TCM Prescription: Xiao Ke Ping Tablets



Prescription Description
Prescription IDTCMF6180
Pinyin NameXiao Ke Ping Pian
Chinese Name消渴平片
English NameXiao Ke Ping Tablets
Function Description消渴
IndicationsWasting thirst disorder, Diabetes
Disease ICD-11 Category SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH2175 Galla chinensis 五倍子 TCMH2175
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 13.1309
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MAOB, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 10.7615
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 9.80951
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FUT7, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.59746
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 9.54092
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 9.23757
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 9.21788
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 8.94948
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 8.91604
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, NQO2, PTGS1, RORC 8.91604
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, MAOB, MMP2, MMP9, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 8.70087
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.69982
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 8.44043
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, NR3C1, PIK3CA, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 8.17774
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 8.01328
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 7.82357
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 7.63966
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP2, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.5465
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PIM1, PTGS1, PTGS2, SLC6A4, SRC, TERT, XDH 7.30615
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 7.20375
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, PTGS1, PTGS2 6.83183
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F3, FABP4, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 6.73043
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, MAOB, NR3C1, PTGS2, RORC, SLC6A4, SRC, TYR 6.71015
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, MAOB, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1, TYR 6.67332
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.64916
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.63559
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 6.63493
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 6.6185
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 6.49145
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, PPARA, PTGS2, SLC6A4, SRC, TRPV1 6.31172
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.30389
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 6.29257
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CES1, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 6.25638
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TERT, TRPV1 6.18147
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 6.07735
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 6.01145
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 5.99794
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.93451
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.92431
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6, CYP3A4 5.92431
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGS2, SRC, TERT 5.92431
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, FABP3, KCNH2, KDR, MAOB, NR3C1, POLB, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 5.90828
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 5.85884
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.75705
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.74162
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CDC25B, CES1, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, RORC, SLC6A4, SRC, TERT, TYR 5.72789
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CDC25B, CES1, CES2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, TYR, XDH 5.72397
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, HCAR2, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 5.68541
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, FLT3, KCNH2, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC, TERT, TRPV1 5.56253
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.4926
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 5.48922
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 5.09667
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.06251
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.97455
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.90756
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.90756
[BP] GO:0007200 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, ESR1 4.85768
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT 4.85099
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, MAOB, TYR 4.68818
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 4.67159
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.64478
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 4.62595
[BP] GO:0015872 None CHRM5, DRD1, SLC6A2, SLC6A4 4.57838
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.48991
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, SRC, TYR 4.48036
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.45809
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT 4.4445
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KCNH2, KDR, NR3C1, PTGS2, SRC, TRPV1 4.4131
[BP] GO:0003018 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4, SRC 4.38159
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 4.37039
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SRC, TYR 4.35804
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 4.35007
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 4.33
[BP] GO:0006940 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PTGS2 4.33
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 4.32766
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, F3, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.32766
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SLC6A4, SRC, TRPV1 4.31088
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 4.28374
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, POLA1, SRC, TYR 4.27585
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.27582
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 4.23051
[BP] GO:0051937 None CHRM5, DRD1, SLC6A2, SLC6A4 4.23021
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.20137
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.20137
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 4.1885
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, CHRM1, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 4.17242
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 4.17242
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.13247
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.13247
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, MET, PIK3CA, TRPV1 4.09695
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, HCAR2, KCNH2, MAOB, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.02714
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, DRD1, KDR, MAOB, POLB, SLC6A4, SRC 4.02342
[BP] GO:0007193 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.99807
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KCNH2, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.97142
[BP] GO:0097746 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4 3.97142
[BP] GO:0035296 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4 3.97142
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 3.95115
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 3.93769
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KCNH2, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIM1, PTGS2, SLC6A4, SRC, TERT, TRPV1, XDH 3.93115
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.9133
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.86719
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.86719
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 3.83781
[BP] GO:0050880 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4 3.82044
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.8081
[BP] GO:0035150 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4 3.80458
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CHRM1, CYP19A1, DRD1, HCAR2, KCNH2, MMP12, PTGS2, SLC6A4, SRC, TERT, TRPV1 3.79335
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.78462
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, MAOB 3.77042
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 3.7692
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.74962
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC, TERT 3.74962
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DRD1, ESRRB, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.74096
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, DRD1, ESRRB, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.74096
[BP] GO:0015844 None CHRM5, DRD1, SLC6A2, SLC6A4 3.7211
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.7211
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.71112
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.67255
[BP] GO:0003013 None ADORA1, ADRA2A, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4, SRC 3.65436
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.57124
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.57124
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.57124
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, KCNH2, PDE5A, PTGS2 3.57124
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.54512
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.54512
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TERT, XDH 3.52439
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, POLB, PPARA, PTGS2, SLC6A4, SRC, TERT 3.51138
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51138
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.51138
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.47951
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CHRM5, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.43043
[BP] GO:0007188 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1 3.42013
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, CHRM5, DRD1, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.38288
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.37095
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.35991
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC, TERT 3.3522
[BP] GO:0006937 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 3.34698
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.33656
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, TYR 3.33656
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.3352
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, KCNH2, MET, PIK3CA, PIK3CB, TRPV1 3.30628
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTPN1, RORC, SRC, TRPV1 3.30628
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.28404
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGS2, TERT 3.23993
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DRD1, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 3.22761
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 3.22761
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, PTGS2, SLC6A4 3.19265
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.16299
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2C19, CYP2D6, CYP3A4, MAOB 3.15462
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, CHRM1, CHRM2, CHRM3, HCAR2, KCNH2, PDE5A, PTGS2, TRPV1 3.14723
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CHRM3, CYP1B1, ESRRB, F3, HCAR2, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, SRC, TERT, TRPV1 3.12065
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.09825
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, MAOB, PTGS2, SLC6A2, SLC6A4, TRPV1 3.06184
[BP] GO:0007187 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5, DRD1 3.04109
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, MMP2, POLB, PPARA, PTGS2, SLC6A4, SRC, TERT, TRPV1, TYR 3.03397
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, TRPV1 3.03344
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 3.02565
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 3.02545
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 3.00518
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.98117
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SLC6A4, SRC, TERT 2.93985
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.90672
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 2.90394
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.88025
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.88025
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.88025
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.88025
[BP] GO:0009115 None AOX1, XDH 2.82325
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.82325
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.82325
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.82325
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, DRD1, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SLC6A4, SRC, TRPV1 2.82325
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.79846
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.7971
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.79472
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.78497
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 2.77672
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KCNH2, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 2.76441
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC, TRPV1 2.75167
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.73351
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, KCNH2, MAOB, MMP9, PTGS2 2.7171
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC, XDH 2.7171
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71201
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.67875
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, DRD1, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.65488
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, FABP3, FABP4, MAOB, PDE5A, PIK3CB, SRC, XDH 2.62396
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.6088
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, CA2, CA7, CHRM1, DRD1, KCNH2, MAOB, MMP9, PTGS2, SLC6A4 2.60415
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, MET, PIK3CA, PIK3CB, SRC 2.55926
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, HCAR2, PIK3CB, PTGS2 2.55534
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.55534
[BP] GO:0032225 None DRD1, PTGS2, SLC6A4 2.55534
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.55182
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, KDR, PDE5A, PIK3CB, PTPN1, SRC, XDH 2.53829
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.53809
[BP] GO:0090257 None ADORA1, ADRA2A, CHRM1, CHRM2, CHRM3, PDE5A, PTGS2 2.53809
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KCNH2, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, SRC, XDH 2.5128
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.48936
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, DRD1, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SRC, TERT, XDH 2.47474
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.45989
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.43303
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.43303
[BP] GO:0046110 None AOX1, XDH 2.43303
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.43303
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.43303
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.39237
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, CYP1A1, CYP1A2, CYP1B1, MAOB 2.37384
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.37316
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TERT, XDH 2.36089
[BP] GO:0015696 None CHRM5, DRD1, SLC6A2, SLC6A4 2.34348
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.34321
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2 2.33547
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TERT, TRPV1, XDH 2.33526
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, PDE5A, PIK3CB, PTPN1, SRC 2.32828
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.31542
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.30927
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PTGS2, TERT 2.28125
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.27802
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.27764
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.25019
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, NR3C1, SRC 2.24774
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.24741
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.24064
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, PDE5A, PIK3CB, PTPN1, SRC 2.20452
[BP] GO:0003012 None ADORA1, CHRM3, DRD1, KCNH2, PDE5A, PIK3CA, TRPV1 2.20452
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, MAOB 2.20452
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.20351
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.20351
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.20351
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.19938
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, AOX1, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, SRC, TYR, XDH 2.1958
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.1958
[BP] GO:0006145 None AOX1, XDH 2.1958
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.1958
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1958
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.19149
[BP] GO:0019229 None ADRA2A, CHRM1, CHRM3, PTGS2 2.18722
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, CHRM1, CHRM3, CHRM5, CYP1B1, DRD1, KCNH2, PDE5A, PIK3CA, PTGS2, SLC6A4, SRC, TRPV1, TYR 2.18034
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.1787
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16732
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.1432
[BP] GO:0090066 None ADORA1, ADRA2A, ALOX15, CHRM1, CHRM3, DRD1, PTGS2, SLC6A4 2.13803
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, MAOB, PDE5A, XDH 2.13803
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, PTGS2 2.09556
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, IGF1R, KDR, PDE5A, PIK3CB, PTPN1, SRC, XDH 2.08579
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ALOX15, AURKB, CA9, CDC25B, CHRM5, CSNK2A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.07995
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.07071
[BP] GO:0022600 None ADRA2A, CHRM1, CHRM3, CHRM5 2.07071
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.07071
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.06983
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, PTGS2, SLC6A4 2.05458
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.05431
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SLC6A4, SRC, TRPV1 2.05105
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.04329
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.03016
[BP] GO:0006693 None CES2, PTGS1, PTGS2 2.03016
[BP] GO:0006692 None CES2, PTGS1, PTGS2 2.03016
[BP] GO:0046541 None CHRM1, CHRM3 2.0177
[BP] GO:0010641 None F3, SRC 2.0177
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.0177
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.0177
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.0176
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2, TERT 2.00992
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, ESR1, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 3.34343
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 3.16429
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, IGF1R, KDR, MET, SLC6A2, SLC6A4, TRPV1 2.84523
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, HCAR2, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 2.75167
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CDC25B, CES1, CES2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MAOB, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTGS1, PTGS2, PTPN1, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.60415
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, MET, PTGS2, SRC, TRPV1 2.59731
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 2.46422
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, IGF1R, KCNH2, KDR, MET, PTGS2, SLC6A2, SLC6A4, SRC, TRPV1 2.22762
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, CHRM3 2.1787
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, FLT3, IGF1R, KDR, MET, SLC6A2, SLC6A4, TRPV1 2.12195
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 16.5455
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 13.0691
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, SRC, TERT, TYR, XDH 13.0691
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TYR, XDH 9.78328
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.68506
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 9.59746
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, XDH 8.70087
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE5A, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 8.12041
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, HSD17B1, MAOB, NQO2, POLA1, PTGS1, PTGS2, SRC, XDH 7.30615
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.20375
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 6.89344
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A4, SRC, TRPV1 6.83227
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC 6.73043
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.72047
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 6.71015
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4 6.6185
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR 6.55792
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.54835
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.49145
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.30389
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.14354
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.08655
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.92431
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.89422
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, TYR 5.8817
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.67322
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, RORC, TRPV1 5.13634
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97455
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.97455
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.83195
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6, CYP3A4 4.33
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 4.31088
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.9406
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.93769
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NQO2, NR3C1 3.77042
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, XDH 3.75757
[MF] GO:0008227 None ADRA2A, CHRM1, CHRM2, CHRM3, CHRM5 3.39265
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.38124
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 3.3352
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MAOB, MET, MMP9, NQO2, PTGS2, SLC6A4, TERT, TRPV1, TYR, XDH 3.31188
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.24962
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.23242
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.17134
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.10658
[MF] GO:0016788 None ACHE, ADORA1, CA1, CA2, CDC25B, CES1, CES2, CHRM1, CHRM3, CHRM5, PDE5A, POLA1, PTPN1 3.05086
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TERT 3.00347
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.98793
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.88551
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.84933
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.82325
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.82325
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.82325
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.82325
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.82325
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.6047
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 2.60002
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 2.60002
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.58958
[MF] GO:0008081 None ADORA1, CHRM1, CHRM3, CHRM5, PDE5A 2.5681
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.43303
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.43303
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.43303
[MF] GO:0005330 None SLC6A2, SLC6A4 2.43303
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.43303
[MF] GO:0047374 None CES1, CES2 2.43303
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIM1, SRC 2.37505
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.33321
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.30557
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP12, NQO2, NR3C1, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 2.30456
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, FLT3, KCNH2, MAOB, NQO2, PTGS2, SLC6A4, TERT, TYR, XDH 2.29485
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1 2.2619
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.21343
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, KCNH2, MET, NR3C1, POLA1, POLB, PPARA, PTGS2, PTPN1, SLC6A4, SRC 2.1958
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1958
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.1958
[MF] GO:0032795 None ADORA1, ADRA2A 2.1958
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.1958
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 2.12706
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.04411
[MF] GO:0016298 None ADORA1, CES1, CHRM1, CHRM3, CHRM5 2.0177
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0177
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0177


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.8969
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5382
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.5308
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP2C19, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 7.5643
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1, SLC6A4 7.731
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.7637
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.764
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.761
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, TRPV1, DRD1, NR3C1, ADRA2A 5.761
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4, CYP2C19 6.1118
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, PIK3CB 5.5005
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, CYP2C19, PTGS1 5.6908
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP2D6, CYP1A2, AOX1, CYP3A4, CYP2C19 5.4827
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, PIK3CB, DRD1, PPARA 5.0052
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3678
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.324
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.4495
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 3.8213
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.1407
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB 3.8642
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1044
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB, F3 3.5686
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 3.6077
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PDE5A, PIK3CB, ADRA2A 3.5686
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.1695
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 3.1553
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8642
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.1339
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4006
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.8492
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1695
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3942
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.7038
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1919
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1339
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1 2.5879
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.6461
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1553
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.9905
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4889
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4936
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.2082
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3604
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3952
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3952
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.3777
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.1273
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1627
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 2.0198
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0198
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8567
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.6949
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.1844
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1949
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 1.87
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8901
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8184
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1739
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 1.8965
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.7296
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.5948
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5432
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.486
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4378
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, TERT, PIK3CB 1.4378
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.486
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.4722
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.453
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3862
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2018
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 1.268
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.143
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2883
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2971
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3656
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.222
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3656
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9234
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4025
Axon guidance_Homo sapiens_hsa04360 MET 0.3973
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4025
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.8633
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1 0.7245
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8788
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8649
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7366
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8877
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4655
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4655
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4546
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.9431
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1 0.9007
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8502
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.8374
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4655
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4789
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0291
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1085
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1002
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0391
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0534
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0569
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4955
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0391
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4966
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1085
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4966
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0682
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4966
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5074
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0799
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5016
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4966
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1002
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.1259
Peroxisome_Homo sapiens_hsa04146 XDH 0.5074
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1, TYR 2.8536
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5196
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2552
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.2552
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2882
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5461
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5588
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.2972
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.249
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.2902
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.268
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3589
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.268
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2882
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5839
Shigellosis_Homo sapiens_hsa05131 SRC 0.5839
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.3427
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5839
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.399
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.605
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4431
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3672
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1 1.4748
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.486
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5211
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.6214
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6731
Malaria_Homo sapiens_hsa05144 MET 0.6778
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6876
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6826
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8094
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7421
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7615
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6821
DNA replication_Homo sapiens_hsa03030 POLA1 0.7812
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8351
Base excision repair_Homo sapiens_hsa03410 POLB 0.813
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9931
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8502
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8788
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8416
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8668
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9007
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.0291
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1553
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3553


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)