TCM Prescription: Qing Jin Zhi Sou Xi Gua Ointment



Prescription Description
Prescription IDTCMF5348
Pinyin NameQing Jin Zhi Sou Xi Gua Gao
Chinese Name清金止嗽西瓜膏
English NameQing Jin Zhi Sou Xi Gua Ointment
Function Description咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2221 Citrullus vulgaris 西瓜 TCMH2221
TCMH2722 Perilla frutescens var. arguta 紫苏叶 TCMH2722 ITSAF2620-14
TCMH1219 Semen armeniacae amarum 苦杏仁 TCMH1219
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH1398 Ephedra sinica 麻黄 TCMH1398 ITSAM882-14
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH2629 Cortex mori radicis praeparata 桑白皮 TCMH2629
TCMH706 Trichosanthes kirilowii 瓜蒌皮 TCMH706 ITSAO4359-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH1617 Eriobotrya japonica thunb 枇杷叶 TCMH1617 ITSAN1970-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH1677 Pinellia ternata 清半夏 TCMH1677 GBVT1123-13, GBVY1693-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH1223 Tussilago farfara 款冬花 TCMH1223 ITSAH4326-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH925 Exocarpium citri grandis 化橘红 TCMH925
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH176 Daucus carota var. sativa 卞萝卜 TCMH176 WAT221-12
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, KDR, MAOA, MET, MIF, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, POLA1, POLB, PPARA, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 15.048
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PTGES, RORC, SRC, TRPV1, TYR 15.048
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PTGES, RORC, SRC, TRPV1, TYR 13.0939
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1 13.0939
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, MIF, PDE3A, PPARA, PTGES, TBXAS1, TRPV1 11.6583
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HTR2A, IGF1R, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLB, PPARA, PTGES, RORC, SRC, TRPV1, TYR 11.527
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 11.3717
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, OPRK1, OPRM1, PDE3A, PTGES, RORC, SRC, TRPV1, TYR 10.8975
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR7, OPRD1, OPRK1, OPRM1 10.2983
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, OPRK1, OPRM1, PTGES, RORC, SRC, TYR 10.0548
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLB, PPARA, PTGES, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2, TRPV1 9.86503
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.93966
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 8.93352
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 8.93352
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, NR3C1, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1 8.27748
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, HSD11B2, HTR2A, KDR, NR3C1, OPRK1, OPRM1, PDE3A, POLB, SRC, TRPV1 8.27748
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, TYR 8.13849
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR2A 8.06986
[BP] GO:0007268 None CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 8.05929
[BP] GO:0098916 None CHRM2, DRD1, DRD2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 8.05929
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FUT7, GBA2, MIF, PDE10A, PDE3A, PDE3B, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.04115
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1 7.94298
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.93512
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A 7.93512
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.66373
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 7.62672
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, MTNR1B, OPRK1 7.61906
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 7.59472
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, RORC, SRC, TRPV1 7.54588
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, APP, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 7.4949
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 7.44413
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 7.39327
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 7.28532
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.237
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD1, DRD2, HTR2A, KDR, MIF, OPRK1, SRC, TNKS, TNKS2, TRPV1 7.21568
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, GBA2, HTR1A, MAOA, TYR 7.14374
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SRC, TRPV1, TYR 7.11735
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 7.06177
[BP] GO:0007200 None CHRM2, DRD1, DRD2, ESR1, GRM5, HTR2A, OPRD1, OPRK1, OPRM1 6.79417
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 6.78616
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, OPRM1, PIM1, PTGES, SRC, XDH 6.68924
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 6.62233
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1, TYR 6.61848
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, FLT3, GRM1, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 6.60665
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MIF, MMP2, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, POLA1, POLB, PTPN1, RORC, SRC, TRPV1 6.60665
[BP] GO:0042391 None ADORA1, APP, BCL2, CNR1, CNR2, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, OPRD1, OPRM1, SRC, TRPV1 6.47122
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1, TRPV1 6.4606
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, KDR, OPRD1, OPRK1, POLB, SRC 6.4606
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HTR2A, MET, MTNR1B, POLA1, POLB, SRC, TRPV1 6.4407
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, FABP3, FABP4, FUT7, GBA2, MET, MIF, PDE3A, PPARA, PTGES, TBXAS1 6.4407
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, MTNR1A, MTNR1B, OPRK1, OPRM1, PPARA, RORC, SRC 6.40381
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 6.40381
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.28939
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.28444
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.27363
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, FABP3, FLT3, GRM5, HSD11B2, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, PPARA, SRC, TRPV1, TYR 6.16332
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 6.16332
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 6.16332
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, OPRK1, PDE3B, PPARA, SRC, TRPV1 6.10514
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, GRIK5, GRM5, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TRPV1 6.10514
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTGES, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 6.03827
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, DRD1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, OPRK1, PDE3A, PDE3B, RORC, SRC, TRPV1 6.01535
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MIF, PTGES, TBXAS1 5.94813
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGES, SRC 5.76548
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, DRD1, DRD2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR7, MTNR1B, OPRD1, OPRK1, OPRM1, SLC1A1 5.7623
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2 5.65053
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MIF, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 5.63195
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, IGF1R, KDR, MIF, MMP9, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 5.56479
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, GRM1, HSD11B2, HTR2A, MMP2, OPRD1, OPRK1, OPRM1, POLB, PPARA, SRC, TRPV1, TYR 5.51777
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 5.49876
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, OPRM1, PDE3A, RORC, SRC, TRPV1 5.4471
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.39641
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.37219
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, MIF, PPARA, PTGES, TBXAS1 5.32604
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 5.3111
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, HTR2A, MET, MTNR1B, TRPV1 5.2701
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGES, TBXAS1 5.19829
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, MIF, SRC, TNKS, TNKS2, TRPV1 5.14461
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.14461
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 5.11909
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CNR1, DRD1, DRD2, GRM5, HTR1A, HTR2A, MIF, MMP9, OPRD1, OPRK1, OPRM1 5.10074
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, GRM1, HTR2A, KDR, MET, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 5.0623
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, PPARA, PTGES, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 5.04186
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F3, FLT3, GRM1, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 5.03903
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, F3, FLT3, HTR1A, HTR2A, IGF1R, KDR, MIF, MMP12, MMP2, MMP9, PIM1 5.03447
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TRPV1, XDH 5.01623
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TRPV1, XDH 5.00421
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, GRM1, GRM5, HTR1A, HTR2A, MTNR1A, OPRD1, OPRK1, OPRM1, PPARA, TRPV1 5.00048
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, ESRRB, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.99662
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.99336
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.94087
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.90672
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, HTR2A, KDR, SRC, TRPV1 4.89302
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, OPRM1, TRPV1 4.78136
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, MAOA, TYR 4.74551
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F3, FLT3, GRM1, HTR2A, IGF1R, KDR, MET, MIF, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, XDH 4.73794
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 4.7366
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, HTR2A, MET, TRPV1 4.72263
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.63567
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, GRIK5, GRM5, HTR1A, HTR2A, MIF, MMP12, MMP9, MTNR1B, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, TRPV1 4.57551
[BP] GO:0003008 None ADORA1, AKR1B1, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HSD11B2, HTR1A, HTR2A, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC, TRPV1, TYR 4.56046
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, ESR1, FABP4, GRM3, IGF1R, MET, MMP9, OPRM1, PIM1, PPARA, PTPN1, SRC, TNKS 4.56046
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, ESRRB, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, SRC, XDH 4.5493
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 4.5493
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SIGMAR1, SRC, TRPV1, XDH 4.5493
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, HTR2A, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 4.54186
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 4.53662
[BP] GO:0019233 None CNR1, CNR2, GRM1, OPRD1, OPRK1, OPRM1 4.4853
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, KDR, MET, MIF, MMP2, MMP9, PDE3A, PDE3B, PIM1, POLB, PPARA, RORC, SIGMAR1, SRC, TNKS2, TYR 4.45384
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.45074
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, OPRK1, SRC 4.37502
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, ESRRA, F3, FABP4, FLT3, GRM1, HTR2A, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PTPN1, SRC, TNKS, TNKS2, XDH 4.3363
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.26534
[BP] GO:0030534 None APP, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, PPARA 4.22023
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.2094
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 4.17676
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MIF, PTGES 4.16948
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 4.16948
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.15852
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, GRM1, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SLC1A1, SRC, TNKS2, TRPV1, XDH 4.13267
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.11501
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, MIF, PPARA, PTGES, TBXAS1 4.09664
[BP] GO:0051930 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.08929
[BP] GO:0051931 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 4.08929
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 4.0526
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.04604
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 3.92381
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 3.92381
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, MIF, PTGES 3.91673
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MIF, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2, TRPV1 3.90393
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGES, SRC 3.88731
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.88731
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, OPRM1, TRPV1 3.87506
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, HSD11B2, IGF1R, OPRK1, PDE3B, PPARA, SRC, TRPV1 3.86932
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, NR3C1, OPRM1, SRC, TRPV1 3.83195
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, F3, FABP4, KDR, MET, MIF, MMP12, OPRM1, PPARA 3.8236
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GRM1, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.77046
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, RORC 3.76938
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MIF, MMP9, SRC 3.75406
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, POLB, PPARA, SRC 3.72323
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 3.72323
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, OPRD1, OPRM1, PDE3B, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.66293
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, OPRK1, OPRM1, PTGES, SRC 3.66293
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, HTR2A, OPRK1 3.65795
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, OPRK1, OPRM1, PDE3A, SRC 3.62986
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, GRM1, HTR2A, IGF1R, KDR, MIF, OPRK1, OPRM1, PTPN1, SRC, XDH 3.62322
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP2, NQO2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 3.61867
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.61152
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.61152
[BP] GO:1900542 None DRD1, DRD2, ESRRB, GRM3, GRM8, HTR2A, MTNR1A, OPRM1, PPARA 3.61148
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD1, DRD2, ESR1, ESR2, IGF1R, MET, MIF, MMP12, MMP9, PDE3B, PPARA, PTPN1, SRC, XDH 3.58772
[BP] GO:0048148 None DRD1, DRD2, HTR2A, OPRK1 3.57725
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 3.53602
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, OPRM1, PPARA 3.52811
[BP] GO:0007626 None APP, DRD1, DRD2, GRM1, GRM5, OPRD1, OPRK1, OPRM1 3.52811
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, GRIK5, HTR1A, HTR2A, MIF, MMP12, MTNR1B, OPRK1, OPRM1, SRC, TRPV1 3.52729
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.5232
[BP] GO:0006140 None DRD1, DRD2, ESRRB, GRM3, GRM8, HTR2A, MTNR1A, OPRM1, PPARA 3.5232
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, HTR1A, MAOA 3.4847
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SRC, TNKS, TNKS2, TRPV1, XDH 3.45245
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 3.44724
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PPARA, PTPN1, SRC 3.44348
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD1, DRD2, ESR1, ESR2, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE3B, PTPN1, SRC, XDH 3.43262
[BP] GO:0006939 None DRD1, DRD2, HTR2A, HTR7, TRPV1 3.43262
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 3.4271
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGES 3.4271
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.41472
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, HTR2A, KDR, MET, MIF, MMP12, MMP9, OPRM1, PDE3A, PIM1, SLC1A1, SRC, TRPV1 3.40542
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, SRC, TYR 3.37054
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 3.35703
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, GRIK5, HTR1A, MAOA, SLC1A1, TRPV1 3.35679
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 3.32789
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR2A, MET, OPRK1 3.32261
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, SRC 3.30762
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.29621
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, POLB, PPARA, RORC, SIGMAR1, SRC, TYR 3.27685
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, MIF, OPRM1, SRC 3.27257
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.27257
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, GRIK5, HTR1A, HTR2A, MIF, MMP12, MTNR1B, OPRK1, OPRM1, SRC 3.25836
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, DRD1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, OPRM1, PDE3A, PDE3B, SRC, TRPV1 3.25293
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.25237
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 3.227
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, OPRD1, PPARA, SRC 3.22273
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CDK6, CNR1, CNR2, CYP19A1, DRD2, ESR1, F3, FABP4, IGF1R, MET, MIF, MMP12, MMP2, OPRK1, PPARA, PTPN1, SRC, XDH 3.20937
[BP] GO:0050877 None ADORA1, APP, CNR1, CNR2, CYP1B1, DRD1, DRD2, GRM1, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, TRPV1, TYR 3.20798
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.18894
[BP] GO:0007631 None APP, DRD1, DRD2, OPRD1, OPRK1, OPRM1 3.18891
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, IGF1R, MET, MIF, MMP9, OPRD1, OPRM1, PIM1, PPARA, PTPN1, SRC, TNKS, TRPV1, XDH 3.18443
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.18179
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, NR3C1, OPRK1, OPRM1 3.17312
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TNKS, TNKS2, TRPV1, XDH 3.16954
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, GRM5, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC, TRPV1 3.15321
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, HTR2A, KDR, MIF, OPRM1, PTPN1, SRC 3.14971
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 3.08995
[BP] GO:0014059 None CNR1, DRD2, HTR2A, OPRK1 3.06884
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, MAOA 3.05312
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.04246
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 3.03034
[BP] GO:0003018 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 3.02831
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, MIF, PTGES 3.01832
[BP] GO:0019098 None APP, DRD1, MTNR1A, OPRK1 3.01832
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HTR2A, PDE3B, PPARA, RORC, SRC 3.01832
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.96825
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.96825
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, POLB, PTPN1, SRC, TNKS, XDH 2.9605
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, ESR1, F3, FLT3, GRM1, GRM5, HTR2A, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.95458
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.95458
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA, SLC1A1, TRPV1 2.93941
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR2A 2.91393
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, TNKS, TNKS2 2.91393
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HTR2A, IGF1R, MIF, MMP9, OPRM1, PTPN1, SRC, TNKS, XDH 2.89559
[BP] GO:0043278 None CNR1, DRD2, OPRK1, OPRM1 2.86581
[BP] GO:0014072 None CNR1, DRD2, OPRK1, OPRM1 2.86581
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MIF, MMP9, PDE3A, PIM1, PTPN1, SRC 2.86328
[BP] GO:0050730 None ADORA1, APP, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC 2.85773
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, MIF, PIM1, POLA1, SRC, TYR 2.85023
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.84865
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, MIF, MMP2, MMP9, OPRD1, OPRK1, OPRM1, POLA1, POLB, PPARA, PTGES, PTPN1, SRC, TRPV1 2.78934
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, MIF, PTPN1, SRC 2.77014
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, FABP3, GRM1, GRM5, HTR2A, TRPV1 2.77014
[BP] GO:0031635 None OPRK1, OPRM1 2.77014
[BP] GO:0009115 None AOX1, XDH 2.77014
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.77014
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.77014
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.77014
[BP] GO:0031644 None ADORA1, GRM1, OPRD1, OPRK1, OPRM1 2.7645
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.76191
[BP] GO:1900543 None DRD2, GRM3, GRM8, OPRM1, PPARA 2.74007
[BP] GO:0030802 None DRD1, DRD2, GRM3, GRM8, MTNR1A, OPRM1 2.73121
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, OPRK1, SRC 2.71955
[BP] GO:0045980 None DRD2, GRM3, GRM8, OPRM1, PPARA 2.71603
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, DRD2 2.69576
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, MIF, MMP12 2.67391
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.66471
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PDE3B, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.60142
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, KDR, MIF, MMP9, OPRD1, OPRK1, OPRM1, PTPN1, SRC, XDH 2.58397
[BP] GO:0097756 None ADORA1, HTR1A, HTR2A, HTR7 2.57381
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.57092
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.57092
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.57092
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, OPRK1, OPRM1, PTGES, SRC 2.57053
[BP] GO:1900371 None DRD1, DRD2, GRM3, GRM8, MTNR1A, OPRM1 2.55395
[BP] GO:0030808 None DRD1, DRD2, GRM3, GRM8, MTNR1A, OPRM1 2.53777
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HSD11B2, HTR2A, MMP12, OPRK1, OPRM1, PTGES, SRC, TRPV1, TYR 2.52693
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, HTR1A, HTR2A, MTNR1B, OPRK1 2.51847
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, MIF, PTGES 2.51847
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, IGF1R, MET, MIF, MMP9, PDE3B, PTPN1, SRC, XDH 2.51842
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, DRD2, GRM1, HTR2A, OPRD1, OPRK1, OPRM1, SLC1A1, TRPV1 2.50516
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TNKS 2.50463
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.49377
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.49377
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 2.48351
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.48351
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, MIF 2.48086
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, OPRM1, SRC, TRPV1, TYR 2.48086
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, IGF1R, KDR, MET, MMP12, MTNR1A, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, TRPV1 2.47603
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.47603
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, MIF, OPRM1, POLB, PTGES, TRPV1 2.46074
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, F3, FLT3, GRM1, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, PTPN1, SRC, TNKS, TNKS2, XDH 2.45366
[BP] GO:0007623 circadian rhythm DRD2, HTR7, MTNR1A, MTNR1B, PPARA, RORC 2.45366
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, GBA2, MAOA, PDE10A, PDE3A, PDE3B, XDH 2.44638
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.44638
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.44638
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.44638
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, SRC 2.44638
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, OPRM1, PPARA, SLC1A1, TRPV1 2.44613
[BP] GO:0050890 None ADORA1, APP, CNR1, DRD1, DRD2, GRM5, HTR2A, OPRK1 2.44613
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.44185
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, IGF1R, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NR3C1, OPRD1, OPRK1, OPRM1, PIM1, POLA1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.43404
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.4311
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.4311
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.42102
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, OPRK1, OPRM1, PTGES, SRC 2.42102
[BP] GO:0032868 None FABP3, HSD11B2, OPRK1, PDE3B, PPARA, SRC 2.42102
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, BCL2, CNR1, CSNK2A1, CYP2D6, DRD2, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, IGF1R, MET, MIF, MMP12, MMP9, NR3C1, OPRM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2, TRPV1, XDH 2.42102
[BP] GO:0030818 None DRD2, GRM3, GRM8, OPRM1 2.42102
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, HTR1A, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, POLB, PPARA, PTPN1, SENP6, SRC, TNKS, TNKS2, TYR, XDH 2.39877
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.39573
[BP] GO:0003013 None ADORA1, DRD1, HTR1A, HTR2A, HTR7, PDE3A, SRC 2.39573
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.39573
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, HTR2A, MMP9 2.39386
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD1, DRD2, MIF, PPARA 2.39386
[BP] GO:0070848 response to growth factor APP, KDR, NR3C1, OPRD1, OPRM1, PDE3A, SRC, TRPV1 2.39386
[BP] GO:0099566 None GRM1, GRM5 2.39386
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.39386
[BP] GO:0046110 None AOX1, XDH 2.39386
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39386
[BP] GO:0033602 None CNR1, DRD2 2.39386
[BP] GO:0030799 None DRD1, DRD2, GRM3, GRM8, MTNR1A, OPRM1 2.39175
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, MIF, PIM1, PPARA, PTGES, TBXAS1, TYR 2.38887
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.38721
[BP] GO:0060359 None CNR1, DRD1, DRD2, OPRK1, OPRM1 2.38715
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.3829
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.3829
[BP] GO:0030803 None DRD2, GRM3, GRM8, OPRM1 2.37289
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOA, PDE10A, PDE3A, PDE3B, XDH 2.35905
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AXL, CNR1, CYP1A1, DRD1, ESR1, MTNR1A, OPRK1, OPRM1, SRC 2.34927
[BP] GO:0050433 None CNR1, DRD2, HTR2A, OPRK1 2.3392
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.33086
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GRIK5, GRM1, GRM5, HTR2A, TRPV1 2.32762
[BP] GO:0043279 None CNR1, DRD2, OPRK1, OPRM1, TRPV1 2.32762
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.31686
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.31513
[BP] GO:0030815 None DRD2, GRM3, GRM8, OPRM1 2.31173
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HTR2A, MET, MIF, MMP9, OPRD1, PTPN1, SRC, TNKS, XDH 2.29151
[BP] GO:1900372 None DRD2, GRM3, GRM8, OPRM1 2.27959
[BP] GO:0030809 None DRD2, GRM3, GRM8, OPRM1 2.27959
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, NR3C1, SRC 2.25629
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.25488
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.25488
[BP] GO:0007617 None APP, DRD1, MTNR1A 2.25488
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MIF, MMP9, PTPN1, SRC 2.25488
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.25451
[BP] GO:0030800 None DRD2, GRM3, GRM8, OPRM1 2.25451
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.25218
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.2479
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, MIF, MMP12, OPRK1, SRC, TRPV1 2.24032
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.23958
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, NR3C1, SRC 2.21833
[BP] GO:0007600 None CNR1, CNR2, CYP1B1, DRD2, GRM1, GRM8, OPRD1, OPRK1, OPRM1, TRPV1, TYR 2.20745
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, MIF, OPRK1, OPRM1, POLB, PTGES, SRC, TRPV1 2.20435
[BP] GO:0030817 None DRD1, DRD2, GRM3, GRM8, OPRM1 2.20235
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.20235
[BP] GO:0050994 None ADORA1, CNR1, PDE3B, PPARA 2.19887
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GRIK5, GRM1, GRM5, HTR2A, POLA1, TRPV1 2.19732
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, IGF1R, MET, MMP12, MTNR1A, NR3C1, PPARA, RORC, SRC, TNKS, TNKS2, TRPV1 2.1944
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, MIF, PTPN1, SRC, TNKS 2.19106
[BP] GO:0050793 regulation of developmental process ALOX12, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F3, HTR2A, KDR, MIF, OPRM1, PDE3A, PDE3B, PIM1, PPARA, RORC, SRC, TNKS2, TRPV1, XDH 2.18676
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, GRM1, GRM5, HTR2A, IGF1R, MIF, PTPN1, SRC 2.18599
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.18009
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.17448
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, MIF, PTPN1, SRC, TNKS 2.17175
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.16566
[BP] GO:0007198 None HTR1A, HTR7 2.15698
[BP] GO:0070213 None TNKS, TNKS2 2.15698
[BP] GO:0006145 None AOX1, XDH 2.15698
[BP] GO:0038171 None CNR1, CNR2 2.15698
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.15698
[BP] GO:0032094 None CYP1A1, HSD11B2, OPRM1 2.15575
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.15575
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MIF, POLB 2.15421
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1 2.14522
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.14418
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.14418
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.14007
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, GBA2, MAOA, PDE10A, PDE3A, PDE3B, SRC, XDH 2.12976
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, GRM5, HTR2A, OPRK1 2.11496
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.10511
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.10511
[BP] GO:0050995 None ADORA1, CNR1, PDE3B 2.10511
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HSD11B2, OPRM1, SRC, TRPV1, TYR 2.09105
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.07818
[BP] GO:0072347 None CNR1, DRD2, OPRK1, OPRM1 2.07809
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, DRD2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.06288
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.05159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.05159
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.04577
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.04577
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA 2.03252
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.02727
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.02727
[BP] GO:0071363 cellular response to growth factor stimulus APP, KDR, NR3C1, OPRD1, PDE3A, SRC, TRPV1 2.01889
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, MIF, PDE3A, SENP6, TNKS 2.0125
[BP] GO:0007210 None HTR1A, HTR2A, HTR7 2.00746
[BP] GO:0098664 None HTR1A, HTR2A, HTR7 2.00746
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.00746
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.00746
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, DRD1, DRD2, ESR1, GRM1, GRM5, HTR2A, TRPV1 2.00746
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, GRM1, GRM5, HTR2A, MIF, PTPN1, SRC 2.00732
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.00443
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, TRPV1 8.93352
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, TRPV1 8.0034
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SLC1A1, SRC, TRPV1 6.99252
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, PTGES, PTPN1, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR 6.61845
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM2, CNR1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 6.47159
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, SLC1A1, SRC, TRPV1 6.4606
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTGES, PTPN1, SIGMAR1, SLC1A1, SRC, TBXAS1, TRPV1, TYR 5.84085
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, ESR1, F3, FLT3, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PIM1, PTPN1, SLC1A1, SRC, TRPV1 5.59292
[CC] GO:0097060 None CHRM2, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, OPRD1, SIGMAR1, TRPV1 5.45405
[CC] GO:0043005 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 5.02364
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 4.58439
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC, TRPV1 4.58439
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 4.11501
[CC] GO:0097458 None ADORA1, APP, CA2, CHRM2, CNR1, CNR2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, OPRD1, OPRK1, OPRM1, PDE10A, SIGMAR1, SRC, TRPV1 3.95271
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTGES, SIGMAR1, SLC1A1, TBXAS1, TRPV1, TYR 3.88192
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.8524
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, OPRD1, OPRK1, OPRM1, SRC 3.51926
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PTGES, SIGMAR1, SLC1A1, TBXAS1, TRPV1, TYR 3.47175
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.26041
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.26041
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.24379
[CC] GO:0045211 None CHRM2, GRIA2, GRIA4, GRIK5, GRM3, OPRD1, SIGMAR1, TRPV1 3.09326
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGES, SIGMAR1, TBXAS1 3.07623
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3, OPRM1 3.07549
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, SIGMAR1, TBXAS1 2.93941
[CC] GO:0098793 None ADORA1, APP, CHRM2, DRD2, GRIK5, OPRD1, OPRK1 2.86485
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.85773
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, KDR, MAOA, MIF, MMP2, MMP9, NQO2, NR3C1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, PTGES, PTPN1, SENP6, SIGMAR1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.83288
[CC] GO:0043204 None CNR2, DRD2, GRIK5, OPRK1, OPRM1, PDE10A 2.78832
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC, TRPV1 2.75519
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.7478
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.71477
[CC] GO:0032589 None ADORA1, OPRD1, OPRM1, TRPV1 2.50516
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, KDR, OPRM1, PDE3B, PTPN1, SIGMAR1, XDH 2.46466
[CC] GO:0043679 None CHRM2, DRD2, OPRD1, OPRK1 2.13009
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 15.1756
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 14.1602
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 13.0939
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 12.7268
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, NR3C1, OPRD1, OPRK1, OPRM1, PPARA, RORC, SIGMAR1, TRPV1 11.4946
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 9.79273
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1, TRPV1 9.79273
[MF] GO:0030594 None CHRM2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR7, OPRM1 9.624
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.42356
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 9.39322
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR2A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 8.68409
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, XDH 7.92391
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 7.62672
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.62672
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PTGES, PTPN1, SENP6, SRC, TBXAS1, TNKS, TNKS2, TYR, XDH 7.47197
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 6.8323
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.45718
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1, RORC, TNKS 6.23881
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 6.16332
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.08259
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC1A1, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.98069
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, DRD1, DRD2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR7, MTNR1A, MTNR1B, OPRD1, OPRK1, OPRM1, SIGMAR1 5.77928
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.67084
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B2, HSD17B1, NQO2, POLA1, PTGES, SRC, TBXAS1, XDH 5.53906
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.48728
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR 5.35874
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.14461
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, FLT3, HTR2A, IGF1R, KDR, MET, NQO2, PDE10A, PIM1, PPARA, SIGMAR1, SRC, TRPV1 5.14192
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 4.85748
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.65205
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.65205
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, PPARA, RORC, TRPV1 4.56046
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC, TBXAS1 4.49416
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.30846
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC, TBXAS1 4.26534
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TBXAS1, TYR 3.92381
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR7, OPRM1 3.87147
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR2A, HTR7 3.75035
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.4535
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2, NR3C1 3.42582
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.12329
[MF] GO:0008227 None CHRM2, DRD2, HTR1A, HTR2A, HTR7 3.12329
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.09537
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.01832
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 2.96825
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.91956
[MF] GO:0043176 None HTR1A, HTR2A, HTR7 2.85773
[MF] GO:0051378 None HTR1A, HTR2A, HTR7 2.85773
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 2.77658
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.77014
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.77014
[MF] GO:0003845 None HSD11B1, HSD11B2 2.77014
[MF] GO:0004119 None PDE3A, PDE3B 2.77014
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.73121
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.57092
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.53959
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.49377
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.42102
[MF] GO:0008502 None MTNR1A, MTNR1B 2.39386
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.39386
[MF] GO:0004949 None CNR1, CNR2 2.39386
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.39386
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.39386
[MF] GO:0099583 None GRM1, GRM5 2.39386
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR7, IGF1R, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NR3C1, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, POLA1, POLB, PPARA, PTGES, PTPN1, RORC, SENP6, SIGMAR1, SLC1A1, SRC, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 2.31173
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.31173
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.25488
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.25488
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR7 2.19887
[MF] GO:0033218 amide binding ACHE, GRIA2, IGF1R, NQO2, OPRD1, OPRK1, OPRM1, PTGES 2.19106
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.15698
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.15698
[MF] GO:0004971 None GRIA2, GRIA4 2.15698
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.15698
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.10511
[MF] GO:0004993 None HTR1A, HTR2A, HTR7 2.00746
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.00746
[MF] GO:0099589 None HTR1A, HTR2A, HTR7 2.00746


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, CHRM2, GRIA2, GRIK5, HTR1A, OPRK1, OPRM1, TRPV1, HTR2A, NR3C1, GRM1, GRM3, GRM5, MTNR1A, HTR7, CNR2, CNR1, MTNR1B, ADORA3, GRM8, ADORA1, DRD1, DRD2, GRIA4 20.9401
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.4208
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.1996
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.942
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR7, MAOA, CYP2D6, ALOX5, ALOX15, HTR1A, ALOX12, HTR2A 6.942
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2, PPARA, GRIA4 6.0221
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 5.8908
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.8677
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, GRM1, ESR2 5.1061
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7406
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7406
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 4.2823
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2A, DRD1, DRD2, GRM1 4.3351
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA, DRD1, DRD2 4.343
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, ALOX12, PTGES 3.9303
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.416
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP2D6, CYP1A2, AOX1, CYP3A4 3.73
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.633
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CNR1, GRM1, GRIA4 3.0723
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, HTR7, HTR2A, DRD1, GRM1 2.845
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.4629
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.691
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.4629
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.5318
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 2.5779
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, DRD1, DRD2, GRIA4 2.6966
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.5704
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, DRD1, GRIA4 2.7605
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.7943
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A 2.265
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.2286
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, GRIA4 2.2895
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1, HTR2A 2.265
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7277
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE10A, PDE3B, PDE3A, XDH 2.1946
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 1.9678
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, BCL2, ADORA1 1.9897
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, KDR, BCL2, MET, IGF1R 1.7501
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.7762
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.7875
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.0095
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.791
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7875
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5043
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.9674
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, CDC25B, IGF1R 1.4849
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.8703
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.2175
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.3636
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 1.8983
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.0782
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.039
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1, DRD2 0.937
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.8371
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7167
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.149
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.149
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7515
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.6629
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8533
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.9
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B, PPARA 0.7972
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.8642
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.6955
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.7881
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7144
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2142
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7144
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2198
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.242
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7144
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.6629
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2198
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6588
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.8788
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8425
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.6938
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.242
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.4661
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.937
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.2556
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.269
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6531
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PDE3B 0.6548
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.266
Apoptosis_Homo sapiens_hsa04210 BCL2 0.2798
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6548
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.2785
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0463
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5324
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6531
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.4569
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0354
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.2927
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.0833
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.3087
Axon guidance_Homo sapiens_hsa04360 MET 0.3042
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3087
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.313
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3383
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1237
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.0025
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3507
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0301
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3639
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.375
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.3754
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.3747
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.3872
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.103
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.3872
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3872
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.3872
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3872
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3872
Peroxisome_Homo sapiens_hsa04146 XDH 0.3954
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4312
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4096
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4297
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.443
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.199
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4569
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4569
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4447
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4569
Shigellosis_Homo sapiens_hsa05131 SRC 0.4569
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4569
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4584
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.4891
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.2683
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.3678
Malaria_Homo sapiens_hsa05144 MET 0.5324
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5286
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5364
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5324
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5364
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5675
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.5972
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5216
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4475
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.5914
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6588
DNA replication_Homo sapiens_hsa03030 POLA1 0.6249
Base excision repair_Homo sapiens_hsa03410 POLB 0.6531
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6629
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.6938
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7762
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6629
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.687
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7144
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 1.9674
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.7981
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8752
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.845
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1453


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)