TCM Prescription: Zi Shen Ning Shen Pills



Prescription Description
Prescription IDTCMF6736
Pinyin NameZi Shen Ning Shen Wan
Chinese Name滋肾宁神丸
English NameZi Shen Ning Shen Pills
Function Description眩晕, 耳鸣, 不寐, 怔忡, 健忘, 遗精
IndicationsSpontaneous palpitation disorder, Involuntary ejaculation disorder, Tinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Dizziness
Disease ICD-11 Category SA11 [Spontaneous palpitation disorder (TM1), 怔忡 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Heart, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH1133 Rosa laevigata 金樱子 TCMH1133 ITSAJ4477-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH1565 Millettia speciosa champ 牛大力 TCMH1565
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2215 Ficus simplicissima 五指毛桃 TCMH2215
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT402 ALK ALK tyrosine kinase receptor Kinase Q9UM73
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT441 PTK2 Focal adhesion kinase 1 Kinase Q05397
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT555 HDAC6 Histone deacetylase 6 Hydrolase Q9UBN7
TCMT557 HDAC1 Histone deacetylase 1 Hydrolase Q13547
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT860 HDAC10 Histone deacetylase 10 Hydrolase Q969S8
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 15.6024
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 12.9036
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 12.0528
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALK, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, PTK2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 11.9172
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTK2, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 11.4478
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 11.1189
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.086
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 11.0741
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, PTGS1, PTGS2 10.91
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR, XDH 10.9017
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FUT7, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 10.7181
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALK, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 10.6945
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 10.6945
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, PTGS1, PTGS2 10.6866
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, PTGS1, PTGS2 10.627
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.0302
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 9.96138
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 9.82732
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 9.42531
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALK, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 9.30627
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 9.28513
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 9.15091
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TRPV1 9.10003
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 8.9958
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TEK, TRPV1, TYR 8.97821
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALK, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 8.97761
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, PTGS1, PTGS2 8.87186
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1 8.82098
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TRPV1, TYR 8.61576
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALK, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 8.39761
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALK, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 8.39761
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.30474
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.30474
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.30474
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 8.30474
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, PTGS1, PTGS2 8.24211
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F10, GPR35, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 8.1827
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 8.17202
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 7.9211
[BP] GO:0046777 protein autophosphorylation ALK, AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PTK2, SRC, TEK 7.85043
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT 7.85043
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.81438
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALK, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.81438
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.78092
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT 7.76105
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, NQO2, PTGS1, RORC 7.76105
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.62692
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, DRD3, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.58006
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, PTK2, SRC, TEK, XDH 7.55355
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, ALPL, APP, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TRPV1 7.48291
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.47641
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 7.45514
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.36153
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT, TRPV1 7.31101
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 7.29005
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 7.2617
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 7.18734
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 7.16694
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT 7.12099
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALK, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.07825
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 7.04672
[BP] GO:0018108 peptidyl-tyrosine phosphorylation ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTK2, SRC, TEK 7.02856
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT, TRPV1 7.02477
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTK2, SMAD3, SRC, TEK, TYR 7.00706
[BP] GO:0018212 peptidyl-tyrosine modification ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTK2, SRC, TEK 6.97096
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.92571
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, PTK2, TEK, TERT 6.91004
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 6.84948
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 6.84948
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, PTK2, SMAD3, SRC, TEK, TERT 6.84924
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82436
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC, TERT 6.73554
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, PTK2, SRC, TEK 6.7106
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, AURKB, CDC25B, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.65546
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALK, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.65005
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.63564
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 6.61535
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, PPARA, PTGS1, PTGS2 6.55885
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALK, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.5217
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, APP, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, TRPV1 6.49455
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 6.41552
[BP] GO:0007167 enzyme linked receptor protein signaling pathway ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTK2, PTPN1, SMAD3, SRC, TEK 6.30886
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 6.2992
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALK, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 6.23798
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 6.21203
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 6.1868
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.97455
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 5.89646
[BP] GO:0006793 phosphorus metabolic process ACHE, ALK, ALOX15, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 5.8367
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.8194
[BP] GO:0006468 protein phosphorylation ALK, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTK2, SRC, TEK 5.81494
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 5.74423
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 5.65264
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ALK, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.60959
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALK, ALOX15, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTK2, RORC, SMAD3, SRC, TEK, TYR 5.52541
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.52541
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD3, EGFR, GPR35, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1 5.47871
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.47191
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ALK, APP, AURKB, CDC25B, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.43368
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19 5.42169
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD3, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.37989
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALK, ALOX15, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.3789
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.35762
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.34164
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 5.26614
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, PPARA, PTGS2, PTK2, RORC, SRC, TEK 5.24266
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, EGFR, HSPA1A 5.23103
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALK, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 5.19813
[BP] GO:0016310 phosphorylation ALK, APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK 5.18717
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, PTK2, SRC 5.18627
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.1292
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.11946
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.1122
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, APP, AXL, CA2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTK2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 5.10602
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, KCNH2, KDR, NR3C1, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 5.07724
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.06647
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.02429
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ALK, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 5.01126
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.99114
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, DRD3, EGFR, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT, TRPV1 4.97517
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.94669
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 4.90413
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, INSR, PTGS2, SLC6A2, SLC6A4, SMAD3, TRPV1 4.82526
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 4.77686
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.77026
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, NR3C1, PTGS2, SLC6A4, SMAD3, SRC, TRPV1 4.74608
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.74608
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 4.72305
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, TYR 4.72024
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ALK, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC 4.72024
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ALK, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 4.68466
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.67307
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, ALK, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.66999
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HSD11B1, HSD17B1, HSD17B2 4.64158
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.59413
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 4.59106
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD3, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 4.50976
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.50115
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 4.47065
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR 4.41372
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.40697
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 4.35462
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 4.35267
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 4.32097
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTK2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 4.32026
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.31064
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, ALK, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 4.30935
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.29651
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SRC, TEK, XDH 4.29651
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ALK, APP, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.27475
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.26055
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.25751
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, PTK2, SRC 4.20918
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD3, EGFR, KDR, PIK3CB, PTGS2, SRC, TRPV1 4.15222
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.08557
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 4.08557
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 4.0777
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, PTK2, SRC, TEK 4.04667
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2, TERT 4.03279
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, ALK, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 4.02279
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, EGFR 4.00567
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, APP, AXL, CA2, CYP1B1, DRD3, EGFR, ESRRB, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 4.00233
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PTK2, SRC, TEK 3.99448
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.98855
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ALK, APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.90605
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA, TRPV1 3.86448
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.84386
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.84386
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, ALK, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTK2, PTPN1, SRC 3.82442
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, ALK, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 3.79077
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.77318
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 3.71169
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, DRD3, GPR35, KCNH2, MMP9, PTGS2 3.68464
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.68421
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 3.62751
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.60797
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.55974
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.55763
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD3, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 3.55763
[BP] GO:0051893 regulation of focal adhesion assembly KDR, PTK2, SMAD3, SRC, TEK 3.54058
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, PTK2, SMAD3, SRC, TEK 3.54058
[BP] GO:0040008 regulation of growth ALOX12, APP, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PTK2, SLC6A4, SMAD3 3.54058
[BP] GO:0008283 cell proliferation ACHE, ALK, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.53518
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 3.49288
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALK, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.47616
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 3.44496
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 3.44496
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PTK2, SMAD3, SRC, TEK 3.44496
[BP] GO:1903391 regulation of adherens junction organization KDR, PTK2, SMAD3, SRC, TEK 3.44496
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.44496
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, CA2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTK2, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.4368
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD3, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.41736
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.40426
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.39548
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, PTK2, SMAD3, SRC, TEK 3.39351
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, PTGS2, SLC6A4 3.39351
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD3, EGFR, PTGS2, SLC6A4 3.39351
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.37858
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, TYR 3.34641
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.34374
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, ALK, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTK2, PTPN1, SMAD3, SRC, TEK, TRPV1 3.34301
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTK2, PTPN1, SMAD3 3.34301
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.31209
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.29754
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.28813
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, ALK, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.26848
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.26413
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, DRD3, KDR, SLC6A4, SRC 3.25496
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.25174
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, TRPV1, XDH 3.25033
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, PTK2, SRC 3.23865
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, PTK2, SRC, TEK 3.23865
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, ALK, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 3.23769
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ALK, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.20975
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.20975
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 3.19969
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 3.18594
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 3.17502
[BP] GO:0001775 cell activation ADRA2A, ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC, TRPV1 3.13179
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 3.12047
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.11097
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 3.11058
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 3.11058
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.10776
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, PTGS2, PTK2, SLC6A4, SRC 3.10582
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, PTK2, SRC, TEK 3.09706
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.09706
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.0734
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.06295
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC, TRPV1 3.06231
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, PTK2, TEK 3.06176
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 3.04129
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PTK2, SRC, TEK 3.03318
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 3.01367
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, KDR, PIK3CB, PTK2, SMAD3, SRC, TEK 3.00225
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, ALK, AXL, CYP1B1, DRD3, EGFR, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTK2, PTPN1, SRC, TEK 3.00225
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.998
[BP] GO:0098771 inorganic ion homeostasis APP, CA12, CA2, CA7, DRD3, EGFR, ESR1, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 2.99144
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 2.98419
[BP] GO:0018193 peptidyl-amino acid modification ALK, AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PTK2, SRC, TEK 2.95469
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, ALK, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.94957
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.94626
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD3, FABP3, PPARA, TRPV1 2.94142
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTK2, PTPN1 2.94142
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, SLC6A4, TRPV1, TYR 2.94142
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.93416
[BP] GO:0009115 None AOX1, XDH 2.93416
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.93416
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.93416
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.93416
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.93228
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC, TERT 2.92827
[BP] GO:0046683 response to organophosphorus APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.92827
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT 2.90631
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.89719
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.89297
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.88846
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.87496
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT 2.8549
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.85452
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC, TRPV1 2.84316
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.83553
[BP] GO:0048869 cellular developmental process ACHE, ALK, ALPL, APP, AXL, CBR1, CDC25B, CES1, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, PTGS2, PTK2, RORC, SMAD3, SRC, TEK, TERT 2.8294
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT 2.81663
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.81135
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.81135
[BP] GO:1901888 regulation of cell junction assembly KDR, PTK2, SMAD3, SRC, TEK 2.81135
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.81092
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 2.81092
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 2.81092
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AURKB, CSNK2A1, DRD3, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.81092
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.80536
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.80536
[BP] GO:1904063 None ADRA2A, DRD3, GPR35, KCNH2, MMP9 2.79459
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD3, KDR, SRC, TRPV1 2.77661
[BP] GO:0042058 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.72234
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, PTK2, SRC, TEK 2.71411
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, MMP12, SLC6A4, SRC, TRPV1 2.71411
[BP] GO:0051172 None ADRA2A, APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.69965
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, PTK2, SRC, TEK 2.69088
[BP] GO:0014074 response to purine-containing compound APP, PTGS2, SLC6A4, TEK, TRPV1, TYR 2.6796
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, ALK, ALOX15, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTK2, PTPN1, SMAD3, SRC, TEK, XDH 2.66903
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.66866
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 2.64594
[BP] GO:2000811 negative regulation of anoikis PIK3CA, PTK2, SRC 2.64174
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.64174
[BP] GO:0070920 None EGFR, ESR1, TERT 2.64174
[BP] GO:0032225 None DRD3, PTGS2, SLC6A4 2.64174
[BP] GO:0008217 None ADORA1, DRD3, PPARA, PTGS1, PTGS2, SMAD3 2.64127
[BP] GO:0031331 positive regulation of cellular catabolic process ADRA2A, ESRRB, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTK2, PTPN1 2.61788
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTK2, SRC, TEK 2.60054
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9, PTK2 2.57849
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT 2.57653
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD3, EGFR, PIK3CB, PTGS2 2.57291
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9, PTK2 2.57291
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, DRD3, GPR35, KCNH2, MMP9, PTGS2, SLC6A4 2.57291
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, KDR, PTGS2, TEK, TERT 2.57041
[BP] GO:0034766 None ADRA2A, DRD3, GPR35, KCNH2, MMP9 2.56483
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, PTGS2, SRC 2.55703
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.55378
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.54623
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.53852
[BP] GO:0006928 movement of cell or subcellular component ADRA2A, ALOX12, APP, AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTK2, SRC, TEK 2.53852
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, ESRRA, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTK2, PTPN1, SMAD3, SRC 2.53852
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.53852
[BP] GO:0046110 None AOX1, XDH 2.53852
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53852
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.53852
[BP] GO:0050730 None ADORA1, ADRA2A, APP, EGFR, FLT3, PTPN1, SRC 2.536
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, PTK2, TEK 2.51975
[BP] GO:1901184 None ADORA1, ADRA2A, APP, EGFR, MMP9 2.47845
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, DRD3, EGFR, GPR35, KCNH2, PTGS2, SMAD3, TRPV1 2.47363
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.47363
[BP] GO:0055080 cation homeostasis APP, CA2, CA7, DRD3, EGFR, ESR1, GPR35, KCNH2, PIK3CB, SMAD3, TRPV1 2.47363
[BP] GO:0034763 None ADRA2A, DRD3, GPR35, KCNH2, MMP9 2.46307
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.44677
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.44677
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.44677
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.44677
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.44566
[BP] GO:0043550 regulation of lipid kinase activity FLT3, PTK2, SRC, TEK 2.44566
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, EGFR 2.42958
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.42506
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, MET, PIK3CA, PIK3CB 2.41489
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.4145
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, CYP1A1, EGFR, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.36889
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, TERT, XDH 2.36341
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.3619
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.3596
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 2.35018
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTK2, SRC, TEK 2.34955
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTK2, PTPN1, SMAD3, SRC, TEK 2.34046
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AXL, CA2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, INSR, KDR, PIM1, PTGS2, PTK2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.34046
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.33464
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.33464
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.32854
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, KDR, PTGS2, TEK, TERT 2.31597
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SMAD3, SRC, TERT 2.31298
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.29467
[BP] GO:0045596 None APP, DRD3, EGFR, ESRRB, PPARA, PTK2, SLC6A4, SMAD3, TERT, TRPV1, XDH 2.29002
[BP] GO:0000122 None AURKB, DRD3, ESR1, ESR2, ESRRA, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, TRPV1 2.28995
[BP] GO:0043542 endothelial cell migration CYP1B1, KDR, PIK3CA, PTK2 2.28995
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.28995
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.28995
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.28995
[BP] GO:0006145 None AOX1, XDH 2.28995
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28995
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28995
[BP] GO:0007173 epidermal growth factor receptor signaling pathway EGFR, PIK3CA, PTK2, SRC 2.26671
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTK2, SRC, TEK 2.26356
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALK, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.2418
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP3A4 2.24031
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, EGFR, MET, PIK3CA, PPARA, SMAD3 2.23989
[BP] GO:2000209 regulation of anoikis PIK3CA, PTK2, SRC 2.23989
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.23989
[BP] GO:0051254 None APP, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT 2.23637
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.22727
[BP] GO:0071396 cellular response to lipid AXL, EGFR, ESR1, FLT3, NR3C1, RORC, SLC6A4, SRC 2.2272
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.2204
[BP] GO:0051894 None KDR, SMAD3, TEK 2.18995
[BP] GO:0061900 None APP, EGFR, TRPV1 2.18995
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.18995
[BP] GO:0048608 reproductive structure development AXL, CYP19A1, ESR1, HSD17B2, INSR, PTK2, SRC 2.17833
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, APP, CA2, DRD3, EGFR, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.17415
[BP] GO:0050890 None ADORA1, APP, DRD3, EGFR, INSR, PTGS2, SLC6A4 2.16329
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, PTGS2, SLC6A4 2.14985
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD3, INSR, TERT 2.14649
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.13766
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.12645
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CYP1B1, FABP3, HSPA1A, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.1127
[BP] GO:0043434 None FABP3, INSR, PPARA, PTGS2, SRC, TEK, TRPV1 2.11269
[BP] GO:0010628 positive regulation of gene expression APP, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PIK3CB, PPARA, RORC, SLC6A4, SMAD3, SRC, TERT 2.11269
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, PTK2, TEK 2.10885
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD3, PPARA, SMAD3, TEK 2.10885
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.10885
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.10885
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.10885
[BP] GO:1903393 None KDR, SMAD3, TEK 2.10885
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.10885
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.10885
[BP] GO:0097746 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.10523
[BP] GO:0035296 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.10523
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, SRC, TEK 2.09414
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.08979
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, APP, CYP1B1, DRD3, EGFR, INSR, KCNH2, PIK3CA, PTGS2, SLC6A4, SRC, TEK, TRPV1, TYR 2.08658
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, HSPA1A, PIK3CB, SRC, XDH 2.0853
[BP] GO:0051241 negative regulation of multicellular organismal process ADORA1, ALOX12, APP, AXL, DRD3, EGFR, GPR35, PTGS2, PTK2, SLC6A4, SMAD3, TEK, TERT, XDH 2.08028
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.07219
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.06151
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.02876
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, ALK, APP, CYP1B1, ESR1, ESR2, HSPA1A, PIM1 2.02031
[BP] GO:0045893 None APP, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT 2.01482
[BP] GO:1903508 None APP, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT 2.01482
[BP] GO:1902680 None APP, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT 2.01219
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.00977
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, APP, DRD3, GPR35, HSPA1A, KCNH2, MMP9, PTGS2 2.00977
[BP] GO:0050880 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4 2.00161
[BP] GO:0051253 None AURKB, DRD3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, NR3C1, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 2.00161
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD3, EGFR, ESR1, F10, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTK2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1 4.69485
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTK2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TRPV1, TYR, XDH 3.77261
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTK2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR 3.71242
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALK, ALOX15, APP, AXL, CA2, CA4, CA9, DRD3, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, PTK2, SLC6A2, SLC6A4, SRC, TEK, TRPV1 3.71169
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.46199
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 3.44496
[CC] GO:0044432 endoplasmic reticulum part APP, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, EGFR, F10, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 3.34944
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALK, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTK2, PTPN1, SLC6A2, SLC6A4, SRC, TEK, TRPV1, TYR 3.31245
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, ALK, APP, AXL, CA4, DRD3, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK, TRPV1 3.2065
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 3.02855
[CC] GO:0098589 membrane region APP, EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A4, SRC, TEK 2.93416
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, ALK, APP, AXL, DRD3, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A4, TEK, TRPV1 2.46849
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 2.17415
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALK, ALOX12, ALPL, AOX1, APP, AURKB, AXL, CA1, CA2, CA4, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SMAD3, SRC, TERT, TYR, XDH 2.0417
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, INSR, MET, PTGS2, PTK2, SRC, TEK, TRPV1 2.04053
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 17.9206
[MF] GO:0043167 ion binding ACHE, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, TYR, XDH 15.6024
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALK, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, F10, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTK2, PTPN1, SRC, TEK, TERT, TYR, XDH 13.8046
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.94467
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 9.79893
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 9.54802
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, XDH 8.73308
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 8.67742
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 8.61576
[MF] GO:0008144 drug binding ACHE, ALK, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, DRD3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTK2, SLC6A4, SRC, TEK, TRPV1 8.61576
[MF] GO:0019199 transmembrane receptor protein kinase activity ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.78092
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, SMAD3 7.46047
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 7.32227
[MF] GO:0004713 protein tyrosine kinase activity ALK, AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTK2, SRC, TEK 7.12601
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, SRC 7.05406
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, PTGS1, PTGS2, TYR 6.64206
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4 6.63919
[MF] GO:0004672 protein kinase activity ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, PTK2, SRC, TEK 6.5025
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.23798
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.20318
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK 6.18757
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.99565
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 5.92817
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, TYR 5.92363
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.64731
[MF] GO:0016301 kinase activity ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK 5.63765
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, PTK2, RORC, SMAD3, TEK, TRPV1 5.52541
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.34164
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TERT 5.34164
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.28127
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.23903
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.09254
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.09254
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 5.07434
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 5.02156
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.89413
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.85409
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TEK, TRPV1 4.85409
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.83167
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.79275
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ALK, AOX1, APP, CSNK2A1, EGFR, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TRPV1, TYR, XDH 4.74827
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SMAD3, SRC 4.69485
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A6, CYP2C19, CYP3A4 4.46297
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ALK, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.30529
[MF] GO:0019899 enzyme binding ADRA2A, APP, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, KCNH2, MET, NR3C1, PPARA, PTGS2, PTK2, PTPN1, SLC6A4, SMAD3, SRC, TEK 4.27103
[MF] GO:1901363 heterocyclic compound binding ADORA1, ALK, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTK2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TRPV1, XDH 3.55898
[MF] GO:0043168 anion binding ALK, ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1, XDH 3.55763
[MF] GO:0036094 small molecule binding ADORA1, ALK, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1, XDH 3.46199
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.44496
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.39351
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.31245
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.31245
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.29754
[MF] GO:0140096 catalytic activity, acting on a protein ALK, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTK2, PTPN1, SRC, TEK 3.23769
[MF] GO:0005524 ATP binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 3.18581
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.09706
[MF] GO:0000166 nucleotide binding ALK, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1, XDH 3.08162
[MF] GO:1901265 nucleoside phosphate binding ALK, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1, XDH 3.0797
[MF] GO:0032559 adenyl ribonucleotide binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 3.06327
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.0533
[MF] GO:0030554 adenyl nucleotide binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 3.0328
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.93416
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93416
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.93416
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.6796
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.64174
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.53852
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.53852
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.53852
[MF] GO:0005330 None SLC6A2, SLC6A4 2.53852
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.53852
[MF] GO:0047374 None CES1, CES2 2.53852
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.38877
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.37495
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTK2, PTPN1, SMAD3, SRC 2.31597
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28995
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28995
[MF] GO:0032795 None ADORA1, ADRA2A 2.28995
[MF] GO:0051425 None APP, INSR 2.28995
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28995
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.25534
[MF] GO:0035639 purine ribonucleoside triphosphate binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 2.17415
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.17368
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, NR3C1, PTK2, PTPN1, SMAD3, SRC 2.15565
[MF] GO:0005057 signal transducer activity, downstream of receptor ALK, EGFR, INSR, KDR, SMAD3 2.12277
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.10885
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.10885
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.10885
[MF] GO:0043559 insulin binding IGF1R, INSR 2.10885
[MF] GO:0032555 purine ribonucleotide binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 2.07037
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.06792
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.05495
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, ALK, AXL, DRD3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK, TRPV1 2.05495
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.05291
[MF] GO:0017076 purine nucleotide binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 2.04053
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, EGFR, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.04053
[MF] GO:0032553 ribonucleotide binding ALK, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTK2, SRC, TEK, TRPV1 2.0338
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.02619


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 10.4936
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.4936
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 7.9776
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.1212
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, PTK2, IGF1R 7.9144
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 8.6469
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.4861
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9144
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.3224
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 7.0501
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, PTK2, IGF1R 6.1004
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 6.6245
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.6245
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.7111
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2, PTK2 5.7172
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, PTK2, IGF1R 4.8726
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.5391
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 4.5391
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, PTK2, IGF1R 4.2451
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.2238
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.3791
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.9931
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.3169
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.3643
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.2418
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 3.8952
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.2272
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.0712
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4, CYP2C19 4.2708
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB 3.608
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.6584
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA2A 3.5919
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET, PTK2 4.0715
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR, PTK2 3.8952
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.4766
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.4849
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, TRPV1, NR3C1, DRD3, ADRA2A 3.316
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9, PTK2 3.3541
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 2.9809
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.0273
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.841
Non-small cell lung cancer_Homo sapiens_hsa05223 ALK, PIK3CA, PIK3CB, EGFR 3.4884
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.4043
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.2984
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4803
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 2.8374
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.2823
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, PTK2, IGF1R 2.626
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.704
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.7642
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2, PTK2 2.8768
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5399
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR, PTK2 2.3586
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9965
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4492
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4101
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.4492
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2169
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.4293
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.391
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.2713
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.3
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.2067
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.2497
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.1447
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.0862
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB, PTK2 1.8462
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.768
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB, PPARA 1.7799
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.45
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.4383
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4055
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2761
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2824
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2918
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2813
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2818
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.9027
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2918
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3169
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.8055
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3565
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, PTK2 1.8119
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.1057
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.7799
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.7249
Dopaminergic synapse_Homo sapiens_hsa04728 DRD3 0.3661
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3791
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.263
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.1473
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.8348
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4441
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4441
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8573
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8353
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.9122
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8529
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4538
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4441
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8921
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4531
Axon guidance_Homo sapiens_hsa04360 MET, PTK2 0.8784
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8312
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8122
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4662
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.001
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4722
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4722
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4829
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2497
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0114
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4712
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.4763
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0845
Peroxisome_Homo sapiens_hsa04146 XDH 0.4841
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.305
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0526
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4991
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.1015
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5054
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5188
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.0845
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.517
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.1104
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2226
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5314
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5586
Shigellosis_Homo sapiens_hsa05131 SRC 0.5561
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2527
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2914
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.58
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.5624
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2659
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2659
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6103
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3828
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.3229
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.7959
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3886
Malaria_Homo sapiens_hsa05144 MET 0.6521
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6615
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6568
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5896
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.776
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8529
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8182
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8716
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8348
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8573
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7791
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8283
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.828
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8529
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7657
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0862
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2238
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0843
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3886


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)