Prescription Description
| Prescription ID | TCMF5306 |
| Pinyin Name | Tang Niao Ling Pian |
| Chinese Name | 糖尿灵片 |
| English Name | Tang Niao Ling Tablets |
| Function Description | 消渴 |
| Indications | Wasting thirst disorder, Diabetes |
| Disease ICD-11 Category |
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1)
]; 5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ]; |
| Human Tissues Associated with Indication | Pancreas, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2086 | Trichosanthes kirilowii | 天花粉 | TCMH2086 | ITSAO4359-14 |
| TCMH677 | Pueraria lobata | 葛根 | TCMH677 | ITSAJ4206-14 |
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
| TCMH1595 | NA | 糯米 | TCMH1595 | |
| TCMH1539 | Cucurbita moschata | 南瓜 | TCMH1539 | GBVL1329-11, GBVL1328-11 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
Showing 1 to 10 of 83 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 64 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, PPARA, SRC | 2.0208 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 | 2.7904 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, SRC | 2.24568 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, TYR | 2.07041 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.26324 |
| [BP] GO:0006352 | DNA-templated transcription, initiation | ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA | 2.47211 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA | 2.9207 |
| [BP] GO:0006468 | protein phosphorylation | AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS | 3.34379 |
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, TRPV1 | 11.2159 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA | 3.34481 |
Showing 1 to 10 of 240 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.4439 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.3782 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.6071 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.4391 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | BCL2, PIM1, F3 | 1.838 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2 | 0.7471 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.476 |
| Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.683 |
| Apoptosis_Homo sapiens_hsa04210 | BCL2 | 0.4514 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, ALOX12 | 2.2309 |
Showing 1 to 10 of 126 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples