TCM Prescription: Si Ji San Huang Pills



Prescription Description
Prescription IDTCMF5866
Pinyin NameSi Ji San Huang Wan
Chinese Name四季三黄丸
English NameSi Ji San Huang Pills
Function Description口疮, 鼻疮, 牙痛, 便秘
IndicationsConstipation disorder, Constipation, Aphtha
Disease ICD-11 Category SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
ME05.0 [Constipation, 便秘 ];
DA01.10 [Oral aphthae or aphtha-like ulceration, 口腔阿弗他溃疡或阿弗他样溃疡 ];
Human Tissues Associated with IndicationLiver, Spleen, Large Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 15.7679
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TERT 12.6717
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.7269
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, FABP3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC 10.1888
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 10.187
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 10.1633
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 9.92168
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 9.76276
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, SRC 9.74522
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT 8.98024
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 8.71513
[BP] GO:0007187 None CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 8.47016
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 8.28989
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, DNMT1, DRD2, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, TERT, XDH 8.00131
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 7.98503
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.95827
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 7.91204
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.6878
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2 7.66523
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.61043
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, KIT, PTGS2 7.34082
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, BACE1, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, KIT, PTGS2 7.34082
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.27529
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 7.25681
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC 7.23293
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 7.23077
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 7.14073
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.11284
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 7.02756
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.99455
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, XDH 6.98336
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR1B, HTR1D, KDR, SRC 6.98336
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, SRC 6.97737
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.89604
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT 6.89604
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, TERT 6.78921
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT 6.78921
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR2A, HTR2C 6.69923
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 6.57677
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.54248
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.47438
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, APP, CA2, CNR1, CNR2, DRD1, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 6.4443
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.40656
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 6.35577
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1 6.25812
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, DRD2, HTR1B 6.2403
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, SRC 6.15031
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, KIT, MMP9, PTGS2, TERT 6.15031
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.06476
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC, TERT 6.06476
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, FABP4, FLT3, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2 6.0335
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, XDH 6.0335
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.95373
[BP] GO:0050795 None CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.95373
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, XDH 5.94893
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 5.91266
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.86837
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 5.84218
[BP] GO:0003018 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.77619
[BP] GO:0007188 None CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.75653
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 5.6322
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.62865
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DYRK1A, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPRS, SRC, TNKS, XDH 5.5297
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, PIK3CB, PTGS2, TNKS, TNKS2 5.52599
[BP] GO:0007193 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.47633
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.4715
[BP] GO:0099536 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.46447
[BP] GO:0099537 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.46447
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, PIK3CA, PIK3CB, PTGS1, PTGS2 5.4396
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, DRD2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC 5.38457
[BP] GO:0097746 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.3369
[BP] GO:0035296 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.3369
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.31144
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.31104
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, SRC, TERT 5.2939
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 5.28363
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.28287
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 5.27426
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 5.24673
[BP] GO:0050880 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.1603
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.1446
[BP] GO:0035150 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.14235
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 5.10937
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HTR1A 5.07419
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.01655
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 5.01223
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DNMT1, DRD1, DRD2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC 5.00589
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 5.00589
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.99566
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.96581
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.93719
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CNR1, CNR2, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TNKS, TNKS2 4.9275
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TERT 4.92728
[BP] GO:0032845 None BCL2, DRD2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 4.92703
[BP] GO:0003013 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.88757
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, DRD1, DRD2, HTR1B, HTR2A, PTGS2 4.82087
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.81701
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.79229
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.79229
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, XDH 4.79003
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 4.79003
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.79003
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.79003
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.7815
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, HTR7, KIT, PPARA, SRC 4.76716
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 4.76716
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 4.76716
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 4.73808
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.73317
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.69668
[BP] GO:0007268 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.67887
[BP] GO:0098916 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.67887
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 4.62984
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.61641
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.60035
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.5994
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT 4.59409
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.59158
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.55332
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.54559
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.50015
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TNKS 4.48667
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DNMT1, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 4.46194
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT 4.44556
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.44523
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.37517
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.36351
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.34585
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.30466
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.28783
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 4.28783
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 4.27769
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 4.2633
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, PIK3CB, SRC, XDH 4.2633
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH 4.22373
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC, TERT 4.22182
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.21271
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.20303
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, TNKS, XDH 4.19751
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 4.18031
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.17616
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.17436
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.1575
[BP] GO:0003008 None AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC 4.12771
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, DNMT1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.12771
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, DRD2, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 4.09707
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.08498
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 4.08213
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 4.05655
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 4.04568
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC 3.98659
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 3.98252
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD2, HTR1B, HTR2A, MMP9, PTGS2 3.94089
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.93956
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 3.93439
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A, MET 3.9329
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.92729
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 3.89211
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 3.85421
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2C, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT 3.82172
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CNR1, CNR2, CYP19A1, DRD2, DYRK1A, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 3.82006
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 3.82006
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SRC, TERT 3.80924
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 3.80692
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, KDR, KIT, PIK3CA, PPARA, PTPRS, SRC 3.78906
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.75181
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 3.75181
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.73481
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.70325
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.6179
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, XDH 3.60139
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 3.59093
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DRD2, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, PIK3CB, SRC, XDH 3.58805
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.56472
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TUBB3 3.55347
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.55121
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT 3.48917
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.48273
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.45933
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 3.44501
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, ESR1, FLT3, HSD11B1, HTR5A, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC 3.42974
[BP] GO:0007154 None AXL, BCL2, CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.41741
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.39215
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.39215
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.38121
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, DRD1, DRD2, DYRK1A, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 3.37524
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.37161
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, DRD1, DRD2, DYRK1A, ESR1, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPRS, SRC, TERT, XDH 3.3609
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.35785
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.35785
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.35785
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.33466
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA, TNKS2 3.30991
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 3.29901
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.29901
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.29901
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A 3.29901
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.29901
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.27658
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.27658
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.26892
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2, PTGS2 3.25585
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, PPARA, PTGS2, PTPRS 3.23738
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, SRC 3.23593
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.22257
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.18836
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DYRK1A, ESR1, IGF1R, MET, MMP9, PPARA, PTGS2, PTPRS, SRC, TERT, XDH 3.18836
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DYRK1A, ESR1, F3, FLT3, FUT7, HTR1A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS, TNKS2, XDH 3.18545
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1 3.16977
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 3.16466
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.16466
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.16466
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.15104
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2, TERT 3.14103
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 3.14103
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DNMT1, DRD1, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 3.14103
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.14103
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.13405
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.11135
[BP] GO:0051952 None CNR1, DRD1, DRD2, HTR1B, HTR2A 3.09905
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.09905
[BP] GO:0090066 None ALOX15, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.09766
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.06919
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, HTR1B, KDR, PTGS2, SRC 3.06436
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.05685
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A 3.05277
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, F3, HTR2A, HTR2B, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TERT 3.03627
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 3.0275
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.00075
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9, TERT 2.97709
[BP] GO:0007208 None HTR2A, HTR2C 2.97709
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.93346
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.93346
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, F3, HTR2A, HTR2C, KDR, KIT, PIM1, PTGS2, SRC, TERT 2.93187
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.92159
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.91031
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DNMT1, DRD1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.89433
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 2.88782
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CBR1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 2.88706
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88115
[BP] GO:0051967 None DRD2, HTR1B, HTR2A 2.88115
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, MET, MMP9, PIK3CA, PIK3CB, SRC, TERT, TNKS, XDH 2.87939
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.87845
[BP] GO:0009892 negative regulation of metabolic process APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.86801
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.83975
[BP] GO:0008217 None CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2 2.8246
[BP] GO:0007267 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.80779
[BP] GO:0050999 None CNR1, CNR2, HTR2B, TERT 2.80091
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC, TNKS 2.80091
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.80091
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.80091
[BP] GO:0051588 None DRD1, DRD2, HTR1A, HTR1B, HTR2C 2.7992
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, ESR1, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.78725
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, DNMT1, DRD2, DYRK1A, ESR1, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.77248
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.77007
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.77007
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, PTGS2, TERT 2.74196
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.7332
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.72686
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72686
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.72686
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.72686
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2 2.72288
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 2.70573
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, HTR2A, KIT, PTGS2 2.70573
[BP] GO:0007631 None APP, DRD1, DRD2, HTR1B, HTR2C 2.70573
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.6739
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DNMT1, DRD1, HTR1B, IGF1R, MMP2, PTGS2, SRC 2.66759
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.65428
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.64207
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.63691
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESR1, F3, HTR2A, HTR2B, HTR2C, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.63274
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 2.62838
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.62434
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.62322
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 2.62305
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.61931
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, HSD11B2, KIT, MMP2, MMP9, PTGS2, SRC 2.61476
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, KIT, MET, PIK3CA, PIK3CB 2.60868
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CNR1, CYP1A1, DRD1, ESR1, KIT, PTGS2, SRC 2.5961
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57997
[BP] GO:0033602 None CNR1, DRD2 2.57997
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD1, DRD2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, SRC 2.57163
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC 2.57163
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.53421
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.53421
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.53421
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.53421
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.53305
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, PTGS2 2.53199
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.51338
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.51338
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.50808
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TERT 2.50343
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.50117
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.50117
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.48722
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.48722
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.48722
[BP] GO:0032768 None CNR1, CNR2, HTR2B, TERT 2.48722
[BP] GO:0048148 None DRD1, DRD2, HTR2A 2.48152
[BP] GO:0023052 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.46094
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.46094
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, HTR2B, PTGS2, SRC, TERT 2.46029
[BP] GO:0003012 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.44505
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.4352
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.425
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.425
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESR1, F3, HTR2A, HTR2C, KDR, KIT, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TERT, TNKS2, XDH 2.42456
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, DRD2, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, PIK3CA, PIK3CB, SRC, TERT, TNKS, XDH 2.4193
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.40901
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.40834
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.39623
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.39623
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.38972
[BP] GO:0080090 regulation of primary metabolic process ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.38449
[BP] GO:0050890 None APP, CNR1, DRD1, DRD2, HTR2A, KIT, PTGS2 2.3806
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.36543
[BP] GO:0070213 None TNKS, TNKS2 2.33924
[BP] GO:0038171 None CNR1, CNR2 2.33924
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33924
[BP] GO:0014827 None HTR1D, HTR2B 2.33924
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.33094
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.32851
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.32851
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2, XDH 2.32827
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.32145
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CYP1A1, DRD1, DRD2, ESR1, FABP4, FLT3, FUT7, HTR2B, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, SRC, TERT 2.31571
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, CSNK2A1, DNMT1, DRD2, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, PIK3CB, PTPRS, SRC, TNKS, TNKS2 2.28067
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.28023
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.28023
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.28023
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, KIT, PTGS2 2.27695
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.27695
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C 2.27695
[BP] GO:0051338 regulation of transferase activity APP, AURKB, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, SRC, TNKS 2.2737
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.26867
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, PPARA, PTGS2, SRC, TERT, TNKS, TNKS2 2.26027
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.25093
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.24136
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.24136
[BP] GO:0048169 None APP, DRD2, KIT 2.23634
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, DRD2, HTR2B, HTR2C, KIT, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.22084
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, BCL2, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH 2.20674
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 2.20235
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.19446
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.19446
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.19446
[BP] GO:0045597 positive regulation of cell differentiation APP, AXL, BCL2, CA2, CNR1, DRD2, HTR2A, HTR2C, KDR, KIT, PTGS2, TERT 2.19344
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.18956
[BP] GO:0021853 None DRD1, DRD2 2.15985
[BP] GO:0010641 None F3, SRC 2.15985
[BP] GO:0071502 None HTR1B, HTR2B 2.15985
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.15985
[BP] GO:1904936 None DRD1, DRD2 2.15985
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.15642
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.15546
[BP] GO:1900543 None DRD2, HTR1B, HTR1E, PPARA 2.13444
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.13444
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.13444
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, KIT, MET, PIK3CA, PIK3CB 2.13021
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.1262
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, ESR1, KIT, MMP2, PIK3CA, PIK3CB, PTPRS, SRC 2.12125
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.1176
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.1176
[BP] GO:0001667 ameboidal-type cell migration CYP1B1, HTR2B, KDR, KIT, PIK3CA 2.1176
[BP] GO:0045980 None DRD2, HTR1B, HTR1E, PPARA 2.1176
[BP] GO:0007612 None APP, DRD1, DRD2, KIT, PTGS2 2.10406
[BP] GO:0048638 regulation of developmental growth APP, BCL2, DRD2, PIK3CA, PIM1, PTPRS, TNKS2 2.08531
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, MMP2, PPARA, PTGS2, PTPRS, SRC 2.08274
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.07754
[BP] GO:0045859 regulation of protein kinase activity APP, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, SRC 2.07696
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PIK3CB, SRC 2.07308
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, HSD11B2, PTGS2 2.06735
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.05836
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, PPARA 2.0547
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.04077
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.04077
[BP] GO:0022602 ovulation cycle process BCL2, ESR1, KIT, SRC 2.04077
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C 2.04077
[BP] GO:0010631 epithelial cell migration CYP1B1, KDR, KIT, PIK3CA 2.02351
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.02351
[BP] GO:0055065 metal ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.02351
[BP] GO:0021843 None DRD1, DRD2 2.02351
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.02351
[BP] GO:0021830 None DRD1, DRD2 2.02351
[BP] GO:0014831 None HTR1D, HTR2B 2.02351
[BP] GO:0032229 None CNR2, HTR1B 2.02351
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.02351
[BP] GO:0021826 None DRD1, DRD2 2.02351
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.02351
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.02351
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, FABP3, KDR, MMP2, PTGS2, SRC 2.01698
[BP] GO:0042220 None CNR1, DRD2, HTR1B 2.01386
[BP] GO:0001659 None DRD1, DRD2, HTR2A 2.01386
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.01386
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, TNKS 2.01357
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.01357
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC 2.00564
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, BACE1, CA4, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 8.19804
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TERT 7.7195
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2 7.51506
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, BACE1, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SRC 7.37122
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, BACE1, CNR1, CNR2, DRD1, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 7.1802
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPRS, SRC 6.01515
[CC] GO:0030424 None APP, BACE1, CA2, CNR1, DRD2, HTR2A, PTPRS, TUBB3 3.29901
[CC] GO:0120025 None AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SRC, TUBB3 3.29074
[CC] GO:0043005 None APP, BACE1, CA2, CNR1, CNR2, DRD2, HTR2A, HTR2B, HTR5A, PTGS2, PTPRS, SRC, TUBB3 3.18836
[CC] GO:0042995 cell projection AKR1B1, APP, BACE1, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, PTPRS, SRC, TUBB3 3.0275
[CC] GO:0031224 None ABCB1, ACHE, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTPRS 2.93276
[CC] GO:0016021 None ABCB1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTPRS 2.36811
[CC] GO:0045121 membrane raft APP, BACE1, CNR1, HTR2A, KDR, PTGS2, SRC 2.21342
[CC] GO:0098857 membrane microdomain APP, BACE1, CNR1, HTR2A, KDR, PTGS2, SRC 2.19818
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8749
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.728
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.728
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 14.6784
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5619
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.3543
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 13.0011
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.5128
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.1982
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DYRK1A, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 8.93288
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, TNKS, XDH 8.47016
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TERT, TNKS, TNKS2, XDH 8.25992
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 8.19849
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.09244
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 8.01646
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 7.32844
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 7.32844
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 7.11104
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.88076
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, XDH 6.39054
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, ESR1, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.35032
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.3369
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.25717
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.1087
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 5.03218
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.98337
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.73317
[MF] GO:0004930 None ADORA3, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.73317
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 4.63858
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.48667
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.30195
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 4.28783
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.1969
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.0806
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, XDH 4.03994
[MF] GO:0097159 organic cyclic compound binding ABCB1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DRD2, DYRK1A, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TERT, TUBB3, XDH 3.72811
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2 3.70325
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.39215
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 3.29901
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1 3.29071
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 3.23483
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.16466
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, TNKS 3.10693
[MF] GO:1901363 heterocyclic compound binding ABCB1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, ESR1, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, SRC, TERT, TUBB3, XDH 3.03714
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.97709
[MF] GO:0003845 None HSD11B1, HSD11B2 2.97709
[MF] GO:0071886 None HTR2A, HTR2C 2.97709
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.89109
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT 2.8031
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.70573
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.57997
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57997
[MF] GO:0004949 None CNR1, CNR2 2.57997
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, ESR1, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, TERT, TNKS, TNKS2, XDH 2.57163
[MF] GO:0043168 anion binding ABCB1, ALOX15, APP, AURKB, AXL, CSNK2A1, DYRK1A, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TUBB3, XDH 2.50343
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.48722
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.48152
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.45127
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.40834
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.39623
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TUBB3, XDH 2.3945
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.33924
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.33924
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DRD2, DYRK1A, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, PTGS2, TERT, XDH 2.29569
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.233
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.19446
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.16989
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15985
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1 2.15642
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.15642
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1 2.07754
[MF] GO:0035004 phosphatidylinositol 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.07717
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.00553


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.7233
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, DRD1, DRD2 12.6293
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, DRD1, DRD2, PPARA, HTR4 8.3438
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.8742
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 7.8431
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.934
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.0479
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, DRD2, MET, IGF1R 5.9496
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.572
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, HTR2A, DRD1, DRD2 6.2126
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.3698
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4 5.454
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.4674
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET 4.8456
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.8268
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, ALOX15, AKR1B1, PTGS2, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 4.8268
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.8268
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 4.8268
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.8105
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.8268
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.684
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.2462
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 3.9523
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.6688
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.5204
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 2.9859
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.0595
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.1603
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.1514
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1776
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.042
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1213
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9859
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.8989
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0595
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 2.9442
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5892
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5936
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.6908
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5191
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.5191
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.4837
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5191
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.5013
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.1485
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.147
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.147
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.967
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.8324
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.2955
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.2978
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9901
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 1.8811
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9176
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3288
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 1.7734
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6722
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2847
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9237
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.6398
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.582
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5455
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 2.2019
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.5677
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.582
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.2955
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.5261
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.5346
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.5293
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5084
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4958
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.8204
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.3966
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.307
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3195
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3293
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2126
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3561
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1778
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3798
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3085
Axon guidance_Homo sapiens_hsa04360 MET 0.4144
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4225
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7986
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, TERT, PIK3CB 1.0247
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7655
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.765
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7737
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7989
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9122
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9307
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 0.9205
Melanogenesis_Homo sapiens_hsa04916 KIT 0.4896
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4889
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9205
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9435
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9566
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.502
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5013
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1213
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.5147
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5157
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5177
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0971
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1221
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1651
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1221
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1077
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5167
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1327
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1778
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1077
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.1221
Peroxisome_Homo sapiens_hsa04146 XDH 0.5363
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1953
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5514
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5748
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5728
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5875
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.33
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.33
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3684
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.601
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.343
Shigellosis_Homo sapiens_hsa05131 SRC 0.6094
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.3828
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6371
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3684
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4504
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.3613
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5312
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.4958
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6678
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.459
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.694
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5991
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5693
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5637
Malaria_Homo sapiens_hsa05144 MET 0.7066
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7196
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.587
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.739
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7335
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8891
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8477
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7675
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8633
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0814
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9205
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9129
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1327
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1603


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)