TCM Prescription: Qing Re Jie Du Granules



Prescription Description
Prescription IDTCMF5540
Pinyin NameQing Re Jie Du Ke Li
Chinese Name清热解毒颗粒
English NameQing Re Jie Du Granules
Function Description感冒, 风温, 痄腮
IndicationsCommon cold disorder, Common cold, Mumps
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
1D80 [Mumps, 腮腺炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1997 Bubalus bubalis 水牛角 TCMH1997 GBMA0080-06
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1127 Lonicera japonica 金银花 TCMH1127 ITSAI3881-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH381 Isatis indigotica 大青叶 TCMH381 KJ765825
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1333 Human rhinovirus 1A
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AR, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, MAOB, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TYR 9.54016
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, F3, FABP3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 9.16717
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GSK3B, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 9.16717
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GSK3B, HCAR2, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 9.16717
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 9.13344
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MAOB, MMP2, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TYR 9.13344
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, FABP3, FUT7, IDO1, NR1H4, PDE5A, PIM1, PPARA, PTGS2, TYR, XDH 9.00547
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD17B1, HSD17B2, KDR, MAOB, MET, NR1H4, PPARA, PTGS2, SRC, THRA, THRB, XDH 8.89628
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 8.19546
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, NR1H4, PPARA, PTGS2 7.93066
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 7.87567
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MAOB, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, RORC, SRC, TYR 7.87567
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 7.55589
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, F3, FABP3, FLT3, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PDE5A, PGR, PIM1, PTGS2, SRC, XDH 7.17435
[BP] GO:0033993 response to lipid AR, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, IDO1, MAOB, NR1H4, NR3C1, PTGS2, RORC, SRC, TYR 7.17435
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC, THRA, XDH 7.17435
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, THRA, XDH 7.01039
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, CA2, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, GSK3B, IGF1R, MAOB, MMP2, NR1H4, NR3C1, PPARA, PTGS2, SRC 6.96334
[BP] GO:0009755 hormone-mediated signaling pathway AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, SRC, THRA, THRB 6.96334
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 6.82527
[BP] GO:0030522 intracellular receptor signaling pathway AR, NR1H4, NR3C1, PGR, PIM1, PPARA, RORC, SRC, THRA, THRB 6.82527
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, GSK3B, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, THRA 6.67892
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, HSD17B2, NR1H4 6.64614
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, DRD1, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 6.50477
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DAO, DHFR, DRD1, MAOB, NR1H4, TYR 6.47737
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC, THRA, XDH 6.44244
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC 6.44244
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 6.41676
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 6.41676
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, F3, FLT3, GSK3B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 6.41244
[BP] GO:0014070 response to organic cyclic compound APP, AR, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FLT3, MAOB, NR3C1, PTGS2, RORC, SRC, TYR 6.41244
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MET, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC 6.22165
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, FABP3, FABP4, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 6.22165
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 6.16845
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HCAR2, NR1H4, PPARA, PTGS2, RORC, SRC, THRA 6.15714
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, DHFR 6.1553
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, F3, FABP4, HSD17B2, IDO1, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, THRA, THRB, TYR 6.10367
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, DRD1, F3, FABP3, FLT3, GSK3B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 6.09247
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 6.06818
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 6.06818
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, NR1H4, NR3C1, PTGS2, RORC, SRC 5.89042
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, F3, FABP4, FLT3, GSK3B, IDO1, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 5.79855
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, APP, AR, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, NR1H4, NR3C1, PTGS2, RORC, SRC 5.76265
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 5.7623
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, THRA, XDH 5.74057
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.69582
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 5.69582
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HCAR2, HSD17B1, HSD17B2, NR1H4 5.63971
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, THRA, XDH 5.63971
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CYP1B1, F3, FLT3, KDR, MET, PDE5A, PTGS2, PTPN1, SRC, XDH 5.61407
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GSK3B, IDO1, IGF1R, KDR, MMP9, NR1H4, PIM1, PTGS2, PTPN1, SRC 5.59135
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, IDO1, MAOB 5.50506
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, DRD1, F3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PDE5A, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 5.49611
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, DRD1, GSK3B, IGF1R, MMP2, MMP9, NR1H4, NR3C1, PTGS2, RORC, SRC 5.47394
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.39937
[BP] GO:0006352 DNA-templated transcription, initiation AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.2921
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, IGF1R, KDR, MET, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 5.24545
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP4, FLT3, FUT7, GSK3B, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SRC, THRA, THRB, TYR 5.1653
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, MAOB, MMP12, MMP2, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, TYR 5.04224
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP3, FLT3, KDR, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 4.9573
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP3, FLT3, KDR, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, XDH 4.9573
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.86234
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, APP, CYP19A1, DHFR, F3, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, SRC, XDH 4.66297
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GSK3B, IGF1R, MET, MMP9, NR1H4, PIM1, PPARA, PTGS2, PTPN1, SRC 4.61409
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, DRD1, FABP3, FLT3, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TYR 4.61409
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, F3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, NR1H4, PDE5A, PPARA, PTGS2, PTPN1, SRC, THRA, XDH 4.5907
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.54049
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.49958
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AR, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, MAOB, NR3C1, PPARA, PTGS2, SRC 4.48984
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FLT3, GSK3B, HSD17B2, KDR, MAOB, MMP9, PGR, PIM1, PPARA, PTGS2, RORC, SRC, THRA, TYR 4.47628
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, HSD17B2, IDO1, MMP2, MMP9, PGR, PTGS2, SRC, THRA, THRB 4.45872
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ADRA2C, APP, AXL, CA2, CA7, CYP19A1, DRD1, GSK3B, HCAR2, MAOB, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, THRA 4.45614
[BP] GO:0071407 cellular response to organic cyclic compound APP, AR, CYP1A1, CYP1B1, DRD1, FLT3, NR3C1, PTGS2, RORC, SRC 4.44329
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, HCAR2, IDO1, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTGS2, SRC 4.39463
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, APP, AR, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP2, MMP9, NR1H4, NR3C1, PTGS2, PTPN1, RORC, SRC 4.3923
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 4.35634
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, APP, AR, DRD1, FLT3, GSK3B, IGF1R, MMP2, NR1H4, NR3C1, PTGS2, SRC 4.35634
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, ADRA2C, APP, CA2, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 4.33173
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, DRD1, FABP3, FLT3, GSK3B, IGF1R, MMP2, NR1H4, PPARA, PTGS2, SRC, TYR 4.27789
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, NR1H4, PDE5A, PPARA, PTGS2, PTPN1, SRC, XDH 4.2775
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 4.27337
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MET, PPARA, PTGS2 4.23789
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, NR1H4, PDE5A, PPARA, PTGS2, PTPN1, SRC, XDH 4.23623
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, HCAR2, KDR, NR1H4, PTGS2, SRC 4.23623
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 4.16046
[BP] GO:0007617 None APP, DRD1, THRA, THRB 4.15535
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DAO, DHFR, DRD1, F3, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, PDE5A, PIM1, PPARA, PTGS2, PTPN1, SRC, TYR, XDH 4.14051
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 4.08071
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, KDR, PDE5A, PTPN1, SRC, XDH 3.94911
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, F3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 3.93683
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA, THRA 3.91997
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.91997
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.91997
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 3.91311
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, XDH 3.91311
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, APP, CYP19A1, CYP1B1, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.91311
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 3.86984
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.8608
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, NR1H4, PTGS2, SRC 3.8535
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, F3, FLT3, GSK3B, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTPN1, RORC, SRC, THRA, THRB 3.83866
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, GSK3B, HCAR2, IDO1, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PIM1, PTGS2, SRC, THRA, THRB, XDH 3.80817
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.79722
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.79722
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.78308
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.77587
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, FUT7, GSK3B, IDO1, MAOB, PDE5A, XDH 3.74992
[BP] GO:0045932 None ADORA1, ADRA2C, PDE5A, PTGS2 3.7417
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, DRD1, PGR, PTGS2, SRC, THRA, THRB 3.71775
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, DRD1, F3, FABP4, FLT3, GSK3B, IGF1R, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.71209
[BP] GO:0030335 positive regulation of cell migration ADRA2A, APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.69688
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, FLT3, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.67796
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, F3, FABP4, FLT3, GSK3B, IGF1R, MET, MMP9, NR1H4, PDE5A, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 3.67542
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.67316
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 3.65396
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, APP, AXL, CA2, CYP19A1, DRD1, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, SRC 3.60186
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.59708
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DAO, DHFR, FABP3, IDO1, NR1H4, PIM1, PPARA, PTGS2, TYR 3.59708
[BP] GO:2000147 positive regulation of cell motility ADRA2A, APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.58462
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, DRD1, MAOB 3.57586
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ADRA2C, AR, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 3.54439
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ADRA2C, AR, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, NR1H4, PTGS2, PTPN1, SRC, XDH 3.52962
[BP] GO:0019098 None APP, DRD1, THRA, THRB 3.52517
[BP] GO:0007176 None ADORA1, ADRA2A, ADRA2C, APP 3.52517
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.50012
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.50012
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, FLT3, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.50012
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, PTGS2 3.48024
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ADRA2C, APP, AR, FLT3, IGF1R, KDR, PDE5A, PTPN1, SRC, XDH 3.47213
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, NR1H4, PPARA, PTGS2, SRC 3.4489
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, NR1H4, PPARA, PTGS2 3.4489
[BP] GO:0032496 response to lipopolysaccharide AXL, CYP1A1, CYP1A2, IDO1, MAOB, NR1H4, PTGS2, SRC 3.43821
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, PTGS2, SRC 3.38477
[BP] GO:0040017 positive regulation of locomotion ADRA2A, APP, DRD1, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.38477
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, DHFR, DRD1, FABP3, KDR, MAOB, NR3C1, PTGS2, SRC 3.37969
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, ADRA2C, PDE5A, PTGS2, THRA, THRB 3.35699
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, APP, AR, CSNK2A1, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.33367
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, ADRA2C, APP, GSK3B, MAOB, MMP9, NR1H4, PTGS2, THRA 3.33227
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33219
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, THRA, TYR 3.32379
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, PDE5A, PTGS2, PTPN1, SRC, THRA, XDH 3.32379
[BP] GO:0061097 None ADORA1, ADRA2A, ADRA2C, APP, PTPN1 3.31769
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 3.31769
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 3.30144
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, GSK3B, IGF1R, MMP2, NR1H4, PTGS2, SRC 3.26936
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FABP3, FABP4, FLT3, FUT7, GSK3B, HCAR2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 3.26756
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, FABP3, FABP4, GSK3B, IDO1, MAOB, PDE5A, SRC, XDH 3.26756
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 3.26756
[BP] GO:0002237 response to molecule of bacterial origin AXL, CYP1A1, CYP1A2, IDO1, MAOB, NR1H4, PTGS2, SRC 3.26756
[BP] GO:0018958 None AKR1B1, DAO, DRD1, MAOB, TYR 3.22425
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 3.16992
[BP] GO:0045742 None ADORA1, ADRA2A, ADRA2C, MMP9 3.16992
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, APP, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 3.15349
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, F3, FABP4, IDO1, KDR, MET, MMP12, NR1H4, PPARA, PTGS2 3.15015
[BP] GO:0048545 response to steroid hormone AR, CA2, FLT3, MAOB, NR3C1, PTGS2, SRC 3.14333
[BP] GO:0045741 None ADORA1, ADRA2A, ADRA2C 3.11595
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA 3.10559
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 3.10559
[BP] GO:1901186 None ADORA1, ADRA2A, ADRA2C, MMP9 3.0947
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PDE5A, PIM1, PTGS2, PTPN1, SRC, XDH 3.09296
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, HCAR2, NR1H4, PTGS2 3.06951
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGS2 3.06573
[BP] GO:0051094 positive regulation of developmental process ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, IDO1, KDR, NR1H4, PDE5A, PIM1, PTGS2, SRC, THRA 3.05504
[BP] GO:0042058 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 3.05123
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, GSK3B, IGF1R, MMP2, NR1H4, PTGS2, SRC 3.0406
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.02707
[BP] GO:0050730 None ADORA1, ADRA2A, ADRA2C, APP, FLT3, PTPN1, SRC 3.02042
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, CSNK2A1, F3, FLT3, GSK3B, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 3.01604
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, FABP3, IGF1R, KDR, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, THRA, THRB 2.99556
[BP] GO:0008050 None THRA, THRB 2.9742
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.97223
[BP] GO:0003018 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2, SRC 2.97223
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, APP, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, PTPN1, SRC, THRA 2.96995
[BP] GO:0006584 None AKR1B1, DAO, DRD1, MAOB 2.96064
[BP] GO:0009712 None AKR1B1, DAO, DRD1, MAOB 2.96064
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.96064
[BP] GO:0061098 None ADORA1, ADRA2A, ADRA2C, PTPN1 2.96064
[BP] GO:0048869 cellular developmental process ACHE, APP, AR, AXL, CBR1, CDC25B, CYP1A1, DRD1, FABP4, FLT3, FUT7, GSK3B, KDR, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC, THRA, THRB 2.90964
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, CYP19A1, DRD1, GSK3B, IGF1R, MET, MMP12, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, XDH 2.88105
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CYP19A1, CYP3A4, DAO, DHFR, TYR 2.88105
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 2.88105
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP3A4, DAO, IDO1, MAOB, PDE5A, XDH 2.87195
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, IGF1R, MET, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.87195
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FLT3, FUT7, GSK3B, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 2.8595
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DRD1, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.8595
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PDE5A, PIM1, PTGS2, PTPN1, SRC, XDH 2.8595
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, MMP2, PPARA, PTGS2, SRC, THRA, TYR 2.84742
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC 2.83768
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, FABP4, GSK3B, IGF1R, KDR, MMP12, MMP9, NR1H4, NR3C1, PGR, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.80713
[BP] GO:1901184 None ADORA1, ADRA2A, ADRA2C, APP, MMP9 2.80705
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, FABP4, FLT3, GSK3B, IGF1R, PDE5A, PTPN1, SRC 2.80042
[BP] GO:0045986 None ADORA1, ADRA2C, PTGS2 2.79222
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 2.79149
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, F3, FLT3, GSK3B, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 2.7508
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, ADRA2C, FLT3, PTPN1, SRC 2.74975
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, FABP3, FABP4, FLT3, MET, NR1H4, SRC 2.73868
[BP] GO:1901654 None AKR1B1, AR, CSNK2A1, MAOB, NR3C1, SRC 2.6835
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, FLT3, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 2.67571
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.66202
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, CDC25B, DHFR, F3, FLT3, GSK3B, MET, MMP9, PDE5A, PTPN1, SRC, XDH 2.66022
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.64792
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.59226
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.59039
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, DRD1, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 2.5882
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.57959
[BP] GO:0060748 None AR, PGR 2.57959
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57959
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, FABP3, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, THRA, THRB 2.5704
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.56532
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP3A4, DAO, MAOB 2.55746
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.55746
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, GSK3B, PGR, PPARA, RORC, SRC 2.53896
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, FABP4, IDO1, MMP12, MMP2, NR1H4, PPARA, PTGS2, PTPN1, SRC 2.5025
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, IGF1R, PDE5A, PTPN1, SRC 2.49416
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, ADRA2C, HCAR2, PDE5A, PTGS2, THRA, THRB 2.48671
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.47787
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.47787
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, KDR, MAOB, SRC 2.46659
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.42175
[BP] GO:0097746 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2 2.4056
[BP] GO:0035296 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2 2.4056
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.40355
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, DRD1, PTGS2 2.40355
[BP] GO:0003013 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2, SRC 2.39953
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.39693
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.39693
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.39254
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1, HSD17B2 2.38357
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, PTGS2 2.38114
[BP] GO:0051953 None ADORA1, ADRA2A, ADRA2C 2.38114
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.38114
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, KDR, SRC 2.37704
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.3621
[BP] GO:0006940 None ADORA1, ADRA2A, ADRA2C, PTGS2 2.3621
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.36075
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, NR1H4, PPARA 2.36075
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, ADRA2C, APP, AR, CDC25B, CSNK2A1, DHFR, DRD1, F3, FABP4, FLT3, GSK3B, IGF1R, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, XDH 2.35716
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.35508
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, ADRA2C, CYP19A1, HCAR2, MAOB, MMP12, NR1H4, SRC 2.35372
[BP] GO:0035625 None ADRA2A, ADRA2C 2.34813
[BP] GO:0032811 None ADRA2A, ADRA2C 2.34813
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34813
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34813
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.33346
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD17B1, HSD17B2, PTGS2 2.33002
[BP] GO:0051172 None ADRA2A, APP, AR, AURKB, CSNK2A1, DHFR, FABP4, IGF1R, MMP12, MMP9, NR1H4, NR3C1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.32866
[BP] GO:0050880 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2 2.32065
[BP] GO:0035150 None ADORA1, ADRA2A, ADRA2C, DRD1, PTGS2 2.30653
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.28843
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, ADRA2C, APP, CDC25B, FABP4, FLT3, IGF1R, PDE5A, PTPN1, SRC 2.27405
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, PDE5A, PTGS2, XDH 2.26762
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS2 2.25792
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.25749
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, IGF1R, MET, MMP12, NR1H4, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, THRA, THRB 2.25166
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, NR1H4, SRC 2.22598
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.21308
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.20815
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, MAOB, MMP9, PTGS2 2.2062
[BP] GO:1901360 None ACHE, AKR1B1, AKR1B10, APP, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, HSD17B1, HSD17B2, IDO1, MAOB, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PPARA, PTGS2, RORC, THRA, THRB, TYR, XDH 2.20385
[BP] GO:0071383 None AR, FLT3, NR3C1, SRC 2.18921
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, ADRA2C, HCAR2, MMP12, NR1H4, SRC 2.18666
[BP] GO:0042417 None DAO, DRD1, MAOB 2.17444
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, CYP19A1, CYP1A2, GSK3B, IDO1, MAOB, XDH 2.17336
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, NR1H4, SRC 2.16938
[BP] GO:0035624 None ADRA2A, ADRA2C 2.16938
[BP] GO:0010641 None F3, SRC 2.16938
[BP] GO:0060509 None THRA, THRB 2.16938
[BP] GO:0014060 None ADRA2A, ADRA2C 2.16938
[BP] GO:0051952 None ADORA1, ADRA2A, ADRA2C, DRD1 2.15891
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.15891
[BP] GO:0060341 regulation of cellular localization ADRA2A, APP, AR, CSNK2A1, DRD1, GSK3B, NR1H4, PTGS2, PTPN1, SRC, THRA 2.15701
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, IGF1R, PDE5A, PTPN1, SRC 2.15484
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, GSK3B, IDO1, MMP2, MMP9, NR1H4, PPARA, PTGS2, PTPN1, SRC, THRA 2.14992
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, ADRA2C, CYP19A1, HCAR2, MAOB, MMP12, NR1H4, SRC 2.14992
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.14703
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 2.13772
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 2.13772
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.13516
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, NR3C1, PGR, SRC 2.12679
[BP] GO:0010629 None APP, AR, AURKB, DHFR, FABP4, KDR, MMP12, NR1H4, NR3C1, PGR, PPARA, RORC, SRC, THRA, THRB, XDH 2.12067
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.11238
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.11238
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.1117
[BP] GO:0070542 None FABP3, NR1H4, PTGS2, SRC 2.09301
[BP] GO:0045833 None ADORA1, ADRA2A, HCAR2, NR1H4 2.09301
[BP] GO:0043065 positive regulation of apoptotic process CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.08054
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, APP, CA2, CA7, DRD1, MAOB, MMP9, PTGS2 2.07836
[BP] GO:1901655 None AKR1B1, AR, NR3C1, SRC 2.07836
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.07836
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, ADRA2C, APP, AURKB, CDC25B, DHFR, F3, FLT3, GSK3B, PDE5A, PTPN1, SRC, XDH 2.07672
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.06123
[BP] GO:0031960 response to corticosteroid FLT3, MAOB, NR3C1, PTGS2, SRC 2.06123
[BP] GO:0071396 cellular response to lipid AR, AXL, FLT3, NR1H4, NR3C1, RORC, SRC 2.06061
[BP] GO:0043068 positive regulation of programmed cell death CYP1B1, F3, GSK3B, HCAR2, IDO1, MMP9, PTGS2, SRC, XDH 2.05967
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, GSK3B, HCAR2, MMP12, NR1H4, PTGS2, SRC 2.04961
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.04961
[BP] GO:2000273 None ADORA1, ADRA2A, ADRA2C 2.04961
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, PTGS2 2.04961
[BP] GO:0045924 None THRA, THRB 2.04355
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.04355
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.04355
[BP] GO:0050793 regulation of developmental process ADRA2C, APP, AR, AXL, CA2, CYP1B1, F3, GSK3B, IDO1, KDR, NR1H4, PDE5A, PIM1, PPARA, PTGS2, RORC, SRC, THRA, XDH 2.02362
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.0203
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, DRD1, MAOB, PTGS2 2.00968
[BP] GO:0002793 None ACHE, ADORA1, HCAR2, MMP12, NR1H4, SRC 2.00968
[BP] GO:0006937 None ADORA1, ADRA2A, ADRA2C, PDE5A, PTGS2 2.00704
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.00545
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HCAR2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.00259
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA2C, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, KDR, MAOB, MMP2, MMP9, NR3C1, NR3C2, PDE5A, PGR, PIM1, PTGS2, PTPN1, SRC, THRA, TYR, XDH 2.7729
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, DAO, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, NR3C1, NR3C2, PDE5A, PGR, PIM1, PTPN1, SRC, THRA, TYR, XDH 2.21308
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04355
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.83555
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ADRA2C, ALOX5, APP, AR, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DRD1, F3, FLT3, FUT7, GSK3B, HCAR2, HSD17B2, IGF1R, KDR, MAOB, MET, MMP2, NR3C2, PGR, PIM1, PTGS2, PTPN1, SRC, TYR 1.72667
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, THRA, THRB, TYR, XDH 15.4026
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, TYR, XDH 11.4751
[MF] GO:0003707 steroid hormone receptor activity AR, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 9.16717
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.15545
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, THRA, THRB 8.14912
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HSD17B1, HSD17B2, IDO1, MAOB, PTGS2, TYR, XDH 7.94522
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, F3, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PTGS2, PTPN1, SRC, TYR, XDH 7.81957
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 6.82746
[MF] GO:0004879 nuclear receptor activity AR, NR1H4, PGR, PPARA, RORC, THRA, THRB 6.82746
[MF] GO:0005496 steroid binding AR, CYP3A4, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, RORC 6.67892
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, IDO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, THRA, THRB, TYR, XDH 6.44244
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 6.41244
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, HSD17B1, IDO1, MAOB, PTGS2, SRC, XDH 5.85529
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.62967
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 5.60167
[MF] GO:0046872 metal ion binding ALOX5, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, MMP1, MMP12, MMP2, MMP9, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, THRA, THRB, TYR, XDH 5.59135
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.52603
[MF] GO:0042562 hormone binding ACHE, AR, HSD17B1, IGF1R, NR3C1, THRA, THRB 5.50506
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 5.45053
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 5.40031
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.2921
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.21952
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, ADRA2C, AR, AXL, DRD1, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC, THRA, THRB 4.99737
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.4749
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, F3, FABP3, FABP4, HSD17B1, NR1H4, NR3C1, NR3C2, PGR, PPARA, RORC 4.39463
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.19842
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.94911
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TYR 3.9309
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, ADRA2C, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, DRD1, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MAOB, MET, MMP12, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 3.92284
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 3.86984
[MF] GO:0004887 None NR1H4, THRA, THRB 3.75731
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.75537
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, MAOB, XDH 3.71184
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.62146
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, THRA 3.50221
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.46039
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.24345
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.19925
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC, THRA 3.10559
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DAO, DHFR, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, MAOB, MET, MMP12, NR1H4, NR3C1, NR3C2, PDE5A, PGR, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, THRA, THRB, XDH 2.85917
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.64984
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.61323
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57959
[MF] GO:0004938 None ADRA2A, ADRA2C 2.57959
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD1 2.5338
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.47804
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC 2.47579
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, DAO, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, MAOB, MET, NR1H4, PDE5A, PIM1, SRC, XDH 2.43756
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.34813
[MF] GO:0032795 None ADORA1, ADRA2A 2.34813
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.34813
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, DAO, DHFR, F3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, MAOB, MET, NR1H4, PDE5A, PIM1, SRC, XDH 2.29852
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.25749
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.21308
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.16938
[MF] GO:0019899 enzyme binding ADRA2A, APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP3A4, F3, GSK3B, MET, NR3C1, PGR, PPARA, PTGS2, PTPN1, SRC, THRB 2.11367
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.07836
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.04961
[MF] GO:0004936 None ADRA2A, ADRA2C 2.04355
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04355
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, ADRA2C, APP, CSNK2A1, FLT3, IGF1R, KDR, MAOB, MET, MMP9, PGR, PTGS2, TYR, XDH 2.04009


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.4409
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.6189
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.2337
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, DHFR, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH, IDO1 6.1188
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1, IDO1 5.3855
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.3269
Pathways in cancer_Homo sapiens_hsa05200 AR, GSK3B, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, IGF1R 4.3098
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 THRB, THRA, ADORA3, ADORA1, DRD1, NR3C1, ADRA2C, ADRA2A 4.3633
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.3098
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.3098
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3431
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0043
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A, ADRA2C, ADRA2A 2.8035
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1738
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 2.564
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 2.501
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOB, ALOX5, PTGS2 2.501
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, THRB, THRA, SRC 2.4395
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.2227
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.3101
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2 2.2223
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.1819
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, CYP3A4 2.1252
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, PPARA 1.7983
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, IGF1R 1.8752
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9129
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.7953
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.7983
Bile secretion_Homo sapiens_hsa04976 CA2, NR1H4, CYP3A4 2.1071
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7983
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7783
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.7486
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5571
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.637
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B, MAOB, DRD1 1.6012
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KDR, MET, IGF1R 1.2568
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1177
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.2887
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9821
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2585
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.1343
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.2568
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1207
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2887
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3948
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.0672
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.0061
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1207
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2852
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 1.1327
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2066
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1643
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.1177
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3754
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9646
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1 0.8993
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9714
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.9104
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDC25B 0.9458
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.9337
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.8952
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 0.8952
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8798
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.8952
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8952
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.8674
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.8422
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1 0.7093
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1 1.5017
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7883
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8125
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1 0.7812
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOB 1.4943
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.2569
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2571
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.7592
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.306
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3161
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3455
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.3512
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3515
Influenza A_Homo sapiens_hsa05164 GSK3B 0.3539
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3846
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3922
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.4145
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5449
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.434
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7953
Platelet activation_Homo sapiens_hsa04611 SRC 0.4578
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4554
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.4603
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9129
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.7983
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4816
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4629
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.502
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5057
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.502
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5096
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5141
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5139
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5057
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5137
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5267
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5275
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5275
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOB 1.6317
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.712
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5286
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5271
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.5795
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5571
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5795
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5782
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5877
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6084
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6066
Glioma_Homo sapiens_hsa05214 IGF1R 0.6084
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.765
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6994
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6084
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6142
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6084
Shigellosis_Homo sapiens_hsa05131 SRC 0.6084
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6084
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.6621
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6442
Malaria_Homo sapiens_hsa05144 MET 0.677
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.6735
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.7592
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.7883
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8254
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8726
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8339
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8674
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8952
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0269
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.9314
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9714
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.0311


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)