TCM Prescription: Yang Xian Feng Dian Pills



Prescription Description
Prescription IDTCMF6735
Pinyin NameYang Xian Feng Dian Wan
Chinese Name羊痫疯癫丸
English NameYang Xian Feng Dian Pills
Function Description急惊风
IndicationsAcute convulsion disorder, Convulsions
Disease ICD-11 Category SE33 [Acute convulsion disorder (TM1), 急惊风 (TM1) ];
8A68.Z [Type of seizure, unspecified, 癫痫发作类型，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1677 Pinellia ternata 清半夏 TCMH1677 GBVT1123-13, GBVY1693-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH2102 Concretio silicea bambusae 天竺黄 TCMH2102
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH1179 Citri exocarpium rubrum 橘红 TCMH1179
TCMH2094 Arisaema consanguineum 天南星 TCMH2094 GBVY604-14
TCMH2090 Gastrodia elata 天麻 TCMH2090
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH1695 Pericarpium citri reticulatae viride 青皮 TCMH1695
TCMH1068 Dalbergia odorifera 降香 TCMH1068 ITSAJ4189-14
TCMH1090 Brassica juncea 芥子 TCMH1090 ITSAJ4546-14
TCMH249 Aquilaria agallocha 沉香 TCMH249 KU879012
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH2208 Lindera strychnifolia 乌药 TCMH2208
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1294 Cornu saigae tataricae 羚羊角 TCMH1294
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT899 ALDH2 Aldehyde dehydrogenase Oxidoreductase P05091
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1297 Punta Toro virus
TCMT1310 Enterococcus hirae
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR7, KDR, MAOA, MET, MIF, POLA1, POLB, SLC1A1, SRC, TNKS, TNKS2, XDH 13.8179
[BP] GO:0007187 None ADORA1, ADRA1A, ADRB1, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 13.6047
[BP] GO:0007188 None ADORA1, ADRA1A, ADRB1, CHRM2, CNR1, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 12.1527
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 11.696
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 11.696
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 11.2567
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 11.2398
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 10.3932
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, POLB, PTGES, RELA, SRC, TYR 10.1405
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A 10.0432
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 9.90308
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 9.76744
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CYP1B1, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, RELA, SRC, XDH 9.51221
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 9.30423
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, APEX1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR5A, IGF1R, KDR, MMP2, POLB, PTGES, RELA, SRC, TYR 9.25341
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, HSD17B3, MET, MIF, PTGES, TBXAS1 9.2492
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, PIM1, POLB, PTGES, RELA, SIGMAR1, SRC, TNKS, TNKS2 8.95515
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET, POLA1, POLB, SRC 8.89049
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, APEX1, APP, AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, POLB, PTGES, RELA, SRC, TYR 8.79516
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 8.07901
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.05891
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, HTR2A, HTR2B, KDR, MIF, SRC, TNKS, TNKS2 7.94963
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AR, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MIF, MMP2, MMP9, PIM1, PTGES, RELA, SRC, XDH 7.88097
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 7.85566
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, AR, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, FLT3, HTR5A, PTGES, RELA, SRC, TYR 7.79524
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, APEX1, AXL, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, POLB, RELA, SRC 7.70984
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AXL, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, RELA, SRC, TNKS, TNKS2, XDH 7.70984
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.70984
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.70984
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 7.6556
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, XDH 7.58194
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, SRC, XDH 7.5591
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 7.53442
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALDH2, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, GLO1, HSD17B3, HTR2B, MIF, PIM1, PTGES, TBXAS1, TYR, XDH 7.48543
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 7.48543
[BP] GO:0023052 None ADORA1, ADRA1A, ADRB1, AR, CACNA1C, CHRM2, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.29088
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGES, RELA, SRC 7.2755
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, RELA, SIGMAR1, SRC, TOP2A, XDH 7.25403
[BP] GO:0007267 None ADORA1, ADRA1A, ADRB1, AR, CHRM2, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 7.17461
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.84981
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.84981
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, POLA1, POLB, PTGES, RELA, SRC, TOP2A, TYR 6.84745
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A 6.73151
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MAP2K1, MIF, MMP9, PIM1, RELA, SIGMAR1, SRC, TOP2A, XDH 6.69316
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69128
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69128
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.66224
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, HSD17B1, HSD17B2, HSD17B3 6.66224
[BP] GO:0007154 None ADORA1, ADRA1A, ADRB1, AR, AXL, CACNA1C, CHRM2, CNR1, DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 6.66224
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AR, AURKB, AXL, CNR1, CSNK2A1, CYP1B1, EGFR, F3, FLT3, GLO1, GRIK5, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, RELA, SIGMAR1, SRC, TOP2A, XDH 6.65486
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRB1, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 6.65171
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 6.44829
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, DRD1, DRD2, EGFR, ERBB2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 6.44829
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF, PTGES, TBXAS1 6.44639
[BP] GO:0003018 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 6.44639
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, SRC, XDH 6.39038
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.379
[BP] GO:0033993 response to lipid AR, AXL, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, HTR5A, PTGES, RELA, SRC, TYR 6.3709
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, RELA, SRC 6.29774
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 6.2942
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CACNA1C, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, KDR, MAP2K1, MET, MIF, MMP2, MMP9, PIM1, POLB, RELA, SIGMAR1, SRC, TNKS2, TOP2A, TYR 6.24584
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 6.17799
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALDH2, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HSD17B3, HTR1A, MAOA, TYR 6.15575
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, EGFR, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, HTR2B, MET 6.12556
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 6.1151
[BP] GO:0097746 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.11489
[BP] GO:0035296 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 6.11489
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRB1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, MMP9, SRC, TNKS, XDH 6.07293
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, MIF, PTGES, TBXAS1 5.99558
[BP] GO:0050880 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.8908
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRB1, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 5.89073
[BP] GO:0035150 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 5.86967
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ERBB2, FABP3, FLT3, GRM5, HTR5A, IGF1R, MMP2, RELA, SRC 5.868
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CSNK2A1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MIF, MMP2, MMP9, PIM1, RELA 5.84875
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 5.76954
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRB1, AKR1B1, ALOX5, APP, AR, AXL, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, GRM1, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, RELA, SRC, TNKS2, TYR 5.73692
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.71803
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6692
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.6692
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.655
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, RELA, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 5.64703
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGES, TBXAS1 5.63341
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, MAP2K1, MIF, SRC 5.57253
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.52301
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, DRD2, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MAP3K7, MET, MIF, MMP2, MMP9, RELA, SRC, TNKS, TNKS2 5.49823
[BP] GO:0042391 None ADORA1, ADRA1A, APP, CACNA1C, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 5.46789
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC 5.43596
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 5.43268
[BP] GO:0003013 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.42803
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 5.39886
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 5.39886
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRB1, AKR1B1, AXL, CACNA1C, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, POLB, RELA, SRC 5.39788
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRB1, APP, AR, AXL, CA2, CNR1, CYP1B1, DRD2, DRD3, EGFR, F3, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, RELA, SLC1A1, SRC 5.36556
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, SRC 5.36556
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.35482
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, RELA, SRC, TYR 5.34013
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, SRC 5.3294
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, HSD17B2, HSD17B3, KDR, MAP2K1, POLB, RELA, SRC, TYR 5.31722
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, EGFR, ERBB2, HTR2A, HTR2B, KDR, MAP2K1, MIF, SRC 5.30839
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.18427
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 5.16752
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.12174
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOA, TYR 5.12174
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 5.10806
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HTR2A, HTR2B, MMP2, POLB, RELA, SRC, TYR 5.09188
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3, EGFR, TNKS, TNKS2 5.08857
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR 5.06855
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRB1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, RELA, SRC, TNKS, XDH 5.05734
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.04731
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, ALDH2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, MAOA 5.01328
[BP] GO:0007568 aging ADRA1A, APEX1, AURKB, CNR1, CYP1A1, HTR2A, MAP2K1, MIF, POLB, RELA 5.01328
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PTGES, TBXAS1 5.01268
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, AR, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 4.92902
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, MMP2, RELA, SRC, TYR 4.91734
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, ERBB2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.90492
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP2, MMP9, POLA1, POLB, RELA, SRC, TOP2A 4.86352
[BP] GO:0007200 None ADRA1A, CHRM2, DRD1, DRD2, GRM5, HTR2A, HTR2B 4.84361
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.79538
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 4.78126
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 4.78056
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 4.72384
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ERBB2, FLT3, HTR1A, MAP2K1, MET, MIF, PIM1, POLA1, SRC, TYR 4.71014
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 4.69574
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.69574
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, MAOA, SLC1A1 4.65473
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRB1, APP, AR, AXL, CA2, CACNA1C, CHRM2, CNR1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, GRM1, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, RELA, SLC1A1, SRC, TNKS2, XDH 4.61285
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, RELA, SRC 4.60698
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 4.60698
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, FABP3, GRM1, GRM5, HTR2A, HTR2B 4.60115
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.56861
[BP] GO:0001659 None ADORA1, ADRB1, DRD1, DRD2, HTR2A 4.5652
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, MIF, SRC, TNKS, TNKS2 4.55764
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APEX1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, GLO1, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PTGES, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 4.52766
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC, TNKS 4.48791
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 4.48791
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, SRC 4.45591
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRB1, APP, AR, AURKB, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, XDH 4.4552
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.42503
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.41418
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, SRC, TNKS 4.39228
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC 4.38034
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.38034
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, ERBB2, F3, MET, SRC, XDH 4.37812
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, AR, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 4.36495
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC 4.36328
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, DRD3, GRM5, HTR1A, HTR2A, MIF, MMP9 4.35762
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.33295
[BP] GO:0003008 None ADORA1, ADRA1A, ADRB1, AKR1B1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 4.33295
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM2, DRD2, EGFR, HTR2A, SLC1A1 4.27664
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 4.21317
[BP] GO:0042737 drug catabolic process ACHE, ALDH2, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOA 4.13117
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HTR2B, IGF1R, KDR, MET, MIF, MMP9, PIM1, RELA, SRC 4.12185
[BP] GO:0033674 positive regulation of kinase activity ADORA1, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC 4.10113
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B 4.10113
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, SRC 4.08595
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GLO1, HTR2B, IGF1R, KDR, MIF, MMP9, PIM1, RELA, SRC 4.0478
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, ADRB1, AKR1B1, DRD1, DRD2, HTR2A, MET 4.04417
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AR, AXL, CYP1B1, DRD1, EGFR, GRIK5, GRM5, IGF1R, MMP2, MMP9, RELA, SRC 4.02397
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 4.00338
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 4.00075
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 3.98498
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, HTR5A, RELA, SRC 3.98498
[BP] GO:0045776 None ADORA1, ADRB1, CNR1, DRD2, DRD3 3.96585
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RELA, SRC 3.96585
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PTGES, TBXAS1 3.9285
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.92208
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOA 3.92208
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.92208
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ERBB2, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RELA, SRC 3.89457
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, RELA, SRC, TNKS, TNKS2, XDH 3.89319
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, AR, CSNK2A1, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, RELA, SRC, XDH 3.89068
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOA 3.88176
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, GLO1, GRM3, GRM8, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, PIM1, PTGES, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.86198
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRB1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, HTR2A, HTR2B, HTR6, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 3.86198
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, F3, FABP4, KDR, MAP2K1, MET, MIF, RELA 3.84837
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, SRC 3.83922
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, AR, DRD1, DRD2, EGFR, ERBB2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, RELA, SRC, XDH 3.83922
[BP] GO:0019725 cellular homeostasis ADRA1A, APEX1, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B, POLA1 3.83527
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.83361
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.82847
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.75019
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, EGFR, ERBB2, FLT3, GRM1, HTR2A, HTR2B, IGF1R, MAP2K1, MAP3K7, MIF, SRC 3.74335
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B 3.71551
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, SLC1A1 3.71551
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 3.70602
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 3.63571
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, SRC, TNKS 3.63539
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRB1, APP, AURKB, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, MAP2K1, MAP3K7, MIF, SRC, TNKS, XDH 3.6275
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM2, DRD2, DRD3, EGFR, GRM1, HTR2A, SLC1A1 3.62062
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.60982
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, APP, AR, AXL, CA2, CACNA1C, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FLT3, HSD17B2, HSD17B3, HTR5A, KDR, MAP2K1, MMP9, PIM1, POLB, RELA, SIGMAR1, SRC, TYR 3.59603
[BP] GO:0019933 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.58957
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, SLC1A1 3.58957
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.58262
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A 3.58262
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53508
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.53508
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B 3.53183
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, GRIK5, GRM5, HTR1A, HTR2A, HTR2B, MAP2K1, MIF, MMP9, SRC 3.52975
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HTR1A, HTR2A, HTR2B, MIF, SRC 3.51662
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, RELA 3.5161
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, DRD1, EGFR, KDR, RELA, SRC 3.46653
[BP] GO:0008217 None ADORA1, ADRA1A, ADRB1, AR, CNR1, DRD2, DRD3 3.46086
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.43382
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.43382
[BP] GO:0030817 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.42669
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.40939
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.40939
[BP] GO:0019935 None ADRA1A, ADRB1, DRD1, DRD2, DRD3, HTR5A 3.38052
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APEX1, APP, AXL, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, HTR1A, MAP2K1, MAP3K7, MIF, MMP2, MMP9, POLA1, POLB, PTGES, RELA, SRC, TOP2A 3.38046
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRIK5, GRM1, GRM5, HTR2A, HTR2B 3.37238
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 3.36684
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, PIM1, POLA1, POLB, PTGES, RELA, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 3.34727
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP2D6, CYP3A4 3.32228
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TNKS, TOP2A 3.32228
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOA 3.29146
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.29146
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 3.28918
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.28693
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRB1, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.28693
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 3.28693
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA 3.26524
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.23678
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, MIF, SRC 3.21702
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, RELA, SRC 3.21647
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, DRD2, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, KDR, MAP2K1, MAP3K7, MIF, MMP9, SRC, XDH 3.20781
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, AR, DRD1, EGFR, ERBB2, FLT3, GRM5, IGF1R, MMP2, RELA, SRC 3.19102
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 3.19102
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 3.19102
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MET, MIF, MMP1, MMP9, SRC 3.18215
[BP] GO:0060402 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 3.1762
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, MMP2, RELA, SRC 3.1762
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A 3.17589
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AR, AURKB, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 3.16266
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, DRD1, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.15932
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.1589
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.1589
[BP] GO:0008016 None ADORA1, ADORA3, ADRA1A, ADRB1, CACNA1C, CHRM2, DRD2, SLC1A1 3.15768
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 3.15768
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, AR, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MIF, MMP9, RELA, SRC, XDH 3.14994
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling ERBB2, HTR2A, HTR2B, IGF1R 3.14766
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, AR, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2A, IGF1R, MET, MIF, MMP9, RELA, SRC, XDH 3.13568
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MAP2K1, MIF, MMP1, MMP9, SRC 3.13568
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 3.11029
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGES 3.10781
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, DRD2, DRD3, TNKS2 3.10367
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.10367
[BP] GO:0043278 None CNR1, DRD2, DRD3, RELA 3.10367
[BP] GO:0014072 None CNR1, DRD2, DRD3, RELA 3.10367
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, RELA, SRC 3.08229
[BP] GO:0030814 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.07666
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 3.05311
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.04974
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 3.04312
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SIGMAR1, SRC, TNKS, TNKS2, TOP2A, XDH 3.02942
[BP] GO:1903524 None ADRA1A, ADRB1, EGFR, HTR2A, SLC1A1 3.02667
[BP] GO:0030802 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 3.02667
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, RELA 3.00856
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, MIF, MMP1, MMP9, SRC 2.97731
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.97335
[BP] GO:0007189 None ADRA1A, ADRB1, DRD1, DRD2, DRD3 2.97335
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.94461
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.94461
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DRD1, EGFR, GRM5, IGF1R, MMP2, RELA, SRC 2.92955
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, HTR2A, HTR2B 2.92567
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 2.92051
[BP] GO:0001997 None ADRA1A, ADRB1 2.91545
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.91545
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3 2.90634
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TOP2A, XDH 2.90634
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 2.90278
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR2A 2.88699
[BP] GO:0060401 None ADRA1A, CACNA1C, DRD2, HTR2A, HTR2B 2.87775
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PTGES, TBXAS1, TYR 2.86384
[BP] GO:1900371 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 2.85544
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.85465
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85465
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.85465
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.85465
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 2.85184
[BP] GO:0030808 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 2.84504
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, FLT3, SRC 2.83878
[BP] GO:0007610 None APP, CNR1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B 2.83315
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, SLC1A1 2.80004
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR2A, HTR2B 2.80004
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MET, RELA, SRC, TNKS, TNKS2, TOP2A 2.77508
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.76336
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.76336
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLB, SRC, TNKS, XDH 2.76315
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, DRD2, DRD3, EGFR, HTR2B, MIF, SRC 2.76298
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, APEX1, APP, AR, AURKB, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, POLA1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.76096
[BP] GO:0032496 response to lipopolysaccharide AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.75269
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MIF, PTGES 2.75163
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.74517
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, SRC 2.74108
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, TYR 2.70874
[BP] GO:0009056 catabolic process ACHE, ADORA1, ALDH2, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MAOA, MMP1, MMP2, MMP9, SRC, XDH 2.70066
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.70059
[BP] GO:0090066 None ADORA1, ADRA1A, ADRB1, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7 2.69136
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, HTR7, SRC, TOP2A 2.68613
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.68418
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GRM1, GRM5, HTR2A, HTR2B 2.67938
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, EGFR, RELA, TYR 2.67938
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, DRD2, DRD3, EGFR, MIF, SRC 2.67938
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, GRM5, IGF1R, RELA, SRC 2.67938
[BP] GO:0043271 negative regulation of ion transport ADORA1, CNR1, DRD2, DRD3, HTR2A, MMP9 2.67774
[BP] GO:0030799 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8 2.66276
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, APEX1, APP, AR, AURKB, CA9, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, POLA1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.64839
[BP] GO:0050808 None ACHE, APP, DRD1, DRD2, ERBB2, GRM5 2.64791
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.63558
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.63558
[BP] GO:0060359 None CNR1, DRD1, DRD2, DRD3, RELA 2.61985
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.61225
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.61225
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.60214
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HTR2B, MIF, SRC 2.596
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, CNR1, DRD2, DRD3, IGF1R, KDR, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.59258
[BP] GO:0002237 response to molecule of bacterial origin AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, RELA, SRC 2.5817
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A 2.5817
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.56955
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, CACNA1C, DRD1, DRD2, DRD3, GRM1, GRM5, HTR2A, HTR2B 2.54346
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.53825
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, DRD2, DRD3, EGFR, ERBB2, HTR2B, MIF, SRC 2.53825
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.53777
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.53777
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.52753
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DRD2, EGFR, F3, FABP4, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP2, RELA, SRC, XDH 2.52753
[BP] GO:0099566 None GRM1, GRM5 2.52753
[BP] GO:0033590 None EGFR, RELA 2.52753
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.52753
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.52753
[BP] GO:0001996 None ADRA1A, ADRB1 2.52753
[BP] GO:0060160 None DRD2, DRD3 2.52753
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52753
[BP] GO:0003099 None ADRA1A, ADRB1 2.52753
[BP] GO:0033602 None CNR1, DRD2 2.52753
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, AR, CYP1B1, DRD2, ERBB2, FABP3, MAP2K1, PTGES, XDH 2.52658
[BP] GO:0006793 phosphorus metabolic process ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, FLT3, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLB, SRC, TNKS, XDH 2.52134
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.52134
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.52134
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.48989
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.48989
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.48989
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.48847
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PTGES, TBXAS1, TYR 2.48462
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.47271
[BP] GO:0002027 None ADRA1A, ADRB1, CACNA1C, DRD2, SLC1A1 2.46143
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.46118
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, AR, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, IGF1R, MET, MIF, MMP9, RELA, SRC, XDH 2.45653
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AR, AURKB, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, HTR2A, HTR2B, IGF1R, MAP2K1, MET, RELA, SRC, TNKS, TNKS2, TOP2A 2.44335
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.42613
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.42613
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, ERBB2, HTR2B, MIF, SRC 2.4218
[BP] GO:1900542 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A 2.41841
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, GLO1, MIF, PIM1, PTGES, TBXAS1, TYR 2.41418
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.39165
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HTR2A, MET, SRC 2.39165
[BP] GO:0030260 entry into host cell AXL, EGFR, HTR2A, MET, SRC 2.39165
[BP] GO:0044409 entry into host AXL, EGFR, HTR2A, MET, SRC 2.39165
[BP] GO:0098900 None ADRA1A, CACNA1C, CNR1, CNR2 2.37791
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.37791
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.37791
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.36966
[BP] GO:0071880 None ADRA1A, ADRB1, DRD2 2.36966
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MET, MIF, MMP9, RELA, SRC, XDH 2.36683
[BP] GO:0006140 None ADRB1, DRD1, DRD2, DRD3, GRM3, GRM8, HTR2A 2.35192
[BP] GO:0000186 activation of MAPKK activity ADORA1, EGFR, GRM1, MAP3K7 2.35168
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, ADRB1, APEX1, APP, AR, AURKB, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, POLA1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.34703
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, MAP2K1, RELA, TYR 2.34355
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, ERBB2, FUT7, HTR2B, HTR6, KDR, MAP2K1, MIF, MMP1, MMP9, SRC 2.33978
[BP] GO:0009314 response to radiation APP, AURKB, DRD1, DRD2, DRD3, EGFR, POLB, RELA, TYR 2.33063
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.326
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.326
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, DRD2, DRD3, EGFR, HTR2B, MIF, SRC 2.31787
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.31545
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AR, AURKB, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, DRD3, EGFR, FABP4, GRM3, GRM8, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP9, RELA, SRC, TNKS, TNKS2, XDH 2.3107
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, CACNA1C, DRD1, DRD2, GRM1, HTR2A, HTR2B 2.28487
[BP] GO:0070213 None TNKS, TNKS2 2.28119
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28119
[BP] GO:0038171 None CNR1, CNR2 2.28119
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28119
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, SRC 2.27908
[BP] GO:0072347 None CNR1, DRD2, DRD3, RELA 2.27908
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GLO1, HTR1A, HTR2B, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLB, RELA, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.27908
[BP] GO:0050679 None AR, EGFR, ERBB2, F3, HTR2B, KDR 2.25451
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.22457
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HTR2B, MIF, SRC 2.22457
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.21303
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.21303
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21303
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, ERBB2 2.20766
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, GRM1, GRM5 2.20766
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.20444
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.20274
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B 2.20274
[BP] GO:0019722 calcium-mediated signaling CACNA1C, EGFR, GRM5, HTR2B, KDR 2.20274
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, GRM5, IGF1R, RELA, SRC 2.17813
[BP] GO:0048015 phosphatidylinositol-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.17813
[BP] GO:0010460 None ADRA1A, ADRB1, SLC1A1 2.16613
[BP] GO:0071875 None ADRA1A, ADRB1, DRD2 2.16613
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16613
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.15586
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, HTR2A, HTR2B 2.15586
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.14756
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.13833
[BP] GO:0048169 None APP, DRD2, GRM5 2.11807
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP3K7, MET, MMP2, MMP9, SRC 2.11501
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.10829
[BP] GO:0048017 inositol lipid-mediated signaling ERBB2, HTR2A, HTR2B, IGF1R 2.10829
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.10548
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B2, HSD17B3, MAP2K1, SRC 2.09906
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.09906
[BP] GO:0021853 None DRD1, DRD2 2.09906
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.09906
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.09906
[BP] GO:0010641 None F3, SRC 2.09906
[BP] GO:0090325 None DRD2, DRD3 2.09906
[BP] GO:1904936 None DRD1, DRD2 2.09906
[BP] GO:0042321 None ADORA1, DRD2 2.09906
[BP] GO:0010513 None HTR2A, HTR2B 2.09906
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.08144
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.08144
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, AR, CSNK2A1, DRD1, DRD2, EGFR, ERBB2, F3, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MIF, MMP9, RELA, SRC, XDH 2.06829
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.05768
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.03746
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.03746
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, EGFR, F3, IGF1R, KDR, MET, MMP9, SRC 2.03362
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, MIF 2.02671
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF 2.02671
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, DRD2, MIF 2.01806
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, ADRB1, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, MIF, MMP9, PIM1, POLA1, RELA, SRC, TNKS, TNKS2, TOP2A, XDH 2.01523
[BP] GO:0042180 None AKR1B1, CYP19A1, GLO1, HSD17B3 2.00596
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.00596
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 10.2492
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TYR 9.44063
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1 9.30423
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC1A1, SRC 9.21675
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP2, PIM1, SLC1A1, SRC 7.98627
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, SIGMAR1, SLC1A1, SRC 7.94963
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTGES, SIGMAR1, SLC1A1, SRC, TBXAS1, TYR 6.51116
[CC] GO:0044456 None ACHE, ADORA1, APP, CACNA1C, CHRM2, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 5.10983
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, SRC 5.10297
[CC] GO:0014069 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.57685
[CC] GO:0099572 None ADORA1, CACNA1C, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 4.57685
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.45218
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 4.33676
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTGES, SIGMAR1, SLC1A1, TBXAS1, TYR 4.33295
[CC] GO:0097060 None CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 4.251
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, SRC 4.10362
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, ALDH2, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, HSD17B1, HSD17B2, HSD17B3, HTR2A, HTR5A, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, PIM1, POLA1, PTGES, RELA, SIGMAR1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 4.00683
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, ADRB1, APP, AXL, CA12, CA14, CA9, CACNA1C, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, FUT7, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, PTGES, SIGMAR1, SLC1A1, TBXAS1, TYR 3.84433
[CC] GO:0097458 None ADORA1, APP, CA2, CACNA1C, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, SIGMAR1, SRC 3.71872
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, HSD17B2, HSD17B3, PTGES, SIGMAR1, TBXAS1 3.70602
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.43382
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, FLT3, GRIA2, HSD17B2, HSD17B3, PTGES, SIGMAR1, TBXAS1 3.12341
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.05249
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, SIGMAR1, SRC 3.05249
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.04312
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 3.00856
[CC] GO:0031090 None ADRA1A, ALOX5, APP, CA4, CHRM2, CNR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, EGFR, ERBB2, FUT7, GRIA2, GRIA4, MAOA, MAP3K7, SIGMAR1, SRC, TNKS, TNKS2, TYR 2.80034
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.52753
[CC] GO:0005783 None ADORA1, APEX1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSD17B3, HTR5A, KDR, MAP2K1, SIGMAR1, XDH 2.51301
[CC] GO:0043235 receptor complex APP, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 2.37791
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, PTGES, SRC, TNKS2, TYR 2.25451
[CC] GO:0043226 organelle ACHE, ADORA1, ADRA1A, ADRB1, AKR1B1, ALDH2, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HSD17B3, HTR2A, HTR5A, HTR6, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, PIM1, POLA1, POLB, RELA, SHBG, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.15586
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.13007
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 13.8179
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 12.5774
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 12.5774
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AR, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 12.4233
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AR, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, SIGMAR1 11.5765
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRB1, AR, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 11.2149
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRB1, AR, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 10.8503
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 10.1991
[MF] GO:0008227 None ADRA1A, ADRB1, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 10.1572
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.83729
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.83268
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, GLO1, MMP1, MMP2, MMP9, PIM1, TBXAS1, TNKS, TYR, XDH 9.5142
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.45866
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 8.15938
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, FLT3, HTR2A, HTR2B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SIGMAR1, SRC, TOP2A 8.01038
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.97277
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.84375
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.75309
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, XDH 7.39045
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRB1, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 7.34791
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 7.11031
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.03987
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALDH2, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, HSD17B2, HSD17B3, MAOA, TBXAS1, TYR, XDH 7.0134
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, GLO1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MAP3K7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, SLC1A1, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.99767
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, SRC, TBXAS1 6.83117
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.72229
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.72229
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALDH2, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, ERBB2, F3, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 6.72229
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69128
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.69128
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.61324
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, TBXAS1, TYR 6.44639
[MF] GO:0048037 cofactor binding ALDH2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, POLA1, PTGES, SRC, TBXAS1, XDH 6.23189
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.07108
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.85375
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 5.82061
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.73692
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.09464
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 4.86605
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.85791
[MF] GO:1901338 None ADRB1, DRD1, DRD2, DRD3 3.83361
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, SHBG 3.74241
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 3.37238
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.28693
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.28693
[MF] GO:0046872 metal ion binding ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, GLO1, MAP3K7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, SLC1A1, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 3.05249
[MF] GO:0005057 signal transducer activity, downstream of receptor ADRB1, EGFR, ERBB2, KDR, MAP2K1, MAP3K7 2.97284
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.94461
[MF] GO:0008389 None CYP2A13, CYP2A6 2.91545
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.85465
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, POLA1, POLB, SRC 2.72241
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.67445
[MF] GO:0004935 None ADRA1A, ADRB1, DRD2 2.61225
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52753
[MF] GO:0004949 None CNR1, CNR2 2.52753
[MF] GO:0099583 None GRM1, GRM5 2.52753
[MF] GO:0046982 protein heterodimerization activity ADORA1, ADRA1A, ADRB1, AXL, DRD2, EGFR, ERBB2, RELA, TOP2A, TYR 2.4852
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.42613
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.42613
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC 2.35424
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.28119
[MF] GO:0004971 None GRIA2, GRIA4 2.28119
[MF] GO:0005497 None AR, SHBG 2.28119
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.28119
[MF] GO:0009055 electron transfer activity AKR1B1, ALDH2, CYP19A1, CYP1A2, XDH 2.28102
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09906
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, ADRB1, AKR1B1, ALDH2, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ERBB2, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTGES, RELA, SHBG, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TOP2A, TYR, XDH 2.08144
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, DRD2, EGFR, ERBB2, FLT3, GRIK5, IGF1R, KDR, MAP3K7, MET, MIF, MMP9, RELA, TOP2A, TYR, XDH 2.04447
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP2, MMP9, TNKS 2.03746
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD17B1, HSD17B2, HSD17B3 2.03746


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, GRIK5, HTR2B, HTR1A, ADRB1, HTR2A, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 20.6847
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR2B, ADRB1, CACNA1C, HTR2A, HTR5A, ADRA1A, GRM1, EGFR, HTR6, GRM5, HTR7, ERBB2, DRD1 11.5699
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, MAP2K1, HTR7, MAOA, CYP2D6, ALOX5, HTR2B, HTR1A, CACNA1C, HTR2A, HTR5A 11.5351
Gap junction_Homo sapiens_hsa04540 GRM5, MAP2K1, SRC, HTR2B, ADRB1, HTR2A, DRD1, DRD2, GRM1, EGFR 9.8592
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, HTR6, MAP2K1, ADORA1, HTR1A, ADRB1, CACNA1C, DRD1, DRD2, RELA, GRIA4 8.8502
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 8.5014
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 7.5777
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.7838
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 8.0574
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.52
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.383
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MAP3K7, MET, EGFR, IGF1R 6.3791
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.5844
Pathways in cancer_Homo sapiens_hsa05200 AR, MAP2K1, FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, RELA, IGF1R 5.0024
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2, RELA 6.0841
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, CACNA1C, DRD1, DRD2, DRD3, GRIA4 4.8986
Metabolic pathways_Homo sapiens_hsa01100 MAOA, HSD17B3, AKR1B1, TYR, CYP3A4, CYP19A1, POLA1, CYP2A6, FUT7, ALDH2, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH, PTGES 4.5259
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, CNR1, KDR, DRD2, MET, EGFR, IGF1R 4.5586
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, ERBB2, EGFR, RELA, IGF1R 4.7113
Tryptophan metabolism_Homo sapiens_hsa00380 ALDH2, MAOA, CYP1A2, CYP1A1, CYP1B1 5.0818
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, GRM1, EGFR 4.5016
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, CACNA1C, GRM1, GRIA4 4.4695
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.8986
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.8179
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, CACNA1C, DRD1, GRIA4 4.1908
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, MAP2K1, CACNA1C, GRM1 4.1908
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, KDR, MET, EGFR, RELA, IGF1R 3.5379
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, MAP2K1, GRM8, GRM1, EGFR 3.6855
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, ERBB2, MET, EGFR 4.1908
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.6029
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP2D6, CYP1A2, CYP3A4 4.1437
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, ADRB1, CACNA1C, ADRA1A 3.381
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, ERBB2, EGFR, RELA, IGF1R 3.381
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR 2.9223
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, MAP2K1, KDR, MET, EGFR, RELA, IGF1R 2.594
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.4798
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.2841
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, ERBB2, EGFR, RELA 3.0713
Long-term depression_Homo sapiens_hsa04730 GRIA2, MAP2K1, GRM1, IGF1R 3.2091
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3, RELA 2.45
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, EGFR, IGF1R 2.971
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, SRC, ERBB2, EGFR 2.6645
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.0323
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 3.0854
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4156
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, MAP2K1, CACNA1C 2.3338
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, MMP9, MAP3K7, RELA 2.3396
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.2352
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, GRM1, EGFR, IGF1R 2.1108
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, MMP9, RELA 1.994
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, EGFR, RELA 1.9041
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, EGFR 1.9041
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.7414
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, MAP2K1, SRC, EGFR 1.5343
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR 2.1364
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.6882
Taste transduction_Homo sapiens_hsa04742 HTR1A, CACNA1C, GRM1 1.8505
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, SRC, RELA 1.9905
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, ERBB2, EGFR 2.2352
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.2352
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.7192
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6183
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, MAP3K7, RELA 1.6295
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, ERBB2, EGFR 2.3035
Glioma_Homo sapiens_hsa05214 MAP2K1, EGFR, IGF1R 2.0953
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2859
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, MAP3K7, RELA 1.7387
Measles_Homo sapiens_hsa05162 CSNK2A1, MAP3K7, RELA 1.3825
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4772
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.4065
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C, ADRA1A 1.297
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.5147
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2501
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, ADRA1A, IGF1R 1.473
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C, ADRA1A 1.5006
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.1072
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, MAP3K7, RELA 1.0247
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.0288
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3064
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.1026
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 RELA 0.3179
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC, RELA 1.0199
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1 0.3415
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, SRC, RELA 1.0953
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3484
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGES 2.1316
Axon guidance_Homo sapiens_hsa04360 MET 0.3658
HTLV-I infection_Homo sapiens_hsa05166 POLB, RELA 0.4717
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 0.7627
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7627
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7627
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6457
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8312
Influenza A_Homo sapiens_hsa05164 MAP2K1, RELA 0.6457
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.6413
Hepatitis C_Homo sapiens_hsa05160 EGFR, RELA 0.7833
Insulin resistance_Homo sapiens_hsa04931 RELA 0.4145
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, IGF1R 0.7627
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, RELA 0.8395
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6676
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.848
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, MAP3K7 0.7627
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, SRC 0.848
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4256
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4248
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 0.9714
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4368
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, TYR 0.9598
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4496
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4486
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4231
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4546
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, EGFR 0.9562
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4637
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 0.9991
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4638
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0199
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.025
Salivary secretion_Homo sapiens_hsa04970 ADRB1, ADRA1A 1.0247
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4694
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4694
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4637
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4637
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0202
Small cell lung cancer_Homo sapiens_hsa05222 RELA 0.4694
Peroxisome_Homo sapiens_hsa04146 XDH 0.4717
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4748
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4717
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4831
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, RELA 1.1536
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.1536
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4812
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1059
Pertussis_Homo sapiens_hsa05133 RELA 0.4947
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4969
Adipocytokine signaling pathway_Homo sapiens_hsa04920 RELA 0.5117
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4969
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5197
Leishmaniasis_Homo sapiens_hsa05140 MAP3K7, RELA 1.1536
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1622
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.1688
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.211
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5339
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5339
Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 ALDH2 0.5224
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, MIF, TYR 2.7249
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5309
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1 0.5399
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2185
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.305
Glycerolipid metabolism_Homo sapiens_hsa00561 ALDH2, AKR1B1 1.2868
Legionellosis_Homo sapiens_hsa05134 RELA 0.5827
Lysine degradation_Homo sapiens_hsa00310 ALDH2 0.6015
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6059
Malaria_Homo sapiens_hsa05144 MET 0.6185
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6234
Arginine and proline metabolism_Homo sapiens_hsa00330 ALDH2, MAOA 1.4018
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 ALDH2 0.6234
Fatty acid degradation_Homo sapiens_hsa00071 ALDH2 0.6457
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5496
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6733
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7203
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7627
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7627
Pyruvate metabolism_Homo sapiens_hsa00620 ALDH2, GLO1 1.5496
DNA replication_Homo sapiens_hsa03030 POLA1 0.7122
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.8164
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7627
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7533
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.762
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.6826
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 ALDH2, AKR1B1 1.6209
beta-Alanine metabolism_Homo sapiens_hsa00410 ALDH2 0.7627
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7921
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7841
Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 ALDH2 0.7841
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9212
Histidine metabolism_Homo sapiens_hsa00340 ALDH2, MAOA 1.9041
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.1316
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0818


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)