TCM Prescription: She Xiang San Miao Ointment



Prescription Description
Prescription IDTCMF5217
Pinyin NameShe Xiang San Miao Gao
Chinese Name麝香三妙膏
English NameShe Xiang San Miao Ointment
Function Description乳痈, 疔疮, 疮疡, 黄水疮
IndicationsImpetigo disorder, Impetigo
Disease ICD-11 Category SB31 [Impetigo disorder (TM1), 黄水疮 (TM1) ];
1B72 [Impetigo, 脓疱病 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1880 Moschus moschiferus 麝香 TCMH1880 GBMA2112-09
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH2682 Cinnabaris 朱砂 TCMH2682
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH1343 Aloe vera 芦荟 TCMH1343 ITSAO4714-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT203 G6PD Glucose-6-phosphate 1-dehydrogenase Oxidoreductase P11413
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT974 GPER1 G-protein coupled estrogen receptor 1 GPCR Q99527
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5786
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7597
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 10.4641
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 9.95395
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MET, PPARA 9.90794
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FUT7, HSD17B3, PIM1, PPARA, TYR, XDH 9.7938
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 9.02567
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 8.9031
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, PGR, PIM1, PPARA, RORC, SRC 8.70245
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, AR, AXL, CA2, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.20593
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, HSD17B2, NR3C1, RORC, SLC6A4, SRC, TYR 8.01887
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.93128
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, GPER1, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, RORC, SLC6A4, SRC, TYR 7.88484
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 7.22937
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TYR, XDH 7.18787
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 7.1333
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FLT3, GPER1, NR3C1, RORC, SLC6A4, SRC, TYR 7.1333
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, RORC, SLC6A4, SRC, TYR 6.97267
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GPER1, NR3C1, PPARA, SLC6A4, SRC 6.8876
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 6.87002
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GPER1, IGF1R, MMP2, NR3C1, PPARA, SLC6A4, SRC 6.79693
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, RORC 6.69856
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.69856
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, GPER1, IGF1R, KDR, MMP12, MMP2, MMP9, PGR, PIM1, SLC6A4, SRC, TERT, XDH 6.69207
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, GPER1, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.63846
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, ESR1, F3, FABP3, FABP4, FLT3, GPER1, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MET, PPARA, SLC6A2, SLC6A4, SRC, TERT, XDH 6.31926
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AR, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC, TERT 6.04351
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.95173
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 5.95173
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 5.87689
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.7665
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 5.74077
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 5.66112
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, GPER1, NR3C1, RORC, SLC6A4, SRC 5.65447
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, MET, PPARA 5.43442
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 5.38959
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GPER1, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.30759
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, GPER1, NR3C1, PGR, SRC 5.28617
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, FLT3, GPER1, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 5.28617
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.15001
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.94943
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.8932
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, PPARA, SRC, TYR 4.87855
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 4.85021
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AR, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, IGF1R, KDR, MMP2, NR3C1, RORC, SLC6A4, SRC 4.71893
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 4.71049
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 4.691
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19, CYP3A4 4.62586
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.59933
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.53817
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 4.5301
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AR, CDC25B, CSNK2A1, ESR1, F3, FLT3, GPER1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 4.48297
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 4.37776
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRB, F3, FABP4, GPER1, HSD17B2, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TYR 4.35786
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CA6, CA9, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GPER1, HSD17B2, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 4.29733
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CA9, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, KDR, MET, MMP2, MMP9, PGR, PIM1, PPARA, RORC, SLC6A4, SRC, TERT, TYR 4.06367
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GPER1, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PTPN1, RORC, SLC6A4, SRC, TERT 4.06367
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GPER1, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.03407
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, AXL, CYP1B1, DRD1, ESR1, GPER1, IGF1R, MMP2, MMP9, NR3C1, RORC, SLC6A4, SRC 3.8282
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.76013
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.71273
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, GPER1, HCAR2, PPARA, RORC, SRC 3.67832
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.65527
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 3.62931
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TYR, XDH 3.5683
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 3.52647
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PPARA 3.48958
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.43947
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.43947
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.42968
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.42968
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.41618
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 3.39885
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.38708
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CES1, CYP1A1, CYP1B1, DRD1, KDR, SLC6A4, SRC 3.33487
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, FABP3, KCNH2, KDR, NR3C1, SLC6A2, SLC6A4, SRC 3.24613
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.24613
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, HSD17B3, TYR 3.24105
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, XDH 3.24105
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.20307
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.20307
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, AR, DRD1, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.17464
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP3A4, DRD1 3.16369
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, AR, DRD1, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.16369
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.15417
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.10896
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, CYP19A1, CYP1B1, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.09562
[BP] GO:0030335 positive regulation of cell migration ADRA2A, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 3.04193
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 3.04193
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.00387
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F3, FLT3, GPER1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 2.97198
[BP] GO:0071396 cellular response to lipid AR, AXL, ESR1, FLT3, GPER1, NR3C1, RORC, SLC6A4, SRC 2.96044
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 2.93987
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.93805
[BP] GO:2000147 positive regulation of cell motility ADRA2A, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.93661
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KDR, MMP9, PGR, PIM1, PPARA, RORC, SRC, TYR 2.93385
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD17B2, HSD17B3, MMP2, MMP9, PGR, SLC6A4, SRC 2.92257
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AR, DRD1, ESR1, FLT3, GPER1, IGF1R, MMP2, NR3C1, SLC6A4, SRC 2.92257
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, ESR1, FABP3, FABP4, FLT3, GPER1, KCNH2, MET, SRC, TERT 2.91321
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.91321
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, F3, FLT3, GPER1, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.91093
[BP] GO:0071383 None AR, FLT3, GPER1, NR3C1, SRC 2.90731
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.90243
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.85795
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KCNH2, KDR, NR3C1, SRC 2.83396
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, DRD1, GPER1, HCAR2, KDR, SRC 2.83187
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AR, AURKB, CDC25B, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPER1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.82062
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PGR, PPARA, RORC, SLC6A4, SRC 2.82038
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.81827
[BP] GO:0045742 None ADORA1, ADRA2A, GPER1, MMP9 2.81827
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, DRD1, GPER1, HCAR2, KCNH2, MMP12, SLC6A4, SRC, TERT 2.8068
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.77962
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, GPER1, KDR, SRC 2.76595
[BP] GO:0040017 positive regulation of locomotion ADRA2A, DRD1, F3, GPER1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.75764
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AR, AXL, CYP1B1, F3, FLT3, GPER1, KDR, MET, PTPN1, SRC, XDH 2.75764
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, PGR, SRC 2.75764
[BP] GO:1901186 None ADORA1, ADRA2A, GPER1, MMP9 2.75023
[BP] GO:1904705 regulation of vascular smooth muscle cell proliferation GPER1, MMP2, MMP9, TERT 2.75023
[BP] GO:0009115 None AOX1, XDH 2.74275
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.74142
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.7162
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 2.69739
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, FLT3, GPER1, NR3C1, SRC 2.6531
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.64856
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.64856
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.64611
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 2.63004
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, FABP3, KCNH2, PPARA, SLC6A2, SLC6A4 2.61548
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.56751
[BP] GO:0003018 None ADORA1, ADRA2A, DRD1, GPER1, SLC6A4, SRC 2.52154
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT 2.51969
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, AR, CYP19A1, DRD1, ESR1, ESR2, GPER1, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 2.51142
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GPER1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.49114
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.49066
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPER1, HCAR2, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 2.48649
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AR, AXL, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, GPER1, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, XDH 2.45903
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HSD17B3, TYR 2.43267
[BP] GO:0060748 None AR, PGR 2.33475
[BP] GO:0046110 None AOX1, XDH 2.33475
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.33475
[BP] GO:0010676 None ESRRB, GPER1, PPARA, SRC 2.32924
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.32924
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 2.31346
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT 2.29708
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, AR, CDC25B, DRD1, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.27097
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, AR, CDC25B, DRD1, ESRRB, FABP3, FLT3, GPER1, KDR, MMP9, PTPN1, SRC, XDH 2.27097
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.26089
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.2538
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, FABP3, PIM1, PPARA, TYR 2.24964
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC 2.24632
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.19461
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.18328
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, SRC 2.16825
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP3A4 2.16067
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.15702
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, DRD1, ESR1, ESR2, ESRRA, ESRRB, FABP3, GPER1, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT 2.14292
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.13508
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.13508
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.13508
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.13002
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CYP19A1, ESR1, F3, FABP4, GPER1, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.10853
[BP] GO:0006145 None AOX1, XDH 2.10715
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.10715
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.10715
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10093
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, GPER1, HCAR2, MMP12, SLC6A4, SRC 2.08783
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, GPER1 2.07897
[BP] GO:0010675 None ESRRB, GPER1, PPARA, RORC, SRC 2.07897
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.07221
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.05441
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, SLC6A4 2.05441
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.05409
[BP] GO:0097746 None ADORA1, ADRA2A, DRD1, GPER1, SLC6A4 2.04156
[BP] GO:0035296 None ADORA1, ADRA2A, DRD1, GPER1, SLC6A4 2.04156
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, GPER1, SLC6A4 2.04156
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.03722
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AR, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GPER1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, SRC, TERT, XDH 2.03722
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, ESR1, ESR2, ESRRA, ESRRB, GPER1, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, RORC, SRC, TERT 2.03594
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.02832
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, AR, CDC25B, DRD1, ESRRB, FABP4, FLT3, GPER1, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.01379
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, FABP3, FLT3, GPER1, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.00318
[CC] GO:0044432 endoplasmic reticulum part CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, FLT3, GPER1, HSD11B1, HSD17B2, HSD17B3, NR3C2, PTPN1 3.71273
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, GPER1, HSD11B1, HSD17B2, HSD17B3, NR3C2 2.97529
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, F3, FLT3, FUT7, GPER1, HCAR2, HSD11B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP2, NR3C2, PGR, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT, TYR 2.22271
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GPER1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KCNH2, KDR, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PTPN1, SLC6A4, SRC, TERT, TYR, XDH 2.13002
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.82024
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, TYR, XDH 22.5784
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.0609
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 13.3599
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, NR3C1, NR3C2, PGR, PPARA, RORC 11.94
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC 11.5369
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR, XDH 11.4208
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7597
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 9.75577
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, RORC 9.68726
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, GPER1, PGR, PPARA, RORC 9.68726
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.62563
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, F3, FLT3, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TERT, TYR, XDH 9.24881
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TYR, XDH 8.7625
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 8.3603
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, XDH 7.86814
[MF] GO:0008289 lipid binding AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, GPER1, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 7.5688
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 7.26174
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD11B1, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 7.11687
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.91185
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4 6.79693
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 6.65844
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 6.29793
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.16234
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, SRC 6.03379
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP3A4 5.95173
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 5.74077
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, TYR 5.65913
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 5.51389
[MF] GO:0042562 hormone binding ACHE, AR, GPER1, HSD17B1, IGF1R, NR3C1, SHBG 5.03773
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AR, AXL, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPER1, HCAR2, IGF1R, KCNH2, KDR, MET, NR3C1, NR3C2, PGR, PPARA, RORC 5.02554
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 4.91494
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, HSD17B1, SRC, XDH 4.28891
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2, GPER1 3.92741
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.24613
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.24576
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP3A4, DRD1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC 3.21827
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.20253
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.15786
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.14566
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.04193
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 2.96919
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.7967
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.74275
[MF] GO:0008389 None CYP2A13, CYP2A6 2.74275
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.57226
[MF] GO:0019899 enzyme binding ADRA2A, AR, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, F3, KCNH2, MET, NR3C1, PGR, PPARA, PTPN1, SLC6A4, SRC 2.43747
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.42167
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.42167
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.33475
[MF] GO:0005330 None SLC6A2, SLC6A4 2.33475
[MF] GO:0047374 None CES1, CES2 2.33475
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.2538
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.24067
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.2123
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, PGR, SLC6A4, TERT, TYR, XDH 2.10853
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.10715
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.10715
[MF] GO:0032795 None ADORA1, ADRA2A 2.10715
[MF] GO:0005497 None AR, SHBG 2.10715
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.10715
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPER1, HSD17B1, IGF1R, KDR, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTPN1, RORC, SHBG, SLC6A4, SRC, TERT, XDH 2.02674
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.02223


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.343
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP3A4, CYP19A1 10.4561
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.7688
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 7.7688
Metabolic pathways_Homo sapiens_hsa01100 HSD17B3, AKR1B1, TYR, CYP3A4, CYP2C19, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 5.9889
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.7077
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, GPER1, MMP9, ESR1, ESR2 4.677
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH, CES2, CES1 4.9987
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.0909
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.3388
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1, CYP3A4, CYP2C19 4.2513
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1388
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9423
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9289
Pathways in cancer_Homo sapiens_hsa05200 AR, FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.4105
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0586
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.833
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, NR3C1, ADRA2A 1.7162
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 1.6271
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6375
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.5812
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, PPARA 1.5812
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B, IGF1R 1.5812
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.5812
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4, CYP2C19 2.9492
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.5444
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, CYP2C19, SLC6A4 1.5349
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2944
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.437
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.1759
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2198
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2171
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1853
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9348
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2005
Prostate cancer_Homo sapiens_hsa05215 AR, IGF1R 0.9813
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1508
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5812
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9813
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1334
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.1853
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1489
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8184
Gap junction_Homo sapiens_hsa04540 SRC, DRD1 0.9813
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9813
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.8661
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0674
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7162
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8216
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.1334
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8216
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8184
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.7144
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7277
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7291
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0998
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.6396
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.684
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5444
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5812
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2161
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2161
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5367
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2706
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2608
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2946
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2698
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.2946
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2946
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2901
Alcoholism_Homo sapiens_hsa05034 DRD1 0.2946
Platelet activation_Homo sapiens_hsa04611 SRC 0.362
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3482
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3318
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3837
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3208
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4138
Measles_Homo sapiens_hsa05162 CSNK2A1 0.351
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2901
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.362
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3545
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3482
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3837
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3482
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3545
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.362
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4043
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4062
Axon guidance_Homo sapiens_hsa04360 MET 0.3579
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4016
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1 0.3567
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.409
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3665
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4043
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4138
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4138
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.409
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.409
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4138
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4138
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.409
Peroxisome_Homo sapiens_hsa04146 XDH 0.419
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4519
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4323
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.48
Glioma_Homo sapiens_hsa05214 IGF1R 0.48
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4678
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4827
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4796
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.48
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4793
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.48
Shigellosis_Homo sapiens_hsa05131 SRC 0.48
Malaria_Homo sapiens_hsa05144 MET 0.5564
Cocaine addiction_Homo sapiens_hsa05030 DRD1 0.5564
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5564
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5564
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 NR3C2 0.6236
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6979
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.712
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7291
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7049
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7277
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9348
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1853


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)