TCM Prescription: Xiao Granulesng Tablets



Prescription Description
Prescription IDTCMF6173
Pinyin NameXiao Ke Ling Pian
Chinese Name消渴灵片
English NameXiao Granulesng Tablets
Function Description消渴
IndicationsWasting thirst disorder, Diabetes
Disease ICD-11 Category SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA, TRPV1 8.33112
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.12374
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, KDR, MET, PPARA, SRC, TRPV1, XDH 6.97353
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.32947
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.08007
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, PIM1, PPARA, XDH 5.99933
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.99933
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.86745
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.86745
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.62428
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.61444
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 5.60367
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.5994
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 5.42462
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TRPV1 5.13598
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 4.96101
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1 4.93141
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PPARA 4.9114
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TRPV1, XDH 4.75039
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.73568
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1 4.73179
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PPARA, SRC, TRPV1 4.44338
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.34588
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, F3, FABP4, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1 4.33076
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.31718
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, IGF1R, MMP2, MMP9, NR3C1, PPARA, SRC, TRPV1 4.25084
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.23711
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.22232
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, SRC, TRPV1 4.11098
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 4.02067
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 3.99136
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.91033
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 3.89114
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 3.88439
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.85342
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CDC25B, CHRM1, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 3.85342
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.84713
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.84713
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, CHRM1, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.84713
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 3.84197
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, XDH 3.83816
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, SRC, TRPV1 3.81269
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.77159
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.73472
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.71559
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, MET, TRPV1 3.68373
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, SRC, TRPV1 3.67402
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD11B1, HSD17B1 3.6661
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.6661
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, SRC, TRPV1 3.64443
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.63973
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, SRC, TRPV1 3.57201
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.55656
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.50566
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC, TRPV1 3.50552
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1 3.50192
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.46281
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, FUT7, HSD11B1, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC 3.42106
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1 3.42106
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 3.38538
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.37851
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31327
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, SRC, TRPV1 3.30427
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FLT3, NR3C1, SRC, TRPV1 3.25564
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, FABP3, KDR, NR3C1, SRC, TRPV1 3.20576
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 3.20576
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 3.16891
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 3.15598
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1 3.15304
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PTPN1, SRC, XDH 3.15253
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1 3.15253
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, HCAR2, KDR, SRC, TRPV1 3.11849
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.0393
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, SRC 3.0393
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PTPN1, SRC, TRPV1 2.99173
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F3, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.98012
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.96994
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.96994
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 2.90649
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, CYP1B1, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 2.90649
[BP] GO:0008283 cell proliferation ACHE, AURKB, CHRM1, CHRM3, CHRM5, CYP1A1, FLT3, MET, PIM1, SRC 2.90649
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.90649
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.90649
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.90649
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, FLT3, HSD11B1, KDR, MMP9, PIM1, PPARA, SRC 2.86523
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, DRD1, FABP3, FABP4, FLT3, MET, SRC, TRPV1 2.86523
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1 2.83706
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.82645
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.81361
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, F3, MET, XDH 2.81361
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.81361
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.80685
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.80685
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.78702
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.76489
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, SRC, TRPV1 2.70158
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CHRM1, CYP19A1, DRD1, HCAR2, MMP12, MMP9, PPARA, PTPN1, SRC, TRPV1 2.65474
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 2.6512
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 2.64284
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, NR3C1, SRC 2.61184
[BP] GO:0030335 positive regulation of cell migration ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.54228
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.53596
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.52702
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52702
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.49269
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, IGF1R, MMP2, MMP9, NR3C1, SRC, TRPV1 2.4744
[BP] GO:2000147 positive regulation of cell motility ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.45826
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F3, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 2.45744
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1 2.45744
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.44721
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.44721
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.4338
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, CDC25B, CHRM5, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.42334
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.40048
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.39906
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, CA2, CHRM3, CYP1B1, F3, HCAR2, KDR, MET, MMP12, MMP9, PIM1, SRC, TRPV1 2.39661
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, CDC25B, CHRM5, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.39574
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, F3, FABP4, KDR, MET, MMP12, PPARA 2.36818
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.36167
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.36167
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36167
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, DRD1, HCAR2, MMP12, SRC, TRPV1 2.3497
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, DRD1, FLT3, NR3C1, SRC, TRPV1 2.34272
[BP] GO:0040017 positive regulation of locomotion ALOX12, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.31808
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.31579
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.3068
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.3068
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.3068
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.3068
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.28909
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.28694
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 2.28021
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, KDR, PPARA, SRC 2.2557
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, DRD1, SRC 2.20975
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.19973
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.17029
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SRC, TRPV1 2.16478
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.16384
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1 2.13701
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4 2.13701
[BP] GO:0046541 None CHRM1, CHRM3 2.13701
[BP] GO:0010641 None F3, SRC 2.13701
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.13701
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.13701
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, F3, HCAR2, KDR, MET, MMP12, MMP9, PIM1, SRC, TRPV1, XDH 2.13625
[BP] GO:0001659 None ADORA1, DRD1, TRPV1 2.10889
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.10889
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.08789
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.07412
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CYP19A1, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.07412
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, KDR, SRC 2.06215
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 2.0471
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.0427
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.02104
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, CDC25B, CSNK2A1, DRD1, F3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, SRC, TRPV1, XDH 2.01614
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, CYP19A1, DRD1, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.01461
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.00441
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.00441
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TRPV1 3.68373
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, IGF1R, KDR, MET, TRPV1 3.12385
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, MET, SRC, TRPV1 2.90236
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FLT3, FUT7, HCAR2, HSD11B1, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TRPV1 2.54228
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, IGF1R, KDR, MET, SRC, TRPV1 2.44721
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, FLT3, IGF1R, KDR, MET, TRPV1 2.20975
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00441
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, XDH 11.0062
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3964
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F3, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, XDH 9.62667
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 7.3923
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.53431
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.32947
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.18387
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 5.98577
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.86745
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.49161
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.23929
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, XDH 4.61904
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 4.57652
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, TRPV1, XDH 4.46276
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.22232
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1 4.20694
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.20694
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.97
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.84713
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.77159
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.77159
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.76233
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.71204
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, TRPV1 3.56395
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.53367
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.51485
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.43299
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.38941
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.31327
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, TRPV1, XDH 3.19625
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 3.18566
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 3.18385
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.99339
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.90649
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.86563
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.8609
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 2.81361
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1 2.79057
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.62502
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.52702
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.52702
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.52702
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD11B1, HSD17B1, XDH 2.40488
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, SRC, XDH 2.34272
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.33941
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.3068
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.3068
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.28909
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.25812
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.25275
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.25275
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.20975
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.13701
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.10889
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.07412
[MF] GO:0017171 serine hydrolase activity ACHE, F3, MMP1, MMP12, MMP2, MMP9 2.01461
[MF] GO:0008081 None ADORA1, CHRM1, CHRM3, CHRM5 2.01461
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.01351
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00441


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.9918
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.1382
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.9378
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, TRPV1, DRD1, NR3C1 6.0549
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.6153
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.6153
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5 3.9458
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, XDH 3.9458
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4599
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2857
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.914
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, DRD1, PPARA 3.9255
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1 3.1636
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.588
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.8633
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.5126
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.302
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0027
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, MET, IGF1R 2.1058
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.5075
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.3418
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2366
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4684
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.1058
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0798
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.0798
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 2.0698
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.0798
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.8465
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12 1.9714
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.3088
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5462
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5429
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5086
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4414
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1866
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.4094
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4339
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2853
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4396
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5253
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2422
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.4377
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.2853
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.1731
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.2952
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3755
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4339
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9743
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.2506
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1124
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.118
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.005
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8935
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6998
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.5479
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5479
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3181
Platelet activation_Homo sapiens_hsa04611 SRC 0.4839
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5009
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5479
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.484
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3856
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4839
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.5479
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.521
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5236
Purine metabolism_Homo sapiens_hsa00230 XDH 0.415
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4728
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4839
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1193
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3845
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4728
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5479
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.484
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4756
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4467
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4077
Tuberculosis_Homo sapiens_hsa05152 SRC 0.415
Alcoholism_Homo sapiens_hsa05034 DRD1 0.415
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4548
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5479
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5753
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4728
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5421
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4839
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4756
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4728
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.4782
Axon guidance_Homo sapiens_hsa04360 MET 0.4795
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5919
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4728
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4467
Peroxisome_Homo sapiens_hsa04146 XDH 0.5479
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5479
Glioma_Homo sapiens_hsa05214 IGF1R 0.5919
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4077
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.5479
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5479
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5479
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5421
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5421
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5984
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5805
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5919
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5919
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5919
Shigellosis_Homo sapiens_hsa05131 SRC 0.5919
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8834
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9714
Malaria_Homo sapiens_hsa05144 MET 0.6739
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.6739
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8496
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.902
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8935
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3056


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)