TCM Prescription: Li Gan Long Granules



Prescription Description
Prescription IDTCMF601
Pinyin NameLi Gan Long Ke Li 
Chinese Name利肝隆颗粒
English NameLi Gan Long Granules
Function Description急, 慢性肝炎, 迁延性肝炎, 慢性活动性肝炎, 对血清谷丙转氨酶, 麝香草酚浊度, 黄疸指数均有显著的降低作用, 对乙型肝炎表面抗原转阴有较好的效果
IndicationsJaundice disorder, Hepatitis, Hepatic sclerosis, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
DB97.Z [Inflammatory liver disease, unspecified, 某些特指的炎症性肝病,未特指的 ];
DB93.0 [Hepatic fibrosis, 肝纤维化 ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceChinese pharmacopoeia (2015)
Reference Book/linkISBN 978-7-5067-7337-9
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH329 Eleutherococcus senticosus 刺五加浸膏 TCMH329 KR080439
Reference: Chinese pharmacopoeia (2015)

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PPARA, PTGES, PTGS2, TRPV1 14.7648
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1, TYR 13.312
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, FABP3, FUT7, GBA2, HSD17B3, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR, XDH 13.312
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 12.8364
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 12.4174
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DHFR 12.4174
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1, TYR 12.3261
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, NR3C1, PTGES, PTGS2, RELA, SRC, TYR 11.8441
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, PTGS2, TYR, XDH 11.7657
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5741
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 10.9004
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, PTGES, PTGS2, RELA, SRC, TRPV1, TYR 10.8466
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2 10.6833
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, ESR1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KDR, KIT, MAOA, MET, PPARA, PTGS2, SRC, TNKS, TNKS2, TRPV1, XDH 10.5414
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, PTGES, PTGS2, RELA, SRC, TRPV1, TYR 10.3569
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1 10.0431
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 9.95305
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PPARA, PTGS2, RELA, SRC, TRPV1 9.7892
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2 9.70743
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC 9.44482
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2 9.40014
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 9.29705
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MAP2K1, MMP2, MMP9, PIM1, PTGES, PTGS2, RELA, SRC, XDH 9.27001
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TRPV1, XDH 9.26388
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TRPV1, XDH 9.26388
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 9.24259
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, GSK3B, HCAR2, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 9.2078
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 8.73629
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, PPARA, RELA, SRC, TYR 8.49342
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2 8.2682
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, GBA2, HSD17B3, MAOA, TYR 8.24662
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 7.94978
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 7.91467
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAP2K1, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC, TRPV1, XDH 7.90499
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA, PTGES, PTGS2 7.82745
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, PTGS2 7.74547
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR3C1, PTGS2, RELA, SRC, TRPV1 7.52262
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.35547
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, RELA, SRC, TRPV1 7.30227
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, GSK3B, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MMP9, PIM1, PPARA, PTGS2, RELA, SRC, TYR 7.25108
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, NR3C1, PIM1, PPARA, RELA, SRC 7.23391
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 7.17046
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 7.16257
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC 7.16257
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.06717
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES, PTGS2 7.06586
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 7.05326
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC 7.05314
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, F3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, RELA, SRC, XDH 7.01246
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD17B2, HSD17B3, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TYR 6.73657
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PTGES, PTGS2 6.59634
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 6.55024
[BP] GO:0032787 None AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, IDO1, PPARA, PTGES, PTGS2 6.52353
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PTGS2, PTPN1, RELA, SRC, TRPV1 6.50694
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1, PTGS2, RELA, SRC 6.3296
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.15903
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, ALOX12, AR, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, RELA 6.15774
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TRPV1, TYR 5.87956
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGES, PTGS2 5.71746
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TRPV1, TYR 5.68494
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, HCAR2, KDR, PTGS2, SRC, TNKS, TNKS2, TRPV1 5.67409
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 5.64247
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CDK6, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, RELA, SRC, TRPV1 5.61809
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AR, AURKB, AXL, BCL2, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, RELA, SRC 5.61809
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 5.59523
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.59523
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT, MAP2K1, SRC 5.46902
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.46717
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 5.43436
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, IDO1, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC 5.35652
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 5.33831
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.33831
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, MAP2K1, PTGS2, SRC 5.33831
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 5.33226
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP3A4, DHFR, HSD17B3, TYR 5.30661
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HSD17B3, IDO1, PTGES, PTGS2 5.21435
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 5.16604
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 5.08933
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 5.08933
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 5.06696
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DHFR, FABP3, HSD11B2, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 5.02452
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 5.01765
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MAOA, MMP1, MMP2, MMP9, SRC, XDH 5.01089
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GSK3B, HCAR2, IDO1, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 5.00712
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGES, PTGS2, TYR 4.92057
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.91463
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 4.91463
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, IDO1, IGF1R, MAP2K1, MAP3K7, MET, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 4.87189
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, F3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PPARA, PTGS2, PTPN1, SRC, TRPV1 4.83674
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 4.80899
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, RELA, SRC, TRPV1 4.69095
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 4.68966
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.68966
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AR, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, HCAR2, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SRC, TNKS2, TRPV1, XDH 4.61572
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 4.54417
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, HCAR2, IDO1, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PTGS2, RELA, SRC, TRPV1 4.53807
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.5135
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, HSD11B2, IGF1R, PPARA, PTGS2, RELA, SRC, TRPV1 4.4846
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.44238
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DHFR, IDO1, MAOA 4.40396
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, NR3C1, PTGS2, RELA, SRC, TRPV1 4.39257
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2, SRC 4.3892
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.36603
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 4.30154
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, TRPV1 4.26625
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3, IDO1 4.20246
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGES, PTGS2 4.18921
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGS2, PTPN1, SRC, TNKS, XDH 4.17815
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, SRC 4.17265
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 4.17265
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 4.17265
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TRPV1, TYR 4.16717
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.15581
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 4.14083
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.09006
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, RELA, SRC 4.05433
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.04318
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 4.041
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.01985
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DHFR, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TYR, XDH 3.96843
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.95561
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TNKS 3.92187
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.86028
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B2, IDO1, KIT, MAP2K1, MAP3K7, MMP2, MMP9, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TRPV1 3.85093
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, ESR1, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.83326
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.8186
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.7995
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, RELA, SRC, TRPV1, TYR 3.7995
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.75767
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 3.74392
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS2, RELA, SRC 3.72266
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, DHFR, ESR1, ESR2, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, MET, MMP9, PTPN1, RELA, SRC, TNKS, XDH 3.71675
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1 3.70239
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TRPV1, TYR 3.69703
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 3.64819
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.60575
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC 3.58713
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.5832
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.5505
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC, TRPV1 3.5505
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.5505
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.5505
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PTGS2, SRC 3.53147
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.50168
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, ESR1, FLT3, KIT, MAP2K1, MET, PIM1, SRC, TYR 3.49911
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49911
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.48317
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, KIT, MMP2, PPARA, PTGS2, RELA, SRC, TRPV1, TYR 3.45905
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, XDH 3.40503
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGES, PTGS2, RELA, SRC 3.38103
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.38103
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.38103
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.38103
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.38103
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, GSK3B, IDO1, MAOA, XDH 3.375
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GSK3B, PTGES, PTGS2, RELA, SRC, TRPV1 3.33243
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 3.31744
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, KIT, MAP3K7, PIM1, RELA 3.31744
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, HCAR2, IGF1R, KDR, MAP2K1, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 3.30033
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.29738
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DHFR, ESR1, ESR2, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TRPV1, XDH 3.26929
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.26599
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.26599
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.25137
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.24387
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.23882
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.23819
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCL2, CDK6, CYP1B1, FABP3, IDO1, MAP2K1, PTGES, PTGS2, XDH 3.22199
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGES, PTGS2 3.22125
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.20371
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, DHFR, PTGS2, TRPV1, XDH 3.19388
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CYP1A1, HSD11B2, PTGS2, RELA, SRC, TRPV1, TYR 3.18851
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.1684
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.15027
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 3.15027
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, PTPN1, SRC, XDH 3.13919
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, AR, BCL2, CDK6, CYP19A1, ESR1, ESR2, GSK3B, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, RELA, SRC, XDH 3.11869
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 3.11305
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11286
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, RELA, SRC 3.06377
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA 3.04978
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, GSK3B, IDO1, KDR, KIT, MAP2K1, PIM1, PPARA, PTGS2, RELA, SRC, TNKS2, TRPV1, XDH 2.99852
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.99274
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.99274
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.99274
[BP] GO:0019371 None AKR1C3, PTGES, PTGS2 2.99274
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.96434
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, ESR1, F3, FLT3, GSK3B, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.96071
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 2.96071
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TNKS 2.96071
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, DHFR, ESR1, F3, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, TNKS, XDH 2.96071
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, GBA2, GSK3B, IDO1, MAOA, SRC, XDH 2.94571
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.92619
[BP] GO:0051094 positive regulation of developmental process ALOX12, APP, AR, AXL, BCL2, CA2, CYP1B1, ESRRB, F3, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC 2.92161
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TNKS 2.91516
[BP] GO:0071383 None AKR1C3, AR, FLT3, NR3C1, SRC 2.91214
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS2 2.89847
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GSK3B, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1 2.89368
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.89368
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGES, PTGS2 2.89368
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.89368
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CYP1A1, PTGS2, RELA, TRPV1, TYR 2.87874
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, RELA, SRC 2.86594
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, CDK6, ESR1, FLT3, NR3C1, RELA, SRC 2.86197
[BP] GO:0016488 None AKR1B10, AKR1C3 2.86197
[BP] GO:0016487 None AKR1B10, AKR1C3 2.86197
[BP] GO:0016107 None AKR1B10, AKR1C3 2.86197
[BP] GO:0009115 None AOX1, XDH 2.86197
[BP] GO:0006714 None AKR1B10, AKR1C3 2.86197
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.86197
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.86197
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.86197
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.86197
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.84393
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, SRC 2.84393
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.84078
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, ESR1, F3, FABP4, IDO1, KDR, MAP2K1, MET, PPARA, PTGS2, RELA 2.82288
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.82288
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGES, PTGS2 2.79665
[BP] GO:2000026 regulation of multicellular organismal development ALOX12, APP, AR, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, F3, GSK3B, IDO1, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SRC, XDH 2.76133
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 2.75397
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PTGS2, RELA, TYR 2.75071
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, KIT, PPARA, SRC 2.75
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HCAR2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.73648
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73282
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, NR3C1, PTGS2 2.73282
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 2.73282
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC, XDH 2.68719
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, MMP9, PTGS2, PTPN1, RELA, SRC 2.68719
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, GSK3B, MAP2K1, TNKS 2.68719
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.68664
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2, TRPV1 2.65723
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.65511
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FLT3, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, SRC, XDH 2.63835
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, IDO1, PTGES, PTGS2 2.59472
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, FLT3, MET, SRC, TRPV1 2.58959
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MAP2K1, MET, NR3C1, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, TRPV1 2.58165
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, RELA, SRC, TRPV1 2.57418
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.57418
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.54616
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, SRC 2.54135
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PTGS2, TNKS, TNKS2 2.52222
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, RELA, SRC 2.52222
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, DHFR, GSK3B, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, RELA, SRC, TRPV1 2.52222
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, KIT, MAP3K7, MMP2, PTPN1, RELA, SRC 2.51617
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, AOX1, APP, AR, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, MAP3K7, NR3C1, PPARA, PTGS2, RELA, TYR, XDH 2.50722
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.50396
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.48749
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PTGS2, SRC 2.48378
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.46844
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, HSD11B2, IDO1, KIT, PTGES, PTGS2, RELA, SRC, TRPV1, TYR 2.46639
[BP] GO:0046110 None AOX1, XDH 2.46639
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46639
[BP] GO:0016095 None AKR1B10, AKR1C3 2.46639
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CSNK2A1, DHFR, ESR1, ESR2, ESRRA, FABP4, GSK3B, IGF1R, MET, MMP9, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 2.46334
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.4501
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.41995
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, DHFR, ESR1, F3, FLT3, GSK3B, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS, XDH 2.39538
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.37857
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, MAP2K1, RELA, TYR 2.36953
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.36805
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, KIT, MAP3K7, RELA 2.3613
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TYR 2.35638
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC, TNKS 2.35638
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, RELA, SRC, TRPV1 2.35554
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.35554
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.35554
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DHFR, GSK3B, IGF1R, MAP2K1, MAP3K7, MET, PTGS2, PTPN1, XDH 2.32786
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, PTGES, PTGS2, RELA, TRPV1 2.30512
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP2, MMP9, TRPV1 2.30009
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, IGF1R, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.28362
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.28254
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.26887
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.26658
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.26552
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, ESR1, FLT3, KIT, NR3C1, RELA, SRC 2.26341
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, PTGS2 2.26128
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MMP9, PTGS2, PTPN1, RELA, SRC, XDH 2.25747
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MAP3K7, MMP2, PPARA, PTGS2, PTPN1, RELA, SRC 2.23744
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MAP2K1, MET, NR3C1, PPARA, PTGS2, RELA, SRC, TNKS, TNKS2, TRPV1 2.2306
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, GSK3B, IDO1, KDR, MAP3K7, PPARA, SRC 2.2272
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21363
[BP] GO:0070213 None TNKS, TNKS2 2.21363
[BP] GO:0006145 None AOX1, XDH 2.21363
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.21363
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PTPN1, SRC 2.2096
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.20199
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, IDO1, MAOA, XDH 2.19238
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, MAOA 2.18709
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOA 2.18225
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.18225
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 2.18225
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.181
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, KIT, MAP2K1, MAP3K7, PTPN1, SRC 2.181
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17287
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.15713
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CACNA1C, ESR1, FABP3, FABP4, MET, TRPV1 2.12331
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, GSK3B, KDR, SRC 2.12331
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12331
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.12331
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 2.11438
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.09243
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.08611
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.07778
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, DHFR 2.07772
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.06443
[BP] GO:0043434 None FABP3, HSD11B2, PPARA, PTGS2, RELA, SRC, TRPV1 2.06179
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.04087
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.04087
[BP] GO:0006693 None AKR1C3, PTGES, PTGS2 2.04087
[BP] GO:0006692 None AKR1C3, PTGES, PTGS2 2.04087
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CYP19A1, GSK3B, HCAR2, MAP2K1, MMP9, PPARA, PTGS2, PTPN1, SRC, TRPV1 2.04087
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, ESR1, MET, SRC 2.04087
[BP] GO:0043696 None CDK6, ESRRB 2.04087
[BP] GO:0043697 None CDK6, ESRRB 2.04087
[BP] GO:0010641 None F3, SRC 2.04087
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.04087
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.04087
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.04087
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, XDH 2.03971
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.03589
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PTPN1, RELA, SRC 2.03526
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, ESR1, ESR2, GSK3B, IGF1R, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PTPN1, SRC, TNKS, TNKS2 2.02917
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, GSK3B, IDO1, PTGES, PTGS2, RELA, SRC 2.02393
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, GSK3B, MMP9, PTGS2, PTPN1, RELA, SRC 2.02054
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, KIT, PTGS2, RELA, TYR 2.02054
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.00579
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.00579
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIM1, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 5.49788
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, F3, FLT3, FUT7, GBA2, GSK3B, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIM1, PTGES, PTGS2, PTPN1, SRC, TNKS, TNKS2, TRPV1, TYR 3.44622
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.38103
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2, PTPN1 3.32747
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS2 3.29036
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SHBG, SRC, TNKS, TNKS2, TYR, XDH 2.57762
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GSK3B, HSD17B3, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SHBG, SRC, TNKS, TNKS2, TYR, XDH 2.51142
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, GBA2, HSD17B3, KDR, MAP2K1, PTGS2, PTPN1, XDH 2.13494
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA1, CA2, CA7, CDC25B, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, MAP2K1, MAP3K7, NR3C1, PIM1, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 2.12322
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 19.2925
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.5745
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGES, PTGS2, PTPN1, RELA, SRC, TNKS, TNKS2, TRPV1, TYR, XDH 14.4001
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, F3, FLT3, FUT7, GBA2, GSK3B, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, IGF1R, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, MMP9, PIM1, PTGES, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 14.4001
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, IDO1, MAOA, PTGS2, TYR, XDH 12.6488
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6211
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.36578
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MAP3K7, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 9.24724
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, IDO1, KIT, MAP3K7, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, PTPN1, TNKS, TNKS2, TRPV1, TYR, XDH 8.94148
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, SHBG 8.87202
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 8.83535
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, PPARA, PTPN1, TNKS 8.29415
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.29108
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, HSD11B2, HSD17B1, IDO1, PTGES, PTGS2, SRC, XDH 7.32481
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.28993
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 7.14143
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 7.08164
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, IDO1, PTGS2, SRC 7.05314
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.89473
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS2, TYR 6.58853
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.47579
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.28467
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, SHBG, TRPV1 6.26975
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.92195
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA 5.91427
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 5.19968
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.16604
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.01089
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.01089
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.91463
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PPARA, SRC, TRPV1 4.89464
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 4.83799
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.45387
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 4.36603
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 4.18038
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MAP2K1, MET, SRC 3.94143
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.90638
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.85982
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.75767
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, SHBG 3.74442
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.38103
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.23882
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.23819
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, NR3C1, PPARA, TRPV1 3.01257
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 3.00762
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NR3C1, PPARA, TRPV1 2.86197
[MF] GO:0045550 None AKR1B10, AKR1C3 2.86197
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86197
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.86197
[MF] GO:0003845 None HSD11B1, HSD11B2 2.86197
[MF] GO:0008389 None CYP2A13, CYP2A6 2.86197
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, ESR1, ESR2, ESRRB, F3, GSK3B, KIT, MET, NR3C1, PPARA, PTGS2, PTPN1, RELA, SRC, TNKS2 2.86148
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, NR3C1, PPARA, TRPV1 2.75397
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DHFR, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, PTGES, RELA, SRC, TRPV1, XDH 2.67963
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, PTGS2, RELA, TRPV1, TYR, XDH 2.67963
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 2.58165
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.46639
[MF] GO:0047718 None AKR1B10, AKR1C3 2.46639
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.46639
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.46639
[MF] GO:0047045 None AKR1C3, HSD17B3 2.46639
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.46639
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, KIT, MET, NR3C1, PPARA, TRPV1 2.45608
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC 2.36953
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.21363
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.21363
[MF] GO:0005497 None AR, SHBG 2.21363
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.21363
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, PIM1, SRC, TRPV1, XDH 2.17233
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AR, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DHFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GSK3B, HSD11B2, HSD17B1, IDO1, IGF1R, KDR, KIT, MAP2K1, MAP3K7, MET, NR3C1, PIM1, PPARA, PTGS2, PTPN1, RELA, SHBG, SRC, TRPV1, XDH 2.07121
[MF] GO:0008134 transcription factor binding AR, BCL2, ESR1, ESRRB, FLT3, GSK3B, PIM1, PPARA, RELA, SRC 2.05177
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.04087
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.04087
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04087


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.6938
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP3A4, CYP19A1 13.437
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.6586
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1B1, ALOX12, PTGS2, CYP3A4, GBA2, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, AOX1, XDH, AKR1C3, TYR, DHFR, CYP2A6, AKR1B10, CYP1A2, CYP1A1, ALPL, PTGES, IDO1 10.3823
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, MAP2K1, FLT3, MMP1, MMP2, PTGS2, MMP9, RELA, IGF1R, AR, CDK6, KIT, BCL2, MET 7.7071
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.409
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 6.5184
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, MAOA, ALOX5, ALOX15, ALOX12, CACNA1C, PTGS2 6.4763
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.4763
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, ALOX12, PTGS2, PTGES 5.4991
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, MAP2K1, SRC, ESR1, ESR2, RELA 5.1492
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.7617
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MAP3K7, MET, IGF1R 5.1158
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, MAP2K1, BCL2, RELA, IGF1R 4.7617
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, CDK6, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.5378
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, SRC, MMP2, MMP9, ESR1, ESR2 4.5378
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9 5.0988
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, MAP2K1, CDK6, KIT, KDR, BCL2, MET, RELA, IGF1R 4.1394
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, FLT3, KIT, PIM1, RELA 4.5122
Focal adhesion_Homo sapiens_hsa04510 GSK3B, MAP2K1, SRC, KDR, BCL2, MET, IGF1R 3.8854
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, CDK6, SRC, BCL2, MMP9, RELA 3.7001
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.2503
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP3A4 4.1432
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3, RELA 3.4312
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PTGS2, MMP9, MAP3K7, RELA 3.2708
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.5864
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, MAP2K1, ADORA1, CACNA1C, PPARA, RELA 3.0546
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, KIT, KDR, MET, IGF1R 2.967
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, ADORA3, BCL2, ADORA1, RELA 3.123
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, SRC, KDR, PTGS2 3.1694
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, KIT, KDR, MET, RELA, IGF1R 2.833
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1, MAP3K7, RELA 2.9622
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, FLT3, KIT, MET 3.0546
Melanoma_Homo sapiens_hsa05218 MAP2K1, CDK6, MET, IGF1R 2.9838
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C 2.6544
Melanogenesis_Homo sapiens_hsa04916 GSK3B, MAP2K1, KIT, TYR 2.5105
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0187
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2, RELA 2.7366
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.4823
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, BCL2, RELA, IGF1R 2.4823
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, BCL2, CACNA1C 2.4002
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, MAP2K1, MAP3K7, RELA 2.4772
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2, MAP3K7, RELA 2.3243
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA, RELA 2.4202
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, MAP2K1, SRC, ESR1 2.3243
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, MAP3K7, RELA 2.3243
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, MAP2K1, BCL2, RELA 2.3118
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, MAP2K1, ESRRB, IGF1R 2.0949
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, CACNA1C, MAP3K7, RELA, CDC25B 1.9784
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 1.9702
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, SRC, CACNA1C, PTGS2 1.9702
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, ADORA3, ADORA1, CACNA1C 1.9031
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, MAP2K1, SRC, RELA 1.7503
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, MAP2K1, RELA 2.0291
Glioma_Homo sapiens_hsa05214 MAP2K1, CDK6, IGF1R 2.1277
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, CDK6, RELA 2.0291
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.7378
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, CDC25B, IGF1R 1.7378
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, CDK6, RELA 2.1166
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, MAP3K7, RELA 1.6564
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, MAP2K1, SRC 1.8557
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4936
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, MAP2K1, BCL2 2.1786
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, MAP3K7, RELA 1.429
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOA, CACNA1C 1.4499
Apoptosis_Homo sapiens_hsa04210 MAP2K1, BCL2, RELA 1.3886
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.2979
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.3394
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.0291
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA, RELA 1.4267
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.49
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, MAP2K1 1.3887
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1, MAP3K7 1.3776
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, RELA 2.0949
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA, RELA 1.3282
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1 1.3045
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3014
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2921
Calcium signaling pathway_Homo sapiens_hsa04020 CACNA1C 0.2878
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3019
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3303
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP, CACNA1C 1.2603
Influenza A_Homo sapiens_hsa05164 GSK3B, MAP2K1, RELA 1.2325
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.1803
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1 0.3682
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2181
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC, RELA 1.0903
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, RELA 0.495
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.4759
Platelet activation_Homo sapiens_hsa04611 SRC 0.3995
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, SRC 0.5799
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.6641
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.808
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4201
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, IGF1R 0.8294
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.7802
AMPK signaling pathway_Homo sapiens_hsa04152 MAP3K7, IGF1R 0.8665
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, KIT 0.7929
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.856
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8955
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 RELA 0.4495
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8867
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4573
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1 0.4573
Amoebiasis_Homo sapiens_hsa05146 RELA 0.4573
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4689
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.754
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1 0.4715
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4678
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4689
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4766
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 0.9974
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4781
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4781
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 RELA, IGF1R 1.0486
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.4942
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4781
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4866
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4883
Peroxisome_Homo sapiens_hsa04146 XDH 0.4942
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.495
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.0917
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0917
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5006
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC 1.0917
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4942
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4987
Pertussis_Homo sapiens_hsa05133 RELA 0.5124
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.9642
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5146
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5146
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1 0.5378
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5352
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.174
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2388
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.2683
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.555
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, MET 1.2683
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.555
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.2607
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RELA 0.5521
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2325
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3173
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.2793
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2388
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, CDK6 1.3437
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, MAP2K1 1.3887
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2715
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3394
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3213
Legionellosis_Homo sapiens_hsa05134 RELA 0.6045
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6045
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4267
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6278
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6326
Malaria_Homo sapiens_hsa05144 MET 0.6343
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6326
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6394
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6415
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6394
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6415
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7029
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6959
Prion diseases_Homo sapiens_hsa05020 MAP2K1 0.7433
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7667
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7433
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.803
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1 0.8222
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7825
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6494
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7368
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.803
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8294
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9702
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8222
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.856
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0988
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9136
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9743
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9539
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.3118
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3182


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)