TCM Prescription: Zhi Li Infusion



Prescription Description
Prescription IDTCMF6553
Pinyin NameZhi Li Chong Ji
Chinese Name止痢冲剂
English NameZhi Li Infusion
Function Description痢疾
IndicationsDysentery disorder, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH182 Areca catechu 槟榔 TCMH182 ITSAA732-14
TCMH454 Euphorbia humifusa 地锦草 TCMH454 GBVH2295-11, GBVH2294-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT551 CHRM4 Muscarinic acetylcholine receptor M4 GPCR P08173
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.16823
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.25393
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.25393
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.20766
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 6.79557
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 6.73937
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, PPARA, SMAD3, SRC, TEK, TOP1, TYR 6.72437
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TYR, XDH 6.62024
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.35957
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.24455
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.05006
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TYR, XDH 6.03778
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 5.84162
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 5.77952
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, PPARA, SRC, TEK, TYR 5.70115
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.69901
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK 5.69818
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.28852
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, SRC, TYR 5.22101
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.21486
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FLT3, SRC, TEK, TYR 5.21486
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.21486
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.19981
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.19774
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CBR1, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS2, TYR 5.19774
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, CA2, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 5.17858
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX15, ALOX5, ALPL, AXL, CHRM1, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD17B2, IGF1R, INSR, MET, MMP12, PIM1, PPARA, SLC5A1, SMAD3, SRC, TEK, TNKS2, TOP1, TYR 5.11003
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TYR, XDH 5.11003
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.11003
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CHRM1, CHRM4, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 5.01508
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 4.98165
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.98165
[BP] GO:0042127 regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 4.95439
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.93117
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.92867
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.91468
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, SRC, TEK, XDH 4.91468
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.86203
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 4.82475
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.73783
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CSNK2A1, DRD1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TNKS, TOP1, XDH 4.70451
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 4.67952
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, MET, SRC, TEK, XDH 4.61314
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TYR, XDH 4.49999
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.49999
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.44364
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS, TOP1 4.43766
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.42891
[BP] GO:0040012 regulation of locomotion CHRM1, CHRM4, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.38173
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.35675
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.3291
[BP] GO:0030335 positive regulation of cell migration DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.28208
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CHRM1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1, TYR, XDH 4.23976
[BP] GO:2000147 positive regulation of cell motility DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.15765
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.12576
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TEK 4.11845
[BP] GO:0015701 bicarbonate transport CA12, CA2, CA4, CA7, CA9 4.07502
[BP] GO:0051272 positive regulation of cellular component movement DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 4.07005
[BP] GO:0007197 None CHRM1, CHRM2, CHRM4 4.06897
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.96473
[BP] GO:0040017 positive regulation of locomotion DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.95336
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.94135
[BP] GO:0080134 regulation of response to stress ABCB1, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 3.85975
[BP] GO:0016310 phosphorylation AURKB, AXL, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS, TOP1 3.85295
[BP] GO:0007207 None CHRM1, CHRM2, CHRM4 3.84011
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 3.84011
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, SMAD3, SRC, TEK, XDH 3.83668
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.81938
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, SMAD3, SRC 3.79597
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.7717
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.73599
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, HSPA1A 3.70171
[BP] GO:0030334 regulation of cell migration CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.68769
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.68266
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, MET, PIM1, SMAD3, SRC, TEK, XDH 3.6777
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTPRS, SMAD3, TEK 3.63111
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PPARA, SMAD3, SRC, TEK, TOP1, TYR 3.61379
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, SMAD3, SRC 3.61379
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.51771
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.51624
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, SMAD3, SRC, TEK 3.4754
[BP] GO:2000145 regulation of cell motility CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.42161
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, CYP19A1, DRD1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, PPARA, PTPRS, SMAD3, SRC, TEK, XDH 3.19114
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, SMAD3, SRC, TEK 3.18741
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, KDR, SRC, TOP1 3.18316
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.18316
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.18316
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.18316
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.16584
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 3.14606
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK, XDH 3.14606
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CHRM1, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, TEK 3.13434
[BP] GO:0051270 regulation of cellular component movement CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 3.08983
[BP] GO:0042592 homeostatic process AKR1B1, AXL, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.07615
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HSD17B1, HSD17B2 3.07615
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.04436
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.0269
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 3.0269
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.94174
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, EGFR, TNKS, TNKS2 2.90279
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.87827
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.87822
[BP] GO:0007200 None CHRM1, CHRM2, CHRM4, DRD1, ESR1 2.87439
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.86026
[BP] GO:0009115 None AOX1, XDH 2.83802
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.79907
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.7941
[BP] GO:0010648 negative regulation of cell communication ACHE, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPRS, SMAD3, SRC, XDH 2.77981
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.77981
[BP] GO:0023057 negative regulation of signaling ACHE, DRD1, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, PTPRS, SMAD3, SRC, XDH 2.76997
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.71193
[BP] GO:0015758 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.70757
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, SMAD3, SRC 2.68664
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.68313
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.65819
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, SRC 2.65315
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK 2.65315
[BP] GO:0051239 regulation of multicellular organismal process AXL, CA2, CHRM1, CHRM2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 2.65315
[BP] GO:0007213 None CHRM1, CHRM2, CHRM4 2.65315
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.65315
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.62858
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62858
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.62858
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62858
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.62858
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK, TNKS, TNKS2 2.62777
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.5915
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, DRD1, EGFR, KDR, SRC, TNKS, TNKS2 2.58512
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 2.55881
[BP] GO:0009893 positive regulation of metabolic process ALOX15, AURKB, CSNK2A1, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.54753
[BP] GO:0008645 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.54753
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.54753
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.53818
[BP] GO:0009611 response to wounding ACHE, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.53818
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.53518
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.52579
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.52458
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.50659
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.50659
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.50659
[BP] GO:0015749 None DRD1, SLC5A1, SLC5A2, SLC5A4 2.50659
[BP] GO:0065009 regulation of molecular function ABCB1, AURKB, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, SMAD3, SRC, TEK, TNKS, XDH 2.48671
[BP] GO:0046110 None AOX1, XDH 2.47767
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.47767
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.47536
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, SMAD3, SRC, TEK, XDH 2.475
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.46591
[BP] GO:0043412 macromolecule modification ALPL, AURKB, AXL, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.44164
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.44164
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.43427
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.43338
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, SRC 2.43338
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, PPARA, SRC, TOP1 2.41744
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.40554
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.39525
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.39115
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.3853
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CHRM1, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP1 2.3853
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, PPARA, PTPRS, SMAD3, SRC, TEK 2.37392
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.37387
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, KDR, SRC 2.34825
[BP] GO:0035428 None SLC5A1, SLC5A2, SLC5A4 2.34173
[BP] GO:1904659 None SLC5A1, SLC5A2, SLC5A4 2.34173
[BP] GO:1905950 None SLC5A1, SLC5A2, SLC5A4 2.34173
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.34173
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.32816
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.29658
[BP] GO:0095500 None CHRM1, CHRM2, CHRM4 2.29126
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.29126
[BP] GO:1903831 None CHRM1, CHRM2, CHRM4 2.29126
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.28938
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.28922
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, AXL, CA2, CHRM1, CYP19A1, DRD1, EGFR, INSR, MMP12, SMAD3, SRC 2.28623
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, TYR 2.28623
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SMAD3, SRC, TEK 2.2659
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA2, CA4, CA7, CA9, FABP3, PPARA 2.2659
[BP] GO:0070213 None TNKS, TNKS2 2.2659
[BP] GO:0006145 None AOX1, XDH 2.2659
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.2659
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2659
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.2659
[BP] GO:0051894 None KDR, SMAD3, TEK 2.2659
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2659
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, SMAD3, SRC, TNKS, TNKS2 2.2659
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, EGFR, GPR35, HSPA1A, INSR, MMP12, PPARA, SMAD3, SRC 2.24908
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.22491
[BP] GO:0050927 None F3, KDR, SMAD3 2.2244
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2 2.2244
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.1791
[BP] GO:0050926 None F3, KDR, SMAD3 2.1791
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.1791
[BP] GO:1903393 None KDR, SMAD3, TEK 2.1791
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, SRC, TNKS 2.16489
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, CA2, CYP1A1, DRD1, EGFR, HSPA1A, PPARA, SMAD3, SRC, TEK, TYR 2.16489
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.14313
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.13698
[BP] GO:0007271 None CHRM1, CHRM2, CHRM4 2.13698
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TBXAS1, TYR 2.12071
[BP] GO:0050678 None EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.11421
[BP] GO:0034219 None SLC5A1, SLC5A2, SLC5A4 2.09665
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.09665
[BP] GO:0043408 regulation of MAPK cascade ALOX15, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, SRC, TEK, XDH 2.09665
[BP] GO:0010641 None F3, SRC 2.09665
[BP] GO:0007598 None F10, F3 2.09665
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.07182
[BP] GO:0042060 None ALOX15, EGFR, PPARA, SMAD3 2.05275
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4 2.03604
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.03397
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.02534
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.02534
[CC] GO:0044459 plasma membrane part ABCB1, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, DUSP3, EGFR, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TEK 4.52329
[CC] GO:0031226 intrinsic component of plasma membrane AXL, CA4, CHRM1, CHRM2, CHRM4, DRD1, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 4.39792
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALOX15, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, DRD1, EGFR, ESR1, F10, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PIM1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TEK 3.07312
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, PIM1, PTPRS, SLC5A1, SLC5A2, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR 2.93113
[CC] GO:0005887 integral component of plasma membrane AXL, CHRM1, CHRM2, CHRM4, DRD1, FLT3, GPR35, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, TEK 2.92567
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, AXL, CA12, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, MET, PTPRS, SLC5A1, SLC5A2, SLC5A4, SRC, TBXAS1, TEK, TYR 2.76997
[CC] GO:0098590 plasma membrane region ABCB1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM4, DRD1, EGFR, INSR, MET, SRC, TEK 2.74469
[CC] GO:0031233 None CA4, F10, F3 2.43338
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP12, PIM1, PPARA, SMAD3, TBXAS1, TNKS, TYR, XDH 10.9158
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPRS, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 10.9158
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA2, CA4, CA7, CA9, CBR1, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F10, F3, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPRS, SRC, TBXAS1, TEK, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 9.04213
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM1, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1 7.55934
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.20766
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, XDH 6.73937
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.59305
[MF] GO:0004089 carbonate dehydratase activity CA12, CA2, CA4, CA7, CA9 5.99969
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.24896
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.21486
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.19774
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.01508
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.00356
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.94348
[MF] GO:0038023 signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.76778
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPRS, SRC, TEK, TOP1, TUBB3, XDH 4.39792
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.26289
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.23896
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD17B1, PPARA 4.18185
[MF] GO:0004871 signal transducer activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, SMAD3, TEK 4.12065
[MF] GO:0004872 receptor activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 4.1023
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 4.06897
[MF] GO:0016907 None CHRM1, CHRM2, CHRM4 4.06897
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.05128
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.03796
[MF] GO:0060089 molecular transducer activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, TEK 3.94184
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.90384
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90136
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90136
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, MMP12, NUAK1, PIM1, PPARA, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 3.87561
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.84011
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 3.81938
[MF] GO:0016836 hydro-lyase activity CA12, CA2, CA4, CA7, CA9 3.7036
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.58145
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP12, PPARA, SMAD3, TNKS 3.48469
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.30725
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.30725
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP12, NUAK1, PIM1, PPARA, SMAD3, TBXAS1, TNKS, TNKS2, TYR, XDH 3.22118
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, TBXAS1, XDH 3.22118
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.19114
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 3.14411
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA2, CA4, CA7, CA9 3.13476
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, CBR1, HSD17B1, HSD17B2, XDH 3.07615
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 3.00792
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3, XDH 3.00777
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.9125
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.83802
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.71246
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, SMAD3, SRC 2.71042
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.62847
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.59776
[MF] GO:0015464 None CHRM1, CHRM2, CHRM4 2.53396
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.52458
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.47767
[MF] GO:0099600 transmembrane receptor activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.39115
[MF] GO:0004888 transmembrane signaling receptor activity AXL, CHRM1, CHRM2, CHRM4, DRD1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.39115
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.3853
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, SMAD3, SRC 2.34825
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.34173
[MF] GO:0015149 None SLC5A1, SLC5A2, SLC5A4 2.34173
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2659
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.2659
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.2659
[MF] GO:0015145 None SLC5A1, SLC5A2, SLC5A4 2.2659
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.26039
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.25602
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.23031
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1, TUBB3 2.22491
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.09665
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.09665
[MF] GO:0043559 insulin binding IGF1R, INSR 2.09665
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.06104
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PTPRS, SRC, TEK, TOP1 2.02534


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.3736
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3833
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.9245
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9 7.1217
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP3A4, CYP19A1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5522
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.0447
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.0964
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, INSR, KDR, TEK, MET, EGFR, IGF1R 3.7929
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.6988
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9237
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, ESR1, EGFR, ESR2, HSPA1A 3.7091
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.9714
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, ESR1, EGFR, IGF1R 3.3525
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.1761
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.3525
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.3014
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, SLC5A1, CYP3A4 3.1787
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM1, CHRM4 2.568
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, EGFR 2.9129
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.5658
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.6714
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM1, SRC, CHRM4, EGFR 2.4703
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.3278
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2253
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM1, GPR35, CHRM4, DRD1 2.1093
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.1928
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIM1, CYP1B1, MET, EGFR 2.0032
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM1, DRD1, EGFR 2.0031
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1928
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1712
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1675
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 2.1928
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, CHRM1, DRD1, PPARA 1.8586
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1, F3 1.8239
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.112
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MET, EGFR, IGF1R 1.542
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.1928
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.4897
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.4795
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.2692
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 0.9555
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2734
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.0787
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0888
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.0688
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3164
Insulin resistance_Homo sapiens_hsa04931 INSR, PPARA 0.9555
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0508
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3682
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2705
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.363
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.8976
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.16
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15 0.9427
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9165
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9165
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8348
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.1581
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8453
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8921
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8153
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC 0.8069
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8111
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8248
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8055
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7891
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.7891
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6598
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.5776
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2524
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.502
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3175
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3573
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3512
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3437
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3512
Alcoholism_Homo sapiens_hsa05034 DRD1 0.3512
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3512
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.3581
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.382
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4031
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3434
Phagosome_Homo sapiens_hsa04145 TUBB3 0.382
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4166
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4072
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4337
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4337
Axon guidance_Homo sapiens_hsa04360 MET 0.4286
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.4265
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4981
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4977
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4981
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4904
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4977
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4977
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4987
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5074
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4985
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5077
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5029
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5085
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5085
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5183
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5081
Peroxisome_Homo sapiens_hsa04146 XDH 0.5188
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.556
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5549
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7005
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5435
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5682
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5827
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.581
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6031
Shigellosis_Homo sapiens_hsa05131 SRC 0.5845
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5845
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.5945
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6052
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6214
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6242
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6373
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6242
Malaria_Homo sapiens_hsa05144 MET 0.6519
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6519
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6519
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6519
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.6405
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 SLC5A1 0.6598
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6519
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6609
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7049
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0032
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7387
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8055
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7862
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7781
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7326
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7703
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7891
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8055
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8055
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9722
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1129
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2705


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)