TCM Prescription: Zi Bu Shui Ya Recipe



Prescription Description
Prescription IDTCMF6721
Pinyin NameZi Bu Shui Ya He Ji
Chinese Name滋补水鸭合剂
English NameZi Bu Shui Ya Recipe
Function Description虚劳, 血风劳
IndicationsConsumptive disorder
Disease ICD-11 Category SD72 [Consumptive disorder (TM1), 虚劳 (TM1) ];
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2368 NA 鸭肉 TCMH2368
TCMH494 Cordyceps sinensis 冬虫夏草 TCMH494 AF291749
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA, PTGES, TBXAS1, TRPV1 7.93593
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTGES, RORC, SRC, TRPV1, TYR 6.68666
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.53696
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, PTGES, RORC, SRC, TYR 6.53696
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, PPARA, PTGES, RORC, SRC, TRPV1, TYR 6.26164
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 6.11085
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.06002
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TRPV1, TYR, XDH 6.04157
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, TBXAS1 5.84123
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.72716
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, TBXAS1 5.71122
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.71122
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, KDR, MCL1, MET, MIF, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 5.38701
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, PPARA, PTGES, RORC, SRC, TRPV1, TYR 5.33643
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGES, SRC, XDH 5.32253
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, NQO2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TYR, XDH 5.12415
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MAOA, MCL1, MET, MIF, MTNR1B, PPARA, SRC, TRPV1, XDH 5.09626
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, PTGES, RORC, SRC, TRPV1, TYR 5.09529
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.95835
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 4.90456
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 4.83068
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 4.82123
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 4.70009
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, RORC, SRC, TRPV1, XDH 4.66061
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, TBXAS1 4.63757
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, TBXAS1 4.63432
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 4.58046
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.48866
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, MIF, PPARA, PTGES, TBXAS1 4.4823
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, MCL1, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 4.44972
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.31532
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 4.29783
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.14666
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, MIF, PIM1, SRC, TYR 4.1165
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.10762
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, PPARA, SRC, TRPV1 4.09582
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 4.09582
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 4.04512
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.04512
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGES, SRC 3.94323
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SRC 3.88942
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TRPV1, TYR 3.8797
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1 3.73558
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, PIM1, PPARA, PTGES, PTPN1, RORC, SRC, TRPV1 3.73558
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MET, MIF, MMP9, PIM1, PTPN1, SRC 3.63484
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD17B1, HSD17B2, MTNR1B 3.61417
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.57592
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.57592
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 3.57592
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 3.57592
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, TBXAS1 3.56595
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MIF, MMP12, MMP9, PTPN1, SRC, XDH 3.56126
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.53713
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.53713
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53138
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.46491
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.3374
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, MTNR1A, MTNR1B 3.22526
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.15749
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MCL1, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TRPV1, TYR, XDH 3.15749
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TRPV1, TYR, XDH 3.11012
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CDK6, HCAR2, KDR, MIF, SRC, TRPV1 3.1046
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, TBXAS1 3.0769
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.07008
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MCL1, MIF, MMP9, PIM1, PTPN1, SRC 3.07008
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TRPV1, TYR, XDH 3.06586
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.04718
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC 3.03366
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC, TRPV1 3.00705
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TRPV1, XDH 2.99136
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.95899
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.93376
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MCL1, MIF, MMP2, MMP9, PTPN1, RORC, SRC, TRPV1 2.91334
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SRC, TRPV1 2.91182
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MIF, MMP12, MMP2, MMP9, PPARA, PTGES, PTPN1, RORC, SRC, TRPV1, TYR 2.84035
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC, TRPV1 2.81336
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.72882
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.70998
[BP] GO:0009115 None AOX1, XDH 2.69279
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.68296
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65568
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.58795
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway MCL1, MIF, MMP9, PTPN1, SRC 2.5676
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, MTNR1B, PTPN1, PTPRS, SRC, XDH 2.5676
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.5676
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, ESR1, FABP4, IGF1R, MCL1, MET, MIF, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, XDH 2.55265
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, MTNR1B, PTPN1, PTPRS, SRC, XDH 2.52582
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.51086
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, RORC, SRC, TRPV1 2.48806
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MCL1, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TRPV1, XDH 2.48806
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, XDH 2.48806
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.45564
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, HCAR2, KDR, MET, MIF, MMP12, MMP9, PIM1, PTPRS, SRC, TRPV1, XDH 2.42073
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.37889
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.34593
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MCL1, MET, MTNR1B, SRC, TRPV1 2.34366
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.33813
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CDK6, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.32443
[BP] GO:0046110 None AOX1, XDH 2.3224
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.3224
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, RORC, SRC, TRPV1 2.3078
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.3009
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MIF, MMP12, SRC, TRPV1 2.28033
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.27664
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, RORC 2.27604
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.27604
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, SRC, TRPV1 2.25549
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.21788
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, IGF1R, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 2.1794
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.1758
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.16603
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, MAOA 2.12213
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.12032
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.11948
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.11427
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.10215
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.10215
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, PTPN1, SRC, XDH 2.10215
[BP] GO:0006145 None AOX1, XDH 2.10215
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.10215
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.10215
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.10215
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.10215
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.09248
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ESR1, ESR2, IGF1R, MCL1, MET, MIF, MMP12, MMP9, PTPN1, PTPRS, SRC, XDH 2.09241
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.0861
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, KDR, MCL1, MET, MIF, MMP2, MMP9, PTPRS, RORC, SRC 2.06615
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MIF, MMP9, SRC 2.05083
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, FLT3, KDR, MCL1, MET, MIF, PTPN1, SRC, XDH 2.04618
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF, PTGES 2.01982
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTPRS, TRPV1 2.53761
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTPRS, TRPV1 2.22489
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, PTPRS, SRC, TRPV1 2.08616
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.78434
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HCAR2, HSD17B2, IGF1R, KDR, MAOA, MCL1, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TRPV1, TYR 1.77746
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TYR, XDH 13.7691
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.66878
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PTGES, PTPN1, PTPRS, SRC, TBXAS1, TYR, XDH 9.44251
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTGES, PTPN1, PTPRS, RORC, SRC, TBXAS1, TRPV1, TYR, XDH 7.39903
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC 6.58841
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.06002
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.06002
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 5.7716
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 5.74545
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 5.41353
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.33643
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 5.05262
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05262
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.05262
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.6522
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TRPV1, TYR, XDH 4.6522
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.56101
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TRPV1 4.4823
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIM1, PPARA, SRC, TRPV1 4.43981
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.93339
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.93339
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, MTNR1A, NQO2 3.88942
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 3.87517
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 3.80057
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TRPV1, TYR, XDH 3.73558
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.65058
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.57592
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.40154
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.40087
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.32161
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.21445
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.16683
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.04718
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.89598
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 2.89598
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.83622
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69279
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.68865
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, FLT3, HCAR2, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 2.68865
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.65568
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC, TRPV1 2.65568
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.62267
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.58795
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.527
[MF] GO:0042578 None ADORA1, ALPL, CDC25B, CHRM1, CHRM3, CHRM5, PTPN1, PTPRS 2.37668
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.34366
[MF] GO:0008502 None MTNR1A, MTNR1B 2.3224
[MF] GO:0016788 None ACHE, ADORA1, ALPL, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, PTPN1, PTPRS 2.3078
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.27604
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.19854
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.14657
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.14565
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, MCL1, MET, MIF, MMP9, NQO2, TRPV1, TYR, XDH 2.10932
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.10215


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2027
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.8289
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.8693
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.2803
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2803
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, MTNR1A, CHRM1, MTNR1B, ADORA3, CHRM5, ADORA1, TRPV1 5.2803
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.183
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.183
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.4978
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.158
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.7005
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9234
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 3.3505
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KDR, MET, MCL1, IGF1R 3.0985
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1, PTGES 3.3505
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.739
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1296
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1974
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, PPARA 2.5491
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.426
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0076
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5 1.9241
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 2.1001
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.099
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1577
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 2.1188
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.759
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9241
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7291
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4478
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, MMP9 1.3781
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1, MCL1 1.3143
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0094
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3143
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.2378
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3143
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2797
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0233
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.171
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9914
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 1.007
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.007
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.007
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2328
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9154
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2966
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1376
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9473
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2303
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.007
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5 0.9337
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9038
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9154
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8348
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9154
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9094
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8219
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8983
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8259
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6212
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.745
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2513
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.758
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.317
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3454
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3382
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3454
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3454
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.338
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3883
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3764
Apoptosis_Homo sapiens_hsa04210 MCL1 0.4072
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4072
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4058
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4181
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4283
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4181
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4283
Axon guidance_Homo sapiens_hsa04360 MET 0.4234
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4216
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4602
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4387
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5035
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5035
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4804
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4839
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4839
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5035
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5035
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5035
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6413
Small cell lung cancer_Homo sapiens_hsa05222 CDK6 0.5035
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4989
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5035
Gap junction_Homo sapiens_hsa04540 SRC 0.5035
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5032
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4989
Peroxisome_Homo sapiens_hsa04146 XDH 0.5035
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5033
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4989
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5035
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5319
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5035
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5478
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.539
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5478
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5478
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5478
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5467
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5556
Bile secretion_Homo sapiens_hsa04976 CA2 0.5381
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.54
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7291
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5478
Shigellosis_Homo sapiens_hsa05131 SRC 0.5478
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5777
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9292
Malaria_Homo sapiens_hsa05144 MET 0.6207
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6207
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6178
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6212
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6207
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6212
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.1263
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6698
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7627
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7786
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7786
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8055
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7703
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7959
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8259
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9755
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0993
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2332


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)