TCM Prescription: Wei Li Tablets



Prescription Description
Prescription IDTCMF5712
Pinyin NameWei Li Pian
Chinese Name胃力片
English NameWei Li Tablets
Function Description痞满, 胃脘痛, 便秘
IndicationsStomach ache disorder, Constipation disorder, Constipation
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SA57 [Constipation disorder (TM1), 便秘 (TM1) ];
ME05.0 [Constipation, 便秘 ];
Human Tissues Associated with IndicationStomach, Large Intestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH130 Pinellia ternata 半夏 TCMH130 GBVT1123-13, GBVY1693-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0901
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0901
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, MET, PIK3CA, PIK3CB, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 16.0127
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, POLB, PTGS2, SMAD3, SRC, TEK, TYR 13.4376
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, MMP2, PIK3CA, POLB, PTGS2, SMAD3, SRC, TEK, TYR 11.8911
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, POLB, PTGS2, SRC, TEK, TYR 11.5991
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, SRC, TYR 10.1286
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.89983
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.87632
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 9.71026
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR 9.65678
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 9.6388
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, TBXAS1 9.58226
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.29519
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.2904
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.18075
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 9.09481
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 8.7758
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, POLA1, POLB, SMAD3, SRC 8.58544
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 8.42904
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC, TEK, TYR 8.36185
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TYR 8.36185
[BP] GO:0003018 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 8.29487
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, POLB, PTGS2, SRC 8.29487
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, PTGS2, SRC, TEK 8.13508
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC, TEK 7.9995
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 7.87769
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.70067
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM2, CNR1, CNR2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 7.53983
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 7.36789
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.23176
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 7.23176
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 7.19649
[BP] GO:0003013 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.18226
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.11422
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 7.09378
[BP] GO:0007193 None ADORA1, CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.98342
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, SMAD3, SRC, TEK, TYR 6.85579
[BP] GO:0097746 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.69295
[BP] GO:0035296 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.69295
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3 6.69295
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, POLB, SMAD3, SRC, TEK, TYR 6.68848
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.66099
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.66099
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.62898
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.59983
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.58202
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 6.58202
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK 6.56964
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC 6.51947
[BP] GO:0050880 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.51802
[BP] GO:0035150 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.49416
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.49206
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, EGFR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC 6.45866
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.40654
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PTGS2, TEK 6.36974
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, SRC, TEK, XDH 6.36974
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, MMP2, POLB, PTGS2, SMAD3, SRC, TEK, TYR 6.35809
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, POLB, SRC 6.34734
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TEK 6.30459
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.28862
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.28263
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 6.24636
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.13248
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, HTR2B, HTR2C, PIK3CA, PIM1, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.12949
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 6.05884
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, SRC, TEK, XDH 5.99353
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 5.9908
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.96298
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC 5.82989
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC, TEK 5.79861
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 5.75822
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 5.75822
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.70852
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, POLA1, POLB, PTGS2, SMAD3, SRC 5.70376
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, POLA1, SRC, TEK, TYR 5.70195
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.63784
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, SMAD3, SRC, TEK 5.62889
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, INSR, KDR, MMP9, PIK3CA, PIM1, POLB, PTGS2, SMAD3, SRC, TEK, TYR 5.5962
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC, TEK 5.54838
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 5.54838
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.43511
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.43511
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 5.43045
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.37951
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.36103
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.32649
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.2922
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK 5.25391
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, PIK3CB, SRC, TEK, XDH 5.25391
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.24393
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, PIK3CB, SRC, TEK, XDH 5.23777
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 5.23777
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PTGS2 5.14698
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, TBXAS1 5.14202
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 5.1078
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.04792
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 5.01813
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, PIK3CA, PTGS2, SRC, TEK, TYR 5.01813
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 5.00394
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.97118
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, HTR1B, HTR2A, PTGS2 4.96004
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, PTGS2, SRC, TEK 4.95828
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 4.95351
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.9483
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MMP9, PIK3CB, PTGS2, SMAD3, SRC 4.9436
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.9436
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.89884
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.89884
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.89752
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1 4.89752
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.89752
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, HTR1D, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.89388
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PTGS2, SMAD3, SRC, TEK 4.88742
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.88298
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.84496
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 4.8144
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.81262
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.80845
[BP] GO:0099536 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.80221
[BP] GO:0099537 None CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.80221
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.78316
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PTGS2 4.78316
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, PTGS2 4.78316
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.70538
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.69374
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.63943
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.63587
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.63587
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.62884
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 4.60855
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.59748
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 4.54929
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.46521
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 4.43002
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 4.40183
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SMAD3, SRC, TEK 4.33204
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, SRC 4.33204
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TEK 4.31559
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.30183
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.2727
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, SMAD3, SRC, XDH 4.23527
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PTGS2, SMAD3, SRC, TEK 4.23354
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.22783
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, SMAD3, SRC, XDH 4.22248
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.19768
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 4.19642
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 4.1933
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.18286
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, SRC, TEK 4.15551
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.097
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.09606
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.09138
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.08344
[BP] GO:0090066 None ADORA1, ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.04882
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 4.01099
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.98995
[BP] GO:0007268 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.94954
[BP] GO:0098916 None CHRM2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.94954
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 3.94733
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.946
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2, TBXAS1 3.9069
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PTGS2, SMAD3, TEK 3.87285
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.85857
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 3.83712
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.81981
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.79617
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79489
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.78281
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76297
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76297
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76297
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.76297
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.71499
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.67129
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 3.64625
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.60842
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.60842
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.60842
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.58861
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.56147
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.54853
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.53228
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.53228
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PTGS2, SMAD3, SRC, TEK, XDH 3.52632
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PTGS2, SRC 3.52148
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 3.51183
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.50283
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.50283
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.50283
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CHRM2, CNR1, CYP1B1, EGFR, ESR1, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.49594
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2 3.49594
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, SMAD3 3.4721
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 3.45469
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, SMAD3, SRC, TEK, XDH 3.44838
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PIK3CA, PIK3CB, SMAD3 3.42521
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP2, PTGS2, SMAD3, SRC, TEK 3.41889
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.41232
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, SMAD3 3.38425
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, SRC 3.37383
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.34887
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.34363
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, POLB, SRC, TEK 3.30053
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.30053
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.29452
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.2834
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.27788
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.27095
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.24177
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.23838
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 3.23838
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 3.23749
[BP] GO:0019371 None PTGS1, PTGS2, TBXAS1 3.22459
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.1888
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, HTR1B, KDR, PTGS2, SRC 3.1888
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B 3.16547
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 3.11856
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.10878
[BP] GO:0043549 regulation of kinase activity ADORA1, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, SRC, TEK 3.10574
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 3.06336
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 3.06336
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 3.05461
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.04051
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.02212
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.01458
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CB, SRC 3.0138
[BP] GO:0007208 None HTR2A, HTR2C 3.0138
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, SRC 2.9909
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, SRC, TEK 2.97741
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.97132
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.97132
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.96423
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, SRC, TYR 2.95718
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.957
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC 2.94927
[BP] GO:0007200 None CHRM2, ESR1, HTR2A, HTR2B, HTR2C 2.93872
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.93461
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.93461
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, SRC, XDH 2.93272
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PTGS1, PTGS2, SMAD3 2.92406
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2 2.90899
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, PIK3CB, PTGS2 2.90383
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.87704
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.86635
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.86584
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB, PTGS2 2.84826
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.83271
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 2.8216
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 2.81809
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, PTGS2, SMAD3, TEK 2.80435
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, POLA1, SMAD3 2.79024
[BP] GO:0007610 None BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, PTGS2 2.79024
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, SRC 2.77838
[BP] GO:0045859 regulation of protein kinase activity ADORA1, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, PIK3CA, PIK3CB, SRC 2.77763
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.77763
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.77763
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.77763
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 2.76161
[BP] GO:0033674 positive regulation of kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, SRC, TEK 2.74526
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.74274
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, BCL2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.74206
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.74206
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.70758
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.69751
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.68119
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, SRC 2.67427
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, PTGS2, SMAD3, SRC, TYR 2.67421
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 2.67108
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.66751
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, SRC, TEK 2.6621
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.65447
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.63801
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 2.63319
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, INSR, PTGS2, SRC, TEK 2.62164
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.62025
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, HTR1A, INSR, PTGS2, SMAD3 2.61642
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61566
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 2.61566
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CB, SRC 2.61566
[BP] GO:0050900 leukocyte migration CNR2, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.61566
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 2.61566
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.61566
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.5961
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.58558
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.58403
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.57381
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.57381
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.57239
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.56388
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HTR1A, HTR2A, HTR2C 2.55491
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, AXL, BCL2, CNR2, HTR1A, HTR2C, PIK3CA, PIK3CB, POLB, PTGS1, PTGS2, SRC 2.55491
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.55066
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.49282
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.49282
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.48988
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2, TBXAS1 2.48039
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.47992
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 2.47147
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47147
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47147
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.46816
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, SMAD3, TEK 2.45238
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B 2.44652
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.44357
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, SRC 2.44319
[BP] GO:0009653 anatomical structure morphogenesis AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, HTR2B, INSR, MET, MMP2, POLB, SMAD3, SRC, TEK 2.43417
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PTGS2, SMAD3, SRC, TEK, TYR, XDH 2.4337
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.42042
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.42042
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, FABP4, KDR, MET, PTGS2, SMAD3 2.41992
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.41373
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.41164
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA 2.41164
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.41105
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.40908
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, PTGS2, TYR 2.40204
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, SMAD3, SRC, TEK, XDH 2.39632
[BP] GO:0051051 negative regulation of transport ADORA1, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PTGS2 2.39265
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, SRC 2.38271
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B 2.38195
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.37696
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.37696
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, EGFR, HSPA1A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.37696
[BP] GO:0038171 None CNR1, CNR2 2.37694
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37694
[BP] GO:0014827 None HTR1D, HTR2B 2.37694
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PTGS2 2.37635
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.3711
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 2.35913
[BP] GO:0055074 calcium ion homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.33802
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, HTR5A, PTGS2 2.33463
[BP] GO:0051894 None KDR, SMAD3, TEK 2.33463
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.33463
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.33463
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC 2.32801
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HSPA1A, MMP2, PIK3CA, PIK3CB, SMAD3, SRC 2.31314
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.30733
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, PIK3CA, PIK3CB, SRC 2.29828
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.27508
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, EGFR, GPR35, HTR2A, HTR2C, PTGS2, SMAD3 2.2695
[BP] GO:0006928 movement of cell or subcellular component AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.25001
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, POLA1, SMAD3, SRC 2.24507
[BP] GO:1903393 None KDR, SMAD3, TEK 2.24165
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.23527
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.20847
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HTR1A, TYR 2.20355
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.19245
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.19245
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.19245
[BP] GO:0071502 None HTR1B, HTR2B 2.19245
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.17299
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.15764
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SMAD3, SRC 2.13288
[BP] GO:0055065 metal ion homeostasis BCL2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 2.13164
[BP] GO:0051094 positive regulation of developmental process AXL, BCL2, CA2, CNR1, CYP1B1, HTR2A, HTR2C, INSR, KDR, PIM1, PTGS2, SMAD3, SRC, TEK 2.12604
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, SMAD3, SRC, TEK, XDH 2.12137
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, SRC 2.12137
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.12115
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.12115
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.11055
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.10145
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, SRC 2.0999
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, EGFR, HTR2B, INSR, PTGS2, SMAD3, SRC 2.09918
[BP] GO:0051952 None ADORA1, CNR1, HTR1B, HTR2A 2.09918
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.09918
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.08894
[BP] GO:0002209 None BCL2, HTR1A, HTR2C 2.08894
[BP] GO:0001662 None BCL2, HTR1A, HTR2C 2.08894
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.08894
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.08894
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PTGS2, SMAD3, SRC, TEK, XDH 2.07909
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PTGS2, SMAD3, SRC, XDH 2.0784
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.0665
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, TYR 2.06493
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05426
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05426
[BP] GO:0045777 None ADORA1, CNR1, HSD11B2 2.05426
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.05276
[BP] GO:0014831 None HTR1D, HTR2B 2.05276
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.05276
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 2.04727
[BP] GO:1901570 None ALOX15, ALOX5, PTGS1, PTGS2 2.03076
[BP] GO:0042596 None BCL2, HTR1A, HTR2C 2.01815
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, MET, PIK3CA, PIK3CB 2.01402
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.01293
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SMAD3, SRC 2.01091
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.9995
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.60521
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC, TBXAS1, TEK, TYR 7.53789
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR 7.36789
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DUSP3, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, SRC, TEK 7.36789
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, SMAD3, SRC, TEK 7.34279
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TBXAS1, TEK, TYR 3.40527
[CC] GO:0045121 membrane raft CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.08052
[CC] GO:0098857 membrane microdomain CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.06336
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TBXAS1, TEK, TYR 2.74274
[CC] GO:0098589 membrane region CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.593
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, CNR1, EGFR, HTR2A, INSR, MET, PTGS2, SRC, TEK 2.57026
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.47147
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, TBXAS1 2.25809
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.19245
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM2, CNR1, CNR2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2, SRC, TEK 2.00026
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0901
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 17.0901
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.9018
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.9018
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8282
[MF] GO:0008227 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.5433
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 11.7489
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.3605
[MF] GO:0030594 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.1816
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.89983
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 9.29519
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 9.29519
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 9.29519
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 8.7758
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.29487
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 8.26346
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SMAD3, TEK 8.13508
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, EGFR, ESR1, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.9995
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX15, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SRC, TBXAS1, TEK, TYR, XDH 7.9995
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.60521
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, SMAD3, TBXAS1, TYR, XDH 7.39314
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.85579
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.69295
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, TBXAS1, TYR, XDH 6.69295
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.70195
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 5.70195
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.50205
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.46373
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.43393
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.21656
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.12107
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.07996
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.9436
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TEK 4.89884
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.89752
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.8247
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.81262
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.38514
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.14897
[MF] GO:1901363 heterocyclic compound binding ADORA1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, XDH 4.03135
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.89318
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.86272
[MF] GO:0097159 organic cyclic compound binding ADORA1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, SRC, TBXAS1, TEK, XDH 3.76297
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.66672
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, XDH 3.63959
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.60842
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.50267
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.47671
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.40527
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 3.10666
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, XDH 3.08491
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TEK, XDH 3.08328
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.0138
[MF] GO:0003845 None HSD11B1, HSD11B2 3.0138
[MF] GO:0071886 None HTR2A, HTR2C 3.0138
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.83271
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.61566
[MF] GO:0004949 None CNR1, CNR2 2.61566
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.56388
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, PIM1, SMAD3, SRC 2.53667
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.45994
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.39868
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.3711
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.33933
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.29793
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.249
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.24165
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.23279
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.19671
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP9, SMAD3, SRC 2.19512
[MF] GO:0043559 insulin binding IGF1R, INSR 2.19245
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.12957
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, SMAD3 2.12278
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12115
[MF] GO:0104005 hijacked molecular function AXL, EGFR, HSPA1A, HTR2A 2.09918
[MF] GO:0001618 virus receptor activity AXL, EGFR, HSPA1A, HTR2A 2.09918
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PTGS1, PTGS2, SMAD3, TBXAS1, TYR, XDH 2.07714
[MF] GO:0043168 anion binding ALOX15, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.05574


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 17.2642
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 14.3118
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.2753
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.1159
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.6096
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, HTR4 7.4299
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.4299
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 7.4299
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 7.3136
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 6.817
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4, EGFR 6.817
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.166
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.0046
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.0103
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 5.5535
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 6.1023
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, FUT7, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.1383
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.3513
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB 4.9759
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 5.0318
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.5535
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7891
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.7228
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.2984
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 4.7731
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.39
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5334
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.6413
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.218
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8164
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 4.1545
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.7162
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, EGFR 4.1651
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.2761
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.6135
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.5784
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.5902
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.1309
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6944
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.5261
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 3.045
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.377
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.585
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.5105
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.1722
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.7089
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 4.2761
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.1204
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7662
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.0087
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2672
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.1309
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB, EGFR 2.6264
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.3694
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6828
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6828
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.4895
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.6242
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.4274
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.4184
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.2971
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1057
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.9462
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, PIK3CB 1.6343
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6073
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, IGF1R 2.0009
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.631
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0735
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9702
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.786
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB 1.8952
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, EGFR 1.6753
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, INSR, PIK3CB 1.6343
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB 1.5585
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5766
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3198
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.406
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.9462
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0529
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3777
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.3203
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.0545
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4193
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3495
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9147
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.4402
Axon guidance_Homo sapiens_hsa04360 MET 0.4349
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9326
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4402
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.821
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9069
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.945
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.797
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7926
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.42
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4932
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1033
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5079
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1138
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5207
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1792
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5198
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.1357
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1427
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.1322
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5336
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5399
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3959
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5399
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2005
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5511
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5388
Peroxisome_Homo sapiens_hsa04146 XDH 0.5525
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.6788
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.384
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.6064
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5916
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5776
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5896
Bile secretion_Homo sapiens_hsa04976 CA2 0.5989
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.358
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6068
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.406
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.7506
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6265
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3758
Shigellosis_Homo sapiens_hsa05131 SRC 0.6265
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6265
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6478
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6509
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4332
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4936
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6751
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7016
Malaria_Homo sapiens_hsa05144 MET 0.7142
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7272
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.969
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7324
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.691
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8216
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8658
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8564
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8216
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9055
DNA replication_Homo sapiens_hsa03030 POLA1 0.821
Base excision repair_Homo sapiens_hsa03410 POLB 0.838
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8471
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.821
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9094
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 2.0237
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9055
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1994
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1357
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.377


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)