TCM Prescription: Yi Gan Ointment



Prescription Description
Prescription IDTCMF6440
Pinyin NameYi Gan Gao
Chinese Name益肝膏
English NameYi Gan Ointment
Function Description胁痛, 腹胀
IndicationsHypochondrium pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2256 Curculigo orchioides 仙茅 TCMH2256 GENG778-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH436 Fructus oryzae germinatus 稻芽 TCMH436
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH825 Nelumbo nucifera 荷叶 TCMH825 ITSAI3109-14
TCMH1992 Polygonum orientale 水红花叶 TCMH1992 KU243366
TCMH719 Dryopteris crassirhizoma 贯众 TCMH719 GBVM2585-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 12.863
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.1293
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HMGCR, IDO1, MPO, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.9609
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2269
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 10.0782
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 9.89535
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.88065
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 9.8314
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TOP2A, XDH 9.06705
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 9.06367
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, HMGCR, HSD17B2, IDO1, IGF1R, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, SRC, TYR 8.90086
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, ALPI, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.55567
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, IDO1, IGF1R, KDR, MET, MMP1, MMP2, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 8.44732
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 7.75576
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 7.58336
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, F10, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.54316
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 7.54258
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, F10, FLT3, HCAR2, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.53338
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, MPO, PIK3CA, PPARA, PTGS2, SRC, TYR 7.37727
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, XDH 7.04076
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, FABP3, FLT3, HMGCR, HTR1A, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 6.88031
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, IDO1, IGF1R, KDR, MMP9, MPO, PIK3CA, PIM1, PTGS2, PTPN1, SRC 6.81735
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC 6.72315
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.5144
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.2141
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A 6.21032
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.2051
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, F10, FABP3, FLT3, HCAR2, HMGCR, HTR1A, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 6.14886
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, SRC, TYR 6.14603
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, MPO, PIK3CA, PPARA, PTGS2, SRC, TYR 6.1235
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.00163
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F10, FLT3, HMGCR, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.99821
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALPI, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.82544
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.50369
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F10, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.35413
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.32722
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F10, FLT3, HMGCR, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.32206
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, F10, FABP3, FABP4, FLT3, HMGCR, HSD17B2, HTR1A, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR 5.30637
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HMGCR, HTR1A, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 5.12658
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, HTR1A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.99877
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 4.99877
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, ESR1, F10, FABP4, HMGCR, HSD17B2, HTR1A, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 4.88831
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TOP2A, TYR 4.8244
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.81221
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 4.77003
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 4.75398
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD2, HCAR2, HMGCR, KDR, PIK3CB, PTGS2, SRC 4.75398
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 4.72087
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F10, FABP4, FLT3, HMGCR, HTR6, IDO1, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.7005
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CB, SRC, XDH 4.7005
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.63305
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, F10, FLT3, HCAR2, HMGCR, HTR1A, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.57264
[BP] GO:0014070 response to organic cyclic compound APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, PTGS2, SRC, TYR 4.50279
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, F10, FLT3, HCAR2, HMGCR, HTR1A, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.47095
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR, IDO1 4.47095
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, F10, HCAR2, HMGCR, HTR1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 4.42622
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.38677
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, MPO, PTGS1, PTGS2, SRC 4.24056
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.21061
[BP] GO:0009725 response to hormone AKR1B1, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, PPARA, PTGS2, SRC 4.17417
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 4.14991
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.93791
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.9075
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, MET, PIK3CA, PIK3CB, SRC, XDH 3.87619
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR 3.85548
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, HTR1A, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.81927
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC 3.76418
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.72531
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR 3.71518
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, FABP3, HMGCR, KDR, PTGS2, SRC 3.69216
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, HMGCR, KDR, SRC 3.68614
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPI, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.66434
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.59816
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 3.5889
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, HMGCR, HTR1A, TYR 3.5889
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.58598
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.58598
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.57001
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.57001
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.57001
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, F10, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.56362
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, HTR1A, IDO1, MMP2, MMP9, MPO, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A 3.56298
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, SRC, TYR 3.4727
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.47059
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.47059
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD2, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 3.45207
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.42574
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.42574
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPI, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, FLT3, HMGCR, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.41613
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.4053
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1 3.36052
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.33802
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.32578
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.2737
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD2, FABP3, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.2737
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.25837
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, SRC 3.22361
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.15958
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.14048
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.13451
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.13443
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13324
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.13195
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, SRC, TOP2A 3.09176
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, HMGCR, MMP2, MPO, PPARA, PTGS2, SRC, TYR 3.08197
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 3.06576
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 3.03563
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 3.03559
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SRC 3.03559
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.03559
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, KDR, SRC 3.01094
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 2.99897
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.97931
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, FABP3, FABP4, GLO1, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.97931
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD2, ESR1, F10, FLT3, FUT7, GLO1, HMGCR, HTR1A, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.93473
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALPI, CSNK2A1, DRD2, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.92276
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1, PIK3CB 2.91027
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, PTGS2 2.88534
[BP] GO:0071310 cellular response to organic substance AKR1B1, APEX1, AXL, BCL2, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, SRC 2.84634
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.84133
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DRD2, IDO1, MPO 2.84133
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.83437
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, ESR1, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2 2.8289
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, HCAR2, PIK3CB, PTGS2 2.81731
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC 2.81242
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 2.80522
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.80368
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, HCAR2, HMGCR, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH 2.79481
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.78282
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, HMGCR, MPO, PTGS2 2.77775
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, DRD2, FABP3, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.76673
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.76389
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.72941
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, HMGCR, IDO1, MPO, PTGS1, PTGS2 2.69103
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.65357
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.64404
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HCAR2, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR6, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 2.61841
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.60223
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.60223
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60223
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DRD2, ESR1, FABP4, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, XDH 2.58881
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, F10, FABP4, FLT3, HMGCR, HTR6, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.58459
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, MPO 2.52921
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, FABP3, FABP4, GLO1, HCAR2, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, MPO, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TOP2A, XDH 2.5146
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, SRC, TOP2A 2.46566
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, HCAR2, HMGCR, HTR1A, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.4641
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.44247
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, PPARA 2.4344
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD2, FUT7, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.42672
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40496
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, HTR1A 2.40496
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.40496
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.40355
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.35978
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.3458
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.3458
[BP] GO:0031401 positive regulation of protein modification process ADORA1, BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.33739
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.33002
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.32289
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.32022
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, KDR, PTGS2, SRC 2.30776
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F10, FLT3, HMGCR, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.29358
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.29293
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.28033
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD2, MET, PIK3CA 2.28033
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD2, FUT7, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC 2.27044
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, DRD2, FLT3, HMGCR, KDR, PIK3CB, PTPN1, SRC, XDH 2.26474
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.25405
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.25147
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, PTGS2 2.24108
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.21133
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.20793
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.20793
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 2.20793
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.20793
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.20481
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.20481
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.19836
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.19836
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD2, PTGS2 2.19797
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.19058
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, DRD2, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.19058
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.1868
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1868
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.18128
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.16567
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.16504
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 2.14572
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.13094
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2 2.12024
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 2.12024
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 2.09487
[BP] GO:0009991 response to extracellular stimulus AXL, BCL2, CYP1A1, HMGCR, MPO, PTGS2, SRC, TYR 2.04431
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DRD2, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 2.03766
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.03048
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.01866
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.01381
[BP] GO:0042321 None ADORA1, DRD2 2.00302
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MMP9, PTGS2 2.00302
[BP] GO:2000108 None HCAR2, IDO1, PIK3CB 2.00302
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, HCAR2, PIK3CB 2.00302
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IDO1, KDR, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 3.11138
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.60223
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPI, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FLT3, FUT7, GLO1, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR6, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TYR 2.40066
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B2, PTGS1, PTGS2 2.26803
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPI, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FLT3, FUT7, HCAR2, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR6, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 2.00317
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.2356
[MF] GO:0046914 transition metal ion binding ALOX5, ALPI, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TYR, XDH 14.9869
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 14.7187
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPI, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TOP2A, TYR, XDH 13.033
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5374
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.2464
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD11B1, HSD17B1, HSD17B2, IDO1, MPO, NQO2, PTGS1, PTGS2, TYR, XDH 10.5978
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS1, PTGS2, SRC 9.20146
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPI, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DRD2, ESR1, F10, GLO1, HTR1A, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TYR, XDH 8.98901
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 8.95893
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS1, PTGS2, SRC 8.95711
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1 7.99373
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HMGCR, HSD17B1, IDO1, MPO, NQO2, PTGS1, PTGS2, SRC, XDH 7.45795
[MF] GO:0046872 metal ion binding ALOX5, ALPI, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F10, GLO1, IDO1, MMP1, MMP12, MMP2, MMP9, MPO, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TOP2A, TYR, XDH 7.27764
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.81982
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR 5.96679
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.32093
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.94591
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.7005
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DRD2, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP2A 4.48151
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.01493
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.97235
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.47059
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.4053
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.27035
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.08197
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.03206
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97931
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.80788
[MF] GO:0008389 None CYP2A13, CYP2A6 2.80788
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.5765
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.41208
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.22436
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.20481
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.19836
[MF] GO:0042802 identical protein binding ACHE, BCL2, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TOP2A, TYR, XDH 2.14721
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.07772
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.03501
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.03501
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.00302


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.7251
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.5262
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.4265
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.2361
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPI, XDH, IDO1 5.9646
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.1629
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.4761
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.0921
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, HTR6, PIK3CA, ADORA1, HTR1A, PIK3CB, DRD2, PPARA 5.3503
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.5869
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 4.9731
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7187
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.3624
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, DRD2, MET, IGF1R 4.303
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.303
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3624
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.8251
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, HTR1A, PTGS2, PTGS1 3.6293
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.5249
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6048
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1354
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1153
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.2061
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3652
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.3013
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.2939
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.9965
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.8539
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3328
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.0397
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.1894
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, MPO, IGF1R 2.8539
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.7069
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.7934
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7097
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.7126
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.5223
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5207
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5967
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.6404
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6404
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6404
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.5807
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2837
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.2837
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, ADORA3, ADORA1, HTR1A, DRD2 2.2197
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.2123
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.965
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.4066
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.408
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9784
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.4388
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.1017
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.022
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.6596
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3962
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7696
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.4388
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0275
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.6686
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6686
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4066
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.66
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6499
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.6499
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.6019
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6392
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.5845
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3043
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.247
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.2616
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3923
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3477
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3402
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3579
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6 0.3461
Alcoholism_Homo sapiens_hsa05034 DRD2 0.3461
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.081
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.4104
Phagosome_Homo sapiens_hsa04145 MPO 0.3857
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4104
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.6026
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4456
Axon guidance_Homo sapiens_hsa04360 MET 0.4402
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4456
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.9408
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2 0.4377
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9634
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.991
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9809
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8292
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8207
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5136
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1699
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5136
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1496
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1733
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1601
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2213
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.234
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5237
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1846
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5136
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.523
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1601
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5367
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5376
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5396
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5396
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5552
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5387
Gap junction_Homo sapiens_hsa04540 SRC, DRD2 1.2559
Peroxisome_Homo sapiens_hsa04146 XDH 0.5552
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4192
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5674
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3916
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5909
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.3916
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5891
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6026
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.433
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3994
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.3994
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4192
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4124
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5057
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6282
Shigellosis_Homo sapiens_hsa05131 SRC 0.6256
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6499
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5518
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5141
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6019
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6686
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7109
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6499
Malaria_Homo sapiens_hsa05144 MET 0.7233
Cocaine addiction_Homo sapiens_hsa05030 DRD2 0.7233
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7693
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.66
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7328
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2963
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.965
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8377
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7945
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8236
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9169
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8765
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8377
Base excision repair_Homo sapiens_hsa03410 APEX1 0.8545
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.149
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9374
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9259
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.991
Folate biosynthesis_Homo sapiens_hsa00790 ALPI 1.1601


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)