Prescription Description
| Prescription ID | TCMF6712 |
| Pinyin Name | Xie Li Ning Pian |
| Chinese Name | 泻痢宁片 |
| English Name | Xie Li Ning Tablets |
| Function Description | 腹泻, 痢疾 |
| Indications | Dysentery disorder, Diarrhea, Dysentery |
| Disease ICD-11 Category |
SA56 [Dysentery disorder (TM1), 痢疾 (TM1)
]; ME05.1 [Diarrhoea, 腹泻 ]; 1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ]; |
| Human Tissues Associated with Indication | Intestine, Stomach |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH454 | Euphorbia humifusa | 地锦草 | TCMH454 | GBVH2295-11, GBVH2294-11 |
| TCMH1672 | Cortex fraxini | 秦皮 | TCMH1672 | |
| TCMH462 | Sanguisorba officinalis | 地榆 | TCMH462 | GENG545-14, GBVT2403-13 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
Showing 1 to 10 of 87 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1214 | Enterococcus faecium |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
Showing 1 to 10 of 52 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.83233 |
| [BP] GO:0002009 | morphogenesis of an epithelium | CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC | 2.71629 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.32893 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA | 2.10418 |
| [BP] GO:0006464 | cellular protein modification process | AURKB, AXL, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 | 2.63993 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 | 4.72913 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA | 6.30447 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 3.37711 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 | 3.8557 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.96852 |
Showing 1 to 10 of 282 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6951 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4145 |
| Adherens junction_Homo sapiens_hsa04520 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.2466 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6041 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIM1 | 1.0668 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR | 0.7333 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9543 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5802 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, ALOX15 | 2.3234 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4744 |
Showing 1 to 10 of 136 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples