TCM Prescription: Qu Ji Zhi Zhu Pills



Prescription Description
Prescription IDTCMF5227
Pinyin NameQu Ji Zhi Zhu Wan
Chinese Name曲积枳术丸
English NameQu Ji Zhi Zhu Pills
Function Description积滞
IndicationsDyspepsia
Disease ICD-11 Category MD92 [Dyspepsia, 消化不良 ];
Human Tissues Associated with IndicationSpleen, Intestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1430 Hordeum vulgare 麦芽 TCMH1430 ITSAI3101-14
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT335 MPO Myeloperoxidase Oxidoreductase P05164
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 10.3294
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IDO1, IGF1R, INSR, MPO, POLB, PPARA, PTGS2, RORC, SRC, TEK, TYR 9.05048
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, IDO1, MPO, PTGS2, RORC, SRC, TYR 8.62838
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MPO, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.3302
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.0243
[BP] GO:0023056 positive regulation of signaling AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.0243
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.88663
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR, XDH 7.84358
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.6355
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.42317
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 7.42317
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.34894
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.25893
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 7.11568
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.99295
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.96594
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.82265
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.73426
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 6.67346
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 6.67346
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MPO, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.6626
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, PTGS2, TBXAS1 6.57917
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.31497
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, PTGS2, PTPN1, SRC, TEK, XDH 6.22844
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 6.22489
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SMAD3, SRC, TEK 6.20613
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC, TEK, TYR 6.19144
[BP] GO:0042127 regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 6.11084
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 6.09428
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTGS2, PTPN1, SRC, TEK, XDH 5.91427
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, HTR6, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.89995
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.89971
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.84837
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.83381
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.73423
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.73423
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, PTGS2, SRC 5.64066
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 5.60513
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MPO, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.56242
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTGS2, PTPN1, RORC, SMAD3, SRC 5.3832
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 5.12459
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.99039
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.92122
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.89793
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, INSR, KDR, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.83082
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS2, TBXAS1 4.7512
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, PTGS2, RORC, SMAD3, SRC 4.57876
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MPO, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.53984
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.53442
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 4.39728
[BP] GO:0042592 homeostatic process AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 4.39728
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTGS2, RORC, SMAD3, SRC 4.2879
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.17563
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 4.14312
[BP] GO:0032879 regulation of localization ACHE, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.109
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.05859
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 4.04648
[BP] GO:0080134 regulation of response to stress CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IDO1, IGF1R, MET, MMP12, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.01904
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.95868
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, MPO 3.94099
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.94099
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.92617
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MPO, PTGS2, SRC 3.91293
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.91293
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 3.91293
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.90886
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.86284
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.85302
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MPO 3.85302
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.84585
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.77545
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 3.75547
[BP] GO:0019220 regulation of phosphate metabolic process BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.75547
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, PTGS2, SRC 3.73522
[BP] GO:0051174 regulation of phosphorus metabolic process BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.71975
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PTGS2, TEK 3.71975
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.71666
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.70705
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.67478
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.64974
[BP] GO:0009966 regulation of signal transduction AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, HTR6, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.64974
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SRC, TEK 3.59959
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.57736
[BP] GO:0030334 regulation of cell migration BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.55338
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MPO 3.5239
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, POLB, PPARA, PTGS2, SMAD3, SRC, TEK 3.5104
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, FABP4, HSPA1A, IDO1, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.47809
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2, TBXAS1 3.47227
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, MPO, PTGS2, SRC 3.47227
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.47227
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.47227
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.46801
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 3.45003
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO 3.42853
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.40883
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 3.39636
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.35481
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PTPN1, SMAD3, SRC, TEK 3.35003
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.35003
[BP] GO:2000145 regulation of cell motility BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.32777
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, PTGS2, SRC 3.32251
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 3.25851
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.25645
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC 3.23726
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.2309
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, IDO1, KDR, MET, MMP12, PIM1, PTGS2, SMAD3, SRC, TEK 3.22985
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.13888
[BP] GO:0051704 multi-organism process AXL, BCL2, CHRM2, CYP1A1, EGFR, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MPO, POLA1, SMAD3, SRC 3.09941
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, PTGS2, SRC 3.09941
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 3.09941
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 3.08216
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 3.07869
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 3.07635
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 3.07635
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 3.06588
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.03946
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.03946
[BP] GO:0040012 regulation of locomotion BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.03841
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, FLT3, PTGS2, RORC, SRC 3.02962
[BP] GO:0051270 regulation of cellular component movement BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PTGS2, SMAD3, SRC, TEK 3.02953
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, PTGS2, SRC 3.02953
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.01596
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, EGFR, HCAR2, KDR, PTGS2, SRC 2.99556
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.97969
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PPARA, PTGS2, TBXAS1 2.97191
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, POLB, TEK, TYR 2.96346
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, IDO1, MMP12, MPO, SRC, XDH 2.95565
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TYR 2.95242
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MPO, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.95242
[BP] GO:0006950 response to stress ACHE, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, IDO1, MPO, NUAK1, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.94619
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 2.94619
[BP] GO:0051049 regulation of transport ACHE, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC 2.89796
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1 2.89796
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 2.89435
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.89435
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.89435
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.89435
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.89435
[BP] GO:0010562 positive regulation of phosphorus metabolic process BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.89435
[BP] GO:0045937 positive regulation of phosphate metabolic process BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.89435
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, PPARA, PTGS2, SMAD3, SRC, TEK 2.88623
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 2.88356
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 2.87072
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, FABP4, IDO1, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 2.86977
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.86595
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.86103
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.84861
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.84751
[BP] GO:0048585 negative regulation of response to stimulus BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.84496
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HCAR2, HSD17B1, HSD17B2 2.83055
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, FABP4, IDO1, PPARA, PTGS2, SMAD3, TEK 2.80529
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.80464
[BP] GO:0042325 regulation of phosphorylation BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 2.79989
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.79989
[BP] GO:0051050 positive regulation of transport ACHE, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 2.79989
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.79989
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.79989
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MPO, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.79989
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HSPA1A, IGF1R, MET, PTGS2, PTPN1, SRC, XDH 2.79989
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.78961
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.78694
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.78694
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.785
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC 2.77375
[BP] GO:0009987 cellular process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, HTR6, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 2.74787
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.74236
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.74236
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, IDO1, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.74236
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK, TYR 2.74236
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, MPO, PTGS2, SRC, TYR 2.71825
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.71238
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.71238
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, PPARA, PTGS2, PTPN1, SRC 2.71238
[BP] GO:0065009 regulation of molecular function AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.70556
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.67055
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.66884
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.66884
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.66161
[BP] GO:0031399 regulation of protein modification process BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, NUAK1, PTGS2, PTPN1, SRC, TEK, XDH 2.64453
[BP] GO:0001932 regulation of protein phosphorylation BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.62746
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.62123
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PIM1, PPARA, PTGS2, TBXAS1, TYR 2.5918
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.56772
[BP] GO:0009605 response to external stimulus ALPL, AXL, BCL2, CHRM2, CYP1A1, CYP1A2, EGFR, IDO1, MMP12, MPO, PTGS2, SMAD3, SRC, TYR 2.56329
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.56329
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.56329
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.56329
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PTGS2, SRC, TEK 2.56329
[BP] GO:0043408 regulation of MAPK cascade DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.526
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.50786
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.50786
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, PTGS2, SRC 2.48735
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.45374
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, TYR 2.44729
[BP] GO:0050790 regulation of catalytic activity AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.42102
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.40653
[BP] GO:0051894 None KDR, SMAD3, TEK 2.40597
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PTGS2 2.40028
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.39014
[BP] GO:0009894 regulation of catabolic process BCL2, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.37945
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, PTGS2 2.37224
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36835
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.36427
[BP] GO:0007568 aging AURKB, BCL2, CYP1A1, MPO, POLB, PTGS2 2.36361
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.33351
[BP] GO:1903393 None KDR, SMAD3, TEK 2.32409
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.31827
[BP] GO:0001934 positive regulation of protein phosphorylation BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.27285
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.27052
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.26946
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.26196
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK 2.25724
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PTPN1, SMAD3, SRC, TEK 2.25724
[BP] GO:0051239 regulation of multicellular organismal process AXL, BCL2, CA2, CHRM2, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, IDO1, INSR, KDR, MET, MMP12, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.25724
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MPO, RORC, SMAD3, SRC 2.23479
[BP] GO:0033554 cellular response to stress AKR1B1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, NUAK1, POLA1, POLB, PTGS2, PTPN1, SRC 2.23155
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, POLB, PTPN1, SRC, TEK 2.23012
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.20923
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, HSPA1A, IDO1, MPO, SRC, XDH 2.20744
[BP] GO:0080135 regulation of cellular response to stress DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 2.1746
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.1746
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.1746
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, PTGS2, SMAD3 2.1746
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, PTGS2, PTPN1, SRC 2.16867
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, IDO1 2.16685
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.16685
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.16685
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, IDO1, INSR, PTGS2, SRC 2.16451
[BP] GO:0042327 positive regulation of phosphorylation BCL2, CDC25B, EGFR, FLT3, INSR, KDR, PTGS2, PTPN1, SRC, TEK, XDH 2.14783
[BP] GO:0043410 positive regulation of MAPK cascade EGFR, FLT3, INSR, KDR, PTPN1, SRC, TEK, XDH 2.14783
[BP] GO:1901890 None KDR, SMAD3, TEK 2.14783
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.14527
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.13288
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, BCL2, EGFR, HCAR2, MMP12, PTGS2, SMAD3, SRC 2.12945
[BP] GO:0009895 negative regulation of catabolic process BCL2, EGFR, HCAR2, MET, PPARA, SMAD3 2.12252
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PTGS2, TEK 2.12132
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, PTGS2, PTPN1, SMAD3, SRC, XDH 2.1109
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.0787
[BP] GO:0010907 None INSR, PPARA, SRC 2.0787
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, SRC 2.07047
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.07047
[BP] GO:0051338 regulation of transferase activity AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.06685
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.06386
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, IDO1, MMP12, PTGS2, SMAD3, SRC 2.04882
[BP] GO:0031348 negative regulation of defense response CYP19A1, MMP12, PPARA, SMAD3, TEK 2.04719
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.04719
[BP] GO:0043549 regulation of kinase activity CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 2.0446
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, PTGS2 2.03851
[BP] GO:0021885 forebrain cell migration AXL, EGFR, HTR6 2.02188
[BP] GO:0051247 positive regulation of protein metabolic process BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.02188
[BP] GO:0043434 None FABP3, INSR, PPARA, PTGS2, SRC, TEK 2.01996
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.06386
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, PTGS2, SRC, TEK 1.91797
[CC] GO:0016323 basolateral plasma membrane CA2, CA4, CA9, EGFR, TEK 1.90775
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, PTGS2, SRC, TEK 1.90731
[CC] GO:0098590 plasma membrane region CA2, CA4, CA9, CHRM2, EGFR, INSR, MET, PTGS2, SRC, TEK 1.66161
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PTGS2, PTPN1, SRC, TBXAS1, TEK, TYR, XDH 10.3294
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3294
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.99556
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 7.96304
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.85869
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.34894
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.20915
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 7.04472
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MPO, PTGS2, SRC, TBXAS1 6.82265
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82265
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, IDO1, MPO, PTGS2, TBXAS1, TYR, XDH 6.17855
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.97327
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK 5.76777
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, IDO1, MPO, POLA1, PTGS2, SRC, TBXAS1, XDH 5.45064
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.99039
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.76289
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 4.50828
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 4.42
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.16451
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS2, TBXAS1, TYR 4.09814
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 4.08353
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 4.06891
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.03249
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.91219
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.84585
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.73522
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.47227
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.29108
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.16023
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.99731
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.95565
[MF] GO:0032403 protein complex binding ACHE, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.83286
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, XDH 2.79989
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP12, PPARA, PTPN1, RORC, SMAD3 2.77878
[MF] GO:0038023 signaling receptor activity AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.64453
[MF] GO:0036094 small molecule binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.62746
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.48912
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.40653
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.37224
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 2.37209
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.36427
[MF] GO:1901363 heterocyclic compound binding AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 2.33192
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.32409
[MF] GO:0097159 organic cyclic compound binding AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MPO, NUAK1, PIM1, POLA1, POLB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 2.281
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.27901
[MF] GO:0004871 signal transducer activity AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 2.27513
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.27232
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.25296
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.20923
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, HSPA1A, MET, POLA1, POLB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 2.20399
[MF] GO:0043559 insulin binding IGF1R, INSR 2.19485
[MF] GO:0004872 receptor activity AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.17315
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.14783
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MPO, NUAK1, PIM1, SRC, TEK, XDH 2.0787
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06386
[MF] GO:0060089 molecular transducer activity AXL, CHRM2, EGFR, FLT3, GPR35, HCAR2, HTR6, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.06346


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.9662
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.9662
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.9234
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.3763
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.4414
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.3855
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.1128
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.9743
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.1128
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.8784
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PTGS2, MET, EGFR, CDC25B 3.6753
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.6499
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.3998
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, BCL2, PTGS2, MET, EGFR, IGF1R 3.0396
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.7049
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 3.141
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4345
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.348
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, PTGS2 2.4345
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3279
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1, PTGS2 2.348
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2891
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2889
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2691
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, MPO, IGF1R 2.115
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, HTR6, PPARA 2.014
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.0482
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.9462
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.2505
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2882
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.9578
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.8791
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.014
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8791
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7476
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, ALOX5, PTGS2 1.8791
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.8262
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.7093
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.6214
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.5375
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, EGFR 1.4313
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.3298
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.2797
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR6, GPR35 1.0512
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4313
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1724
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2397
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4881
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.2179
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.0198
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1989
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4363
Small cell lung cancer_Homo sapiens_hsa05222 BCL2, PTGS2 1.2415
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.961
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.0198
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9718
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3056
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4268
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2377
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9562
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0198
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4685
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9519
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9519
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9165
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9469
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9562
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4313
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.8952
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4313
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8671
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8505
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.848
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.7781
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6568
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.7265
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3943
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.4098
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3937
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4477
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR 0.4227
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4553
Phagosome_Homo sapiens_hsa04145 MPO 0.4477
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4717
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4843
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5146
Axon guidance_Homo sapiens_hsa04360 MET 0.5005
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.5146
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5088
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9041
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5146
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2 0.5367
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5585
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5585
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5585
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5585
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5508
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5604
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5599
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5507
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5585
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5772
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5786
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5786
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5889
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5779
Peroxisome_Homo sapiens_hsa04146 XDH 0.5897
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.628
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.628
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.628
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6267
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6286
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6149
Bile secretion_Homo sapiens_hsa04976 CA2 0.628
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6434
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.63
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0524
Shigellosis_Homo sapiens_hsa05131 SRC 0.6453
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6688
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8791
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8164
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6921
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6951
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.7133
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7167
Malaria_Homo sapiens_hsa05144 MET 0.7284
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7321
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.745
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.8033
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8383
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8383
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8952
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8589
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.871
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8383
DNA replication_Homo sapiens_hsa03030 POLA1 0.8315
Base excision repair_Homo sapiens_hsa03410 POLB 0.848
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8952
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8671
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8952
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.141
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.076


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)