TCM Prescription: Xiao Er Xiao Shi Jian Wei Pills



Prescription Description
Prescription IDTCMF6456
Pinyin NameXiao Er Xiao Shi Jian Wei Wan
Chinese Name小儿消食健胃丸
English NameXiao Er Xiao Shi Jian Wei Pills
Function Description积滞
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1677 Pinellia ternata 清半夏 TCMH1677 GBVT1123-13, GBVY1693-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, PPARD, RORC, SRC, TYR 9.56486
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, POLB, PPARA, PPARD, RORC, SRC, TYR 8.50596
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, POLB, PPARA, PPARD, RORC, SRC, TYR 8.17482
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, PPARD, RORC, SRC, TYR 8.0437
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, HSD17B1, HSD17B2, MET, PPARA, PPARD, TBXAS1 7.48271
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HMGCR, PIM1, PPARA, PPARD, TBXAS1, TYR, XDH 7.44412
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.36271
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.9235
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSD17B2, KDR, MET, POLA1, POLB, PPARA, PPARD, SRC, XDH 6.20744
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.18003
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TYR 6.18003
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, KDR, POLB, SRC 6.18003
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, PPARD 5.95744
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 5.81437
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC 5.65326
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PPARD, PTPN1, SRC, XDH 5.51315
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HMGCR, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 5.40393
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTPN1, SRC 5.31037
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, POLB, SRC 5.3084
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARD, PTPN1, SRC, XDH 5.29513
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 5.02707
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, SRC, XDH 4.83039
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PPARA, PPARD, TBXAS1 4.82171
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2 4.82171
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 4.82171
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 4.80528
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, FABP4, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, RORC, SRC, TYR 4.75038
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.70676
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MMP9, PIM1, PPARD, PTPN1, SRC, XDH 4.68974
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, PPARD, PTPN1, SRC 4.66435
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 4.60273
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PPARD, SRC, TYR 4.59579
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, PPARD, TBXAS1, TYR, XDH 4.46567
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4394
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, HMGCR, HSD17B1, HSD17B2, PPARD 4.3764
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PPARD, SRC, XDH 4.24113
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 4.19053
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.94578
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, FABP3, FABP4, FLT3, MET, POLA1, POLB, SRC 3.88304
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, POLA1, POLB, PPARD, PTPN1, RORC, SRC 3.82538
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.77567
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD 3.77567
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, XDH 3.77567
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76104
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, RORC, SRC 3.76104
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 3.6905
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.67359
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, PPARD, RORC, SRC, TYR 3.6535
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 3.64029
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.53811
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, POLB, PPARA, PPARD, SRC 3.4968
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARD, RORC, SRC 3.4968
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR, PPARD 3.4968
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, MET, PIM1, POLA1, PPARD, SRC, TYR 3.49108
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 3.47274
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, TBXAS1 3.47274
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, SRC 3.47274
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HMGCR, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 3.42358
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, FLT3, HMGCR, KDR, MET, PPARD, PTPN1, SRC, XDH 3.42358
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, HMGCR, PPARD, TYR 3.40615
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.40003
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, XDH 3.37058
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, PPARD 3.37058
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 3.35548
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC 3.35328
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, HMGCR, KDR, MET, MMP12, MMP2, MMP9, PPARD, PTPN1, SRC, XDH 3.35305
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, POLB, PPARD, PTPN1, SRC, XDH 3.34735
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HMGCR, MMP2, POLB, PPARA, PPARD, SRC, TYR 3.34428
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, PPARD, SRC, TYR 3.31067
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARD, PTPN1, SRC, XDH 3.29881
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28758
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, IGF1R, KDR, MMP2, PPARD, RORC, SRC 3.19852
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, PPARD, PTPN1, SRC, XDH 3.15772
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MET, PIM1, POLB, PPARD, PTPN1, SRC, XDH 3.10373
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, HMGCR, KDR, SRC 3.01134
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC, XDH 3.00014
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.94909
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC 2.93796
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CNR1, CNR2, CYP19A1, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC, XDH 2.92673
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC 2.91558
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PPARD 2.89236
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.89048
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PPARD 2.88779
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, FABP4, MMP12, MMP2, PPARA, PPARD, PTPN1, SRC 2.88779
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.88444
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, PPARD, SRC 2.8577
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.85748
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 2.7994
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, SRC 2.7994
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, PPARA, PPARD 2.79861
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 2.7855
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.7855
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC 2.7467
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.7399
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, XDH 2.73444
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.73444
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.73444
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.73444
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.70387
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, PPARD, SRC, TYR 2.69414
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, SRC 2.67722
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PPARD, TYR 2.66242
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.64657
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, MMP12, PPARD, SRC, TYR 2.63565
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, FLT3, FUT7, HMGCR, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PPARD, PTPN1, SRC, TYR, XDH 2.62887
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.62887
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD17B1, HSD17B2, PPARD 2.61381
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.55442
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.54021
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.50773
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC 2.48958
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PPARD, SRC 2.48313
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48313
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.47679
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 2.47157
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.44657
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PPARD 2.44461
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.37924
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.34827
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.33576
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.32169
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, POLB 2.29116
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.29116
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.29017
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, TBXAS1 2.25925
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 2.25768
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, POLA1, POLB, PPARA, PPARD, PTPN1, SRC 2.23229
[BP] GO:0038171 None CNR1, CNR2 2.23229
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23229
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, TBXAS1, TYR 2.22912
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.22242
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, HSD17B2, MMP2, MMP9, PPARD, SRC 2.19987
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, FABP4, FLT3, HMGCR, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, SRC, XDH 2.1766
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9 2.16425
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.13038
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 2.12866
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.11834
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.11628
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, HMGCR, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.08239
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.08239
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, KDR, MMP1, MMP12, MMP9, PPARD, SRC 2.08239
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.06811
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, TYR 2.06777
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.06632
[BP] GO:1901661 None AKR1B1, AKR1B10, HMGCR 2.06624
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, KDR, MET, MMP1, MMP12, MMP9, PPARD, SRC 2.05285
[BP] GO:0030336 None ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, PPARD 2.04374
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, FABP4, PPARA, PPARD 2.03936
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HMGCR, MMP12, MMP9, PPARA, PPARD, PTPN1, SRC 2.03865
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00873
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PPARD, TBXAS1, TYR 2.00873
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TYR 2.00839
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.935
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TBXAS1, TYR 1.59763
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HMGCR, HSD17B2, IGF1R, KDR, MET, PTPN1, SRC, TBXAS1, TYR 1.33627
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 1.33425
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, FLT3, HMGCR, KDR, PTPN1, XDH 1.27115
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 10.7758
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3337
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TYR, XDH 9.18914
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, SRC, TBXAS1, TYR, XDH 7.99406
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.36271
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.71551
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PPARD, PTPN1, RORC 4.83039
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.72002
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.6016
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, PPARD, SRC 4.6016
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 4.32864
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.04126
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.00027
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PPARD, PTPN1, RORC, TBXAS1, TYR, XDH 3.94578
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.80243
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.71715
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.6535
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.6535
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.46596
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2, XDH 3.35548
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.34361
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.27821
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.08806
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.88779
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.7823
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.75777
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD17B1, HSD17B2 2.56337
[MF] GO:0004949 None CNR1, CNR2 2.48313
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, POLA1, PPARD, SRC, XDH 2.28015
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.22887
[MF] GO:0005504 None FABP3, FABP4, PPARD 2.16573
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, IGF1R, KDR, MET, PPARA, PPARD, RORC 2.1546
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.14188
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.13038
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, POLA1, POLB, SRC 2.08302
[MF] GO:0019902 phosphatase binding BCL2, HMGCR, MET, PPARA, PTPN1 2.0371
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0371


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.8938
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.5124
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.4505
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.9473
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.537
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R, PPARD 3.9031
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.6099
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7038
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.158
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.8697
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.7627
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, MET, IGF1R 2.7069
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7905
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1, PPARD 2.4296
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CNR2, CNR1, ADORA3, ADORA1 2.2249
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, IGF1R 1.963
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0934
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.194
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.2043
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.9129
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9194
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.8321
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.0934
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7133
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7683
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.5756
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, PPARA 1.3221
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1929
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4312
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3863
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.401
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3451
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3221
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1778
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0782
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1699
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.3853
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3445
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3583
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1294
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2646
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0989
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0719
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.162
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.0169
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.0348
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8545
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0348
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.9226
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0122
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.856
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9311
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8359
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8225
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.009
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.7545
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8225
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7501
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7622
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.7249
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8321
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3087
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.3086
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.4115
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4297
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4057
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4782
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4056
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4812
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.558
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4656
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4621
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4856
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4782
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4496
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5242
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4768
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5039
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4996
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4856
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5061
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5482
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4996
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5482
Axon guidance_Homo sapiens_hsa04360 MET 0.4947
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5507
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5482
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.558
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.558
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.5216
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.558
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5507
Gap junction_Homo sapiens_hsa04540 SRC 0.558
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.558
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.558
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5378
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5507
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.5482
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.558
Peroxisome_Homo sapiens_hsa04146 XDH 0.558
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6022
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5964
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6223
Glioma_Homo sapiens_hsa05214 IGF1R 0.6223
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6084
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6223
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6216
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6223
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6223
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6089
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6223
Shigellosis_Homo sapiens_hsa05131 SRC 0.6223
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6819
Malaria_Homo sapiens_hsa05144 MET 0.6925
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7124
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7247
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7883
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8225
DNA replication_Homo sapiens_hsa03030 POLA1 0.783
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0769
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8265
Base excision repair_Homo sapiens_hsa03410 POLB 0.8063
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8508
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8225
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8422
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9062
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0412


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)