Prescription ID | TCMF6847 |
Pinyin Name | Xin Nao Shu Kou Fu Ye |
Chinese Name | 心脑舒口服液 |
English Name | Xin Nao Shu Oral Liquid |
Function Description | 眩晕, 不寐, 健忘, 心悸, 怔忡, 自汗, 盗汗 |
Indications | Spontaneous palpitation disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Palpitations, Dizziness |
Disease ICD-11 Category |
SA11 [Spontaneous palpitation disorder (TM1), 怔忡 (TM1)
]; SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
TCMH426 | Codonopsis pilosula | 党参 | TCMH426 | ITSAL4530-14 |
TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1227 | Streptococcus |
TCMT1229 | Enterococcus faecalis |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1250 | Vesicular stomatitis virus |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1284 | Penicillium expansum |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1292 | Japanese encephalitis virus |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1336 | Yellow fever virus |
TCMT1337 | Dengue virus type 4 |
TCMT1338 | Rift Valley fever virus |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1393 | Vibrio sp. |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 | 14.6368 |
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 10.1992 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 9.74415 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 9.56681 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 9.19986 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 8.77696 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR, XDH | 8.77569 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 8.71972 |
[BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 8.3639 |
[BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TRPV1, XDH | 8.31725 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 8.17013 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.95457 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.70222 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.58162 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 7.47295 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 7.40094 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.38706 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.04679 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 7.04679 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH | 7.03997 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.5536 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 6.4979 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.46393 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 6.3875 |
[BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 6.3751 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 6.3751 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 6.3751 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 6.3751 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 6.09707 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 6.03527 |
[BP] GO:0009725 | response to hormone | AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 5.75354 |
[BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PPARA, PTGS1, PTGS2 | 5.37918 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 5.33743 |
[BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, SRC, TYR | 5.3088 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR | 5.30717 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 5.29406 |
[BP] GO:0014070 | response to organic cyclic compound | APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1, TYR | 5.29406 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.25957 |
[BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 5.25078 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 5.24289 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 5.22348 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 | 5.17868 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 5.12317 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, APEX1, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 4.94626 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, PTGS1 | 4.90379 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR, XDH | 4.88584 |
[BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 4.65391 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 4.60492 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, SRC, TOP2A, TRPV1 | 4.59485 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH | 4.55874 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 | 4.48075 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 4.48075 |
[BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5, PTGS2 | 4.48075 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR | 4.34516 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.3398 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APEX1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 | 4.31718 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 4.3012 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR, XDH | 4.17522 |
[BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR | 4.17335 |
[BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 4.09896 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 4.00791 |
[BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 3.99425 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.96986 |
[BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.94042 |
[BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.94042 |
[BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GLO1, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.94042 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.88624 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.80789 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.80789 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 3.78878 |
[BP] GO:0071407 | cellular response to organic cyclic compound | APEX1, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 | 3.78777 |
[BP] GO:0070988 | demethylation | APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 | 3.75543 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 3.75528 |
[BP] GO:0009820 | alkaloid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.74056 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 3.68838 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 | 3.67958 |
[BP] GO:0042493 | response to drug | AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.65177 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 3.65177 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 | 3.61564 |
[BP] GO:0006636 | unsaturated fatty acid biosynthetic process | ALOX12, ALOX15, PTGS1, PTGS2 | 3.52926 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.50685 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 3.4972 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.48542 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.4692 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.46463 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.3976 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 3.2866 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.2866 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1 | 3.24147 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.24147 |
[BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 3.22721 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.21907 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TRPV1, TYR | 3.21742 |
[BP] GO:1901570 | None | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 3.21086 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.15998 |
[BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 | 3.15301 |
[BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.12955 |
[BP] GO:0044283 | None | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 | 3.12759 |
[BP] GO:0070989 | oxidative demethylation | CYP1A2, CYP2D6, CYP3A4 | 3.07835 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 3.0007 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 2.99304 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.97846 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 | 2.94809 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTGS2 | 2.94809 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 2.93656 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.92473 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APEX1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.91311 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.90667 |
[BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.90667 |
[BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.90667 |
[BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.90667 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.90551 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC | 2.86023 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.83921 |
[BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.82482 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.82482 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.80135 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH | 2.78735 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.75731 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.75731 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.75255 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR | 2.74231 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, TRPV1 | 2.72935 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.72561 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1, SRC | 2.69367 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.67254 |
[BP] GO:0008283 | cell proliferation | ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 2.66924 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.64681 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.64364 |
[BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.5872 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.5872 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC | 2.5872 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.56631 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.55145 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 | 2.53302 |
[BP] GO:0009822 | alkaloid catabolic process | CYP2D6, CYP3A4 | 2.53144 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.53144 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.53009 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.52839 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.52839 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.4802 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.47258 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.47258 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.47206 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.47206 |
[BP] GO:2000021 | regulation of ion homeostasis | ADORA1, CA2, CA7, KDR, SRC, TRPV1 | 2.46939 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.46246 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC, XDH | 2.44121 |
[BP] GO:0010038 | response to metal ion | ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.39599 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 2.38865 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.37455 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.36947 |
[BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 2.3306 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.31669 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1 | 2.29201 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.29201 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.28892 |
[BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.28892 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.28892 |
[BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.22659 |
[BP] GO:0043065 | positive regulation of apoptotic process | CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH | 2.22453 |
[BP] GO:0043068 | positive regulation of programmed cell death | CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH | 2.19374 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, AURKB, CDC25B, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 2.17685 |
[BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.1663 |
[BP] GO:0072330 | monocarboxylic acid biosynthetic process | ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 | 2.15878 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, MMP2, MMP9, PTGS2 | 2.15591 |
[BP] GO:0030258 | lipid modification | ALOX12, CYP1A1, CYP3A4, MET, PIK3CA, PIK3CB | 2.14623 |
[BP] GO:0008209 | androgen metabolic process | CYP19A1, CYP3A4, ESR1 | 2.14623 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC | 2.11187 |
[BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.09798 |
[BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.09798 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 2.052 |
[BP] GO:2000106 | regulation of leukocyte apoptotic process | AURKB, AXL, HCAR2, PIK3CB | 2.0484 |
[BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH | 2.04695 |
[BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 | 2.04481 |
[BP] GO:0016310 | phosphorylation | AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.04467 |
[BP] GO:0014065 | phosphatidylinositol 3-kinase signaling | IGF1R, PIK3CA, PIK3CB | 2.04029 |
[BP] GO:0006691 | None | ALOX12, ALOX15, ALOX5 | 2.04029 |
[BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.02638 |
[BP] GO:0022900 | electron transport chain | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.01289 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, FLT3, KDR, PIK3CB, PTPN1, SRC, XDH | 2.01289 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TRPV1, XDH | 2.0114 |
[BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, XDH | 2.0114 |
[BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7 | 2.01123 |
[BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.00329 |
[BP] GO:0010942 | positive regulation of cell death | CYP1B1, HCAR2, MMP9, PIK3CB, PTGS2, SRC, TOP2A, TRPV1, XDH | 2.00329 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, ESR1, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH | 2.00087 |
[BP] GO:0006633 | None | ALOX12, ALOX15, PTGS1, PTGS2 | 2.00087 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR, XDH | 4.09312 |
[CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, FUT7, GLO1, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR | 2.73578 |
[CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, GLO1, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC, TRPV1 | 2.06202 |
[CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 1.97899 |
[CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR | 1.80743 |
[MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, TYR, XDH | 14.6368 |
[MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH | 12.8986 |
[MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TRPV1, TYR, XDH | 11.2783 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 10.5848 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 10.5726 |
[MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH | 7.4947 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 7.40094 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.40094 |
[MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TRPV1, TYR, XDH | 7.2925 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.09691 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 7.07578 |
[MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TRPV1, TYR, XDH | 6.89203 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 6.86571 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.86571 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR | 6.46393 |
[MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A, TRPV1 | 6.3751 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 | 5.89715 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 5.81639 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1 | 5.54374 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR | 5.35576 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.35576 |
[MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.69308 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.67372 |
[MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.65044 |
[MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.42519 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH | 3.29158 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2D6, CYP3A4 | 3.2866 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.22721 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.18187 |
[MF] GO:0042562 | hormone binding | ACHE, HSD17B1, IGF1R, NQO2, NR3C1 | 3.10136 |
[MF] GO:0051213 | dioxygenase activity | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 2.99234 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.90667 |
[MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.90667 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.73857 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.72899 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.69367 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.67234 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC | 2.57135 |
[MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, ESR1, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 | 2.56631 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 | 2.53144 |
[MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.53144 |
[MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.53144 |
[MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.53144 |
[MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.53144 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.46939 |
[MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP2A, TRPV1, XDH | 2.45862 |
[MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.28892 |
[MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.28892 |
[MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.18249 |
[MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.10364 |
[MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.09798 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC | 2.08913 |
[MF] GO:0005158 | None | IGF1R, PTPN1, SRC | 2.04029 |
[MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.01123 |
[MF] GO:0005496 | steroid binding | CYP3A4, ESR1, HSD17B1, NR3C1 | 2.00087 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.1075 |
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.6071 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.7383 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.7683 |
Metabolic pathways_Homo sapiens_hsa01100 | ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 6.2194 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.5188 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 5.9614 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 | 5.2762 |
Pathways in cancer_Homo sapiens_hsa05200 | PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 4.7997 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 | 5.7144 |
Serotonergic synapse_Homo sapiens_hsa04726 | CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.0123 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 5.0123 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.0123 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.6942 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 | 4.1495 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 3.813 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.8038 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.7196 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.3105 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.813 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.601 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.5412 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.5358 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 3.0454 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 3.0807 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.5709 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.417 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA | 2.9686 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.9594 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 2.961 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.7943 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.8374 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.8684 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.8684 |
Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, PIK3CB, MMP9 | 2.5664 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.8529 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.5007 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.4211 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.3108 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.1532 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.5662 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.5662 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.2734 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.5571 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, PIK3CB, IGF1R | 2.2562 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 3.0441 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.1968 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.2734 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, PIK3CB | 2.0325 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, CYP3A4 | 2.5662 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, PIK3CB, IGF1R | 2.1006 |
Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.8652 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, CYP3A4 | 2.5109 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB | 1.9658 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.9205 |
FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, IGF1R | 1.8639 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.8441 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.8639 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, TRPV1, NR3C1 | 1.8164 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.8251 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.4044 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.8184 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.764 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.7224 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.5688 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB | 1.5082 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.4963 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB | 1.4526 |
MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2899 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.3987 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3883 |
Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.398 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.2623 |
HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.7042 |
Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4699 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 1.0967 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.5123 |
Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.5123 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.5068 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 1.0979 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.9531 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 1.1161 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 1.0626 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, PIK3CB | 1.0793 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 1.1292 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 1.1988 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.2875 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.3722 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.3124 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5819 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.3643 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5819 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.2982 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.3157 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.2982 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.3272 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5918 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.5819 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5913 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.6048 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.6057 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.6075 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.6075 |
Gap junction_Homo sapiens_hsa04540 | SRC | 0.6075 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.3643 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.6066 |
Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6196 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.5312 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.5312 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.5688 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.6623 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6605 |
Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.5772 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6753 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.5438 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.6449 |
Bile secretion_Homo sapiens_hsa04976 | CA2, CYP3A4 | 1.5438 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.5688 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.7033 |
Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, PIK3CB | 1.6232 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.7009 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.7217 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.6908 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.6531 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.7409 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.9055 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.8251 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.7959 |
Malaria_Homo sapiens_hsa05144 | MET | 0.7994 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.8125 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP3A4, XDH | 1.8184 |
Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 2.0849 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 2.0373 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.9594 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.8748 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.9646 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.9259 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.9465 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.2734 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 1.0298 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 1.0181 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.3949 |