Prescription Description
| Prescription ID | TCMF6407 |
| Pinyin Name | Yu Ye Jie Du Ke Li |
| Chinese Name | 玉叶解毒颗粒 |
| English Name | Yu Ye Jie Du Granules |
| Function Description | 感冒, 热淋, 中暑 |
| Indications | Common cold disorder, Heat stranguria disorder, Common cold |
| Disease ICD-11 Category |
SA60 [Common cold disorder (TM1), 感冒 (TM1)
]; SA91 [Heat stranguria disorder (TM1), 热淋 (TM1) ]; CA00 [Acute nasopharyngitis, 急性鼻咽炎 ]; |
| Human Tissues Associated with Indication | Lung, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2548 | Mussaenda hirsutissim | 玉叶金花 | TCMH2548 | |
| TCMH1127 | Lonicera japonica | 金银花 | TCMH1127 | ITSAI3881-14 |
| TCMH1181 | Chrysanthemum morifolium | 菊花 | TCMH1181 | KX675020 |
| TCMH2452 | Chrysanthemum indicum | 野菊花 | TCMH2452 | ITSAB1463-14 |
| TCMH667 | Radix ilicis asprellae | 岗梅 | TCMH667 | |
| TCMH1859 | Helicteres angustifolia | 山芝麻 | TCMH1859 | GBVH4071-11 |
| TCMH1033 | Centella asiatica | 积雪草 | TCMH1033 | ITSAJ4523-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 107 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1208 | Escherichia coli K12 |
| TCMT1209 | Staphylococcus haemolyticus |
| TCMT1210 | Streptococcus sobrinus |
| TCMT1211 | Fusobacterium nucleatum |
Showing 1 to 10 of 57 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 3.58085 |
| [BP] GO:0000904 | cell morphogenesis involved in differentiation | AR, AXL, MET, SRC, TEK | 2.70993 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC | 2.23411 |
| [BP] GO:0001503 | ossification | ALPL, EGFR, MMP2, MMP9, TEK | 2.50621 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK, TERT | 3.51843 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, AR, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, SRC, TEK, XDH | 2.11719 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, SRC, TEK | 2.67206 |
| [BP] GO:0001954 | positive regulation of cell-matrix adhesion | CDK6, KDR, SMAD3, TEK | 2.81956 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AR, AXL, CYP19A1, EGFR, HSD17B2, INSR, PGR, SRC | 2.07032 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | AR, NR3C1, NR3C2, PGR, PPARA, RORC | 2.36465 |
Showing 1 to 10 of 369 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3785 |
| Adherens junction_Homo sapiens_hsa04520 | SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 6.9397 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5711 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, MMP2, PIM1 | 1.8248 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | INSR, NR3C2 | 1.6353 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3631 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | INSR, IGF1R | 0.9205 |
| Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5508 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5 | 1.3454 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.4407 |
Showing 1 to 10 of 138 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples