCL2, EGFR, MET, PIK3CA, PPARA, PRKCG, SMAD3 |
2.67174 |
[BP] GO:0051098 |
regulation of binding
|
ADRB2, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC |
2.66772 |
[BP] GO:1900182 |
positive regulation of protein localization to nucleus
|
EGFR, F2, PRKCD, PTGS2, SMAD3, SRC |
2.66772 |
[BP] GO:0043406 |
positive regulation of MAP kinase activity
|
ADORA1, EGFR, FLT3, INSR, MIF, PIK3CB, PTPN1, SRC |
2.66376 |
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.66006 |
[BP] GO:1990845 |
None
|
ADRB1, ADRB2, TRPV1 |
2.66006 |
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, AXL, F2, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 |
2.63062 |
[BP] GO:0045321 |
leukocyte activation
|
ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, MIF, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 |
2.63062 |
[BP] GO:0055080 |
cation homeostasis
|
BCL2, CA2, CA7, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.62852 |
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 |
2.60318 |
[BP] GO:0071902 |
positive regulation of protein serine/threonine kinase activity
|
ADORA1, ADRB2, EGFR, FLT3, INSR, MIF, PIK3CB, PTPN1, SRC |
2.60305 |
[BP] GO:0050900 |
leukocyte migration
|
F2, FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK |
2.60305 |
[BP] GO:0071702 |
None
|
ADORA1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, MMP12, PPARA, PRKCB, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TRPV1 |
2.59971 |
[BP] GO:0044070 |
regulation of anion transport
|
ADORA1, CA2, CA7, MIF, PRKCD |
2.59393 |
[BP] GO:0033273 |
response to vitamin
|
ALPL, CYP1A1, EGFR, PTGS2, TYR |
2.59393 |
[BP] GO:1903426 |
None
|
EGFR, INSR, PTGS2, SMAD3, TRPV1 |
2.59393 |
[BP] GO:0051937 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.57916 |
[BP] GO:0045776 |
None
|
ADORA1, ADRB1, ADRB2, PPARA |
2.5736 |
[BP] GO:0070372 |
regulation of ERK1 and ERK2 cascade
|
DUSP3, EGFR, KDR, MIF, PRKCA, PTPN1, SRC, TEK |
2.57002 |
[BP] GO:0009896 |
positive regulation of catabolic process
|
ADRB2, CSNK2A1, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 |
2.56372 |
[BP] GO:0019752 |
carboxylic acid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.54777 |
[BP] GO:0018210 |
peptidyl-threonine modification
|
BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD |
2.52921 |
[BP] GO:0010595 |
positive regulation of endothelial cell migration
|
KDR, MET, PRKCA, PTGS2, TEK |
2.52921 |
[BP] GO:0032102 |
negative regulation of response to external stimulus
|
ADORA1, CYP19A1, F2, MIF, PPARA, PRKCD, SMAD3, TEK |
2.5217 |
[BP] GO:0003013 |
None
|
ADORA1, ADRB1, ADRB2, EGFR, PTGS2, SRC, TEK |
2.51891 |
[BP] GO:0080135 |
regulation of cellular response to stress
|
DUSP3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH |
2.51337 |
[BP] GO:2000811 |
negative regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.50909 |
[BP] GO:0032075 |
None
|
HSPA1A, PRKCD, PTPN1 |
2.50909 |
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.50909 |
[BP] GO:0045986 |
None
|
ADORA1, ADRB2, PTGS2 |
2.50909 |
[BP] GO:0043271 |
negative regulation of ion transport
|
ADORA1, BCL2, GPR35, MMP9, PRKCE, PTGS2 |
2.50801 |
[BP] GO:0002009 |
morphogenesis of an epithelium
|
BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC |
2.49937 |
[BP] GO:0040008 |
regulation of growth
|
ADRB1, ADRB2, BCL2, CSNK2A1, EGFR, ESR2, F2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 |
2.49806 |
[BP] GO:0055082 |
cellular chemical homeostasis
|
BCL2, CA2, CA7, ESR1, F2, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.49806 |
[BP] GO:1901653 |
cellular response to peptide
|
ADRB2, AKR1B1, APEX1, IGF1R, INSR, PRKCD, SRC |
2.49159 |
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
2.47854 |
[BP] GO:0051128 |
regulation of cellular component organization
|
ADRB2, AURKB, AXL, BCL2, CSNK2A1, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A |
2.47466 |
[BP] GO:0045931 |
positive regulation of mitotic cell cycle
|
APEX1, CDC25B, CYP1A1, DUSP3, INSR, PRKCA |
2.46828 |
[BP] GO:0032845 |
None
|
ADORA1, BCL2, MIF, PRKCE, SRC, TRPV1 |
2.46828 |
[BP] GO:0051172 |
None
|
APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH |
2.46339 |
[BP] GO:2001234 |
negative regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC |
2.46128 |
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH |
2.45438 |
[BP] GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress
|
BCL2, CYP1B1, PRKCD |
2.45438 |
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.45438 |
[BP] GO:0002025 |
None
|
ADRB1, ADRB2 |
2.45438 |
[BP] GO:0051054 |
positive regulation of DNA metabolic process
|
AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC |
2.45065 |
[BP] GO:0006928 |
movement of cell or subcellular component
|
AXL, CYP1B1, EGFR, F2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK, TUBB3 |
2.42509 |
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH |
2.42509 |
[BP] GO:0015893 |
None
|
CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
2.42483 |
[BP] GO:0071248 |
cellular response to metal ion
|
CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.42483 |
[BP] GO:0030003 |
cellular cation homeostasis
|
BCL2, CA2, CA7, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.42432 |
[BP] GO:0051248 |
None
|
CSNK2A1, DUSP3, EGFR, F2, FABP4, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, XDH |
2.40904 |
[BP] GO:0009266 |
None
|
ADORA1, ADRB1, ADRB2, HSPA1A, PTGS2, TRPV1 |
2.39789 |
[BP] GO:0006874 |
cellular calcium ion homeostasis
|
BCL2, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.39789 |
[BP] GO:2001233 |
regulation of apoptotic signaling pathway
|
BCL2, HSPA1A, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC |
2.39789 |
[BP] GO:0033554 |
cellular response to stress
|
AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TOP2A, TRPV1 |
2.39767 |
[BP] GO:0048869 |
cellular developmental process
|
ACHE, ADRB1, ADRB2, ALPL, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A |
2.39767 |
[BP] GO:0072488 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.39704 |
[BP] GO:0048545 |
response to steroid hormone
|
ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC |
2.39533 |
[BP] GO:0051047 |
None
|
ACHE, ADORA1, CYP19A1, EGFR, MIF, MMP12, PRKCE, SRC, TRPV1 |
2.39533 |
[BP] GO:0019725 |
cellular homeostasis
|
APEX1, BCL2, CA2, CA7, ESR1, F2, GPR35, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.39348 |
[BP] GO:0007165 |
signal transduction
|
ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 |
2.38808 |
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
ADRB1, ADRB2, AURKB, EGFR, ESR1, ESR2, F2, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TOP2A, TRPV1 |
2.38253 |
[BP] GO:0046626 |
regulation of insulin receptor signaling pathway
|
PRKCB, PRKCD, PTPN1, SRC |
2.38122 |
[BP] GO:0051222 |
positive regulation of protein transport
|
ACHE, EGFR, F2, MIF, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC |
2.35601 |
[BP] GO:0045766 |
positive regulation of angiogenesis
|
CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK |
2.35558 |
[BP] GO:0006873 |
cellular ion homeostasis
|
BCL2, CA2, CA7, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.35558 |
[BP] GO:0031960 |
response to corticosteroid
|
ALPL, BCL2, EGFR, FLT3, PTGS2, SRC |
2.3413 |
[BP] GO:0051900 |
regulation of mitochondrial depolarization
|
BCL2, KDR, SRC |
2.33892 |
[BP] GO:0014066 |
regulation of phosphatidylinositol 3-kinase signaling
|
EGFR, F2, FLT3, KDR, TEK |
2.32907 |
[BP] GO:0032846 |
positive regulation of homeostatic process
|
AURKB, CA2, CA7, EGFR, F2, PIK3CB, PTGS2 |
2.32593 |
[BP] GO:0044089 |
positive regulation of cellular component biogenesis
|
ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK |
2.32593 |
[BP] GO:0055074 |
calcium ion homeostasis
|
BCL2, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.31941 |
[BP] GO:0042307 |
positive regulation of protein import into nucleus
|
EGFR, F2, PRKCD, PTGS2, SMAD3 |
2.31475 |
[BP] GO:0042752 |
None
|
ADORA1, PPARA, PRKCG, RORC, TOP2A |
2.31475 |
[BP] GO:0032091 |
negative regulation of protein binding
|
ADRB2, AURKB, MET, PPARA, PRKCD |
2.31475 |
[BP] GO:0033138 |
positive regulation of peptidyl-serine phosphorylation
|
BCL2, EGFR, MIF, PIK3CA, PTGS2 |
2.29706 |
[BP] GO:0010676 |
None
|
INSR, PPARA, PRKCE, SRC |
2.29706 |
[BP] GO:0050994 |
None
|
ADORA1, PPARA, PRKCD, PRKCE |
2.29706 |
[BP] GO:0043550 |
regulation of lipid kinase activity
|
F2, FLT3, SRC, TEK |
2.29706 |
[BP] GO:0072503 |
cellular divalent inorganic cation homeostasis
|
BCL2, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.28553 |
[BP] GO:1904591 |
positive regulation of protein import
|
EGFR, F2, PRKCD, PTGS2, SMAD3 |
2.27894 |
[BP] GO:0007568 |
aging
|
APEX1, AURKB, BCL2, CYP1A1, MIF, PRKCD, PTGS2 |
2.27861 |
[BP] GO:0051828 |
entry into other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, MET, SRC |
2.26325 |
[BP] GO:0030260 |
entry into host cell
|
AXL, EGFR, HSPA1A, MET, SRC |
2.26325 |
[BP] GO:0051806 |
entry into cell of other organism involved in symbiotic interaction
|
AXL, EGFR, HSPA1A, MET, SRC |
2.26325 |
[BP] GO:0044409 |
entry into host
|
AXL, EGFR, HSPA1A, MET, SRC |
2.26325 |
[BP] GO:0003006 |
developmental process involved in reproduction
|
ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC |
2.25346 |
[BP] GO:0072593 |
reactive oxygen species metabolic process
|
BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR |
2.24491 |
[BP] GO:0051893 |
regulation of focal adhesion assembly
|
KDR, SMAD3, SRC, TEK |
2.24309 |
[BP] GO:0090109 |
regulation of cell-substrate junction assembly
|
KDR, SMAD3, SRC, TEK |
2.24309 |
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.23109 |
[BP] GO:0015844 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.23109 |
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.23109 |
[BP] GO:0070201 |
None
|
ACHE, BCL2, EGFR, F2, MIF, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC |
2.22845 |
[BP] GO:1901374 |
None
|
SLC22A1, SLC22A2 |
2.22361 |
[BP] GO:0015874 |
None
|
SLC22A1, SLC22A2 |
2.22361 |
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.22361 |
[BP] GO:0010038 |
response to metal ion
|
BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.22357 |
[BP] GO:0043065 |
positive regulation of apoptotic process
|
BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
2.21964 |
[BP] GO:0008150 |
biological_process
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
2.21747 |
[BP] GO:0046649 |
lymphocyte activation
|
AXL, BCL2, FLT3, FUT7, PRKCB, PRKCD, RORC, SMAD3 |
2.21695 |
[BP] GO:0043436 |
oxoacid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.20405 |
[BP] GO:0043068 |
positive regulation of programmed cell death
|
BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH |
2.18881 |
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FDPS, TYR |
2.18881 |
[BP] GO:0035428 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.18881 |
[BP] GO:1904659 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.18881 |
[BP] GO:1905950 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.18881 |
[BP] GO:0030520 |
intracellular estrogen receptor signaling pathway
|
ESR1, ESR2, SRC |
2.18881 |
[BP] GO:0050996 |
None
|
PPARA, PRKCD, PRKCE |
2.18881 |
[BP] GO:1903391 |
regulation of adherens junction organization
|
KDR, SMAD3, SRC, TEK |
2.17752 |
[BP] GO:0031349 |
positive regulation of defense response
|
EGFR, FABP4, HSPA1A, MMP12, MMP2, PRKCD, PRKCE, PTGS2, SRC |
2.16195 |
[BP] GO:0071241 |
cellular response to inorganic substance
|
CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 |
2.14564 |
[BP] GO:0044057 |
None
|
ADORA1, ADORA3, ADRB1, ADRB2, EGFR, GPR35, PRKCA, PTGS2, SMAD3, TRPV1 |
2.14201 |
[BP] GO:0006082 |
organic acid metabolic process
|
ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR |
2.13748 |
[BP] GO:2000209 |
regulation of anoikis
|
BCL2, PIK3CA, SRC |
2.13748 |
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.13748 |
[BP] GO:0070988 |
demethylation
|
APEX1, CYP1A1, CYP1A2, CYP3A4 |
2.12697 |
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F2, FLT3, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR |
2.1213 |
[BP] GO:0050793 |
regulation of developmental process
|
ADRB1, ADRB2, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, F2, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, XDH |
2.11458 |
[BP] GO:1904018 |
positive regulation of vasculature development
|
CYP1B1, KDR, PRKCA, PRKCB, PTGS2, TEK |
2.11348 |
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
ESR1, ESR2, PIM1, PPARA, RORC, SRC |
2.11348 |
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HSPA1A |
2.09127 |
[BP] GO:0051894 |
None
|
KDR, SMAD3, TEK |
2.09127 |
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.09127 |
[BP] GO:1901654 |
None
|
AKR1B1, CA9, CSNK2A1, EGFR, PRKCE, SRC |
2.0794 |
[BP] GO:0009991 |
response to extracellular stimulus
|
ALPL, AXL, BCL2, CYP1A1, EGFR, PTGS2, SRC, TRPV1, TYR |
2.07249 |
[BP] GO:0002793 |
None
|
ACHE, ADORA1, EGFR, MIF, MMP12, PRKCE, SRC |
2.06672 |
[BP] GO:0044419 |
interspecies interaction between organisms
|
AXL, EGFR, F2, FDPS, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 |
2.04453 |
[BP] GO:0032870 |
cellular response to hormone stimulus
|
APEX1, EGFR, ESR1, FLT3, INSR, PRKCD, PRKCE, SRC |
2.04398 |
[BP] GO:0045932 |
None
|
ADORA1, ADRB2, PTGS2 |
2.04398 |
[BP] GO:0046618 |
None
|
SLC47A1, SLC47A2 |
2.04398 |
[BP] GO:0010605 |
negative regulation of macromolecule metabolic process
|
APEX1, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, ESR2, F2, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TRPV1, XDH |
2.04398 |
[BP] GO:0044283 |
None
|
AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, FDPS, MIF, PTGS1, PTGS2 |
2.03158 |
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC |
2.01589 |
[BP] GO:0006706 |
steroid catabolic process
|
CYP19A1, CYP1A2, CYP3A4 |
2.00211 |
[BP] GO:1903393 |
None
|
KDR, SMAD3, TEK |
2.00211 |
[BP] GO:0006693 |
None
|
MIF, PTGS1, PTGS2 |
2.00211 |
[BP] GO:0006692 |
None
|
MIF, PTGS1, PTGS2 |
2.00211 |
[BP] GO:0055065 |
metal ion homeostasis
|
BCL2, EGFR, ESR1, F2, GPR35, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 |
2.00163 |
[CC] GO:0005886 |
plasma membrane
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F2, FLT3, GLO1, GPR35, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLCO1B1, SLCO1B3, SMAD3, SRC, TEK, TRPV1 |
7.05974 |
[CC] GO:0031226 |
intrinsic component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TEK, TRPV1 |
5.0789 |
[CC] GO:0044459 |
plasma membrane part
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, CA2, CA4, CA9, DUSP3, EGFR, F10, F2, FLT3, GPR35, IGF1R, INSR, KCNA3, KDR, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TEK, TRPV1 |
4.97503 |
[CC] GO:0016020 |
membrane
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALOX5, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, F10, F2, FLT3, FUT7, GLO1, GPR35, HSD17B2, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLCO1B1, SLCO1B3, SMAD3, SRC, TBXAS1, TEK, TRPV1, TYR |
4.90609 |
[CC] GO:0016323 |
basolateral plasma membrane
|
ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, SLCO1B1, SLCO1B3, TEK |
4.53517 |
[CC] GO:0005887 |
integral component of plasma membrane
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, BACE1, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, TEK, TRPV1 |
4.29624 |
[CC] GO:0044425 |
membrane part
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, ALPL, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, F10, F2, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KCNA3, KDR, MET, PIK3CA, PIK3CB, PRKCG, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SRC, TBXAS1, TEK, TRPV1, TYR |
3.86454 |
[CC] GO:0031982 |
None
|
ADRB1, ADRB2, AKR1B1, AKR1B10, ALPL, AXL, BACE1, CA1, CA2, CA4, CA6, CBR1, DUSP3, EGFR, F2, FABP3, FABP4, GLO1, HSPA1A, INSR, KDR, MIF, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, PTPN1, SLC22A2, SLC47A1, SLC5A1, SLC5A2, SRC, TUBB3, TYR |
3.19814 |
[CC] GO:0098590 |
plasma membrane region
|
ADORA1, ADRB2, CA2, CA4, CA9, EGFR, INSR, MET, PRKCG, PTGS2, SLC22A1, SLCO1B1, SLCO1B3, SRC, TEK, TRPV1 |
3.03315 |
[CC] GO:0043227 |
membrane-bounded organelle
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC47A1, SLC5A1, SLC5A2, SMAD3, SRC, TOP1, TOP2A, TUBB3, TYR, XDH |
3.01643 |
[CC] GO:0009330 |
None
|
TOP1, TOP2A |
2.82977 |
[CC] GO:0048471 |
perinuclear region of cytoplasm
|
ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TYR |
2.52921 |
[CC] GO:0070062 |
None
|
AKR1B1, AKR1B10, ALPL, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F2, FABP3, FABP4, GLO1, HSPA1A, INSR, MIF, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SLC5A1, SLC5A2, SRC, TUBB3 |
2.42749 |
[CC] GO:0045121 |
membrane raft
|
BACE1, EGFR, INSR, KCNA3, KDR, PTGS2, SRC, TEK |
2.41788 |
[CC] GO:0098857 |
membrane microdomain
|
BACE1, EGFR, INSR, KCNA3, KDR, PTGS2, SRC, TEK |
2.39937 |
[CC] GO:1903561 |
None
|
AKR1B1, AKR1B10, ALPL, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F2, FABP3, FABP4, GLO1, HSPA1A, INSR, MIF, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SLC5A1, SLC5A2, SRC, TUBB3 |
2.39789 |
[CC] GO:0043230 |
None
|
AKR1B1, AKR1B10, ALPL, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, F2, FABP3, FABP4, GLO1, HSPA1A, INSR, MIF, MMP9, NQO2, PRKCA, PRKCB, PRKCD, PTGS1, SLC22A2, SLC5A1, SLC5A2, SRC, TUBB3 |
2.39789 |
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TOP1, TOP2A, TRPV1, TYR, XDH |
2.36014 |
[CC] GO:0005783 |
None
|
ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH |
2.22672 |
[CC] GO:0044464 |
cell part
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
2.04398 |
[MF] GO:0046914 |
transition metal ion binding
|
ALOX5, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH |
12.8561 |
[MF] GO:0003824 |
catalytic activity
|
ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F2, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TOP1, TOP2A, TUBB3, TYR, XDH |
12.3821 |
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
11.0941 |
[MF] GO:0043167 |
ion binding
|
ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
10.5193 |
[MF] GO:0008144 |
drug binding
|
ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 |
8.35194 |
[MF] GO:0008270 |
zinc ion binding
|
CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 |
7.79794 |
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
7.77107 |
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
7.29651 |
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.29651 |
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 |
7.05974 |
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
6.80309 |
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
6.71496 |
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, F10, F2, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH |
6.66887 |
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, INSR, PIK3CA, PIK3CB, PRKCD |
6.48216 |
[MF] GO:0046872 |
metal ion binding
|
ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, F10, F2, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TOP2A, TRPV1, TYR, XDH |
6.45898 |
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK |
5.98469 |
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 |
5.74773 |
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH |
5.74773 |
[MF] GO:0004697 |
None
|
PRKCA, PRKCB, PRKCD, PRKCE, PRKCG |
5.67159 |
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
5.65261 |
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK |
5.5072 |
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 |
5.46557 |
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC, TBXAS1 |
5.42877 |
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TBXAS1, TYR |
5.08025 |
[MF] GO:0005524 |
ATP binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 |
5.0554 |
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 |
4.98353 |
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 |
4.90135 |
[MF] GO:0030554 |
adenyl nucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 |
4.86705 |
[MF] GO:0036094 |
small molecule binding
|
ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.84656 |
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 |
4.76464 |
[MF] GO:0140096 |
catalytic activity, acting on a protein
|
AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TOP1 |
4.6186 |
[MF] GO:0000166 |
nucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.57284 |
[MF] GO:1901265 |
nucleoside phosphate binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.57107 |
[MF] GO:0004497 |
monooxygenase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR |
4.40996 |
[MF] GO:0043168 |
anion binding
|
AURKB, AXL, CSNK2A1, EGFR, F10, F2, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
4.34593 |
[MF] GO:0004698 |
None
|
PRKCA, PRKCB, PRKCG |
4.32643 |
[MF] GO:0035639 |
purine ribonucleoside triphosphate binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
4.17009 |
[MF] GO:0005506 |
iron ion binding
|
ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH |
4.03018 |
[MF] GO:0032555 |
purine ribonucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
4.00425 |
[MF] GO:0017076 |
purine nucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
3.95662 |
[MF] GO:0032553 |
ribonucleotide binding
|
AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
3.94581 |
[MF] GO:0004674 |
protein serine/threonine kinase activity
|
AURKB, CSNK2A1, EGFR, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TOP1 |
3.85228 |
[MF] GO:0097367 |
carbohydrate derivative binding
|
ADORA1, AURKB, AXL, CSNK2A1, EGFR, F2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, TUBB3 |
3.84747 |
[MF] GO:0019899 |
enzyme binding
|
ADRB1, ADRB2, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, HSPA1A, MET, MIF, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A |
3.78938 |
[MF] GO:0005329 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
3.71651 |
[MF] GO:0005412 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
3.71651 |
[MF] GO:0015291 |
None
|
SLC22A1, SLC22A2, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3 |
3.70276 |
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 |
3.68961 |
[MF] GO:1901618 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLCO1B1, SLCO1B3 |
3.68961 |
[MF] GO:0048037 |
cofactor binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, TBXAS1, XDH |
3.60005 |
[MF] GO:0042562 |
hormone binding
|
ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 |
3.56853 |
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, ADRB2, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC |
3.54207 |
[MF] GO:0032403 |
protein complex binding
|
ACHE, ADORA1, ADRB2, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC |
3.43002 |
[MF] GO:0008504 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
3.18102 |
[MF] GO:0016725 |
oxidoreductase activity, acting on CH or CH2 groups
|
CYP1A2, CYP3A4, XDH |
3.18102 |
[MF] GO:0015651 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
3.18102 |
[MF] GO:0004716 |
signal transducer, downstream of receptor, with protein tyrosine kinase activity
|
EGFR, INSR, KDR |
3.18102 |
[MF] GO:0022804 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3 |
3.1515 |
[MF] GO:0097159 |
organic cyclic compound binding
|
ADORA1, ADRB1, ADRB2, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, FDPS, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
3.0121 |
[MF] GO:0009931 |
None
|
PRKCA, PRKCB, PRKCG |
2.93002 |
[MF] GO:0042802 |
identical protein binding
|
ACHE, ADRB2, BCL2, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH |
2.90865 |
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 |
2.8841 |
[MF] GO:0010857 |
None
|
PRKCA, PRKCB, PRKCG |
2.82977 |
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.82977 |
[MF] GO:0038052 |
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
|
ESR1, ESR2 |
2.82977 |
[MF] GO:0035403 |
None
|
PRKCA, PRKCB |
2.82977 |
[MF] GO:0004871 |
signal transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 |
2.64389 |
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH |
2.57709 |
[MF] GO:0005496 |
steroid binding
|
CYP3A4, ESR1, ESR2, HSD17B1, RORC |
2.50962 |
[MF] GO:1901363 |
heterocyclic compound binding
|
ADORA1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, FDPS, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, XDH |
2.47854 |
[MF] GO:0035258 |
None
|
ESR1, FLT3, PRKCB, SMAD3, SRC |
2.47533 |
[MF] GO:0035173 |
histone kinase activity
|
AURKB, PRKCA, PRKCB |
2.45438 |
[MF] GO:0015307 |
None
|
SLC47A1, SLC47A2 |
2.45438 |
[MF] GO:1901375 |
None
|
SLC22A1, SLC22A2 |
2.45438 |
[MF] GO:0070576 |
vitamin D 24-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.45438 |
[MF] GO:0004939 |
None
|
ADRB1, ADRB2 |
2.45438 |
[MF] GO:0005333 |
None
|
SLC22A1, SLC22A2 |
2.45438 |
[MF] GO:0005277 |
None
|
SLC22A1, SLC22A2 |
2.45438 |
[MF] GO:0008513 |
None
|
SLC22A1, SLC22A2 |
2.45438 |
[MF] GO:0004699 |
None
|
PRKCD, PRKCE |
2.45438 |
[MF] GO:0008289 |
lipid binding
|
AXL, CYP3A4, ESR1, ESR2, F10, F2, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 |
2.39767 |
[MF] GO:0015238 |
None
|
SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 |
2.383 |
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
ESR1, ESR2, PPARA, RORC |
2.38122 |
[MF] GO:0004879 |
nuclear receptor activity
|
ESR1, ESR2, PPARA, RORC |
2.38122 |
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 |
2.32593 |
[MF] GO:0019902 |
phosphatase binding
|
BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 |
2.23109 |
[MF] GO:0005355 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.23109 |
[MF] GO:0034056 |
estrogen response element binding
|
ESR1, ESR2 |
2.22361 |
[MF] GO:0034875 |
caffeine oxidase activity
|
CYP1A2, CYP3A4 |
2.22361 |
[MF] GO:0033695 |
oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor
|
CYP1A2, CYP3A4 |
2.22361 |
[MF] GO:0003674 |
molecular_function
|
ACHE, ADORA1, ADORA3, ADRB1, ADRB2, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, ESR1, ESR2, F10, F2, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SLCO1B1, SLCO1B3, SMAD3, SRC, TBXAS1, TEK, TOP1, TOP2A, TRPV1, TUBB3, TYR, XDH |
2.21193 |
[MF] GO:0015149 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.18881 |
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, ADRB1, ADRB2, AXL, EGFR, ESR1, ESR2, F2, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK, TRPV1 |
2.18865 |
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, CYP19A1, CYP1A2, NQO2, XDH |
2.15794 |
[MF] GO:0003707 |
steroid hormone receptor activity
|
ESR1, ESR2, PPARA, RORC |
2.12697 |
[MF] GO:0001540 |
amyloid-beta binding
|
ACHE, ADRB2, BACE1, INSR |
2.10287 |
[MF] GO:0015145 |
None
|
SLC5A1, SLC5A2, SLC5A4 |
2.09127 |
[MF] GO:0015101 |
None
|
SLC22A1, SLC22A2, SLC22A3 |
2.09127 |
[MF] GO:0101020 |
estrogen 16-alpha-hydroxylase activity
|
CYP1A1, CYP3A4 |
2.04398 |
[MF] GO:0030284 |
estrogen receptor activity
|
ESR1, ESR2 |
2.04398 |
[MF] GO:0043559 |
insulin binding
|
IGF1R, INSR |
2.04398 |
[MF] GO:0051380 |
None
|
ADRB1, ADRB2 |
2.04398 |
[MF] GO:0005518 |
collagen binding
|
ACHE, MMP12, MMP9, SMAD3 |
2.03662 |