TCM Prescription: Tang Huo Powder



Prescription Description
Prescription IDTCMF5314
Pinyin NameTang Huo San
Chinese Name烫火散
English NameTang Huo Powder
Function Description水火烫伤
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH462 Sanguisorba officinalis 地榆 TCMH462 GENG545-14, GBVT2403-13
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH805 Calcitum 寒水石 TCMH805
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1353 Plasmodium yoelii
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.8477
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.8477
[BP] GO:0007187 None CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 10.2674
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 9.37048
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.10222
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 7.77643
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, CA2, CNR1, CNR2, DRD1, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB 7.74685
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD11B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PPARA, PTGS2 7.52898
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.46101
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 7.09291
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, DRD2, HTR1B 6.83075
[BP] GO:0007188 None CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.80637
[BP] GO:0099536 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.80637
[BP] GO:0099537 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 6.80637
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PTGS2 6.77545
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 6.7476
[BP] GO:0050795 None CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 6.7476
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, PTGS2 6.73213
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD11B1, HSD11B2, HTR1A, HTR2A, HTR2C 6.6626
[BP] GO:0007193 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.27129
[BP] GO:0097746 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.27129
[BP] GO:0035296 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.27129
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 6.11504
[BP] GO:0050880 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.08604
[BP] GO:0035150 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.06992
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 5.91871
[BP] GO:0007268 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.83553
[BP] GO:0098916 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 5.83553
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, ALOX15, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, FDPS, FUT7, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.73541
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.73541
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, CNR1, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.73541
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR1B, HTR1D 5.67989
[BP] GO:0003018 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.63049
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, MMP2, PIK3CA, PPARA, PTGS2 5.59181
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.4734
[BP] GO:0032501 multicellular organismal process AKR1B1, ALOX15, ALPL, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F10, F3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, MMP1, MMP2, MMP9, PIK3CA, PPARA, PTGS2 5.47269
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CYP1A1, CYP3A4, FDPS, HSD11B1, HSD11B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.36377
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F10, F3, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 5.19613
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX15, AOX1, CA12, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, FDPS, FUT7, HTR2B, HTR2C, PIK3CA, PPARA, PTGS1, PTGS2 5.16
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2 5.11011
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CNR1, CNR2, CYP1A1, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PTGS2 5.08907
[BP] GO:0007154 None BCL2, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 5.06199
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CNR1, DRD1, DRD2, HTR2A, HTR2B, HTR2C, PIK3CB, PTGS2 5.0496
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.97482
[BP] GO:0007267 None CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.83476
[BP] GO:0003013 None DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.81416
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, HTR2A, HTR2B, HTR2C 4.77125
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.72311
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, BCL2, CA2, CA7, CYP1B1, DRD1, DRD2, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 4.71161
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, BCL2, CA2, CA7, CYP1B1, DRD1, DRD2, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 4.69037
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD2, HTR1B, HTR2A, MMP9, PTGS2 4.69037
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 4.68084
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2 4.63756
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX15, BCL2, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, FDPS, HTR1A 4.62824
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 4.60332
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 4.58089
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, DRD2, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, PIK3CA, PIK3CB, PTGS2 4.53944
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 4.52846
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, DRD1, ESR1, ESRRA, HSD11B2, HTR1B, HTR5A, MMP2, PPARA, PTGS2 4.51132
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 4.44081
[BP] GO:0023052 None CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.41926
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, BCL2, CA2, CNR1, CNR2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, MMP9, PIK3CA, PIK3CB, PPARA 4.41926
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.41608
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CNR2, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 4.36427
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP1A1, CYP1B1, CYP3A4, ESR1, FDPS, HSD11B1, HSD11B2 4.31072
[BP] GO:0003008 None AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2 4.29811
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 4.2231
[BP] GO:0043269 regulation of ion transport BCL2, CA2, CA7, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 4.12855
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 4.11798
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 4.09958
[BP] GO:0090066 None ALOX15, DRD1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 4.08845
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.92961
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.92017
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.85163
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX15, CYP1A1, CYP1B1, CYP3A4, DRD2, FDPS, FUT7, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 3.8371
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.80915
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, BCL2, CA2, CA7, CNR1, CYP1B1, DRD1, DRD2, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 3.80113
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.76438
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.69985
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.69985
[BP] GO:0009628 response to abiotic stimulus AKR1B1, BCL2, CA2, CYP1A1, DRD1, DRD2, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2 3.66731
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, PIK3CA, PIK3CB 3.6483
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.63371
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 3.63297
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.60535
[BP] GO:0071073 None HTR2A, HTR2B, HTR2C 3.60535
[BP] GO:0051952 None CNR1, DRD1, DRD2, HTR1B, HTR2A 3.56226
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 3.56226
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.55372
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A 3.51313
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, DRD1, DRD2, PIK3CB, PTGS2 3.5047
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.46916
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, DRD2, ESR1, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS2 3.46738
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, BCL2, CYP1B1, DRD2, ESR1, ESRRA, F3, HTR1A, HTR1B, HTR2A, HTR2B, MMP2, MMP9, PTGS1, PTGS2 3.46272
[BP] GO:0051049 regulation of transport ACHE, ALOX15, BCL2, CA2, CA7, CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2 3.43178
[BP] GO:1900542 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, PPARA 3.42486
[BP] GO:0008217 None CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2 3.41993
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, BCL2, CA2, CYP1A1, CYP1B1, DRD2, MMP9, PTGS2 3.38709
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 3.36203
[BP] GO:0006140 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, PPARA 3.3532
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A 3.26922
[BP] GO:0051588 None DRD1, DRD2, HTR1A, HTR1B, HTR2C 3.24845
[BP] GO:0019216 regulation of lipid metabolic process CNR1, CYP1A1, FDPS, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 3.20959
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.2048
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, DRD2, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 3.19653
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CYP1B1, DRD2, ESRRA, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2 3.18698
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.18522
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.17203
[BP] GO:0003012 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 3.12052
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 3.11293
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 3.09435
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 3.09115
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 3.09115
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.08862
[BP] GO:0051967 None DRD2, HTR1B, HTR2A 3.07013
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 3.06566
[BP] GO:0042592 homeostatic process AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB 3.06118
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, ALOX15, BCL2, CA2, CA7, CNR1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 3.04946
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 3.04334
[BP] GO:0007208 None HTR2A, HTR2C 3.04334
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 3.02392
[BP] GO:0006690 icosanoid metabolic process ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 3.01288
[BP] GO:0016477 cell migration CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, MMP1, MMP9, PIK3CA, PIK3CB 2.99823
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, PTGS2 2.99823
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.9972
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, BCL2, CYP1B1, DRD2, ESR1, F10, F3, HTR2A, HTR2B, HTR2C, HTR6, MMP9, PIK3CA, PIK3CB, PTGS2 2.97802
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP1A1, CYP1B1, CYP3A4, ESR1 2.95119
[BP] GO:0071071 None HTR2A, HTR2B, HTR2C 2.94189
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.94189
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1B1 2.9372
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2 2.92438
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, HTR2C 2.86804
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.86788
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, PPARA 2.86788
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.85933
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1B1, CYP3A4, NQO2, PTGS1 2.85933
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.85484
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.82531
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, PIK3CA 2.79379
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.768
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX15, AOX1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 2.75911
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD1, DRD2, PTGS2 2.74805
[BP] GO:0045834 positive regulation of lipid metabolic process HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.71818
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, DRD2, MMP9, PTGS2 2.7001
[BP] GO:0048148 None DRD1, DRD2, HTR2A 2.68049
[BP] GO:0048870 cell motility CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, MMP1, MMP9, PIK3CA, PIK3CB 2.68049
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP3A4, FDPS, HSD11B1, HSD11B2 2.68049
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, BCL2, DRD1, DRD2, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2 2.68049
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, BCL2, DRD1, DRD2, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2 2.68049
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP3A4, HSD11B1, HSD11B2 2.68049
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.68049
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67271
[BP] GO:0033602 None CNR1, DRD2 2.67271
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.67271
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, HSD11B2, HTR1B, PTGS2 2.6518
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 2.64718
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.64685
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, BCL2, DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.64685
[BP] GO:0046889 None HTR2A, HTR2B, HTR2C, PTGS2 2.62983
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C 2.62983
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, PIK3CA, PIK3CB 2.62983
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, BCL2, DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.61393
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.60114
[BP] GO:0048583 regulation of response to stimulus AKR1B1, ALOX15, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.55175
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.49622
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.49622
[BP] GO:1900543 None DRD2, HTR1B, HTR1E, PPARA 2.46946
[BP] GO:0032845 None BCL2, DRD2, HTR2A, HTR2B, HTR2C 2.46167
[BP] GO:0045980 None DRD2, HTR1B, HTR1E, PPARA 2.44942
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, FDPS, HTR2B, HTR2C, PIK3CA, PIK3CB, PTGS2 2.44876
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, BCL2, DRD2, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PTGS2 2.44529
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, HTR1B 2.44084
[BP] GO:0038171 None CNR1, CNR2 2.42209
[BP] GO:0014827 None HTR1D, HTR2B 2.42209
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.41214
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, HSD11B2, HTR1B, MMP2, PPARA, PTGS2 2.41214
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 2.40309
[BP] GO:0031214 biomineral tissue development ALOX15, ALPL, PPARA, PTGS2 2.40068
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, BCL2, CA2, CA9, CNR1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, FUT7, HSD11B1, HTR2A, HTR2B, HTR5A, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.39014
[BP] GO:0060401 None DRD2, HTR2A, HTR2B, HTR2C 2.38177
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, HTR1A, PTGS2 2.34504
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, HTR1B, MMP2, PIK3CA, PTGS2 2.34504
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, HSD11B2, HTR1B, PTGS2 2.34504
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, CYP1A1, CYP1B1, PTGS1, PTGS2 2.34504
[BP] GO:0040011 locomotion CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, MMP1, MMP9, PIK3CA, PIK3CB 2.33998
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGS1, PTGS2 2.28737
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA 2.28666
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2 2.28598
[BP] GO:0021853 None DRD1, DRD2 2.24305
[BP] GO:0007598 None F10, F3 2.24305
[BP] GO:0071502 None HTR1B, HTR2B 2.24305
[BP] GO:1904936 None DRD1, DRD2 2.24305
[BP] GO:0042220 None CNR1, DRD2, HTR1B 2.22018
[BP] GO:0001659 None DRD1, DRD2, HTR2A 2.22018
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.22018
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.21943
[BP] GO:0046890 None FDPS, HTR2A, HTR2B, HTR2C, PTGS2 2.21943
[BP] GO:0006820 anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, PPARA 2.21222
[BP] GO:0055065 metal ion homeostasis BCL2, DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB 2.21222
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, HTR1B, MMP2, MMP9, PIK3CA, PTGS2 2.18844
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.18844
[BP] GO:0060359 None CNR1, DRD1, DRD2, HTR1B 2.17814
[BP] GO:0040012 regulation of locomotion ADORA3, BCL2, CYP1B1, DRD1, DRD2, F10, F3, HTR1D, MMP9, PTGS2 2.16964
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B 2.15286
[BP] GO:0042325 regulation of phosphorylation ALOX15, BCL2, DRD1, DRD2, ESRRB, HTR2A, HTR2B, HTR2C, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2 2.14083
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA 2.14012
[BP] GO:0051480 regulation of cytosolic calcium ion concentration DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 2.13022
[BP] GO:0008152 metabolic process ACHE, AKR1B1, ALOX15, ALPL, AOX1, BCL2, CA12, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FDPS, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR2B, HTR2C, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 2.11316
[BP] GO:0006811 None CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, HTR2A, HTR2B, HTR2C, PPARA 2.11087
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, ALOX15, BCL2, CA12, CA2, CA7, CA9, CNR1, CNR2, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FDPS, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 2.10923
[BP] GO:0021843 None DRD1, DRD2 2.10923
[BP] GO:0021830 None DRD1, DRD2 2.10923
[BP] GO:0014831 None HTR1D, HTR2B 2.10923
[BP] GO:0032229 None CNR2, HTR1B 2.10923
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.10923
[BP] GO:0021826 None DRD1, DRD2 2.10923
[BP] GO:0021885 forebrain cell migration DRD1, DRD2, HTR6 2.09967
[BP] GO:0097164 None ACHE, AKR1B1, DRD1, DRD2, HTR1A 2.08102
[BP] GO:0007631 None DRD1, DRD2, HTR1B, HTR2C 2.08102
[BP] GO:0043112 None ACHE, DRD2, HTR1B, HTR2B 2.08102
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B 2.06893
[BP] GO:0003014 None AKR1B1, BCL2, DRD2, HSD11B2 2.06702
[BP] GO:0006631 fatty acid metabolic process ALOX15, CYP1A1, CYP1B1, PPARA, PTGS1, PTGS2 2.06702
[BP] GO:0060135 None AKR1B1, CNR1, ESR1 2.03916
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, PTGS1, PTGS2 2.03916
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.03486
[BP] GO:0006952 defense response ADORA3, ALOX15, BCL2, CNR2, DRD1, HTR1A, HTR2C, PIK3CA, PIK3CB, PTGS1, PTGS2 2.03486
[BP] GO:0044283 None AKR1B1, ALOX15, CYP1A1, CYP3A4, FDPS, PTGS1, PTGS2 2.01196
[BP] GO:0014075 None CNR2, DRD1, DRD2 2.01181
[BP] GO:0007566 embryo implantation MMP2, MMP9, PTGS2 2.01181
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, CA4, CNR1, CNR2, DRD1, DRD2, F10, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.09303
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, PTGS1, PTGS2 5.84502
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, ESR1, F10, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB 5.22721
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, CA2, CA4, CA9, CNR1, CNR2, DRD1, DRD2, F10, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PTGS2 4.91669
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FUT7, HSD11B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MMP2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.58369
[CC] GO:0005887 integral component of plasma membrane ADORA3, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.2231
[CC] GO:0031224 None ACHE, ADORA3, ALPL, CA12, CA14, CA4, CA9, CNR1, CNR2, CYP3A4, DRD1, DRD2, ESR1, F10, F3, FUT7, HSD11B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 2.71818
[CC] GO:0031233 None CA4, F10, F3 2.68049
[CC] GO:0120025 None AKR1B1, CA2, CNR1, CNR2, DRD1, DRD2, HTR2A, HTR2B, HTR5A, HTR6, PIK3CA, PTGS2 2.10466
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.8477
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 18.8477
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 18.3153
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 18.3153
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4189
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.4161
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.065
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.7384
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.8254
[MF] GO:0043169 cation binding ACHE, ALOX15, ALPL, AOX1, CA12, CA14, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2 11.0467
[MF] GO:0038023 signaling receptor activity ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 9.03613
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.83109
[MF] GO:0043167 ion binding ACHE, ALOX15, ALPL, AOX1, CA12, CA14, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FDPS, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.43007
[MF] GO:0046914 transition metal ion binding ALOX15, AOX1, CA12, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA 8.10222
[MF] GO:0004872 receptor activity ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 8.10222
[MF] GO:0060089 molecular transducer activity ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 7.85556
[MF] GO:0004871 signal transducer activity ADORA3, CNR1, CNR2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PPARA 7.38275
[MF] GO:0004930 None ADORA3, CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 6.73105
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.63049
[MF] GO:0099600 transmembrane receptor activity ADORA3, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.54572
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, CNR1, CNR2, DRD1, DRD2, F3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 5.54572
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA 5.39094
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.91845
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2 4.62824
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 4.41608
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.41608
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 4.04922
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX15, AOX1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD11B2, NQO2, PTGS1, PTGS2 3.46272
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.04334
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.04334
[MF] GO:0003845 None HSD11B1, HSD11B2 3.04334
[MF] GO:0071886 None HTR2A, HTR2C 3.04334
[MF] GO:0046872 metal ion binding ALOX15, ALPL, AOX1, CA12, CA14, CA2, CA4, CA7, CA9, CYP1A1, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, FDPS, MMP1, MMP2, MMP9, NQO2, PPARA, PTGS1, PTGS2 3.02579
[MF] GO:0008289 lipid binding ALOX15, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, HSD11B2, PPARA 2.99823
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.9942
[MF] GO:0008144 drug binding ACHE, CNR1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HTR1B, HTR2A, HTR2B, HTR2C, NQO2, PIK3CA, PIK3CB, PPARA 2.67271
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.67271
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.67271
[MF] GO:0004949 None CNR1, CNR2 2.67271
[MF] GO:0020037 heme binding CYP1A1, CYP1B1, CYP3A4, PTGS1, PTGS2 2.67271
[MF] GO:0070330 aromatase activity CYP1A1, CYP1B1, CYP3A4 2.54534
[MF] GO:0046906 tetrapyrrole binding CYP1A1, CYP1B1, CYP3A4, PTGS1, PTGS2 2.54034
[MF] GO:0048037 cofactor binding AOX1, CYP1A1, CYP1B1, CYP3A4, HSD11B2, NQO2, PTGS1, PTGS2 2.50627
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.42209
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP1A1, CYP1B1, CYP3A4 2.41214
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP1A1, CYP1B1, CYP3A4, PTGS1, PTGS2 2.34504
[MF] GO:0005506 iron ion binding ALOX15, AOX1, CYP1A1, CYP1B1, CYP3A4 2.28666
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.24305
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.24305
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F3, MMP1, MMP2, MMP9 2.14209


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7 17.8671
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, DRD1, DRD2 15.5935
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, DRD1, DRD2, PPARA, HTR4 10.142
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, DRD1, HTR5A, HTR4 6.4191
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 10.142
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.4285
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, CYP1A1, CYP1B1, CYP3A4 5.2031
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIK3CB, F3 4.1967
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, HTR2B, HTR2C, PIK3CB, HTR2A 4.2197
Gap junction_Homo sapiens_hsa04540 HTR2B, HTR2C, HTR2A, DRD1, DRD2 4.4047
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A1, CYP1B1, PTGS2, CYP3A4 4.5057
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 PIK3CA, PIK3CB, PTGS2, PTGS1 3.8935
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9 3.3389
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, PIK3CB, ESR1, ESR2 3.5021
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 3.3389
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A1, CYP1B1, CYP3A4 3.5021
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2 3.3065
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, MMP2, PIK3CB, MMP9, ESR1 3.0225
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 3.0074
Metabolic pathways_Homo sapiens_hsa01100 HSD11B1, FDPS, FUT7, ALOX15, CYP1A1, AOX1, ALPL, AKR1B1, PTGS2, CYP3A4, PTGS1 2.9634
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 3.0074
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.9307
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.9416
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, BCL2, PIK3CB, MMP9 2.6676
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 3.0307
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, AOX1, CYP1B1 3.0225
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.0225
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, AOX1, PIK3CB 2.5812
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, BCL2, CYP1B1, PTGS2, MMP9 2.475
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, PIK3CB, PTGS2 2.6676
Ovarian steroidogenesis_Homo sapiens_hsa04913 CYP1A1, CYP1B1, PTGS2 2.8837
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, CNR1, PIK3CB, DRD2 2.1663
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.6676
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB 2.2633
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX15, PTGS2, PTGS1 2.6676
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1, AOX1, CYP3A4 2.6211
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB 2.1172
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, PIK3CB, PPARA 2.0696
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, BCL2, PIK3CB 1.9935
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, PIK3CB, ESR1 1.9935
Platelet activation_Homo sapiens_hsa04611 PIK3CA, PIK3CB, PTGS1 1.9727
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.983
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.8251
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.8775
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB 1.8173
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.7762
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.7857
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, PIK3CB, PTGS2 1.7416
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.6919
Influenza A_Homo sapiens_hsa05164 FDPS, PIK3CA, PIK3CB 1.6596
Epstein-Barr virus infection_Homo sapiens_hsa05169 PIK3CA, BCL2, PIK3CB 1.5877
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, BCL2, PIK3CB 1.5877
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, PIK3CB 1.4868
HTLV-I infection_Homo sapiens_hsa05166 FDPS, PIK3CA, PIK3CB 1.3949
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB 1.6012
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.5911
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB 1.6055
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.6012
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.6521
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.687
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, PIK3CB 1.5955
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, PIK3CB 1.6799
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.7335
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB 1.6012
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4542
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.4389
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB 1.4025
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4395
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.4291
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, BCL2, PIK3CB 1.1598
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB 1.4257
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, PIK3CB 1.4724
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB 1.5877
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.3949
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.4025
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.3949
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.2194
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.1848
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.5877
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.5877
Measles_Homo sapiens_hsa05162 PIK3CA, PIK3CB 1.2096
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB 1.2592
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB 1.218
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.2108
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 1.2328
NF-kappa B signaling pathway_Homo sapiens_hsa04064 BCL2, PTGS2 1.4291
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.5877
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.3743
Insulin signaling pathway_Homo sapiens_hsa04910 PIK3CA, PIK3CB 1.197
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 1.1783
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.3949
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.3848
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 AOX1, CYP3A4 1.5911
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 1.0415
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, PIK3CB 0.9367
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.3848
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.5877
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, PIK3CB 0.9642
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.7762
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.8044
PPAR signaling pathway_Homo sapiens_hsa03320 MMP1, PPARA 1.5911
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, PIK3CB 1.5449
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PIK3CB 1.0207
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.7673
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.6402
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.54
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6568
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6562
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.67
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.67
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.67
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.7426
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7406
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7557
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.7696
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP3A4 2.0903
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.817
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2568
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.8726
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.8986
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.8938
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4 0.9038
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 1.0458
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 1.0401
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 1.0013
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 1.0309
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9935
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 1.056
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0935
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0818
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 1.1598
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.3028
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.5777


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)