TCM Prescription: Yi Gan Le Infusion



Prescription Description
Prescription IDTCMF6446
Pinyin NameYi Gan Le Chong Ji
Chinese Name益肝乐冲剂
English NameYi Gan Le Infusion
Function Description黄疸, 胁痛
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2563 Polysaccharidum versicolor 云芝 TCMH2563
TCMH312 Sedum sarmentosum 垂盆草 TCMH312 ITSAJ4288-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT903 GRIN2B Glutamate [NMDA] receptor subunit epsilon 2 Ion channel Q13224
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, KCNH2, KDR, MAOA, MET, PPARA, PTGS2, SRC, TRPV1, XDH 10.7623
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CYP1B1, F3, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KDR, MAP2K1, MET, PIM1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 7.66656
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, CBR1, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4, HSD11B1, HSD17B3, MET, PPARA, PTGES, PTGS2, TRPV1 7.4378
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, FABP3, HSD17B3, IDO1, PIM1, PPARA, PTGES, PTGS2, XDH 7.4378
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, F10, F3, FLT3, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 7.18829
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 7.05203
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 7.05203
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CYP1B1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MAP2K1, MET, PIM1, PTGS2, RELA, SRC, TRPV1, XDH 6.86649
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CA2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KDR, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1 6.43803
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 6.3834
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APP, AR, AXL, CA2, CYP1B1, DHFR, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1 6.25978
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.24839
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, CYP1B1, F3, FLT3, GSK3B, IDO1, IGF1R, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC, TRPV1, XDH 6.24839
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, GSK3B, HSD11B1, HSD17B3, IDO1, MAOA, PTGS2, XDH 6.12985
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, F3, FABP3, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 5.9344
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 5.9344
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AR, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, F10, F3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MET, PPARA, PTGS2, SRC, TRPV1 5.84051
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, MET, PIM1, PPARA, PTGS2, RELA, SRC 5.83223
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.82884
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DHFR, FABP3, GRIN2B, GSK3B, IDO1, IGF1R, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1 5.78354
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, CYP1B1, F3, FABP3, FLT3, IDO1, IGF1R, KDR, MAP2K1, PIM1, PTGES, PTGS2, RELA, SRC, XDH 5.78354
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1B1, FABP4, KDR, PTGES, PTGS2, RELA, SRC 5.77688
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 5.65775
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, F10, F3, FLT3, GSK3B, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 5.53673
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, MET, PIM1, PTGS2, RELA, SRC 5.53673
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1B1, DHFR, FABP3, GRIN2B, KCNH2, KDR, NR3C1, PTGS2, RELA, SRC, TOP1, TRPV1 5.52266
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1B1, PTGES, PTGS2 5.4125
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, PTGES, PTGS2 5.39771
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, PTGES, PTGS2 5.24492
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 5.22176
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CYP1B1, F10, F3, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 5.18415
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP3A4, DHFR, HSD17B3, IDO1, PTGES, PTGS2 5.10168
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DHFR, F3, FABP4, GSK3B, IDO1, IGF1R, MAP2K1, MAP3K7, MET, PPARA, PTGS2, RELA, SRC, XDH 5.10168
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1, XDH 5.08627
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, XDH 5.0001
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC, TRPV1 5.0001
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, PIM1, PTGS2, RELA, SRC 4.88406
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, FLT3, GRIN2B, KCNH2, MET, SRC, TRPV1 4.7957
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CYP1B1, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1 4.77779
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1, XDH 4.75192
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES, PTGS2 4.75174
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, DHFR, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGS2, SRC, TOP1, XDH 4.75174
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, F10, F3, FABP4, FLT3, GSK3B, IDO1, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 4.7478
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CACNA1C, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 4.71957
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 4.71957
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 4.71957
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, F10, F3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 4.62234
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, FABP3, PPARA, PTGES, PTGS2 4.58872
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 4.58872
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.57007
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AXL, CACNA1C, CYP19A1, CYP1B1, F10, F3, FABP4, GRIN2B, IDO1, IGF1R, KCNH2, MET, PIM1, PPARA, PTGS2, RELA, SRC, TOP1, TRPV1 4.55032
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, DHFR, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGS2, SRC, TOP1, XDH 4.49994
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, APP, CYP19A1, CYP1B1, CYP3A4, DHFR, HSD17B3, MAOA 4.45203
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AR, AXL, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 4.37677
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 4.321
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, PTGES, PTGS2 4.30025
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, AR, CA2, FABP3, FLT3, GSK3B, IGF1R, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1 4.29948
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 4.28564
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, CA2, CYP1B1, F3, IDO1, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGS2, RELA, SRC, TRPV1 4.21747
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, DHFR, HSD17B3 4.19939
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AR, AXL, CA2, CACNA1C, CYP1B1, F3, GSK3B, IDO1, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGS2, RELA, SRC, TRPV1, XDH 4.18433
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, NR3C1, PTGS2, RELA, SRC, TRPV1 4.16734
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1B1, PTGES, PTGS2 4.16734
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CYP1B1, DHFR, FLT3, NR3C1, PTGES, PTGS2, RELA, SRC, TRPV1 4.08238
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.03288
[BP] GO:0030522 intracellular receptor signaling pathway AR, MAP3K7, NR3C1, PIM1, PPARA, RELA, SRC 4.01048
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 4.00671
[BP] GO:0034097 response to cytokine ALOX15, AXL, FABP4, FLT3, GSK3B, PTGES, PTGS2, RELA, SRC, TRPV1 3.9805
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, FABP3, IDO1, PPARA, PTGES, PTGS2 3.97733
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, GSK3B, IGF1R, NR3C1, PTGS2, RELA, SRC, TRPV1 3.93866
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC, TRPV1 3.90603
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CYP19A1, CYP1B1, DHFR, F10, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, PPARA, PTGS2, RELA, SRC, XDH 3.88778
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1B1, CYP3A4, HSD11B1, HSD17B3 3.88778
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.87897
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B3 3.87897
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.84404
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 3.83508
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, AXL, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 3.82053
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, F3, FABP4, IDO1, KDR, MAP2K1, MET, PPARA, PTGS2, RELA 3.81139
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, CACNA1C, FABP3, FABP4, GRIN2B, KCNH2, MET, TRPV1 3.78961
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, SRC, XDH 3.78735
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 3.76467
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, CYP3A4, FABP3, FABP4, MET, PPARA, PTGES, PTGS2 3.70044
[BP] GO:0009725 response to hormone AKR1B1, AR, CA2, FABP3, FLT3, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1 3.69979
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES, PTGS2 3.6901
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, PPARA, PTGS2, RELA, SRC, TRPV1 3.63763
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.62513
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 3.58576
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, FLT3, GSK3B, IGF1R, NR3C1, PTGS2, RELA, SRC, TRPV1 3.58092
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HSD11B1, HSD17B3, PTGES, PTGS2 3.52686
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CACNA1C, CYP19A1, FLT3, HSD11B1, HSD17B3, KDR, MAP2K1, PPARA, RELA, SRC 3.5166
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, NR3C1, PTGS2, RELA, SRC 3.50305
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, XDH 3.4822
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2 3.47137
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, KDR, PTGES, PTGS2, RELA, SRC 3.46297
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AXL, CA2, CACNA1C, CYP19A1, CYP1B1, DHFR, FLT3, GSK3B, HSD11B1, HSD17B3, KDR, MAP2K1, PIM1, PPARA, PTGS2, RELA, SRC 3.46033
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 3.43149
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, SRC, XDH 3.41534
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGES, PTGS2 3.41499
[BP] GO:0033993 response to lipid AR, AXL, CA2, FABP3, FLT3, IDO1, NR3C1, PTGES, PTGS2, RELA, SRC 3.40491
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, F10, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, SRC, TOP1 3.4015
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 3.32261
[BP] GO:0019371 None CBR1, PTGES, PTGS2 3.31668
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AR, AXL, CA2, CYP1B1, F3, IDO1, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC 3.26108
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 3.24035
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1B1, FLT3, NR3C1, PTGS2, SRC, TRPV1 3.23401
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1B1, CYP3A4, HSD11B1, HSD17B3 3.22029
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, KDR, PTGS2, SRC, TRPV1 3.22029
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CYP1B1, DHFR, F3, FABP4, FLT3, GRIN2B, GSK3B, IGF1R, MAP2K1, MAP3K7, MET, PIM1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 3.18873
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, F10, F3, IGF1R, KDR, MET, PTGS2, SRC 3.14409
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2 3.1095
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, DHFR, IDO1, PTGES, PTGS2 3.03999
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGES, PTGS2 3.03695
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, DHFR, IDO1, PTGES, PTGS2 3.03535
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1B1, CYP3A4, HSD11B1, HSD17B3 3.01439
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.00629
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.00629
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.00629
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, PTGS2, RELA, SRC, TRPV1 2.91918
[BP] GO:0042391 None ADORA1, APP, CACNA1C, GRIN2B, KCNH2, KDR, SRC, TRPV1 2.88791
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA, SRC 2.88165
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1B1, CYP3A4, HSD17B3 2.88165
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, RELA, SRC 2.88165
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, TRPV1 2.81477
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AR, AURKB, DHFR, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 2.81477
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AR, AURKB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 2.77671
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, GSK3B, KCNH2, MAP2K1, PPARA, PTGS2, SRC, TRPV1 2.72438
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 2.71066
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.71066
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GSK3B, IGF1R, PTGS2, RELA, SRC, TRPV1 2.70227
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CYP1B1, F10, F3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PTGS2, RELA, SRC, XDH 2.69618
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.68313
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, PPARA, SRC 2.6814
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.67084
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PTGES, PTGS2, RELA, TRPV1 2.66448
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, RELA, SRC 2.65337
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.64401
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AR, AXL, CA2, CYP1B1, F3, GSK3B, IDO1, KDR, MAP2K1, PIM1, PTGS2, RELA, SRC, XDH 2.62696
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, SRC, XDH 2.62696
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.611
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B3 2.611
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.611
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.57616
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTGS2, SRC, XDH 2.56739
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, FABP3, FLT3, KDR, MAP2K1, MAP3K7, PTGS2, SRC, XDH 2.56739
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AR, AURKB, AXL, CA2, CACNA1C, CBR1, CYP19A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HSD11B1, HSD17B3, KDR, MAP2K1, MET, PIM1, PPARA, PTGS2, RELA, SRC 2.5632
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTGS2, SRC, XDH 2.54913
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CACNA1C, CYP1B1, F3, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, RELA, SRC, TRPV1 2.54126
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, F3, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 2.5172
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTGS2, SRC, XDH 2.50025
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CACNA1C, CYP1B1, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, RELA, SRC 2.48714
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AR, AXL, CA2, CYP1B1, F3, GSK3B, IDO1, KDR, MAP2K1, PIM1, PPARA, PTGS2, RELA, SRC, TRPV1, XDH 2.48459
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTGS2, SRC, XDH 2.4823
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CYP1B1, DHFR, GSK3B, IDO1, MAP2K1, MAP3K7, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1 2.47596
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PPARA, PTGS2, SRC, XDH 2.47493
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, PTGS2, RELA, SRC 2.46979
[BP] GO:0042180 None AKR1B1, CYP19A1, HSD17B3, IDO1 2.44681
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, KCNH2, PTGS2, SRC, TRPV1 2.4246
[BP] GO:0071345 cellular response to cytokine stimulus ALOX15, AXL, FABP4, FLT3, GSK3B, RELA, TRPV1 2.38342
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CYP1B1, FABP4, GSK3B, IGF1R, MET, PIM1, PPARA, PTGS2, SRC 2.36534
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3645
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.34389
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, IDO1, PTGES, PTGS2 2.34331
[BP] GO:0071363 cellular response to growth factor stimulus APP, KDR, NR3C1, RELA, SRC, TRPV1 2.34331
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, FLT3, KDR, MAP2K1, MAP3K7, PTGS2, SRC, XDH 2.33969
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, FABP4, FLT3, IGF1R, KDR, MAP2K1, MAP3K7, PTGS2, SRC, XDH 2.33969
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CYP3A4, DHFR, F10, F3, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PPARA, PTGS2, RELA, SRC, TOP1, XDH 2.33969
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, GSK3B, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, XDH 2.33969
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.31075
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, SRC 2.30333
[BP] GO:0010942 positive regulation of cell death CYP1B1, F3, GRIN2B, GSK3B, IDO1, PTGS2, SRC, TRPV1, XDH 2.28617
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2 2.28028
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, HSD17B3 2.27031
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, MAOA, PTGS2, TRPV1 2.27002
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, F3, FLT3, GSK3B, KDR, MAP2K1, MAP3K7, PTGS2, RELA, SRC, XDH 2.27002
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, CACNA1C, FABP3, GRIN2B, KCNH2, TRPV1 2.25764
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, CYP1B1, GSK3B, IDO1, KDR, MAP3K7, PPARA, SRC 2.25764
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.22377
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CBR1, CYP1B1, CYP3A4, DHFR, IDO1, MAOA 2.20059
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.20059
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, MAP3K7, PIM1, RELA 2.20059
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, FABP4, IDO1, PPARA, PTGS2, RELA 2.20059
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTGS2 2.20059
[BP] GO:0061370 testosterone biosynthetic process CYP19A1, HSD17B3 2.20059
[BP] GO:0010641 None F3, SRC 2.20059
[BP] GO:0007598 None F10, F3 2.20059
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.20059
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.20059
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.16583
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, HSD17B3, MAP2K1, SRC 2.16369
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 2.16369
[BP] GO:0006633 None ALOX12, ALOX15, PTGES, PTGS2 2.15004
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.13575
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, F10, F3, MET, XDH 2.13575
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, DHFR, PTGS2, TRPV1, XDH 2.13575
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1B1, GRIN2B, KDR, RELA, SRC 2.12566
[BP] GO:0042133 neurotransmitter metabolic process ACHE, CYP1B1, DHFR, MAOA 2.12357
[BP] GO:0032496 response to lipopolysaccharide AXL, IDO1, PTGES, PTGS2, RELA, SRC 2.12033
[BP] GO:0043434 None FABP3, PPARA, PTGS2, RELA, SRC, TRPV1 2.11463
[BP] GO:0032103 positive regulation of response to external stimulus F3, FABP4, IDO1, KDR, MET, PTGS2 2.1101
[BP] GO:0070848 response to growth factor APP, KDR, NR3C1, RELA, SRC, TRPV1 2.1101
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, F3, FLT3, GRIN2B, GSK3B, IGF1R, KDR, MAP3K7, MET, RELA, SRC, TRPV1 2.10715
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, AR, F3, FLT3, IGF1R, KDR, PIM1, PTGS2, RELA 2.10715
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, RELA, SRC 2.09514
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, AR, CYP19A1, GSK3B, IGF1R, MET, PPARA, PTGS2, RELA, SRC, XDH 2.08681
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PTGS2 2.08681
[BP] GO:1901654 None AKR1B1, AR, NR3C1, RELA, SRC 2.05542
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, DHFR, PPARA 2.04565
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, FABP3, GRIN2B, KCNH2, PPARA, TRPV1 2.01344
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.69169
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, HSD17B3, IDO1, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, NR3C1, PIM1, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 3.18873
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, F10, F3, FLT3, GRIN2B, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TRPV1 3.14801
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CACNA1C, CYP19A1, CYP1B1, CYP3A4, F10, F3, FLT3, GRIN2B, GSK3B, HSD11B1, HSD17B3, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTGS2, SRC, TRPV1 2.62696
[CC] GO:0031233 None CA4, F10, F3 2.62536
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CACNA1C, F10, F3, FLT3, GRIN2B, IGF1R, KCNH2, KDR, MET, PTGS2, SRC, TRPV1 2.52772
[CC] GO:0009986 cell surface ACHE, APP, AXL, CA4, F3, GRIN2B, KCNH2, MET 2.13933
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, F3, FLT3, GRIN2B, IGF1R, KDR, MET, TRPV1 2.12566
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IDO1, IGF1R, KDR, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGES, PTGS2, RELA, SRC, TOP1, TRPV1, XDH 8.87041
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.04991
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, F10, F3, FLT3, GSK3B, HSD11B1, HSD17B3, IDO1, IGF1R, KCNH2, KDR, MAOA, MAP2K1, MAP3K7, MET, PIM1, PTGES, PTGS2, SRC, TOP1, XDH 7.18905
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1B1, CYP3A4, GRIN2B, NR3C1, PIM1, PPARA, XDH 6.72415
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1B1, CYP3A4, DHFR, HSD11B1, HSD17B3, IDO1, MAOA, PTGS2, XDH 6.28562
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1B1, CYP3A4, DHFR, FLT3, GRIN2B, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TOP1, TRPV1 5.46686
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.39766
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.39766
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.32148
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 5.24492
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, DHFR, F10, F3, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, PTGES, RELA, SRC, TOP1, TRPV1, XDH 5.08627
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.75174
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 4.53185
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, F10, F3, FABP3, FABP4, NR3C1, PPARA, SHBG, TRPV1 4.34454
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1B1, CYP3A4, XDH 4.2244
[MF] GO:0016301 kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 4.16734
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MAP2K1, MET, SRC 3.93714
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.84801
[MF] GO:0020037 heme binding CYP19A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 3.65723
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1B1, CYP3A4, F10, GRIN2B, IDO1, MAP3K7, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 3.64498
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, FLT3, GSK3B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1 3.5166
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 3.50305
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.43149
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CACNA1C, CYP19A1, CYP1B1, CYP3A4, F10, GRIN2B, IDO1, MAP3K7, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 3.31668
[MF] GO:0042562 hormone binding ACHE, AR, IGF1R, NR3C1, SHBG 3.30502
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 3.20202
[MF] GO:0048037 cofactor binding CYP19A1, CYP1B1, CYP3A4, DHFR, IDO1, PTGES, PTGS2, SRC, XDH 3.17412
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIN2B, IGF1R, KCNH2, KDR, MAP2K1, MAP3K7, MET, NR3C1, PPARA, TRPV1 3.11734
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, DHFR, FABP3, FABP4, FLT3, GRIN2B, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TRPV1, XDH 3.00714
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.00629
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIN2B, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, TRPV1 2.91068
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.91068
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.611
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.611
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.611
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HSD11B1, HSD17B3, XDH 2.48459
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP3A4 2.4823
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIN2B, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, TRPV1 2.43189
[MF] GO:0005497 None AR, SHBG 2.3645
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP3A4 2.34389
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, F3, FLT3, GRIN2B, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, TRPV1 2.31075
[MF] GO:0005496 steroid binding AR, CYP3A4, NR3C1, SHBG 2.15004
[MF] GO:0005524 ATP binding AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TRPV1 2.11463
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06578
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TRPV1 2.02996
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, MAP2K1, MAP3K7, MET, PIM1, SRC, TOP1, TRPV1 2.00431


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.3766
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, ALOX12, CACNA1C, PTGS2 7.4756
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, PTGS2, PTGES 6.1955
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1B1, PTGS2, CYP19A1, IGF1R 5.1353
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1B1, ALOX12, PTGS2, CYP3A4, CYP19A1, DHFR, HSD11B1, ALOX5, XDH, PTGES, IDO1 5.0374
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 4.983
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, MAP2K1, FLT3, PTGS2, MET, RELA, IGF1R 3.8901
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, RELA, IGF1R 4.1768
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1B1, PTGS2, CYP3A4 4.2952
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, ADORA1, CACNA1C, PPARA, GRIN2B, RELA 3.7235
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, MET, IGF1R 3.7235
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KDR, MET, GRIN2B, IGF1R 3.6887
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, PIM1, RELA 3.719
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KDR, MET, GRIN2B, RELA, IGF1R 3.5715
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 3.6682
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, RELA 3.4445
Adherens junction_Homo sapiens_hsa04520 SRC, MAP3K7, MET, IGF1R 3.4445
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1B1, CYP3A4 3.4445
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, KDR, MET, IGF1R 2.8722
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, KDR, MET, RELA, IGF1R 2.7828
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.9083
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MAP3K7, RELA 2.8604
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOA, CACNA1C, GRIN2B 2.6682
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, ADORA1, RELA 2.7533
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1, GRIN2B 2.4393
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 2.4393
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1B1, IDO1 2.9083
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.6033
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, GRIN2B 2.4393
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 2.4123
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C, GRIN2B 2.4393
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIM1, CYP1B1, PTGS2, MET 2.3969
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, MET 2.4393
Cocaine addiction_Homo sapiens_hsa05030 MAOA, GRIN2B, RELA 2.7418
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C, GRIN2B 2.4123
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.4393
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 2.4123
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 2.2722
Melanoma_Homo sapiens_hsa05218 MAP2K1, MET, IGF1R 2.4134
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, RELA, IGF1R 2.3228
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.4123
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIM1, F3, RELA 2.1091
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.437
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC 2.247
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, CACNA1C 2.2106
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.1373
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, CACNA1C 2.0357
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, RELA, IGF1R 2.0938
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 2.0758
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PTGS2, MAP3K7, RELA 2.1931
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA 1.9248
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA, RELA 2.0498
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.9083
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, SRC 1.9767
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, MAP3K7, RELA 1.9767
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, RELA 1.9642
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.9416
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.8781
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, RELA 1.8761
Measles_Homo sapiens_hsa05162 GSK3B, MAP3K7, RELA 1.8633
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SRC, RELA 1.7981
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, IGF1R 1.8182
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA, RELA 1.7645
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, RELA 1.6085
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, GRIN2B 1.5943
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, MAP3K7, RELA 1.5224
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.2761
Huntington's disease_Homo sapiens_hsa05016 GRIN2B 0.4084
Apoptosis_Homo sapiens_hsa04210 MAP2K1, RELA 1.0991
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4347
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.4296
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, IGF1R 1.3217
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B, MAP2K1 1.0991
Herpes simplex infection_Homo sapiens_hsa05168 MAP3K7, RELA 0.9237
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C, GRIN2B 1.2235
Tuberculosis_Homo sapiens_hsa05152 SRC, RELA 0.945
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 1.1281
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 1.1702
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, MAP3K7 1.0937
Viral carcinogenesis_Homo sapiens_hsa05203 SRC, RELA 0.8693
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC 1.3181
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4786
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.8459
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4698
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.3458
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1 1.3146
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.1558
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 CACNA1C 0.4878
Tight junction_Homo sapiens_hsa04530 SRC 0.5053
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 1.1917
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1 0.4951
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C, GRIN2B 1.342
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, RELA 0.7467
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.5133
Systemic lupus erythematosus_Homo sapiens_hsa05322 GRIN2B 0.5133
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 1.3112
Platelet activation_Homo sapiens_hsa04611 SRC 0.5424
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.5391
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.3944
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2, RELA 1.4033
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.3944
Glioma_Homo sapiens_hsa05214 MAP2K1, IGF1R 1.5698
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.6068
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, RELA 1.5224
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, RELA 1.5683
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.473
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.5996
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.608
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.5711
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.608
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.5683
Amoebiasis_Homo sapiens_hsa05146 RELA 0.608
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.5414
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1 1.5916
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6203
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.6258
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6192
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.6313
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.4676
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.6385
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP3A4 1.5426
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.6326
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.6371
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.6525
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1 1.7077
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.5349
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.5698
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.5414
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.6463
Salmonella infection_Homo sapiens_hsa05132 RELA 0.6445
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.6531
Peroxisome_Homo sapiens_hsa04146 XDH 0.6525
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.6525
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.6649
Pertussis_Homo sapiens_hsa05133 RELA 0.6774
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6796
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.7069
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.6796
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.7217
Retinol metabolism_Homo sapiens_hsa00830 CYP3A4 0.7217
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.7217
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.7217
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC 1.8687
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7467
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7981
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1 0.7625
Legionellosis_Homo sapiens_hsa05134 RELA 0.7665
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.7665
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIN2B 0.7905
Malaria_Homo sapiens_hsa05144 MET 0.7964
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.7951
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7951
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.8013
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP3A4 2.0758
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2177
Nicotine addiction_Homo sapiens_hsa05033 GRIN2B 0.8693
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.9104
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.9104
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.8693
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9519
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.9626
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.9884
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA 0.9104
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9329
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9024
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9884
Histidine metabolism_Homo sapiens_hsa00340 MAOA 1.0301
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 1.0991
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.1515
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.217
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.5613


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)