TCM Prescription: Qing Huo Wei Mai Capsules



Prescription Description
Prescription IDTCMF5287
Pinyin NameQing Huo Wei Mai Jiao Nang
Chinese Name清火桅麦胶囊
English NameQing Huo Wei Mai Capsules
Function Description喉痹, 发热, 牙痛
IndicationsFever, Pharyngitis
Disease ICD-11 Category MG26 [Fever of other or unknown origin, 其他或不明原因的发热 ];
CA0Z [Upper respiratory tract disorders, unspecified, 上呼吸道疾患，未特指的 ];
Human Tissues Associated with IndicationLung, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH298 Andrographis paniculata 穿心莲 TCMH298 ITSAO3492-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, SRC, TERT 8.11853
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 7.19064
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 7.19064
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.44429
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 6.09737
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 5.91579
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, PIM1, SRC 5.91579
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.86801
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.73657
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.73657
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.67351
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DYRK1A, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.67351
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.67351
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 5.67351
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.67351
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT 5.67351
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, SRC, TERT 5.31874
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, HSD17B1, KIT, MET 5.25738
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 5.08881
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.08881
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.05018
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.98501
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PTPN1, SRC, TERT 4.98501
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT 4.98501
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 4.98501
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.91627
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.91325
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.91325
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, FLT3, IGF1R, KIT, MMP2, SRC 4.79252
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.78452
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 4.77823
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, TERT 4.64265
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP4, FLT3, HCAR2, HSD17B1, KDR, KIT, MET, SRC, TERT, XDH 4.64265
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTPN1, SRC, XDH 4.64265
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.64265
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.64145
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.60887
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP2, SRC 4.60834
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TERT 4.50561
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.4804
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 4.47219
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 4.4084
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, IGF1R, MMP2, MMP9, SRC 4.36004
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, PIM1, SRC, TERT 4.32128
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 4.30806
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, XDH 4.24923
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 4.18382
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SRC, TERT, XDH 4.15195
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 4.12626
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, FLT3, KDR, KIT, MET, PTPN1, SRC, XDH 4.11142
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, PTPN1, SRC, XDH 3.99916
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 3.8302
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, SRC 3.68402
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.6577
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, PIM1, XDH 3.60912
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.5483
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.45372
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.3846
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.3846
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, HCAR2, MMP12, SRC, TERT 3.38427
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, IGF1R, KDR, KIT, MET, MMP9, SRC, TERT 3.35608
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, FABP4, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PTPN1, SRC, TERT 3.2949
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 3.28643
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.28626
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, FLT3, KIT, MET, PIM1, SRC 3.27001
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FLT3, KIT, SRC 3.24562
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 3.22264
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 3.18344
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 3.1416
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.08743
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, APP, CYP19A1, DYRK1A, FABP4, IGF1R, MET, MMP12, MMP2, PTPN1, SRC, TERT, XDH 3.08532
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 3.08266
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 3.03897
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP4, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.03546
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 3.02928
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DYRK1A, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, XDH 3.00844
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FLT3, SRC 2.97857
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.97237
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.97237
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.97237
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT 2.93261
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, KIT 2.93261
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.90738
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, HCAR2, KDR, KIT, MET, MMP12, MMP9, PIM1, SRC, TERT 2.90738
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.89705
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.88338
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.87811
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DYRK1A, FABP4, HCAR2, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIM1, PTPN1, SRC, TERT, XDH 2.79856
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.79856
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.79856
[BP] GO:0046686 response to cadmium ion CYP1A2, KIT, MMP9, TERT 2.78624
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, FABP4, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, SRC 2.7862
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, FABP4, FLT3, MET, SRC, TERT 2.78315
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FUT7, KIT, MET 2.73878
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, IGF1R, MET, MMP9, PIM1, PTPN1, SRC 2.72912
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.72912
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, DNMT1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.71514
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.70097
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PTPN1, SRC, TERT 2.69806
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.69806
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, KDR, KIT, MMP9, PIM1, SRC 2.69635
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.6857
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, KIT, SRC 2.68568
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, HCAR2, KDR, SRC 2.68568
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.67976
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, MMP9, SRC 2.66191
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, SRC, TERT 2.66191
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC 2.63571
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, KIT, MMP2, SRC, TERT 2.63571
[BP] GO:0050730 None ADORA1, APP, FLT3, KIT, PTPN1, SRC 2.61607
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.61521
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 2.61052
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.60959
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.60684
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.57087
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1 2.51699
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.51691
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, FLT3, KDR, KIT, PTPN1, SRC, XDH 2.51076
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, FABP4, FLT3, IGF1R, KIT, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 2.48326
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.48326
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DYRK1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.48326
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.47724
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.47724
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.44813
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.43258
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, FLT3, KIT, MET, MMP9, PTPN1, SRC, TERT, XDH 2.42657
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DYRK1A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.42648
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DYRK1A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.41591
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.39831
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.39573
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, MMP9 2.38508
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.37876
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.37331
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36984
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DYRK1A, FLT3, FUT7, IGF1R, KDR, KIT, MET, MMP1, MMP2, PIM1, PTPN1, SRC 2.35961
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, FABP4, FLT3, IGF1R, KIT, MMP9, PTPN1, SRC, TERT, XDH 2.35477
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.35477
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.35477
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.35477
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.35477
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, FLT3, KDR, KIT, MMP9, PTPN1, SRC, XDH 2.35477
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, FLT3, IGF1R, KDR, KIT, PTPN1, SRC, XDH 2.3519
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP4 2.33428
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.32342
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7 2.30746
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, KDR, SRC 2.28071
[BP] GO:1901989 None APP, CDC25B, CYP1A1, TERT 2.27125
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1 2.26539
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.25529
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, KIT, MMP2, MMP9, SRC 2.25529
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CYP1A1, FABP4, FLT3, FUT7, KDR, KIT, MET, MMP2, MMP9, SRC, TERT 2.25041
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA4, CA7, CA9 2.25041
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DYRK1A, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.25041
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.25041
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, KIT, SRC 2.24607
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, KIT, PTPN1, SRC 2.23965
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, IGF1R, MMP2, MMP9, SRC 2.235
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.22016
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, KIT, MMP2, MMP9, PTPN1, SRC, TERT 2.20573
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, SRC, TERT 2.20573
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.20245
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.16622
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.15539
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC 2.12111
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTPN1, SRC 2.1174
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, KIT, PTPN1, SRC 2.10325
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT 2.09949
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1 2.09071
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.07754
[BP] GO:0014911 positive regulation of smooth muscle cell migration BCL2, SRC, TERT 2.07523
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.07312
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, SRC 2.04983
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1 2.01831
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, KIT, PTPN1, SRC 2.01643
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, FLT3, HCAR2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT 3.28251
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HCAR2, IGF1R, KDR, KIT, MET, MMP2, PIM1, PTPN1, SRC, TERT 2.26539
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.07754
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.88307
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, MET 1.71538
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FLT3, FUT7, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 10.9003
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.28416
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, XDH 8.28416
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, XDH 6.94629
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.50584
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.24265
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, SRC 5.1482
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.91325
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.79252
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 4.26924
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 4.11142
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.11142
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.89997
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, TERT, XDH 3.58041
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.38906
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.29083
[MF] GO:0008270 zinc ion binding CA12, CA2, CA4, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, PTPN1 3.28647
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC 3.23302
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TERT 3.22373
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, KIT, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, TERT, XDH 3.22264
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC 3.11661
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.08266
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 3.03546
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.69532
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PTPN1, SRC 2.68467
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.59988
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.58888
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.30801
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.24559
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, DNMT1, DYRK1A, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, PIM1, SRC, XDH 2.2455
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.235
[MF] GO:0042802 identical protein binding ACHE, APP, BCL2, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, MMP9, TERT, XDH 2.18383
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.1174
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PTPN1, SRC 2.09071


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.8847
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.1013
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 5.0745
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 5.1251
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, IGF1R 4.3709
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.8125
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.0605
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.3814
Metabolic pathways_Homo sapiens_hsa01100 DNMT1, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, AKR1B1, CYP19A1, XDH 3.0809
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 3.0287
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 3.0122
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.6515
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.0144
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.6515
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KIT, KDR, BCL2, MET, IGF1R 2.243
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.4721
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3366
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.3892
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 2.1115
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.0887
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.1172
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1 2.2901
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.9215
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.9674
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.7734
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5745
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.5299
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5444
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4647
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4645
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.311
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3033
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4897
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.263
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1838
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.311
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3978
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.2325
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4645
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.4647
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2958
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.1838
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 1.16
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9559
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.16
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9248
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0474
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.014
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.9248
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.9038
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8377
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1 0.8419
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1693
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.6661
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9755
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9215
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.3538
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.3537
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5974
Insulin resistance_Homo sapiens_hsa04931 PTPN1 0.5578
Platelet activation_Homo sapiens_hsa04611 SRC 0.5394
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5578
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.408
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5394
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.419
Apoptosis_Homo sapiens_hsa04210 BCL2 0.5184
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4712
Measles_Homo sapiens_hsa05162 CSNK2A1 0.5184
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5394
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4607
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.447
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5394
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5882
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5914
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5219
Melanogenesis_Homo sapiens_hsa04916 KIT 0.5852
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.5184
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5394
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.5184
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5974
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5974
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5974
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.5184
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.5113
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4915
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5174
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.447
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.5394
Axon guidance_Homo sapiens_hsa04360 MET 0.5348
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5974
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5974
Gap junction_Homo sapiens_hsa04540 SRC 0.5974
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5914
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6423
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5914
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.637
Peroxisome_Homo sapiens_hsa04146 XDH 0.5974
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6661
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6661
Glioma_Homo sapiens_hsa05214 IGF1R 0.6661
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6659
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.6661
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6661
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6536
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6661
Shigellosis_Homo sapiens_hsa05131 SRC 0.6661
Malaria_Homo sapiens_hsa05144 MET 0.7251
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7153
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7445
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7491
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.7467
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1933
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8735
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8941
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9169
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9087
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1387


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)