TCM Prescription: Xiao Yan Zhi Ke Tablets



Prescription Description
Prescription IDTCMF6420
Pinyin NameXiao Yan Zhi Ke Pian
Chinese Name消炎止咳片
English NameXiao Yan Zhi Ke Tablets
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH918 Elaeagnus pungens 胡颓子叶 TCMH918 GBVJ1128-11, GBVJ1127-11
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2059 Radix pseudostellariae 太子参 TCMH2059
TCMH46 Stemona tuberosa 百部 TCMH46 GBVC4204-11, GBVC4202-11
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH970 Vitex negundo 黄荆子 TCMH970 ITSAJ554-14
TCMH1542 Radix adenophorae 南沙参 TCMH1542
TCMH298 Andrographis paniculata 穿心莲 TCMH298 ITSAO3492-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, MIF, PDE3A, PPARA 10.1935
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.37067
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 9.10123
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, MIF, PDE10A, PDE3A, PDE3B, PIM1, PPARA, TYR, XDH 8.93711
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD11B1, HSD17B1, HSD17B2 8.32139
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 8.32139
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR2A, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 7.62619
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, OPRK1, OPRM1, PDE3A, SRC, TYR 7.43763
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, KDR, MET, MIF, OPRD1, OPRK1, OPRM1, PDE3A, PPARA, SRC, XDH 7.17612
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC 7.15208
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, OPRK1 6.80748
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.80748
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, OPRM1, PIM1, SRC, XDH 6.49836
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HCAR2, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, XDH 6.45372
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HCAR2, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, XDH 6.43546
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, SRC, XDH 6.29847
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SRC, TYR, XDH 5.98992
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 5.98992
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, OPRK1, OPRM1, SRC, TYR 5.87428
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.81616
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, MIF, PDE3A, PPARA 5.81616
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 5.81616
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, FABP4, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, SRC, TYR 5.75084
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 5.72551
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.61794
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.61794
[BP] GO:0007193 None ADORA1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 5.42417
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FLT3, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 5.42417
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.41425
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.38972
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, FLT3, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 5.36069
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, SRC, XDH 5.36069
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.3193
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.2754
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.24564
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 5.24123
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP2, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SRC, TYR, XDH 5.2206
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, OPRD1, OPRK1, OPRM1 5.1674
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 5.1674
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 5.1674
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, KDR, MET, MIF, MMP2, MMP9, PDE3A, PDE3B, PIM1, PPARA, SIGMAR1, SRC, TYR 5.13241
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 5.06741
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 5.01792
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 4.99299
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, DRD1, DRD2, ESR1, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 4.94561
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, OPRK1, PDE3B, PPARA, SRC 4.91428
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 4.90468
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC 4.88031
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.85246
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, MIF 4.78674
[BP] GO:0007188 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.77087
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA 4.75971
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 4.75568
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, HTR2A, KDR, MIF, OPRK1, SRC 4.75568
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SIGMAR1, SRC 4.67545
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 4.67545
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SRC, XDH 4.66634
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.65506
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TYR 4.64751
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.62127
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, PTPN1, SRC, TYR 4.59141
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, SRC 4.57436
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, HTR1A, HTR2A, MIF, MMP9, OPRD1, OPRK1, OPRM1 4.53458
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, DRD2, FLT3, HTR2A, KDR, MET, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 4.49309
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, HTR2A, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 4.47382
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HTR2A, KDR, OPRK1, OPRM1, PDE3A, SRC 4.4435
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, DRD2, ESRRB, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.42944
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 4.40748
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SRC 4.37244
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 4.37141
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, PPARA, SRC, TYR 4.37141
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 4.37141
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 4.36076
[BP] GO:0007187 None ADORA1, DRD1, DRD2, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 4.36076
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 4.31203
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC 4.25026
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SRC, XDH 4.20876
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, OPRM1, PDE3A, SRC 4.20876
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 4.15872
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.08435
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, XDH 4.04917
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, ESR1, HTR7, OPRK1, OPRM1, PPARA, SRC 3.99787
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, HCAR2, HTR1A, HTR2A, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC 3.99499
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC 3.9825
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD2, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.9825
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.97583
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PTPN1, SRC 3.96128
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.96086
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.86921
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DRD2, FLT3, HTR2A, IGF1R, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 3.85505
[BP] GO:0007631 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 3.81537
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.76446
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.70804
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 3.6944
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.66736
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SRC, TYR, XDH 3.66486
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, HTR1A, TYR 3.64965
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 3.64875
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.62204
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SRC, TYR, XDH 3.61185
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MIF, MMP9, OPRK1, SRC 3.61025
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.60081
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, DRD1, DRD2 3.59639
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, ESRRA, FABP4, FLT3, HTR2A, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SRC, XDH 3.57853
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.56442
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MIF, MMP9, SRC 3.55777
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.50292
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 3.48735
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.4768
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, FABP4, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, PTPN1, SRC, XDH 3.42918
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 3.41834
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.41656
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.37848
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, MIF, MMP12, OPRK1, OPRM1, SRC 3.366
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, PDE10A, PDE3A, PDE3B, XDH 3.35796
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.35796
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.34604
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.30841
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 3.30581
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MIF, MMP9, SRC 3.30534
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, HCAR2, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 3.30402
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.30402
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HTR2A, PDE3B, PPARA, SRC 3.28758
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 3.26677
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.25654
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DRD2, HTR2A, KDR, MIF, OPRM1, PTPN1, SRC 3.25654
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PDE3A 3.24549
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.22946
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.21533
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, DRD2, HTR2A, KDR, MIF, OPRM1, SRC 3.20338
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PPARA 3.20238
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, XDH 3.18348
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 3.17282
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 3.17282
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.17008
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.16979
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, MIF, MMP12, OPRK1, SRC 3.14677
[BP] GO:0051952 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 3.12738
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.12422
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, MIF, MMP12, OPRK1, OPRM1, SRC 3.12422
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, HTR1A, TYR 3.08481
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 3.05372
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, HTR2A 3.01672
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, DRD2, HTR2A 3.01672
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MIF, MMP9, SRC 2.997
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 2.97254
[BP] GO:1902532 negative regulation of intracellular signal transduction DRD2, ESR1, IGF1R, MET, MIF, MMP9, PDE3B, PTPN1, SRC, XDH 2.96727
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, ESR1, FLT3, FUT7, HTR1A, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SRC, TYR, XDH 2.95393
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HTR2A, MET, SRC 2.94017
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SRC, XDH 2.94017
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.92761
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, DRD2, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.91853
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, DRD2, ESRRB, HCAR2, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRM1, PDE3A, PIM1, SRC 2.91315
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, PDE10A, PDE3A, PDE3B, SRC, XDH 2.91315
[BP] GO:0031635 None OPRK1, OPRM1 2.91315
[BP] GO:0009115 None AOX1, XDH 2.91315
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SRC, TYR, XDH 2.89788
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, FABP4, KDR, MET, MIF, MMP12, OPRM1, PPARA 2.89414
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIM1, SRC, TYR 2.89095
[BP] GO:2001023 None DRD1, DRD2, HTR2A, MET, OPRK1 2.8621
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8621
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.8621
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.8621
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, MIF, PTPN1, SRC 2.85907
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.85821
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC 2.85821
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.84633
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.82785
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, ESR1, FLT3, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.7441
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.74371
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRM1, PDE3B, PPARA, PTPN1, SRC, XDH 2.74248
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, HCAR2, MIF, MMP12, OPRK1, SRC 2.72488
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.70275
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.69333
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7 2.68741
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.67253
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.67188
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, PDE10A, PDE3A, PDE3B, XDH 2.66901
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, FABP4, FLT3, HTR2A, IGF1R, MET, MIF, MMP9, OPRD1, OPRM1, PIM1, PPARA, PTPN1, SRC, XDH 2.66772
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, FLT3, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 2.65022
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, OPRK1, PDE3B, PPARA, SRC 2.64983
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.63637
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, ESR1, FABP4, IGF1R, MET, MIF, MMP12, MMP2, OPRK1, PPARA, PTPN1, SRC, XDH 2.63634
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HCAR2, MIF, MMP12, SRC 2.62683
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, MIF, PTPN1, SRC 2.60024
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, HCAR2, MIF, MMP12, OPRK1, SRC 2.59744
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.58904
[BP] GO:0050994 None ADORA1, HCAR2, PDE3B, PPARA 2.5742
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, TYR 2.56605
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PPARA, PTPN1, SRC, XDH 2.56428
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, HCAR2, HTR1A, HTR2A, OPRK1 2.55548
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, OPRM1, PPARA 2.5331
[BP] GO:0007626 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.5331
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.52953
[BP] GO:0046110 None AOX1, XDH 2.52664
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52664
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.5259
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.50015
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.45531
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.43467
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 2.43453
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, DRD2, ESR1, FLT3, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.43453
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.42489
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.40498
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, OPRM1, SRC 2.39567
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.39567
[BP] GO:0003008 None ADORA1, AKR1B1, APP, CYP1B1, DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TYR 2.35899
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.35169
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.35169
[BP] GO:0050995 None ADORA1, HCAR2, PDE3B 2.35169
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.35169
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, OPRD1, PPARA, SRC 2.32705
[BP] GO:0007268 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.32081
[BP] GO:0098916 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.32081
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, PPARA, SRC 2.30686
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.30552
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30283
[BP] GO:0097746 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.2963
[BP] GO:0035296 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.2963
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.29295
[BP] GO:0050795 None ADORA1, DRD2, HTR1A, HTR2A 2.28756
[BP] GO:0007198 None HTR1A, HTR7 2.28756
[BP] GO:0006145 None AOX1, XDH 2.28756
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.28756
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28756
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, IGF1R, MIF, PTPN1, SRC 2.28445
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.28186
[BP] GO:0099536 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.28186
[BP] GO:0099537 None DRD1, DRD2, HTR2A, HTR7, OPRD1, OPRK1, OPRM1 2.28186
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.28186
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.28186
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.27863
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.27863
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.27863
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.27863
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, FABP4, HTR2A, MET 2.2629
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, PPARA, PTPN1, SRC, XDH 2.2624
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, TYR 2.24826
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.2215
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.21946
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.21552
[BP] GO:0007610 None APP, DRD1, DRD2, HTR1A, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 2.21426
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC 2.21263
[BP] GO:0050880 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.21263
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, HCAR2, MIF, MMP12, OPRM1, PTPN1, SRC 2.20775
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.20296
[BP] GO:0035150 None ADORA1, DRD1, HTR1A, HTR2A, HTR7 2.20126
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, MIF, PIM1, PPARA, TYR 2.1903
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.18398
[BP] GO:0031644 None ADORA1, OPRD1, OPRK1, OPRM1 2.18398
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SENP6, SIGMAR1, SRC, XDH 2.16944
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CYP1A1, DRD1, ESR1, OPRK1, OPRM1, SRC 2.16871
[BP] GO:0008306 None APP, DRD1, DRD2, OPRK1 2.16622
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, MIF 2.15501
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 2.15249
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC 2.14956
[BP] GO:0032868 None FABP3, OPRK1, PDE3B, PPARA, SRC 2.13062
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.13062
[BP] GO:0021853 None DRD1, DRD2 2.13062
[BP] GO:1904936 None DRD1, DRD2 2.13062
[BP] GO:0042321 None ADORA1, DRD2 2.13062
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC 2.12982
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.1225
[BP] GO:0014059 None DRD2, HTR2A, OPRK1 2.1225
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, HCAR2 2.10917
[BP] GO:0019098 None APP, DRD1, OPRK1 2.08123
[BP] GO:0042310 None HTR1A, HTR2A, HTR7 2.08123
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, IGF1R, MIF, PTPN1, SRC 2.07545
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, MIF, SRC 2.07545
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.04032
[BP] GO:0008344 None APP, DRD1, DRD2, OPRD1 2.03686
[BP] GO:1900542 None DRD1, DRD2, ESRRB, HTR2A, OPRM1, PPARA 2.03686
[BP] GO:0002791 None ACHE, ADORA1, DRD2, HCAR2, MIF, MMP12, OPRM1, SRC 2.03507
[BP] GO:0050714 None ACHE, DRD2, HCAR2, MIF, MMP12, SRC 2.02927
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, IGF1R, MIF, PTPN1, SRC 2.02702
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.02088
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, IGF1R, MIF, PTPN1, SRC 2.01319
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.00832
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.64875
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, DRD1, DRD2, FLT3, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.31351
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTPN1, SIGMAR1, SRC, TYR 3.13736
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTPN1, SIGMAR1, SRC, TYR 3.12361
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC 2.91296
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, ESR1, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SRC 2.41079
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.38338
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.38338
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, CYP2D6, FLT3, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.27464
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, FLT3, HSD11B1, HSD17B2, PTPN1, SIGMAR1 2.17606
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HTR2A, KDR, MIF, MMP2, MMP9, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SIGMAR1, SRC, TYR, XDH 2.16622
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, DRD1, DRD2, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SRC 2.15017
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 14.4578
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.74701
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, SRC, TYR, XDH 9.69681
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, TYR, XDH 8.32139
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.31453
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PTPN1, SENP6, SRC, TYR, XDH 7.62619
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.80755
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 6.75276
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 6.4093
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.23258
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.03173
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.81987
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 5.61794
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.45255
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 5.41959
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.38972
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.36787
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 5.36069
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.28425
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTPN1, TYR, XDH 5.23178
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, SRC 5.10376
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PPARA, SIGMAR1 5.06741
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, MET, PDE10A, PIM1, PPARA, SIGMAR1, SRC 5.01698
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 4.78674
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.58427
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 4.38117
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 4.08435
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, SRC, XDH 3.90534
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90292
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.90292
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.89268
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, DRD1, DRD2, FLT3, HCAR2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 3.89268
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.56442
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR2A, HTR7, OPRM1 3.52352
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.47662
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.35796
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.19186
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 3.12738
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 3.12738
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.05991
[MF] GO:0099528 None HTR1A, HTR2A, HTR7, OPRM1 3.01385
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1 2.91315
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.91315
[MF] GO:0004119 None PDE3A, PDE3B 2.91315
[MF] GO:0008389 None CYP2A13, CYP2A6 2.91315
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.8621
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.85821
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.82386
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.78219
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.5742
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.52953
[MF] GO:0004930 None ADORA1, ADORA3, DRD1, DRD2, HCAR2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 2.52472
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.51814
[MF] GO:0008227 None DRD2, HTR1A, HTR2A, HTR7 2.4417
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.35945
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.35169
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.28756
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.27863
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.27863
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.27863
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.23129
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.15501
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.13062
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.08123
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.00832


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1453
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7729
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.4793
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.8871
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR7, ADORA3, ADORA1, HTR1A, OPRK1, OPRM1, HTR2A, DRD1, DRD2 6.2373
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA 5.2861
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 5.1257
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, ESR2 4.9547
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.2861
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR7, CYP2D6, ALOX5, HTR1A, HTR2A 4.6813
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.3524
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.1146
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3524
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1146
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1146
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.3416
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1 3.288
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A 2.8976
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.288
Gap junction_Homo sapiens_hsa04540 SRC, HTR2A, DRD1, DRD2 2.9136
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.4519
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.0488
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.3662
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0845
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.9274
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.2151
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.9359
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9274
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7916
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.7945
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.9136
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6507
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.488
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, ADORA1 1.6251
Calcium signaling pathway_Homo sapiens_hsa04020 HTR7, HTR2A, DRD1 1.2552
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9996
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2A 1.0068
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0567
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3151
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3506
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9248
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.9996
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2577
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2381
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9562
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2552
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3325
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.171
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9248
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.8642
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PDE3B 0.8222
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9248
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8199
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8125
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8199
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8222
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7612
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.7794
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4655
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7073
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4963
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2427
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3001
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2898
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2992
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3204
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3287
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3204
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3437
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3714
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3601
Platelet activation_Homo sapiens_hsa04611 SRC 0.4158
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3884
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4346
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3994
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4032
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4158
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4158
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4346
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4032
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4765
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4532
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4158
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4169
Axon guidance_Homo sapiens_hsa04360 MET 0.4114
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4598
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4786
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4765
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4704
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4765
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4765
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4704
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4704
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7916
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4765
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4704
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4765
Peroxisome_Homo sapiens_hsa04146 XDH 0.4786
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5124
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5237
Glioma_Homo sapiens_hsa05214 IGF1R 0.537
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.537
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5363
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5357
Bile secretion_Homo sapiens_hsa04976 CA2 0.5235
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5465
Shigellosis_Homo sapiens_hsa05131 SRC 0.537
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.668
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5393
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.2796
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9431
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.756
Malaria_Homo sapiens_hsa05144 MET 0.6214
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6267
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.624
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7786
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.794
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.794
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8136
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8111
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9281
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9948
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2702


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)