GO Term |
GO Name |
Enriched Genes |
Log10 Adjusted P-value |
[BP] GO:1901700 |
response to oxygen-containing compound
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR |
11.7034 |
[BP] GO:0006629 |
lipid metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 |
11.4401 |
[BP] GO:0008152 |
metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
11.4401 |
[BP] GO:0042221 |
response to chemical
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TERT, TOP1, TYR |
10.9358 |
[BP] GO:0010033 |
response to organic substance
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR |
10.9206 |
[BP] GO:0010941 |
regulation of cell death
|
ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, TOP2A, XDH |
10.4217 |
[BP] GO:0044237 |
cellular metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
10.3609 |
[BP] GO:0043067 |
regulation of programmed cell death
|
ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH |
10.3475 |
[BP] GO:0044281 |
small molecule metabolic process
|
AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, GLO1, IDO1, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH |
10.0423 |
[BP] GO:0010035 |
response to inorganic substance
|
AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC, TERT |
8.8922 |
[BP] GO:0042981 |
regulation of apoptotic process
|
ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TERT, TOP2A, XDH |
8.69148 |
[BP] GO:0055114 |
oxidation-reduction process
|
AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH |
8.47658 |
[BP] GO:0065008 |
regulation of biological quality
|
ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSD17B2, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT, XDH |
8.32207 |
[BP] GO:0033993 |
response to lipid
|
AKR1C3, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR |
8.17077 |
[BP] GO:0014070 |
response to organic cyclic compound
|
AKR1C3, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TYR |
8.148 |
[BP] GO:0032502 |
developmental process
|
ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B2, KDR, KIT, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, TYR |
8.148 |
[BP] GO:0060548 |
negative regulation of cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TERT |
8.148 |
[BP] GO:0070887 |
cellular response to chemical stimulus
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TERT |
8.11631 |
[BP] GO:0042127 |
regulation of cell proliferation
|
ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PGR, PIM1, PTGS1, PTGS2, SRC, TERT, XDH |
8.11631 |
[BP] GO:0050896 |
response to stimulus
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B2, IDO1, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR |
8.0943 |
[BP] GO:0010647 |
positive regulation of cell communication
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
8.0943 |
[BP] GO:0023056 |
positive regulation of signaling
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
8.0688 |
[BP] GO:0009719 |
response to endogenous stimulus
|
AKR1B1, AKR1C3, APEX1, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC |
7.99983 |
[BP] GO:0043069 |
negative regulation of programmed cell death
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT |
7.9887 |
[BP] GO:0006730 |
one-carbon metabolic process
|
CA1, CA12, CA2, CA4, CA7, CA9, DHFR |
7.89715 |
[BP] GO:0048522 |
positive regulation of cellular process
|
ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
7.68791 |
[BP] GO:0048518 |
positive regulation of biological process
|
ACHE, ADORA1, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
7.37624 |
[BP] GO:0071310 |
cellular response to organic substance
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SRC |
7.30115 |
[BP] GO:0015701 |
bicarbonate transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
7.29365 |
[BP] GO:0044255 |
cellular lipid metabolic process
|
ACHE, AKR1B10, AKR1C3, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 |
7.28393 |
[BP] GO:1901701 |
cellular response to oxygen-containing compound
|
AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1B1, ESR1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC |
7.12402 |
[BP] GO:0009725 |
response to hormone
|
AKR1B1, AKR1C3, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, KIT, NR3C1, PPARA, PTGS2, SRC |
7.01342 |
[BP] GO:0044238 |
primary metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
7.00613 |
[BP] GO:0019748 |
secondary metabolic process
|
AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, TYR |
6.88632 |
[BP] GO:0051716 |
cellular response to stimulus
|
AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TERT, TOP2A |
6.83714 |
[BP] GO:0008202 |
steroid metabolic process
|
AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 |
6.78084 |
[BP] GO:0019369 |
arachidonic acid metabolic process
|
AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 |
6.73426 |
[BP] GO:0009967 |
positive regulation of signal transduction
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CSNK2A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
6.50674 |
[BP] GO:0033559 |
unsaturated fatty acid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 |
6.44949 |
[BP] GO:0043066 |
negative regulation of apoptotic process
|
ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, GLO1, GSK3B, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, SRC, TERT |
6.38547 |
[BP] GO:0071407 |
cellular response to organic cyclic compound
|
AKR1C3, APEX1, APP, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC |
6.36638 |
[BP] GO:0006690 |
icosanoid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 |
6.23951 |
[BP] GO:0048511 |
rhythmic process
|
AXL, CSNK2A1, ESR1, GSK3B, KIT, PGR, PPARA, RORC, SRC, TOP1, TOP2A |
6.22747 |
[BP] GO:0071704 |
organic substance metabolic process
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, AXL, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
6.21719 |
[BP] GO:0034754 |
cellular hormone metabolic process
|
AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
6.13165 |
[BP] GO:0048584 |
positive regulation of response to stimulus
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CSNK2A1, CYP1B1, F10, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
5.82162 |
[BP] GO:0048523 |
negative regulation of cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
5.60513 |
[BP] GO:1902533 |
positive regulation of intracellular signal transduction
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, F10, FLT3, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
5.59322 |
[BP] GO:0042445 |
hormone metabolic process
|
ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
5.59039 |
[BP] GO:0043401 |
steroid hormone mediated signaling pathway
|
AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC |
5.54172 |
[BP] GO:0032501 |
multicellular organismal process
|
ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, HSD17B2, IDO1, IGF1R, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TOP1, TYR |
5.54171 |
[BP] GO:0046777 |
protein autophosphorylation
|
AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC |
5.40529 |
[BP] GO:0030334 |
regulation of cell migration
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
5.31146 |
[BP] GO:0048513 |
animal organ development
|
ACHE, AKR1C3, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD17B2, KDR, KIT, PIK3CA, PPARA, SRC, TYR |
5.20846 |
[BP] GO:1902531 |
regulation of intracellular signal transduction
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
5.20462 |
[BP] GO:0051896 |
regulation of protein kinase B signaling
|
AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC, XDH |
5.15865 |
[BP] GO:0009056 |
catabolic process
|
ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH |
5.15196 |
[BP] GO:0071495 |
cellular response to endogenous stimulus
|
AKR1B1, AKR1C3, APEX1, APP, AR, ESR1, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC |
5.1206 |
[BP] GO:0051897 |
positive regulation of protein kinase B signaling
|
AKR1C3, AXL, F10, KIT, MET, PIK3CA, PIK3CB, SRC |
5.07718 |
[BP] GO:0019371 |
None
|
AKR1C3, CBR1, PTGS1, PTGS2 |
5.05494 |
[BP] GO:0001676 |
long-chain fatty acid metabolic process
|
AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 |
5.05494 |
[BP] GO:0048519 |
negative regulation of biological process
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
5.05494 |
[BP] GO:0048856 |
anatomical structure development
|
ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FLT3, GSK3B, HSD17B2, KDR, KIT, MMP9, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TYR |
5.05494 |
[BP] GO:0006631 |
fatty acid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 |
5.05494 |
[BP] GO:0032787 |
None
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, IDO1, PPARA, PTGS1, PTGS2 |
5.05494 |
[BP] GO:1901568 |
fatty acid derivative metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 |
5.05494 |
[BP] GO:2000145 |
regulation of cell motility
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
5.03243 |
[BP] GO:0034614 |
cellular response to reactive oxygen species
|
AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC |
4.87244 |
[BP] GO:0009755 |
hormone-mediated signaling pathway
|
AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC, SRC |
4.82845 |
[BP] GO:0019752 |
carboxylic acid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR |
4.8137 |
[BP] GO:0010038 |
response to metal ion
|
AKR1C3, APP, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2, TERT |
4.80206 |
[BP] GO:0030522 |
intracellular receptor signaling pathway
|
AR, ESR1, NR3C1, PGR, PIM1, PPARA, RORC, SRC |
4.69042 |
[BP] GO:0042180 |
None
|
AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, IDO1 |
4.68901 |
[BP] GO:0008284 |
positive regulation of cell proliferation
|
AKR1B1, AKR1C3, AR, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PTGS2, TERT |
4.6662 |
[BP] GO:0010646 |
regulation of cell communication
|
ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
4.64302 |
[BP] GO:0040012 |
regulation of locomotion
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
4.63724 |
[BP] GO:0006950 |
response to stress
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, IDO1, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TERT, TOP2A |
4.63579 |
[BP] GO:0051270 |
regulation of cellular component movement
|
ADORA1, ADORA3, APEX1, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
4.62725 |
[BP] GO:0006979 |
response to oxidative stress
|
AKR1B1, AKR1C3, APEX1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC |
4.55233 |
[BP] GO:0023051 |
regulation of signaling
|
ACHE, ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
4.55233 |
[BP] GO:0008610 |
lipid biosynthetic process
|
ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 |
4.47687 |
[BP] GO:0032879 |
regulation of localization
|
ACHE, ADORA1, ADORA3, APEX1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SRC, TERT |
4.40288 |
[BP] GO:0019216 |
regulation of lipid metabolic process
|
ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, RORC, SRC |
4.34684 |
[BP] GO:0043436 |
oxoacid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR |
4.3309 |
[BP] GO:0009893 |
positive regulation of metabolic process
|
ADORA1, AKR1C3, APP, AR, AURKB, CSNK2A1, DHFR, ESR1, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
4.32835 |
[BP] GO:0006082 |
organic acid metabolic process
|
AKR1C3, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GLO1, IDO1, PIM1, PPARA, PTGS1, PTGS2, TYR |
4.2443 |
[BP] GO:0043393 |
regulation of protein binding
|
APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT |
4.2443 |
[BP] GO:0048583 |
regulation of response to stimulus
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, ESR1, F10, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TERT, XDH |
4.09568 |
[BP] GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway
|
AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC |
4.0472 |
[BP] GO:0042493 |
response to drug
|
AKR1B1, APEX1, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, KDR, NR3C1, PTGS2, SRC, TOP1 |
4.0429 |
[BP] GO:0010243 |
response to organonitrogen compound
|
AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR |
3.89766 |
[BP] GO:0031325 |
positive regulation of cellular metabolic process
|
ADORA1, AKR1C3, APP, AR, AURKB, ESR1, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
3.86067 |
[BP] GO:0006367 |
transcription initiation from RNA polymerase II promoter
|
AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC |
3.85594 |
[BP] GO:0048869 |
cellular developmental process
|
ACHE, AKR1C3, APP, AR, AXL, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MET, MMP2, MMP9, PGR, PTGS2, RORC, SRC, TERT, TOP2A |
3.84715 |
[BP] GO:0022414 |
reproductive process
|
AKR1B1, AKR1C3, APP, AR, AXL, CYP19A1, CYP1A1, ESR1, HSD17B2, IDO1, KIT, MMP2, MMP9, PGR, PTGS2, SRC, TOP2A |
3.84715 |
[BP] GO:0001101 |
response to acid chemical
|
AKR1B1, AKR1C3, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC |
3.84672 |
[BP] GO:0042592 |
homeostatic process
|
ADORA1, AKR1B1, APEX1, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TERT |
3.83623 |
[BP] GO:0008283 |
cell proliferation
|
ACHE, AR, AURKB, CYP1A1, ESR1, FLT3, KIT, MET, PIK3CB, PIM1, SRC, TYR |
3.79233 |
[BP] GO:0046686 |
response to cadmium ion
|
AKR1C3, CYP1A2, KIT, MMP9, TERT |
3.79064 |
[BP] GO:0008210 |
estrogen metabolic process
|
CYP19A1, CYP1B1, HSD17B1, HSD17B2 |
3.79064 |
[BP] GO:0040016 |
embryonic cleavage
|
PIK3CB, TOP1, TOP2A |
3.74434 |
[BP] GO:0006468 |
protein phosphorylation
|
APP, AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 |
3.69787 |
[BP] GO:0030335 |
positive regulation of cell migration
|
APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
3.67188 |
[BP] GO:0000302 |
response to reactive oxygen species
|
AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC |
3.66139 |
[BP] GO:0009892 |
negative regulation of metabolic process
|
ADORA1, AKR1C3, APEX1, APP, AR, AURKB, CSNK2A1, DHFR, ESR1, FABP4, GSK3B, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, RORC, SRC, TERT, XDH |
3.65536 |
[BP] GO:0051173 |
positive regulation of nitrogen compound metabolic process
|
ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
3.6417 |
[BP] GO:0042446 |
hormone biosynthetic process
|
AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 |
3.63894 |
[BP] GO:1901652 |
response to peptide
|
AKR1B1, APEX1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC |
3.6089 |
[BP] GO:1901698 |
response to nitrogen compound
|
AKR1B1, APEX1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR |
3.59935 |
[BP] GO:0006796 |
phosphate-containing compound metabolic process
|
ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH |
3.59383 |
[BP] GO:0006805 |
xenobiotic metabolic process
|
CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC |
3.59383 |
[BP] GO:0044598 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.59383 |
[BP] GO:0044597 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.59383 |
[BP] GO:0030638 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.59383 |
[BP] GO:2000147 |
positive regulation of cell motility
|
APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
3.58462 |
[BP] GO:0018108 |
peptidyl-tyrosine phosphorylation
|
AXL, FLT3, IGF1R, KDR, KIT, MET, SRC |
3.513 |
[BP] GO:0048608 |
reproductive structure development
|
AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, KIT, SRC |
3.49297 |
[BP] GO:0016042 |
lipid catabolic process
|
ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 |
3.49297 |
[BP] GO:0080134 |
regulation of response to stress
|
ADORA1, APP, CYP19A1, DHFR, ESR1, FABP4, GSK3B, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, SRC, TERT, XDH |
3.49297 |
[BP] GO:0051272 |
positive regulation of cellular component movement
|
APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
3.49268 |
[BP] GO:0018212 |
peptidyl-tyrosine modification
|
AXL, FLT3, IGF1R, KDR, KIT, MET, SRC |
3.48352 |
[BP] GO:0030647 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
3.44967 |
[BP] GO:0016310 |
phosphorylation
|
APP, AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 |
3.43993 |
[BP] GO:0045834 |
positive regulation of lipid metabolic process
|
FABP3, FLT3, KIT, PPARA, PTGS2, SRC |
3.43877 |
[BP] GO:0034599 |
cellular response to oxidative stress
|
AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, MMP9, SRC |
3.42142 |
[BP] GO:0019222 |
regulation of metabolic process
|
ACHE, ADORA1, ADORA3, AKR1C3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
3.42142 |
[BP] GO:0044092 |
negative regulation of molecular function
|
ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC |
3.38622 |
[BP] GO:0035690 |
cellular response to drug
|
AKR1B1, APEX1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC |
3.3796 |
[BP] GO:0040017 |
positive regulation of locomotion
|
APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, TERT |
3.3796 |
[BP] GO:0010604 |
positive regulation of macromolecule metabolic process
|
ADORA1, APP, AR, AURKB, CSNK2A1, ESR1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
3.37403 |
[BP] GO:0048010 |
vascular endothelial growth factor receptor signaling pathway
|
AXL, KDR, PIK3CA, PIK3CB, SRC |
3.35743 |
[BP] GO:0018193 |
peptidyl-amino acid modification
|
AURKB, AXL, CSNK2A1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TOP1, TOP2A |
3.35335 |
[BP] GO:0006793 |
phosphorus metabolic process
|
ACHE, APEX1, APP, AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TOP1, XDH |
3.34902 |
[BP] GO:0097267 |
omega-hydroxylase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
3.32969 |
[BP] GO:0009966 |
regulation of signal transduction
|
ADORA1, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
3.31883 |
[BP] GO:0071383 |
None
|
AKR1C3, AR, FLT3, NR3C1, SRC |
3.31096 |
[BP] GO:0006352 |
DNA-templated transcription, initiation
|
AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC |
3.2941 |
[BP] GO:0048661 |
positive regulation of smooth muscle cell proliferation
|
AKR1B1, MMP2, MMP9, PTGS2, TERT |
3.25945 |
[BP] GO:0009987 |
cellular process
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
3.25945 |
[BP] GO:0010817 |
regulation of hormone levels
|
ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 |
3.24771 |
[BP] GO:1901564 |
organonitrogen compound metabolic process
|
ACHE, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, DHFR, ESR1, F10, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TOP1, TOP2A, TYR, XDH |
3.24506 |
[BP] GO:0030518 |
intracellular steroid hormone receptor signaling pathway
|
AR, ESR1, NR3C1, PGR, SRC |
3.21679 |
[BP] GO:0060736 |
prostate gland growth
|
AR, CYP19A1, ESR1 |
3.21679 |
[BP] GO:0048545 |
response to steroid hormone
|
AKR1C3, AR, CA2, FLT3, NR3C1, PTGS2, SRC |
3.1272 |
[BP] GO:0017144 |
drug metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, IDO1 |
3.12429 |
[BP] GO:1901615 |
organic hydroxy compound metabolic process
|
AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR |
3.12103 |
[BP] GO:0001816 |
cytokine production
|
APP, FABP4, IDO1, KIT, PTGS2 |
3.09583 |
[BP] GO:0015711 |
organic anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA |
3.09203 |
[BP] GO:0071248 |
cellular response to metal ion
|
AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 |
3.04367 |
[BP] GO:0044259 |
multicellular organismal macromolecule metabolic process
|
AKR1C3, MMP1, MMP12, MMP2, MMP9 |
3.02692 |
[BP] GO:0080090 |
regulation of primary metabolic process
|
ADORA1, ADORA3, AKR1C3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
3.01761 |
[BP] GO:0007167 |
enzyme linked receptor protein signaling pathway
|
AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC |
3.00525 |
[BP] GO:0006703 |
estrogen biosynthetic process
|
CYP19A1, HSD17B1, HSD17B2 |
3.00525 |
[BP] GO:0048609 |
multicellular organismal reproductive process
|
AKR1B1, APP, AR, AXL, CYP1A1, ESR1, KIT, PGR, PTGS2, SRC |
2.98976 |
[BP] GO:0030154 |
cell differentiation
|
AKR1C3, AR, AXL, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, KDR, KIT, MMP2, MMP9, PTGS2, RORC, TOP2A |
2.98515 |
[BP] GO:0016488 |
None
|
AKR1B10, AKR1C3 |
2.96576 |
[BP] GO:0016487 |
None
|
AKR1B10, AKR1C3 |
2.96576 |
[BP] GO:0016107 |
None
|
AKR1B10, AKR1C3 |
2.96576 |
[BP] GO:0006714 |
None
|
AKR1B10, AKR1C3 |
2.96576 |
[BP] GO:0044283 |
None
|
AKR1B1, AKR1C3, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 |
2.95666 |
[BP] GO:1903727 |
positive regulation of phospholipid metabolic process
|
FABP3, FLT3, KIT, SRC |
2.94207 |
[BP] GO:0060065 |
uterus development
|
CYP19A1, ESR1, SRC |
2.92967 |
[BP] GO:0022900 |
electron transport chain
|
AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
2.86489 |
[BP] GO:0051098 |
regulation of binding
|
APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC, TERT |
2.86439 |
[BP] GO:0032870 |
cellular response to hormone stimulus
|
AKR1C3, APEX1, AR, ESR1, FLT3, KIT, NR3C1, SRC |
2.86439 |
[BP] GO:0031324 |
negative regulation of cellular metabolic process
|
AKR1C3, APEX1, APP, AR, AURKB, CSNK2A1, DHFR, ESR1, FABP4, GSK3B, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TERT, XDH |
2.85797 |
[BP] GO:0060255 |
regulation of macromolecule metabolic process
|
ACHE, ADORA1, ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
2.84173 |
[BP] GO:0009628 |
response to abiotic stimulus
|
ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, KIT, MMP2, PPARA, PTGS2, SRC, TERT, TYR |
2.82777 |
[BP] GO:0031323 |
regulation of cellular metabolic process
|
ACHE, ADORA1, ADORA3, AKR1C3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
2.82209 |
[BP] GO:0030540 |
female genitalia development
|
AXL, CYP19A1, ESR1 |
2.76706 |
[BP] GO:0071396 |
cellular response to lipid
|
AKR1C3, AR, AXL, ESR1, FLT3, NR3C1, RORC, SRC |
2.76001 |
[BP] GO:0010468 |
regulation of gene expression
|
ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, GLO1, GSK3B, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, RORC, SRC, TERT, TOP1, TOP2A, XDH |
2.74498 |
[BP] GO:0071241 |
cellular response to inorganic substance
|
AKR1C3, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 |
2.73732 |
[BP] GO:0001666 |
response to hypoxia
|
ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT |
2.73323 |
[BP] GO:0003006 |
developmental process involved in reproduction
|
AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, KIT, PGR, PTGS2, SRC |
2.72406 |
[BP] GO:0050790 |
regulation of catalytic activity
|
ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TERT, XDH |
2.72406 |
[BP] GO:0002521 |
leukocyte differentiation
|
AXL, FLT3, FUT7, GLO1, KIT, MMP9, RORC |
2.72141 |
[BP] GO:0043065 |
positive regulation of apoptotic process
|
AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH |
2.68143 |
[BP] GO:1901654 |
None
|
AKR1B1, AR, CA9, CSNK2A1, NR3C1, SRC |
2.67048 |
[BP] GO:0044236 |
multicellular organism metabolic process
|
AKR1C3, MMP1, MMP12, MMP2, MMP9 |
2.66749 |
[BP] GO:0036293 |
response to decreased oxygen levels
|
ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT |
2.66749 |
[BP] GO:0043068 |
positive regulation of programmed cell death
|
AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH |
2.65437 |
[BP] GO:0006721 |
terpenoid metabolic process
|
AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 |
2.65284 |
[BP] GO:0016137 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
2.63816 |
[BP] GO:0042542 |
response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1, SRC |
2.63702 |
[BP] GO:0009889 |
regulation of biosynthetic process
|
ADORA3, AKR1C3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A |
2.56373 |
[BP] GO:0065007 |
biological regulation
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
2.56373 |
[BP] GO:0060748 |
None
|
AR, PGR |
2.56373 |
[BP] GO:0032849 |
positive regulation of cellular pH reduction
|
CA2, CA7 |
2.56373 |
[BP] GO:0016095 |
None
|
AKR1B10, AKR1C3 |
2.56373 |
[BP] GO:0043410 |
positive regulation of MAPK cascade
|
ADORA1, APP, AR, FLT3, KDR, KIT, PIK3CB, SRC, XDH |
2.51126 |
[BP] GO:0071417 |
cellular response to organonitrogen compound
|
AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC |
2.48648 |
[BP] GO:0044249 |
None
|
ACHE, AKR1B1, AKR1C3, ALOX5, APEX1, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, HSD17B1, HSD17B2, IDO1, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, TERT, TOP1, TYR |
2.47774 |
[BP] GO:0009891 |
positive regulation of biosynthetic process
|
APP, AR, AURKB, ESR1, FABP3, IGF1R, KDR, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TERT, TOP2A |
2.47193 |
[BP] GO:0010562 |
positive regulation of phosphorus metabolic process
|
ADORA1, APP, AR, FABP3, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.46166 |
[BP] GO:0045937 |
positive regulation of phosphate metabolic process
|
ADORA1, APP, AR, FABP3, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.46166 |
[BP] GO:0070482 |
response to oxygen levels
|
ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC, TERT |
2.46144 |
[BP] GO:0071498 |
cellular response to fluid shear stress
|
CA2, PTGS2, SRC |
2.45932 |
[BP] GO:0019373 |
epoxygenase P450 pathway
|
CYP1A1, CYP1A2, CYP1B1 |
2.45932 |
[BP] GO:0001934 |
positive regulation of protein phosphorylation
|
ADORA1, APP, AR, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.45224 |
[BP] GO:0097237 |
cellular response to toxic substance
|
AKR1B1, APEX1, AXL, CYP1B1, KDR |
2.44882 |
[BP] GO:0046486 |
glycerolipid metabolic process
|
ACHE, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB |
2.43496 |
[BP] GO:0050806 |
positive regulation of synaptic transmission
|
ADORA1, APP, CA2, CA7, PTGS2 |
2.43496 |
[BP] GO:0070301 |
cellular response to hydrogen peroxide
|
AKR1B1, APEX1, AXL, CYP1B1 |
2.43069 |
[BP] GO:0010942 |
positive regulation of cell death
|
AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PIK3CB, PTGS2, SRC, TOP2A, XDH |
2.42129 |
[BP] GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation
|
MMP2, MMP9, TERT |
2.40854 |
[BP] GO:0006807 |
nitrogen compound metabolic process
|
ACHE, AKR1B1, AKR1B10, AKR1C3, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FLT3, FUT7, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
2.39827 |
[BP] GO:0051171 |
regulation of nitrogen compound metabolic process
|
ADORA1, ADORA3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, GLO1, GSK3B, IGF1R, KDR, KIT, MET, MMP12, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A, XDH |
2.39523 |
[BP] GO:0050804 |
modulation of chemical synaptic transmission
|
ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 |
2.39053 |
[BP] GO:0099177 |
regulation of trans-synaptic signaling
|
ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 |
2.39053 |
[BP] GO:0006720 |
isoprenoid metabolic process
|
AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 |
2.38407 |
[BP] GO:0010634 |
positive regulation of epithelial cell migration
|
KDR, MET, MMP9, PTGS2, SRC |
2.38407 |
[BP] GO:0006694 |
steroid biosynthetic process
|
AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 |
2.36918 |
[BP] GO:0009404 |
toxin metabolic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.36367 |
[BP] GO:1901653 |
cellular response to peptide
|
AKR1B1, APEX1, APP, GSK3B, IGF1R, SRC |
2.35963 |
[BP] GO:0010605 |
negative regulation of macromolecule metabolic process
|
APEX1, APP, AR, AURKB, CSNK2A1, DHFR, ESR1, FABP4, GSK3B, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TERT, XDH |
2.34676 |
[BP] GO:0030574 |
collagen catabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.34676 |
[BP] GO:0006081 |
None
|
AKR1B10, AKR1C3, CYP1B1, GLO1 |
2.34676 |
[BP] GO:0048660 |
regulation of smooth muscle cell proliferation
|
AKR1B1, MMP2, MMP9, PTGS2, TERT |
2.34676 |
[BP] GO:0030198 |
extracellular matrix organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.34676 |
[BP] GO:0006820 |
anion transport
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA |
2.34676 |
[BP] GO:0043062 |
extracellular structure organization
|
APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 |
2.33962 |
[BP] GO:0031326 |
regulation of cellular biosynthetic process
|
ADORA3, AKR1C3, APEX1, APP, AR, AURKB, CA9, CSNK2A1, CYP1B1, DHFR, ESR1, FABP3, FABP4, GLO1, GSK3B, IGF1R, KIT, MET, MMP12, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS2, RORC, SRC, TERT, TOP2A |
2.33553 |
[BP] GO:0032847 |
regulation of cellular pH reduction
|
CA2, CA7 |
2.32725 |
[BP] GO:0018894 |
dibenzo-p-dioxin metabolic process
|
CYP1A1, CYP1A2 |
2.32725 |
[BP] GO:1903409 |
reactive oxygen species biosynthetic process
|
CYP1A1, CYP1A2, CYP1B1 |
2.32725 |
[BP] GO:0042327 |
positive regulation of phosphorylation
|
ADORA1, APP, AR, FLT3, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.31469 |
[BP] GO:0042325 |
regulation of phosphorylation
|
ADORA1, APP, AR, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH |
2.31352 |
[BP] GO:0016477 |
cell migration
|
AXL, CYP1B1, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC |
2.31352 |
[BP] GO:0065009 |
regulation of molecular function
|
ADORA1, ADORA3, APP, AR, AURKB, CSNK2A1, CYP1B1, DHFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SRC, TERT, XDH |
2.31234 |
[BP] GO:1901699 |
cellular response to nitrogen compound
|
AKR1B1, APEX1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC |
2.30987 |
[BP] GO:0006954 |
inflammatory response
|
ADORA1, ADORA3, AXL, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 |
2.26666 |
[BP] GO:0051130 |
positive regulation of cellular component organization
|
APP, AR, AURKB, AXL, ESR1, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC |
2.25675 |
[BP] GO:0008285 |
negative regulation of cell proliferation
|
ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, IDO1, PTGS2, TERT, XDH |
2.2537 |
[BP] GO:1901992 |
positive regulation of mitotic cell cycle phase transition
|
APEX1, APP, CYP1A1, TERT |
2.2537 |
[BP] GO:0006693 |
None
|
AKR1C3, PTGS1, PTGS2 |
2.24598 |
[BP] GO:0006692 |
None
|
AKR1C3, PTGS1, PTGS2 |
2.24598 |
[BP] GO:0051240 |
positive regulation of multicellular organismal process
|
APP, AR, AXL, CA2, CYP1B1, IDO1, KDR, KIT, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TERT |
2.23791 |
[BP] GO:0044248 |
cellular catabolic process
|
ACHE, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, GSK3B, IDO1, PIK3CB, SRC, XDH |
2.23296 |
[BP] GO:1903725 |
regulation of phospholipid metabolic process
|
FABP3, FLT3, KIT, SRC |
2.21599 |
[BP] GO:1904646 |
cellular response to amyloid-beta
|
APP, GSK3B, IGF1R |
2.20462 |
[BP] GO:0040011 |
locomotion
|
AXL, CYP1B1, FUT7, KDR, KIT, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC |
2.20446 |
[BP] GO:0019220 |
regulation of phosphate metabolic process
|
ADORA1, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH |
2.20393 |
[BP] GO:0044243 |
multicellular organismal catabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.20254 |
[BP] GO:0043408 |
regulation of MAPK cascade
|
ADORA1, APP, AR, FLT3, IGF1R, KDR, KIT, PIK3CB, SRC, XDH |
2.20022 |
[BP] GO:1901575 |
None
|
ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, IDO1, XDH |
2.19149 |
[BP] GO:0044093 |
positive regulation of molecular function
|
ADORA1, APP, AR, AURKB, DHFR, ESR1, FLT3, GSK3B, KIT, MET, MMP9, PIK3CA, PIK3CB, SRC, TERT, XDH |
2.19025 |
[BP] GO:0009058 |
None
|
ACHE, AKR1B1, AKR1C3, ALOX5, APEX1, AR, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, HSD17B1, HSD17B2, IDO1, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, RORC, TERT, TOP1, TYR |
2.18059 |
[BP] GO:0051174 |
regulation of phosphorus metabolic process
|
ADORA1, APP, AR, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, XDH |
2.17383 |
[BP] GO:0001932 |
regulation of protein phosphorylation
|
ADORA1, APP, AR, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.17303 |
[BP] GO:0006091 |
generation of precursor metabolites and energy
|
AKR1B1, CYP19A1, CYP1A2, GSK3B, IDO1, NQO2, XDH |
2.17199 |
[BP] GO:0061370 |
testosterone biosynthetic process
|
AKR1C3, CYP19A1 |
2.16398 |
[BP] GO:0002318 |
myeloid progenitor cell differentiation
|
FLT3, KIT |
2.16398 |
[BP] GO:0022602 |
ovulation cycle process
|
ESR1, KIT, PGR, SRC |
2.1522 |
[BP] GO:0010631 |
epithelial cell migration
|
CYP1B1, KDR, KIT, PIK3CA |
2.13545 |
[BP] GO:0046427 |
positive regulation of JAK-STAT cascade
|
AKR1B1, CYP1B1, FLT3, KIT |
2.13545 |
[BP] GO:0008217 |
None
|
ADORA1, AR, PPARA, PTGS1, PTGS2 |
2.11087 |
[BP] GO:0031328 |
positive regulation of cellular biosynthetic process
|
APP, AR, AURKB, ESR1, FABP3, IGF1R, MET, MMP12, NR3C1, PGR, PPARA, PTGS2, RORC, SRC, TERT, TOP2A |
2.10888 |
[BP] GO:0035265 |
organ growth
|
AR, CYP19A1, ESR1 |
2.10266 |
[BP] GO:1901661 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
2.10266 |
[BP] GO:0043552 |
positive regulation of phosphatidylinositol 3-kinase activity
|
FLT3, KIT, SRC |
2.10266 |
[BP] GO:1904645 |
response to amyloid-beta
|
APP, GSK3B, IGF1R |
2.10266 |
[BP] GO:1904894 |
positive regulation of STAT cascade
|
AKR1B1, CYP1B1, FLT3, KIT |
2.10266 |
[BP] GO:0022617 |
extracellular matrix disassembly
|
MMP1, MMP12, MMP2, MMP9 |
2.10266 |
[BP] GO:0070542 |
None
|
AKR1C3, FABP3, PTGS2, SRC |
2.08273 |
[BP] GO:0050900 |
leukocyte migration
|
FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC |
2.07959 |
[BP] GO:0051186 |
None
|
AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, DHFR, GLO1, PTGS2 |
2.07213 |
[BP] GO:0071276 |
cellular response to cadmium ion
|
AKR1C3, CYP1A2, MMP9 |
2.07205 |
[BP] GO:0014065 |
phosphatidylinositol 3-kinase signaling
|
IGF1R, PIK3CA, PIK3CB |
2.07205 |
[BP] GO:0032844 |
regulation of homeostatic process
|
ADORA1, AURKB, CA2, CA7, KDR, PIK3CB, PTGS2, SRC |
2.07205 |
[BP] GO:1901655 |
None
|
AKR1B1, AR, NR3C1, SRC |
2.07205 |
[BP] GO:0032963 |
collagen metabolic process
|
MMP1, MMP12, MMP2, MMP9 |
2.07205 |
[BP] GO:0050789 |
regulation of biological process
|
ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
2.06171 |
[BP] GO:2000106 |
regulation of leukocyte apoptotic process
|
AURKB, AXL, IDO1, PIK3CB |
2.05624 |
[BP] GO:0031960 |
response to corticosteroid
|
AKR1C3, FLT3, NR3C1, PTGS2, SRC |
2.05624 |
[BP] GO:0051247 |
positive regulation of protein metabolic process
|
ADORA1, APP, AR, CSNK2A1, ESR1, FLT3, GSK3B, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH |
2.04134 |
[BP] GO:0032228 |
regulation of synaptic transmission, GABAergic
|
ADORA1, CA2, CA7 |
2.04128 |
[BP] GO:0048870 |
cell motility
|
AXL, CYP1B1, FUT7, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC |
2.03921 |
[BP] GO:0016115 |
None
|
AKR1B10, AKR1C3 |
2.03264 |
[BP] GO:1901989 |
None
|
APEX1, APP, CYP1A1, TERT |
2.02702 |
[BP] GO:0032092 |
positive regulation of protein binding
|
APP, GSK3B, MMP9, TERT |
2.00948 |
[BP] GO:0090218 |
positive regulation of lipid kinase activity
|
FLT3, KIT, SRC |
2.00948 |
[CC] GO:0044444 |
cytoplasmic part
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, KDR, KIT, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TERT, TOP1, TOP2A, TYR, XDH |
4.8137 |
[CC] GO:0009330 |
None
|
TOP1, TOP2A |
2.96576 |
[CC] GO:0005829 |
cytosol
|
AKR1B1, AKR1B10, AKR1C3, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, SRC, TYR, XDH |
2.20462 |
[CC] GO:0043227 |
membrane-bounded organelle
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, APEX1, APP, AR, AURKB, AXL, CA1, CA2, CA4, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP3, FABP4, FLT3, FUT7, GLO1, GSK3B, IGF1R, KDR, KIT, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
2.16398 |
[CC] GO:0043231 |
intracellular membrane-bounded organelle
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, APEX1, APP, AR, AURKB, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FABP4, FLT3, FUT7, GLO1, GSK3B, IGF1R, KDR, KIT, MMP12, MMP2, NR3C1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
2.05473 |
[MF] GO:0043167 |
ion binding
|
ACHE, ALOX5, APEX1, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, F10, FABP3, FABP4, FLT3, GLO1, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, TYR, XDH |
14.5287 |
[MF] GO:0046914 |
transition metal ion binding
|
ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, RORC, TYR, XDH |
14.5287 |
[MF] GO:0003824 |
catalytic activity
|
ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, F10, FLT3, FUT7, GLO1, GSK3B, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, SRC, TERT, TOP1, TOP2A, TYR, XDH |
12.3554 |
[MF] GO:0004089 |
carbonate dehydratase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
10.4231 |
[MF] GO:0016491 |
oxidoreductase activity
|
AKR1B1, AKR1B10, AKR1C3, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH |
8.96929 |
[MF] GO:0043169 |
cation binding
|
ACHE, ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, RORC, TERT, TOP2A, TYR, XDH |
8.3545 |
[MF] GO:0008270 |
zinc ion binding
|
AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PPARA, RORC |
8.30402 |
[MF] GO:0046872 |
metal ion binding
|
ALOX5, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, GLO1, IDO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PPARA, PTGS1, PTGS2, RORC, TERT, TOP2A, TYR, XDH |
8.0943 |
[MF] GO:0016835 |
carbon-oxygen lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
7.25056 |
[MF] GO:0016836 |
hydro-lyase activity
|
CA1, CA12, CA14, CA2, CA4, CA7, CA9 |
6.68556 |
[MF] GO:0003707 |
steroid hormone receptor activity
|
AR, ESR1, NR3C1, NR3C2, PGR, PPARA, RORC |
6.48239 |
[MF] GO:0008144 |
drug binding
|
ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1, TOP2A |
6.27146 |
[MF] GO:0016829 |
lyase activity
|
APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 |
5.59673 |
[MF] GO:0020037 |
heme binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC |
5.5881 |
[MF] GO:0005496 |
steroid binding
|
AR, ESR1, HSD17B1, NR3C1, NR3C2, PGR, RORC |
5.44372 |
[MF] GO:0046906 |
tetrapyrrole binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC |
5.36359 |
[MF] GO:0016705 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
|
AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR |
5.05494 |
[MF] GO:0048037 |
cofactor binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH |
5.03243 |
[MF] GO:0004714 |
transmembrane receptor protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, KIT, MET |
4.9375 |
[MF] GO:0004672 |
protein kinase activity
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TOP1 |
4.56743 |
[MF] GO:0016773 |
phosphotransferase activity, alcohol group as acceptor
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 |
4.51298 |
[MF] GO:0019199 |
transmembrane receptor protein kinase activity
|
AXL, FLT3, IGF1R, KDR, KIT, MET |
4.38727 |
[MF] GO:0016614 |
oxidoreductase activity, acting on CH-OH group of donors
|
AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1, HSD17B2, XDH |
4.28187 |
[MF] GO:0042562 |
hormone binding
|
ACHE, AR, HSD17B1, IGF1R, NQO2, NR3C1 |
4.22493 |
[MF] GO:0016301 |
kinase activity
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 |
4.09288 |
[MF] GO:0098531 |
transcription factor activity, direct ligand regulated sequence-specific DNA binding
|
AR, ESR1, PGR, PPARA, RORC |
4.03984 |
[MF] GO:0004879 |
nuclear receptor activity
|
AR, ESR1, PGR, PPARA, RORC |
4.03984 |
[MF] GO:0016772 |
transferase activity, transferring phosphorus-containing groups
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TERT, TOP1 |
4.02112 |
[MF] GO:0004497 |
monooxygenase activity
|
AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR |
3.96746 |
[MF] GO:0070330 |
aromatase activity
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
3.84715 |
[MF] GO:0009055 |
electron transfer activity
|
AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH |
3.68665 |
[MF] GO:0008289 |
lipid binding
|
AR, AXL, ESR1, F10, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC |
3.66503 |
[MF] GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
3.6639 |
[MF] GO:1901363 |
heterocyclic compound binding
|
ADORA1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
3.65893 |
[MF] GO:0097159 |
organic cyclic compound binding
|
ADORA1, APEX1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, ESR1, FLT3, GSK3B, HSD17B1, IDO1, IGF1R, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RORC, SRC, TERT, TOP1, TOP2A, XDH |
3.58609 |
[MF] GO:0004713 |
protein tyrosine kinase activity
|
AXL, FLT3, IGF1R, KDR, KIT, MET, SRC |
3.58609 |
[MF] GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1B1, AKR1B10, AKR1C3, CBR1, HSD17B1, HSD17B2 |
3.50045 |
[MF] GO:0036094 |
small molecule binding
|
ADORA1, AURKB, AXL, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH |
3.37416 |
[MF] GO:0043560 |
insulin receptor substrate binding
|
IGF1R, PIK3CA, PIK3CB |
3.21679 |
[MF] GO:0043168 |
anion binding
|
APP, AURKB, AXL, CSNK2A1, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH |
3.17081 |
[MF] GO:0042802 |
identical protein binding
|
ACHE, APP, CSNK2A1, ESR1, FLT3, IGF1R, KDR, KIT, MET, MMP9, NQO2, PGR, PTGS2, TERT, TOP2A, TYR, XDH |
2.97187 |
[MF] GO:0004666 |
prostaglandin-endoperoxide synthase activity
|
PTGS1, PTGS2 |
2.96576 |
[MF] GO:0045550 |
None
|
AKR1B10, AKR1C3 |
2.96576 |
[MF] GO:0016903 |
None
|
AKR1B1, AKR1B10, AKR1C3, XDH |
2.90591 |
[MF] GO:0005506 |
iron ion binding
|
ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH |
2.89148 |
[MF] GO:0019825 |
oxygen binding
|
CYP19A1, CYP1A1, CYP1A2, CYP1B1 |
2.87068 |
[MF] GO:0000166 |
nucleotide binding
|
AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH |
2.72406 |
[MF] GO:1901265 |
nucleoside phosphate binding
|
AURKB, AXL, CSNK2A1, DHFR, FLT3, GSK3B, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A, XDH |
2.7234 |
[MF] GO:0038023 |
signaling receptor activity
|
ADORA1, ADORA3, AR, AXL, ESR1, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC |
2.67708 |
[MF] GO:0047718 |
None
|
AKR1B10, AKR1C3 |
2.56373 |
[MF] GO:0001223 |
transcription coactivator binding
|
ESR1, PPARA, TERT |
2.51126 |
[MF] GO:0005524 |
ATP binding
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A |
2.38464 |
[MF] GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
|
KIT, MET, PIK3CA, PIK3CB |
2.32979 |
[MF] GO:0044877 |
macromolecular complex binding
|
ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, SRC |
2.32159 |
[MF] GO:0032559 |
adenyl ribonucleotide binding
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A |
2.30589 |
[MF] GO:0030554 |
adenyl nucleotide binding
|
AURKB, AXL, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1, TOP2A |
2.27476 |
[MF] GO:0052813 |
phosphatidylinositol bisphosphate kinase activity
|
KIT, MET, PIK3CA, PIK3CB |
2.27226 |
[MF] GO:0004033 |
None
|
AKR1B1, AKR1B10, AKR1C3 |
2.24598 |
[MF] GO:0016702 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
|
ALOX5, IDO1, PTGS2 |
2.24598 |
[MF] GO:0033764 |
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
|
AKR1C3, HSD17B1, HSD17B2 |
2.20462 |
[MF] GO:0016701 |
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
|
ALOX5, IDO1, PTGS2 |
2.20462 |
[MF] GO:0004872 |
receptor activity
|
ADORA1, ADORA3, AR, AXL, ESR1, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC |
2.19955 |
[MF] GO:0035004 |
phosphatidylinositol 3-kinase activity
|
KIT, MET, PIK3CA, PIK3CB |
2.18644 |
[MF] GO:0008134 |
transcription factor binding
|
APEX1, AR, ESR1, FLT3, GSK3B, PIM1, PPARA, SRC, TERT |
2.15182 |
[MF] GO:0016229 |
steroid dehydrogenase activity
|
AKR1C3, HSD17B1, HSD17B2 |
2.13615 |
[MF] GO:0060089 |
molecular transducer activity
|
ADORA1, ADORA3, AR, AXL, ESR1, FLT3, IGF1R, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC |
2.07959 |
[MF] GO:0008013 |
beta-catenin binding
|
AR, CSNK2A1, ESR1, GSK3B |
2.05624 |
[MF] GO:0051879 |
Hsp90 protein binding
|
CSNK2A1, KDR, NR3C1 |
2.04128 |
[MF] GO:0004064 |
arylesterase activity
|
CA1, CA2 |
2.03264 |
[MF] GO:0047035 |
testosterone dehydrogenase (NAD+) activity
|
AKR1C3, HSD17B2 |
2.03264 |