TCM Prescription: San Han Huo Luo Pills



Prescription Description
Prescription IDTCMF5222
Pinyin NameSan Han Huo Luo Wan
Chinese Name散寒活络丸
English NameSan Han Huo Luo Pills
Function Description痹病
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2195 Zaocys 乌梢蛇 TCMH2195
TCMH2129 Eupolyphaga sinensis 土鳖虫 TCMH2129 GBMIN33972-13
TCMH456 Rhizoma dioscoreae nipponicae 地龙 TCMH456
TCMH517 Angelica pubescens 独活 TCMH517 ITSAF170-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.88389
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, POLB, RORC, SMAD3, SRC, TEK, TYR 9.37176
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, TBXAS1 9.26589
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.09118
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, XDH 7.85058
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, XDH 7.85054
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MET, POLA1, POLB, SMAD3, SRC, TEK, XDH 7.78327
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, POLB, RORC, SMAD3, SRC, TEK, TYR 7.65381
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, POLB, RORC, SRC, TEK, TYR 7.23879
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 7.17777
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.14547
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.11691
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, POLB, SMAD3, SRC, TEK, TYR 7.0067
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, HSPA1A, PIM1, TBXAS1, TYR, XDH 6.88238
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.86419
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, SRC 6.77537
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 6.55851
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, SRC, TEK, XDH 6.55851
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, KIT, SMAD3, SRC, TEK 6.53443
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, SRC, TEK, XDH 6.53443
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 6.53443
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 6.50684
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, PIM1, SMAD3, SRC, TEK 6.42148
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, XDH 6.30138
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC 6.23498
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, HSD17B2 6.23498
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 6.20296
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, KIT, SRC, TEK 6.1373
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 6.0636
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.0636
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 6.04933
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, KIT, MET, PIM1, SMAD3, SRC, TEK 5.9938
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.97508
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, POLA1, POLB, RORC, SMAD3, SRC 5.96188
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 5.94555
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, KIT, MET, TBXAS1 5.94555
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 5.87931
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, SRC, TEK, XDH 5.79475
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 5.79475
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, RORC, SMAD3, SRC 5.79475
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, KIT, PIM1, POLB, RORC, SMAD3, SRC, TEK, TYR 5.68385
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, KIT, MET, PIM1, SMAD3, SRC, TEK, XDH 5.66549
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.63406
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.60455
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 5.59708
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 5.58504
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, RORC, SMAD3, SRC 5.51098
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 5.43183
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, KIT, MET, PIM1, POLA1, SRC, TEK, TYR 5.39667
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, NUAK1, POLA1, POLB, RORC, SMAD3, SRC, TEK, TYR 5.31388
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 5.21574
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, KIT, MET, PIM1, SMAD3, SRC, TEK, XDH 5.21574
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, KIT, MET, PIM1, POLB, RORC, SMAD3, SRC, TEK, TYR 5.20807
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 5.06983
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.03449
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, KIT, POLB, SMAD3, SRC, TEK, TYR 4.98603
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK 4.98219
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 4.9735
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.96223
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 4.83273
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.77815
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.77097
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK, XDH 4.77097
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.74043
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, SMAD3, SRC, TEK 4.73278
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK, XDH 4.66967
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 4.60652
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, KIT, MET, MMP12, PIM1, RORC, SMAD3, SRC, TEK, TYR 4.49948
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, KIT, MET, SRC, TEK 4.42636
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.42636
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.37754
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.32528
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, PIM1, SMAD3, SRC, TEK, XDH 4.31905
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.21392
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 4.17719
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 4.17719
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 4.14023
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 4.08446
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 4.07077
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 4.0434
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PIM1, RORC, SMAD3, SRC, TEK, XDH 4.04162
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 4.02117
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.91957
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.9095
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.9095
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 3.85983
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, KIT, SRC, TEK, XDH 3.76996
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.7577
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, SRC 3.68226
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, TBXAS1 3.67322
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.65665
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.59339
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 3.59262
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PIM1, RORC, SMAD3, SRC, TEK, XDH 3.55198
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, NUAK1, SMAD3, SRC, TEK, XDH 3.54551
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.50431
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, NUAK1, SMAD3, SRC, TEK, XDH 3.50431
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT 3.45967
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.43438
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.30026
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MMP12, PIM1, TEK 3.29061
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, SRC 3.27361
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, PIM1, RORC, SMAD3, SRC, TEK, XDH 3.26746
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SRC 3.26746
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 3.26483
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, SRC 3.2583
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 3.25407
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 3.23955
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, NUAK1, SMAD3, SRC, TEK, XDH 3.20597
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 3.19696
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, SMAD3, SRC, TEK, XDH 3.15679
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, EGFR, FABP3, FLT3, INSR, KDR, KIT, SMAD3, SRC, TEK, XDH 3.11935
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, EGFR, FABP3, FLT3, INSR, KDR, KIT, SMAD3, SRC, TEK, XDH 3.11935
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.11935
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, RORC, SRC, TEK 3.11361
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.11126
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 3.0638
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 3.05947
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 3.05398
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, RORC, SMAD3, SRC 3.00894
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, SRC 3.00894
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC 3.00595
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, KIT, SRC 3.00595
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 3.00595
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 3.00595
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 3.00595
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 3.00595
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 3.00595
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1, HSD17B2 3.00296
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.99274
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HSPA1A, KDR, KIT, MET, MMP12, PIM1, SMAD3, SRC, TEK 2.98349
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, SMAD3 2.9796
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.9796
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.96013
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 2.91114
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.91114
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.91114
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, SRC, TEK, XDH 2.9108
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A 2.90583
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, KIT, RORC, SRC 2.90583
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.90583
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.90583
[BP] GO:0030098 lymphocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.88726
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, KIT, NUAK1, POLA1, POLB, SMAD3, SRC, TEK 2.87997
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.8736
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 2.87021
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, POLB, SMAD3, SRC, TEK 2.85187
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, SRC, TEK 2.84488
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, SRC, TEK 2.82801
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.82801
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.82602
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.82602
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.8192
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.8192
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLB, SMAD3, SRC, TEK, TYR, XDH 2.80639
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT 2.78143
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, KIT 2.78143
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.74734
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.73158
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.71084
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.68488
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, SRC, TEK 2.68275
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.65308
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.65308
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.64672
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, PIM1, RORC, SMAD3, SRC, TEK, XDH 2.63841
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, RORC, SMAD3 2.63356
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, SMAD3, SRC, TEK 2.60016
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, SMAD3, SRC, TEK 2.60016
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, PIM1, SMAD3, SRC, TEK, XDH 2.58377
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.58135
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, SMAD3, SRC, XDH 2.57921
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, SMAD3, SRC, XDH 2.56928
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.56928
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CYP19A1, EGFR, HSD17B2, INSR, KIT, SRC 2.55676
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.5369
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, SRC, TEK, TYR 2.5312
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, SMAD3, SRC, TEK 2.52947
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, SRC, TEK, XDH 2.52729
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.52152
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.51643
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, SMAD3, SRC, TEK 2.48273
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, SRC 2.47858
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, INSR, MET, POLB, SMAD3, SRC, TEK 2.47754
[BP] GO:0051894 None KDR, SMAD3, TEK 2.47754
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.47754
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, EGFR, FLT3, INSR, KDR, KIT, SRC, TEK, XDH 2.47741
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, KIT, MET, NUAK1, POLB, SRC, TEK 2.47315
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, KDR, SRC 2.47228
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, TBXAS1 2.44831
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, SRC, TEK 2.4453
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, SRC 2.42348
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.41744
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.40736
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, XDH 2.40556
[BP] GO:1903393 None KDR, SMAD3, TEK 2.39215
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.36513
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC 2.36235
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, PIM1, SRC 2.36235
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.3447
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, EGFR, FLT3, INSR, KDR, KIT, SRC, TEK, XDH 2.33247
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.32758
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, SRC 2.3268
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DUSP3, EGFR, INSR, SRC 2.30814
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, SRC, TEK, TYR 2.30814
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSPA1A, INSR, KDR, MET, MMP12, POLA1, SMAD3, SRC 2.3072
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.29865
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.29573
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, SMAD3, SRC, TEK 2.25823
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, SMAD3 2.25823
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, KIT, SMAD3, SRC, TEK, XDH 2.24386
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, KIT, RORC 2.24386
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.24386
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.24386
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.24233
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.24233
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, SRC 2.2257
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, EGFR, FLT3, HSPA1A, INSR, KIT, SMAD3, SRC, TEK, XDH 2.21758
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, SMAD3, SRC 2.21158
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, KIT, SMAD3, SRC 2.20869
[BP] GO:1901890 None KDR, SMAD3, TEK 2.2085
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, SMAD3, SRC, TEK 2.20815
[BP] GO:0007155 cell adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, KIT, NUAK1, SRC, TEK 2.20809
[BP] GO:0022610 biological adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, KIT, NUAK1, SRC, TEK 2.18747
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PIM1, TBXAS1, TYR 2.18482
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.17745
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, SRC, TEK 2.15713
[BP] GO:0032989 cellular component morphogenesis APP, AXL, BCL2, EGFR, MET, SRC, TEK 2.14236
[BP] GO:0106027 None APP, IGF1R, INSR 2.14146
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, SMAD3, TEK 2.14131
[BP] GO:0030097 hemopoiesis FLT3, KDR, KIT, TEK 2.1379
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, FABP3, HSPA1A, SMAD3, XDH 2.13656
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET 2.13274
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC 2.12797
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.12797
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.11091
[BP] GO:1990535 None APP, INSR 2.11091
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, INSR, KDR, KIT, PIM1, SMAD3, SRC, TEK 2.11091
[BP] GO:0035295 tube development AKR1B1, CYP1A1, EGFR, KIT, SMAD3 2.11091
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC 2.11091
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, KIT, TYR 2.0872
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, SRC 2.08001
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, SMAD3, SRC, TEK, XDH 2.06447
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.05693
[BP] GO:0045124 None CA2, EGFR, SRC 2.05362
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, RORC, SMAD3, SRC, TEK, XDH 2.03844
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, EGFR, KIT, POLB, TYR 2.03844
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR 2.02754
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, SMAD3, SRC, TEK 2.02662
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, NUAK1, SMAD3, SRC, TEK, XDH 2.01761
[BP] GO:0030217 None BCL2, FUT7, KIT, RORC 2.00016
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, KIT, MET, MPEG1, SRC, TBXAS1, TEK, TYR 3.04203
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.90583
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, FUT7, GPR35, HSD17B2, IGF1R, INSR, KDR, KIT, MET, PIM1, SMAD3, SRC, TBXAS1, TEK, TYR 2.56928
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, CA2, CA4, CA9, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 2.04362
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, HSD17B2, TBXAS1 2.03632
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SRC, TEK 2.03577
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, SRC, TEK 2.02662
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, SRC, TBXAS1, TEK, TYR, XDH 9.88389
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 9.37176
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, TYR, XDH 8.7917
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.70167
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 8.45105
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP12, PIM1, RORC, SMAD3, TBXAS1, TYR, XDH 8.45105
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 7.20565
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 7.14547
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.83884
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.53443
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.20296
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.1878
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.17774
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 6.06071
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.87358
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.8106
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.71912
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 5.71509
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.67494
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 5.59856
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.58504
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 5.40113
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 4.97503
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.87294
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.50948
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, TBXAS1, TYR, XDH 4.0434
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 4.03476
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9, POLB 3.9315
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, KIT, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, TBXAS1, TYR, XDH 3.67407
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.45967
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.27361
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 3.13983
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, XDH 3.13983
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.12606
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.0308
[MF] GO:0008389 None CYP2A13, CYP2A6 3.00894
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 3.00703
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK 3.00595
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 2.99717
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, SMAD3, SRC 2.92893
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, XDH 2.85187
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, RORC, SMAD3, SRC, TBXAS1, TEK, XDH 2.78143
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, SMAD3 2.69567
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.58377
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.51643
[MF] GO:0051425 None APP, INSR 2.41744
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, SMAD3, SRC 2.41036
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, RORC, TEK 2.33416
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.31086
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.27254
[MF] GO:0043559 insulin binding IGF1R, INSR 2.24233
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.22178
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.20078
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 2.19437
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, TEK 2.13656
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, TEK 2.13656
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, RORC, SMAD3, TEK 2.04821
[MF] GO:0019899 enzyme binding APP, AURKB, BCL2, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, HSPA1A, KIT, MET, POLA1, POLB, SMAD3, SRC, TEK 2.03339
[MF] GO:0016740 transferase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK 2.02662


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 10.0916
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4174
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 9.7178
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5394
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 5.7272
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 5.2123
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 5.2123
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.5774
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.5284
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.7064
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 4.5421
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 4.1262
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.8719
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, KIT, BCL2, MET, EGFR, IGF1R 3.2108
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 3.5955
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, MET, EGFR, IGF1R 2.8579
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.5421
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 2.4312
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9059
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.5396
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.5411
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MET, EGFR 2.2806
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.4312
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.3527
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3904
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.1131
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.4299
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, BCL2, PIM1 1.988
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, EGFR, HSPA1A 1.9987
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.8371
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.8292
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.6503
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2 1.6503
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4203
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.5013
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.4633
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.3828
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4633
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, HSPA1A 1.1886
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4472
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2657
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4697
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.1191
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4633
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, EGFR 1.2462
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.1235
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4435
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.1925
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.235
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, TBXAS1 1.4633
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2657
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.2657
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.34
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 1.076
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4472
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5 1.1234
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2362
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 1.0042
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.4241
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.7212
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9197
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.0698
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9897
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9897
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.9197
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9935
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4 1.4241
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8921
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.8804
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6503
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8804
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.8072
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7809
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.6861
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9255
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4098
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.4159
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1 0.3916
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.4223
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4332
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.4093
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4679
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR 0.4641
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4627
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4845
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4936
Insulin signaling pathway_Homo sapiens_hsa04910 INSR 0.4845
Hepatitis C_Homo sapiens_hsa05160 EGFR 0.4936
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5117
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5167
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.5117
Axon guidance_Homo sapiens_hsa04360 MET 0.5064
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5194
Insulin resistance_Homo sapiens_hsa04931 INSR 0.5455
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5711
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.556
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5711
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5634
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.556
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5717
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5714
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5844
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5847
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8834
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5955
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8202
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5855
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.585
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5904
Peroxisome_Homo sapiens_hsa04146 XDH 0.596
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.634
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6353
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6328
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6214
Bile secretion_Homo sapiens_hsa04976 CA2 0.6364
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6611
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6647
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6861
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1131
Shigellosis_Homo sapiens_hsa05131 SRC 0.6629
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.7049
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.7256
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.7075
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7289
Malaria_Homo sapiens_hsa05144 MET 0.7404
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.744
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.8145
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8492
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.909
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8804
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8492
DNA replication_Homo sapiens_hsa03030 POLA1 0.8425
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8904
Base excision repair_Homo sapiens_hsa03410 POLB 0.8633
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9133
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8817
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.909
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1191


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)