TCM Prescription: Li Nao Tablet



Prescription Description
Prescription IDTCMF605
Pinyin NameLi Nao Pian 
Chinese Name利鼻片
English NameLi Nao Tablet
Function Description鼻渊
IndicationsNasal sinusitis disorder, Chronic sinusitis
Disease ICD-11 Category SC91 [Nasal sinusitis disorder (TM1), 鼻渊 (TM1) ];
CA0A [Chronic rhinosinusitis, 慢性鼻窦炎 ];
Human Tissues Associated with IndicationLung, Nose
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH206 Fructus xanthii sibirici 苍耳子 TCMH206 KJ496390
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH2316 Magnolia liliflora 辛夷 TCMH2316 GBVT919-13, GBVT884-13
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1632 Taraxacum mongolicum 蒲公英 TCMH1632 ITSAG679-14
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC, TERT 8.47859
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, HSD17B1, MET, PPARA 7.30662
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, PIM1, PPARA, PTAFR, XDH 7.28922
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.23777
[BP] GO:0010647 positive regulation of cell communication ADRB1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 6.91289
[BP] GO:0023056 positive regulation of signaling ADRB1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 6.91289
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B1, KDR, MET, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 6.91289
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.12431
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARA, PTAFR, SRC, TERT 6.03163
[BP] GO:0032502 developmental process ACHE, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS2, TOP2A 6.01663
[BP] GO:0008152 metabolic process ACHE, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.7921
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, PPARA, PTAFR, SRC 5.64172
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.64172
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.64172
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, MET, PPARA 5.64172
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.64172
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, FABP3, FLT3, IGF1R, MMP2, PPARA, PTAFR, SRC 5.5404
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, SRC, TERT 5.47793
[BP] GO:0009967 positive regulation of signal transduction ADRB1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, MMP12, MMP9, SRC, TERT, TNKS, TNKS2, XDH 5.35552
[BP] GO:0051270 regulation of cellular component movement ADORA3, APEX1, APP, CACNA1C, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 5.22697
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, PTAFR 5.15292
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 5.0935
[BP] GO:0048584 positive regulation of response to stimulus ADRB1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 5.0935
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APEX1, APP, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, SRC, TERT 5.0308
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.00989
[BP] GO:0010646 regulation of cell communication ACHE, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.98354
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, APP, CSNK2A1, CYP1B1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, SRC, TERT, XDH 4.93736
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, IGF1R, MMP2, MMP9, PPARA, PTAFR, SRC 4.93736
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TERT, TOP2A, XDH 4.93736
[BP] GO:0023051 regulation of signaling ACHE, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.92625
[BP] GO:2000145 regulation of cell motility ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 4.90412
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.7729
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.72888
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT, TOP2A, XDH 4.70863
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 4.60568
[BP] GO:0040012 regulation of locomotion ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, ERBB2, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 4.55245
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APEX1, APP, AXL, CYP1A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, PTAFR, SRC 4.5215
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, SRC, TERT, TOP2A 4.49715
[BP] GO:0030334 regulation of cell migration ADORA3, APEX1, APP, CYP19A1, CYP1B1, EGFR, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 4.41055
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, PPARA, PTAFR, SRC 4.25547
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 4.24853
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TERT 4.24853
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, TERT 4.20351
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.1144
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GLO1, IGF1R, KDR, MMP9, PIM1, SRC, TERT, TOP2A, XDH 4.09868
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.08241
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1 4.05947
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 3.9907
[BP] GO:0042592 homeostatic process ADRB1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, CACNA1C, EGFR, FABP3, FABP4, FLT3, MET, SRC, TERT 3.96494
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, KDR, PPARA, PTPRS, SRC 3.96012
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 3.96012
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.9451
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPRS, SRC, TNKS, XDH 3.9451
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MET, MMP9, PIM1, SRC, TERT 3.94344
[BP] GO:0014070 response to organic cyclic compound APEX1, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTAFR, SRC 3.92544
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.91735
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, PTAFR, SRC 3.88965
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TERT 3.88965
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, ERBB2, PPARA 3.85233
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.85233
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, FABP3, FABP4, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 3.74853
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APEX1, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPRS, SRC, TNKS, XDH 3.71674
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 3.71674
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTAFR, SRC 3.67477
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.66411
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.66411
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.53719
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR, TERT 3.52963
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT 3.52441
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRB1, AKR1B1, ALOX15, APP, AXL, CYP1B1, EGFR, ERBB2, FLT3, KDR, MET, SRC, XDH 3.48573
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.42056
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, EGFR, GLO1, IGF1R, KDR, MMP9, PIM1, SRC, TERT 3.29692
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29692
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTAFR, SRC, TERT, TOP2A 3.26481
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.25723
[BP] GO:0032501 multicellular organismal process ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AXL, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, FABP4, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TNKS2 3.23845
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, PTAFR, SRC 3.21748
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.21748
[BP] GO:0006950 response to stress ACHE, ADORA3, ADRB1, AKR1B1, ALOX15, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, MMP2, MMP9, PPARA, PTAFR, SRC, TERT, TOP2A 3.21748
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, FABP3, IGF1R, KDR, MET, MMP12, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A 3.21748
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC, TNKS, TOP2A 3.21748
[BP] GO:1902531 regulation of intracellular signal transduction ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP9, SRC, XDH 3.19284
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.16585
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.15248
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, MMP9, SRC 3.15156
[BP] GO:0051098 regulation of binding APP, AURKB, MET, MMP9, PPARA, SRC, TERT, TNKS 3.15156
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 3.15156
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.13871
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, CA2, CA7, CACNA1C, CYP19A1, EGFR, ERBB2, MMP12, MMP9, PPARA, PTAFR, SRC, TERT 3.09696
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.09696
[BP] GO:0071407 cellular response to organic cyclic compound APEX1, APP, CYP1A1, CYP1B1, EGFR, FLT3, PTAFR, SRC 3.09696
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CYP1B1, EGFR, IGF1R, MMP2, MMP9, PTAFR, SRC 3.08976
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, CACNA1C, EGFR, KDR, SRC, TNKS, TNKS2 3.07702
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTAFR, SRC 3.05906
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA 3.05504
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.99334
[BP] GO:0009966 regulation of signal transduction ADRB1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.97826
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.92731
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 2.89431
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, CA2, CYP19A1, EGFR, ERBB2, MMP12, PTAFR, SRC, TERT 2.88729
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, APP, AXL, CBR1, CYP1A1, EGFR, ERBB2, FABP4, FLT3, FUT7, GLO1, KDR, MET, MMP2, MMP9, PTPRS, SRC, TERT, TOP2A 2.8856
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.87903
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.85943
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.85904
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, EGFR, ERBB2, FLT3, MET, PIM1, SRC 2.85904
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.852
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC, TNKS 2.80773
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, EGFR, FABP3, FLT3, IGF1R, MMP2, PPARA, PTAFR, SRC 2.80773
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.80773
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, MMP2, PTAFR, SRC 2.80472
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRB1, ALOX15, APP, AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.80472
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.79979
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.79979
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.78715
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.78715
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.78368
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, FABP3, IGF1R, MET, MMP12, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A 2.78233
[BP] GO:0009628 response to abiotic stimulus ADRB1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, MMP2, PPARA, PTAFR, SRC, TERT 2.77098
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, MET 2.75991
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, EGFR, ERBB2, FLT3, IGF1R, MMP2, PTAFR, SRC 2.74581
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.74357
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.7388
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, PTAFR 2.69792
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.65171
[BP] GO:0009893 positive regulation of metabolic process ADRB1, ALOX15, APP, AURKB, CSNK2A1, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.62948
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, IGF1R, MMP2, PTAFR, SRC 2.607
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.607
[BP] GO:0031325 positive regulation of cellular metabolic process ADRB1, ALOX15, APP, AURKB, EGFR, ERBB2, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.607
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.607
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.60071
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.58085
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.55449
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, IGF1R, KDR, MET, MMP12, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A 2.54512
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC, XDH 2.54512
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54512
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.54512
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.53935
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, SRC, TNKS, TNKS2 2.53029
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CYP19A1, EGFR, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPRS, SRC, TERT, XDH 2.53025
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, KDR, MMP2, PTAFR, SRC 2.51352
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51352
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, ADRB1, APP, AXL, CA2, CACNA1C, CYP1B1, EGFR, ERBB2, KDR, MET, MMP12, MMP9, PIM1, PTAFR, PTPRS, SRC, TERT, TNKS2, XDH 2.47977
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.4746
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.46089
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.45293
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRB1, ALOX15, APP, EGFR, ERBB2, FABP3, FLT3, KDR, MMP9, PTAFR, SRC, XDH 2.45232
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRB1, ALOX15, APP, EGFR, ERBB2, FABP3, FLT3, KDR, MMP9, PTAFR, SRC, XDH 2.45232
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, SRC, TNKS, TNKS2 2.4228
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, TNKS, TNKS2 2.41835
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41835
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.40349
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.38501
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.38249
[BP] GO:0019220 regulation of phosphate metabolic process ADRB1, ALOX15, APP, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, SRC, XDH 2.38249
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.38249
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.38249
[BP] GO:1901992 positive regulation of mitotic cell cycle phase transition APEX1, APP, CYP1A1, TERT 2.36625
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, CA2, CYP1B1, EGFR, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SRC, TERT 2.35935
[BP] GO:0051174 regulation of phosphorus metabolic process ADRB1, ALOX15, APP, EGFR, ERBB2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, SRC, XDH 2.3547
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.3547
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, PPARA, SRC 2.3547
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, APP, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, KDR, MMP9, PIM1, PPARA, PTPRS, SRC 2.33802
[BP] GO:0070213 None TNKS, TNKS2 2.33466
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33466
[BP] GO:1901529 None ABCB1, PTAFR 2.33466
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33466
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.32095
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.30871
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.26274
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.26274
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.26274
[BP] GO:0051179 None ABCB1, ACHE, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, FABP3, MMP12, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, XDH 2.24829
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, MET, SRC 2.24668
[BP] GO:0042060 None ALOX15, EGFR, ERBB2, PPARA 2.24668
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, EGFR, ERBB2, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TNKS, TNKS2, TOP2A, XDH 2.23325
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.22879
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CYP1A1, EGFR, SRC, TERT 2.22745
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, CYP1A1, EGFR, PIM1, TERT, TNKS, TOP2A 2.21897
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1 2.21825
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.21521
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, EGFR, ERBB2, FLT3, KDR, SRC, XDH 2.21033
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.17666
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.1639
[BP] GO:0044070 regulation of anion transport ABCB1, CA2, CA7, PTAFR 2.15977
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.15536
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PTAFR, SRC 2.14153
[BP] GO:1901989 None APEX1, APP, CYP1A1, TERT 2.12475
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR 2.12475
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, IGF1R, KDR, MET, MMP1, MMP9, PTPRS, SRC, TNKS, TNKS2, TOP2A 2.12332
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.1217
[BP] GO:0030177 positive regulation of Wnt signaling pathway CSNK2A1, SRC, TERT, TNKS, TNKS2 2.11429
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.10255
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.10202
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA 2.10193
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, ERBB2, KDR, SRC 2.07303
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, SRC 2.05185
[BP] GO:0032212 positive regulation of telomere maintenance via telomerase AURKB, TNKS, TNKS2 2.02055
[BP] GO:1903961 None ABCB1, PTAFR 2.0174
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.0174
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ADRB1, ALOX15, APEX1, APP, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTAFR, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.00855
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, PPARA, SRC, TOP2A 2.00582
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ADRB1, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, FLT3, GLO1, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPRS, SRC, TERT 2.97228
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ADRB1, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PTAFR, PTPRS, SRC 2.38249
[CC] GO:0044444 cytoplasmic part ACHE, ADRB1, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, KDR, MMP2, MMP9, PIM1, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, XDH 2.34691
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, ERBB2, SRC, TNKS2 2.26492
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ADRB1, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, FUT7, GLO1, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2 2.04984
[CC] GO:0043226 organelle ABCB1, ACHE, ADRB1, AKR1B1, AKR1B10, ALOX15, APEX1, APP, AURKB, AXL, CA1, CA2, CA4, CA9, CACNA1C, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, FUT7, GLO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 2.00855
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 12.2645
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, FUT7, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPRS, SRC, TERT, TNKS, TNKS2, TOP2A, TUBB3, XDH 10.9352
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.5098
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TNKS, XDH 10.251
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.23777
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.68332
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.33727
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.7921
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.73683
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TERT, TNKS, TNKS2, TOP2A, XDH 4.93736
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.85479
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.65158
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, TERT, TNKS, TNKS2, TOP2A, XDH 4.57092
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, TNKS 4.20351
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.08241
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.91861
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 3.91861
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73751
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, PTAFR, PTPRS, SRC, TOP2A, TUBB3, XDH 3.73751
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.57474
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.43691
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.94926
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.93786
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC 2.80773
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TERT 2.74538
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.68271
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.51113
[MF] GO:0097367 carbohydrate derivative binding ABCB1, APP, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPRS, SRC, TOP2A, TUBB3 2.41835
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.41187
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.38625
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.37192
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, SRC 2.32795
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R 2.11429
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.10591
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, TOP2A, TUBB3, XDH 2.10531
[MF] GO:0004064 arylesterase activity CA1, CA2 2.0174
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TOP2A 2.00855


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.8639
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.1844
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.8199
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, EGFR, IGF1R 5.8633
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 5.8989
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.0396
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, ERBB2, MMP9, MET, EGFR, IGF1R 3.8153
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, ERBB2, PIM1, CYP1B1, MMP9, MET, EGFR 3.7203
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, MET, EGFR, IGF1R 3.6863
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.4257
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 3.24
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.3576
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4166
Calcium signaling pathway_Homo sapiens_hsa04020 PTAFR, ERBB2, ADRB1, CACNA1C, EGFR 3.1087
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 3.1337
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, ADRB1, EGFR 3.1641
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR 3.0399
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2261
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.8735
Metabolic pathways_Homo sapiens_hsa01100 CBR1, FUT7, AKR1B10, ALOX5, HSD17B1, ALOX15, CYP1A2, CYP1A1, AKR1B1, CYP19A1, XDH 2.776
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, CACNA1C 2.8768
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9825
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.359
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.4965
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3966
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2092
Prostate cancer_Homo sapiens_hsa05215 ERBB2, EGFR, IGF1R 2.1341
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.1357
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.942
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, EGFR, IGF1R 1.9702
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.7397
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.5494
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADRB1, CACNA1C 1.5181
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, EGFR, IGF1R 1.4624
cAMP signaling pathway_Homo sapiens_hsa04024 ADRB1, CACNA1C, PPARA 1.4064
Non-small cell lung cancer_Homo sapiens_hsa05223 ERBB2, EGFR 1.5181
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5494
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADRB1 1.5181
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.161
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, PTAFR, ADRB1 1.082
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CACNA1C 1.0933
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4782
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.515
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4624
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9226
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.9809
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.246
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.2562
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9809
Pancreatic cancer_Homo sapiens_hsa05212 ERBB2, EGFR 1.4585
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4962
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRB1, CACNA1C 0.919
Renin secretion_Homo sapiens_hsa04924 ADRB1, CACNA1C 1.4624
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0599
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9535
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3463
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.8489
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6953
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4624
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4068
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR 0.6114
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3086
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3802
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3786
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4135
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4032
Tuberculosis_Homo sapiens_hsa05152 SRC 0.413
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.945
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4027
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4477
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4569
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4721
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5184
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4807
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4535
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4721
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5184
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.4706
Platelet activation_Homo sapiens_hsa04611 SRC 0.5038
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5429
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.5089
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3 0.5049
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5429
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5049
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5549
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5429
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5429
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5429
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5549
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5038
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5038
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5458
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5429
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5429
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5049
Axon guidance_Homo sapiens_hsa04360 MET 0.4985
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5458
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5429
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5458
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4963
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.5049
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5501
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5458
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5774
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5429
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5429
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5764
Peroxisome_Homo sapiens_hsa04146 XDH 0.5549
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.961
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5605
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5918
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5549
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5918
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5837
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5918
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5909
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6087
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5764
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5844
Shigellosis_Homo sapiens_hsa05131 SRC 0.5918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8265
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6256
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6273
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9151
Malaria_Homo sapiens_hsa05144 MET 0.6684
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6712
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1341
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6828
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6951
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.7222
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8604
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8156
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7956
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8633
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8604
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2232


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)