Prescription Description
| Prescription ID | TCMF493 |
| Pinyin Name | Deng Zhan Sheng Mai Jiao Nang |
| Chinese Name | 灯盏生脉胶囊 |
| English Name | Deng Zhan Sheng Mai Capsule |
| Function Description | 中风后遗症"中风后遗症, 症见痴呆, 健忘, 手足麻木症, 冠心病心绞痛, 缺血性心脑血管疾病, 高脂血症见上述证候者 |
| Indications | Numbness disorder, Forgetfulness disorder, Dementia disorder, Stroke, Coronary heart disease, Angina pectoris, Hyperlipidemia |
| Disease ICD-11 Category |
SC62 [Numbness disorder (TM1), 麻木 (TM1)
]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD86 [Dementia disorder (TM1), 痴呆 (TM1) ]; 8B20 [Stroke not known if ischaemic or haemorrhagic, 缺血或出血未知的卒中 ]; BA80.Z [Coronary atherosclerosis, unspecified site, 冠状动脉粥样硬化,未特指部位 ]; BA40 [Angina pectoris, 心绞痛 ]; 5C80.Z [Hyperlipoproteinaemia, unspecified, 高脂蛋白血症，未特指的 ]; |
| Human Tissues Associated with Indication | Brain, Heart |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH440 | Erigeron breviscapus | 灯盏细辛 | TCMH440 | ITSAM3906-14 |
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH2202 | Schisandra chinensis | 五味子 | TCMH2202 | ITSAM2867-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
| TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
| TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
| TCMT174 | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | Oxidoreductase | P28845 |
| TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
| TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
| TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
| TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
| TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
| TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
| TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
| TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
| TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
| TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
| TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
| TCMT327 | TRPV1 | Vanilloid receptor | Ion channel | Q8NER1 |
| TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
| TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
| TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
| TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
| TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
| TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
| TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
| TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
| TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
| TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
| TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
| TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
| TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
| TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
| TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
| TCMT508 | SYK | Tyrosine-protein kinase SYK | Kinase | P43405 |
| TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
| TCMT613 | NR3C1 | Glucocorticoid receptor | Nuclear receptor | P04150 |
| TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
| TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
| TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
| TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
| TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
| TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
| TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
| TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
| TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
| TCMT771 | ATR | Serine-protein kinase ATR | Kinase | Q13535 |
| TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
| TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
| TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
| TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
| TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
| TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
| TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
| TCMT81 | ALOX12 | Arachidonate 12-lipoxygenase | Oxidoreductase | P18054 |
| TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
| TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
| TCMT848 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 | Kinase | O75460 |
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1180 | Human herpesvirus 2 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1208 | Escherichia coli K12 |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1215 | Pseudomonas aeruginosa PAO1 |
| TCMT1218 | Staphylococcus aureus |
| TCMT1222 | Plasmodium falciparum D6 |
| TCMT1223 | Staphylococcus epidermidis |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1229 | Enterococcus faecalis |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1246 | Escherichia coli |
| TCMT1247 | Human herpesvirus 1 |
| TCMT1248 | Hepatitis C virus |
| TCMT1250 | Vesicular stomatitis virus |
| TCMT1251 | Candida albicans |
| TCMT1253 | Penicillium chrysogenum |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1286 | Bacillus cereus |
| TCMT1289 | Shigella dysenteriae |
| TCMT1292 | Japanese encephalitis virus |
| TCMT1294 | Human parainfluenza virus 3 |
| TCMT1336 | Yellow fever virus |
| TCMT1337 | Dengue virus type 4 |
| TCMT1338 | Rift Valley fever virus |
| TCMT1346 | Helicobacter pylori |
| TCMT1349 | Helicobacter pylori SS1 |
| TCMT1361 | Neisseria meningitidis |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1393 | Vibrio sp. |
| TCMT1412 | Salmonella typhimurium |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1442 | Leishmania donovani |
| TCMT1443 | Leishmania amazonensis |
| TCMT1447 | Respiratory syncytial virus |
| TCMT1448 | Enterobacter aerogenes |
| TCMT1449 | Influenza A virus |
| TCMT1450 | Plasmodium falciparum 3D7 |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1462 | Streptococcus mutans |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TRPV1 | 14.9113 |
| [BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 9.45824 |
| [BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 9.35948 |
| [BP] GO:0065008 | regulation of biological quality | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TRPV1, XDH | 8.42094 |
| [BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 8.42094 |
| [BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 8.36298 |
| [BP] GO:0019369 | arachidonic acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 8.36298 |
| [BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.91237 |
| [BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 7.88907 |
| [BP] GO:0006690 | icosanoid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 7.6972 |
| [BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.68319 |
| [BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 7.52993 |
| [BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.51145 |
| [BP] GO:0010033 | response to organic substance | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 7.50216 |
| [BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 7.427 |
| [BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 7.34191 |
| [BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 | 7.06648 |
| [BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR | 7.06259 |
| [BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.80403 |
| [BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 6.7825 |
| [BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TRPV1, XDH | 6.68975 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.60612 |
| [BP] GO:0010035 | response to inorganic substance | AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC | 6.59093 |
| [BP] GO:0042221 | response to chemical | AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, SRC, TRPV1, TYR | 6.53706 |
| [BP] GO:1901568 | fatty acid derivative metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 6.53706 |
| [BP] GO:0006631 | fatty acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 6.48756 |
| [BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 | 6.41971 |
| [BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA7, CA9 | 6.41971 |
| [BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 6.39999 |
| [BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, ALOX12, APP, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH | 6.16323 |
| [BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 6.05005 |
| [BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC | 5.63434 |
| [BP] GO:0048518 | positive regulation of biological process | ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 5.63434 |
| [BP] GO:0009719 | response to endogenous stimulus | AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 5.45064 |
| [BP] GO:0033993 | response to lipid | AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, SRC, TYR | 5.41868 |
| [BP] GO:0014070 | response to organic cyclic compound | APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1, TYR | 5.3886 |
| [BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 5.33454 |
| [BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 5.32449 |
| [BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 | 5.24453 |
| [BP] GO:0048513 | animal organ development | ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR | 5.20196 |
| [BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 5.15048 |
| [BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 5.05668 |
| [BP] GO:0009725 | response to hormone | AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, NR3C1, PPARA, PTGS2, SRC, TRPV1 | 4.98764 |
| [BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, NQO2, PTGS1 | 4.94631 |
| [BP] GO:0032879 | regulation of localization | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 4.73929 |
| [BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.73776 |
| [BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.7145 |
| [BP] GO:0046456 | icosanoid biosynthetic process | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 4.69773 |
| [BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH | 4.69773 |
| [BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 4.66276 |
| [BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 4.62463 |
| [BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC | 4.60465 |
| [BP] GO:0032787 | None | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 | 4.58616 |
| [BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.56122 |
| [BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 4.5363 |
| [BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 4.53305 |
| [BP] GO:0019372 | lipoxygenase pathway | ALOX12, ALOX15, ALOX5, PTGS2 | 4.52998 |
| [BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TRPV1, TYR | 4.45605 |
| [BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC, TRPV1 | 4.45605 |
| [BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 4.44693 |
| [BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR | 4.42678 |
| [BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APP, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, SRC, TRPV1 | 4.42678 |
| [BP] GO:0050896 | response to stimulus | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR | 4.42678 |
| [BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, TYR | 4.2303 |
| [BP] GO:0015711 | organic anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 4.19695 |
| [BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, SRC, TRPV1 | 4.1803 |
| [BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 3.98809 |
| [BP] GO:2001300 | lipoxin metabolic process | ALOX12, ALOX15, ALOX5 | 3.97369 |
| [BP] GO:0016098 | monoterpenoid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.97369 |
| [BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 3.86827 |
| [BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR | 3.8674 |
| [BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.85991 |
| [BP] GO:0071407 | cellular response to organic cyclic compound | APP, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTGS2, SRC, TRPV1 | 3.85766 |
| [BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.85766 |
| [BP] GO:0019752 | carboxylic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.83444 |
| [BP] GO:0009820 | alkaloid metabolic process | CYP1A2, CYP2D6, CYP3A4 | 3.76441 |
| [BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TRPV1 | 3.7466 |
| [BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 | 3.71548 |
| [BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 | 3.71347 |
| [BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.69015 |
| [BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.67166 |
| [BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 | 3.67097 |
| [BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 3.64085 |
| [BP] GO:0035690 | cellular response to drug | AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.5966 |
| [BP] GO:0006636 | unsaturated fatty acid biosynthetic process | ALOX12, ALOX15, PTGS1, PTGS2 | 3.57723 |
| [BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC | 3.57721 |
| [BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.55731 |
| [BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 3.54814 |
| [BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 | 3.53176 |
| [BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.47416 |
| [BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.47416 |
| [BP] GO:0048878 | chemical homeostasis | AKR1B1, ALOX12, APP, CA12, CA2, CA7, ESR1, FABP3, FABP4, MET, PIK3CA, PIK3CB, TRPV1 | 3.46184 |
| [BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 3.4597 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.4597 |
| [BP] GO:0006793 | phosphorus metabolic process | ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.4597 |
| [BP] GO:0080134 | regulation of response to stress | ADORA1, ALOX12, APP, CYP19A1, ESR1, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.4597 |
| [BP] GO:0043436 | oxoacid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.4597 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.38212 |
| [BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC | 3.35687 |
| [BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.35687 |
| [BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.33679 |
| [BP] GO:0006820 | anion transport | CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 | 3.33679 |
| [BP] GO:0042325 | regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.33115 |
| [BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.2947 |
| [BP] GO:0010038 | response to metal ion | ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.29185 |
| [BP] GO:1901570 | None | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 3.2905 |
| [BP] GO:0006954 | inflammatory response | ADORA1, ADORA3, ALOX15, AXL, PIK3CA, PIK3CB, PTGS1, PTGS2, TRPV1 | 3.25363 |
| [BP] GO:0044283 | None | AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, PTGS1, PTGS2 | 3.22763 |
| [BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.21836 |
| [BP] GO:0071248 | cellular response to metal ion | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 3.21836 |
| [BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, ALOX15, APP, CDC25B, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 3.17802 |
| [BP] GO:0070989 | oxidative demethylation | CYP1A2, CYP2D6, CYP3A4 | 3.14351 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.1402 |
| [BP] GO:0006979 | response to oxidative stress | AKR1B1, APP, AXL, CYP1B1, MMP9, PTGS1, PTGS2, SRC | 3.09408 |
| [BP] GO:0048583 | regulation of response to stimulus | ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 3.06846 |
| [BP] GO:0042493 | response to drug | AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, NR3C1, PTGS2, SRC, TRPV1 | 3.05871 |
| [BP] GO:1901652 | response to peptide | AKR1B1, APP, FABP3, IGF1R, PPARA, PTGS2, SRC, TRPV1 | 3.05408 |
| [BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 3.05408 |
| [BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.05294 |
| [BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 3.04096 |
| [BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR | 3.03357 |
| [BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.99051 |
| [BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.96792 |
| [BP] GO:2001301 | lipoxin biosynthetic process | ALOX12, ALOX15 | 2.96792 |
| [BP] GO:2001302 | lipoxin A4 metabolic process | ALOX12, ALOX15 | 2.96792 |
| [BP] GO:2001303 | lipoxin A4 biosynthetic process | ALOX12, ALOX15 | 2.96792 |
| [BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC | 2.96227 |
| [BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.96052 |
| [BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TRPV1 | 2.95179 |
| [BP] GO:0071241 | cellular response to inorganic substance | ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 | 2.91452 |
| [BP] GO:0051049 | regulation of transport | ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, HCAR2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1 | 2.90352 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.87286 |
| [BP] GO:0032101 | regulation of response to external stimulus | ADORA1, ALOX12, CYP19A1, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, PTPRS | 2.85204 |
| [BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC | 2.83647 |
| [BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, ALOX12, ALOX15, CYP19A1, ESR1, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH | 2.82269 |
| [BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.82144 |
| [BP] GO:0044236 | multicellular organism metabolic process | MMP1, MMP12, MMP2, MMP9, TRPV1 | 2.80022 |
| [BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, KDR, PIK3CB, PTPN1, SRC, XDH | 2.79995 |
| [BP] GO:0009893 | positive regulation of metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.78248 |
| [BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, ESR1, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.78117 |
| [BP] GO:0008283 | cell proliferation | ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR | 2.77785 |
| [BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, AXL, CYP1B1, MMP9, SRC | 2.77785 |
| [BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.76352 |
| [BP] GO:0018212 | peptidyl-tyrosine modification | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.72648 |
| [BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.71672 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, CA2, CYP19A1, ESR1, HCAR2, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SRC | 2.7126 |
| [BP] GO:0065007 | biological regulation | ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, XDH | 2.70902 |
| [BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, XDH | 2.70902 |
| [BP] GO:1901698 | response to nitrogen compound | AKR1B1, APP, FABP3, FLT3, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.70902 |
| [BP] GO:0046486 | glycerolipid metabolic process | ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB | 2.69509 |
| [BP] GO:0065009 | regulation of molecular function | ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.6708 |
| [BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APP, ESR1, FLT3, IGF1R, MMP2, NR3C1, PTGS2, SRC, TRPV1 | 2.64465 |
| [BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR | 2.63859 |
| [BP] GO:0070988 | demethylation | CYP1A1, CYP1A2, CYP2D6, CYP3A4 | 2.59012 |
| [BP] GO:0009822 | alkaloid catabolic process | CYP2D6, CYP3A4 | 2.59012 |
| [BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.59012 |
| [BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, PTGS2 | 2.58859 |
| [BP] GO:0043393 | regulation of protein binding | APP, AURKB, MET, MMP9, PPARA, SRC | 2.57441 |
| [BP] GO:0030198 | extracellular matrix organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.56454 |
| [BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC | 2.56274 |
| [BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APP, AURKB, CSNK2A1, CYP2D6, ESR1, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TRPV1, XDH | 2.56182 |
| [BP] GO:0043062 | extracellular structure organization | APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 | 2.56182 |
| [BP] GO:0031401 | positive regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.557 |
| [BP] GO:2000021 | regulation of ion homeostasis | ADORA1, CA2, CA7, KDR, SRC, TRPV1 | 2.55345 |
| [BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.54385 |
| [BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 2.54385 |
| [BP] GO:0010634 | positive regulation of epithelial cell migration | KDR, MET, MMP9, PTGS2, SRC | 2.54385 |
| [BP] GO:0051896 | regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC, XDH | 2.52869 |
| [BP] GO:0043408 | regulation of MAPK cascade | ADORA1, ALOX15, APP, FLT3, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH | 2.51028 |
| [BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, ALOX15, APP, CDC25B, CSNK2A1, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.49013 |
| [BP] GO:0030335 | positive regulation of cell migration | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.47981 |
| [BP] GO:0001101 | response to acid chemical | AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 2.4719 |
| [BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.46423 |
| [BP] GO:0030100 | regulation of endocytosis | ALOX15, APP, AXL, PIK3CB, PTPN1, SRC | 2.45198 |
| [BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.44227 |
| [BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.38708 |
| [BP] GO:2000147 | positive regulation of cell motility | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.3834 |
| [BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2 | 2.3834 |
| [BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.35189 |
| [BP] GO:0032847 | regulation of cellular pH reduction | CA2, CA7 | 2.35189 |
| [BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.35189 |
| [BP] GO:0051098 | regulation of binding | APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC | 2.32281 |
| [BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, ALOX15, APP, AURKB, CDC25B, CSNK2A1, ESR1, FLT3, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH | 2.31788 |
| [BP] GO:0051272 | positive regulation of cellular component movement | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.31528 |
| [BP] GO:0006706 | steroid catabolic process | CYP19A1, CYP1A2, CYP3A4 | 2.30447 |
| [BP] GO:0044243 | multicellular organismal catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.29741 |
| [BP] GO:0072330 | monocarboxylic acid biosynthetic process | ALOX12, ALOX15, CYP1A1, PTGS1, PTGS2 | 2.24429 |
| [BP] GO:0030258 | lipid modification | ALOX12, CYP1A1, CYP3A4, MET, PIK3CA, PIK3CB | 2.23621 |
| [BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, MMP2, MMP9, PTGS2 | 2.23595 |
| [BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, ESR1, HCAR2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TRPV1, XDH | 2.22799 |
| [BP] GO:0040017 | positive regulation of locomotion | ALOX12, APP, IGF1R, KDR, MET, MMP9, PTGS2, SRC | 2.22355 |
| [BP] GO:0008209 | androgen metabolic process | CYP19A1, CYP3A4, ESR1 | 2.22021 |
| [BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TRPV1 | 2.21981 |
| [BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.21898 |
| [BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, MET, PIK3CA, PIK3CB, SRC | 2.2042 |
| [BP] GO:0051050 | positive regulation of transport | ACHE, ADORA1, APP, AXL, CA2, CYP19A1, HCAR2, MMP12, PTGS2, SRC, TRPV1 | 2.19832 |
| [BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, ALOX15, APP, CDC25B, ESR1, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.19599 |
| [BP] GO:0051240 | positive regulation of multicellular organismal process | ALOX12, APP, AXL, CA2, CYP1B1, HCAR2, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SRC, TRPV1 | 2.18933 |
| [BP] GO:0022617 | extracellular matrix disassembly | MMP1, MMP12, MMP2, MMP9 | 2.18933 |
| [BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP3, FABP4, PIK3CB, SRC, XDH | 2.18754 |
| [BP] GO:0051122 | hepoxilin biosynthetic process | ALOX12, ALOX15 | 2.17678 |
| [BP] GO:0051121 | hepoxilin metabolic process | ALOX12, ALOX15 | 2.17678 |
| [BP] GO:0032963 | collagen metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.15703 |
| [BP] GO:0001525 | angiogenesis | CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2 | 2.1458 |
| [BP] GO:2000106 | regulation of leukocyte apoptotic process | AURKB, AXL, HCAR2, PIK3CB | 2.14121 |
| [BP] GO:0031399 | regulation of protein modification process | ADORA1, ALOX15, APP, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 2.12578 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.12292 |
| [BP] GO:0014065 | phosphatidylinositol 3-kinase signaling | IGF1R, PIK3CA, PIK3CB | 2.12265 |
| [BP] GO:0006691 | None | ALOX12, ALOX15, ALOX5 | 2.12265 |
| [BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, ESR1, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 2.11992 |
| [BP] GO:0022900 | electron transport chain | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.10788 |
| [BP] GO:0051047 | None | ACHE, ADORA1, CYP19A1, HCAR2, MMP12, SRC, TRPV1 | 2.09447 |
| [BP] GO:1902532 | negative regulation of intracellular signal transduction | ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 2.09447 |
| [BP] GO:0032228 | regulation of synaptic transmission, GABAergic | ADORA1, CA2, CA7 | 2.09039 |
| [BP] GO:0006633 | None | ALOX12, ALOX15, PTGS1, PTGS2 | 2.08313 |
| [BP] GO:0044259 | multicellular organismal macromolecule metabolic process | MMP1, MMP12, MMP2, MMP9 | 2.08313 |
| [BP] GO:0046394 | None | ALOX12, ALOX15, ALOX5, CYP1A1, PTGS1, PTGS2 | 2.08017 |
| [BP] GO:0016053 | None | ALOX12, ALOX15, ALOX5, CYP1A1, PTGS1, PTGS2 | 2.07436 |
| [BP] GO:0036293 | response to decreased oxygen levels | ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC | 2.07436 |
| [BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 2.04734 |
| [BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.04734 |
| [BP] GO:0033029 | regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.04607 |
| [BP] GO:0002933 | lipid hydroxylation | CYP1A1, CYP3A4 | 2.04607 |
| [BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APP, IGF1R, MMP2, PTGS2, SRC, TRPV1 | 2.02965 |
| [BP] GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | CSNK2A1, MMP9, PTGS2, SRC | 2.02485 |
| [BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, FABP4, FLT3, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC | 2.02412 |
| [CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 3.38212 |
| [CC] GO:0016020 | membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR | 3.08001 |
| [CC] GO:0005886 | plasma membrane | ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SRC, TRPV1 | 2.54385 |
| [CC] GO:0044425 | membrane part | ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR | 2.36592 |
| [CC] GO:0044432 | endoplasmic reticulum part | APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.31346 |
| [CC] GO:0097443 | sorting endosome | KDR, PTPN1 | 2.04607 |
| [MF] GO:0046914 | transition metal ion binding | ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTPN1, TYR, XDH | 16.0258 |
| [MF] GO:0043167 | ion binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TRPV1, TYR, XDH | 11.7867 |
| [MF] GO:0003824 | catalytic activity | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR, XDH | 11.4949 |
| [MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 10.5512 |
| [MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD11B1, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 9.67681 |
| [MF] GO:0005506 | iron ion binding | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH | 7.52993 |
| [MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.41204 |
| [MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 7.10023 |
| [MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 7.10023 |
| [MF] GO:0043169 | cation binding | ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TRPV1, TYR, XDH | 6.87077 |
| [MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC | 6.87077 |
| [MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.8684 |
| [MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PTGS1, PTGS2, TYR | 6.53706 |
| [MF] GO:0046872 | metal ion binding | ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TRPV1, TYR, XDH | 6.51896 |
| [MF] GO:0016835 | carbon-oxygen lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 6.07304 |
| [MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 | 5.85571 |
| [MF] GO:0008144 | drug binding | ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TRPV1 | 5.77691 |
| [MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, PPARA, PTPN1 | 5.65329 |
| [MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.45064 |
| [MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, TYR | 5.42551 |
| [MF] GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.72932 |
| [MF] GO:0016829 | lyase activity | CA1, CA12, CA14, CA2, CA4, CA7, CA9 | 3.71548 |
| [MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.71548 |
| [MF] GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen | ALOX12, ALOX15, ALOX5, PTGS2 | 3.68641 |
| [MF] GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups | CYP1A2, CYP3A4, XDH | 3.46814 |
| [MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2, XDH | 3.38212 |
| [MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2D6, CYP3A4 | 3.35687 |
| [MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, FLT3, IGF1R, KDR, MET | 3.30784 |
| [MF] GO:0043560 | insulin receptor substrate binding | IGF1R, PIK3CA, PIK3CB | 3.24895 |
| [MF] GO:0042562 | hormone binding | ACHE, HSD17B1, IGF1R, NQO2, NR3C1 | 3.17911 |
| [MF] GO:0051213 | dioxygenase activity | ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 | 3.07484 |
| [MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.96792 |
| [MF] GO:0047977 | hepoxilin-epoxide hydrolase activity | ALOX12, ALOX15 | 2.96792 |
| [MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.84943 |
| [MF] GO:0004713 | protein tyrosine kinase activity | AXL, FLT3, IGF1R, KDR, MET, SRC | 2.80876 |
| [MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC | 2.77785 |
| [MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.77785 |
| [MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC | 2.69648 |
| [MF] GO:0008289 | lipid binding | ALOX15, AXL, CYP3A4, ESR1, FABP3, FABP4, HSD17B1, NR3C1, PPARA, TRPV1 | 2.67853 |
| [MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, HSD11B1, HSD17B1, HSD17B2 | 2.60607 |
| [MF] GO:0050473 | arachidonate 15-lipoxygenase activity | ALOX15, PTGS2 | 2.59012 |
| [MF] GO:0070576 | vitamin D 24-hydroxylase activity | CYP1A1, CYP3A4 | 2.59012 |
| [MF] GO:0004052 | arachidonate 12-lipoxygenase activity | ALOX12, ALOX15 | 2.59012 |
| [MF] GO:0051120 | hepoxilin A3 synthase activity | ALOX12, ALOX15 | 2.59012 |
| [MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.57441 |
| [MF] GO:0043168 | anion binding | ALOX15, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TRPV1, XDH | 2.49357 |
| [MF] GO:0034875 | caffeine oxidase activity | CYP1A2, CYP3A4 | 2.35189 |
| [MF] GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor | CYP1A2, CYP3A4 | 2.35189 |
| [MF] GO:0033764 | steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | HSD11B1, HSD17B1, HSD17B2 | 2.25783 |
| [MF] GO:0032403 | protein complex binding | ACHE, ADORA1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC | 2.2042 |
| [MF] GO:0016229 | steroid dehydrogenase activity | HSD11B1, HSD17B1, HSD17B2 | 2.18926 |
| [MF] GO:0101020 | estrogen 16-alpha-hydroxylase activity | CYP1A1, CYP3A4 | 2.17678 |
| [MF] GO:0036094 | small molecule binding | ADORA1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, SRC, TRPV1, XDH | 2.1458 |
| [MF] GO:0005158 | None | IGF1R, PTPN1, SRC | 2.12265 |
| [MF] GO:0051879 | Hsp90 protein binding | CSNK2A1, KDR, NR3C1 | 2.09039 |
| [MF] GO:0005496 | steroid binding | CYP3A4, ESR1, HSD17B1, NR3C1 | 2.08313 |
| [MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC | 2.05942 |
| [MF] GO:0004064 | arylesterase activity | CA1, CA2 | 2.04607 |
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.1829 |
| Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA2, CA4, CA7, CA9, CA14 | 11.6743 |
| Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 | 9.8136 |
| Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R | 6.8499 |
| Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 | 6.5764 |
| Serotonergic synapse_Homo sapiens_hsa04726 | APP, CYP2D6, ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 6.2691 |
| Metabolic pathways_Homo sapiens_hsa01100 | ALOX15, AKR1B1, ALOX12, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH | 5.706 |
| Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 | 6.0185 |
| Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 | 5.3787 |
| Pathways in cancer_Homo sapiens_hsa05200 | PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R | 4.8775 |
| Chemical carcinogenesis_Homo sapiens_hsa05204 | HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 | 5.7716 |
| VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 5.0611 |
| Arachidonic acid metabolism_Homo sapiens_hsa00590 | ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 | 5.0611 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.7428 |
| Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, ALOX12, PIK3CB, TRPV1 | 4.1977 |
| MicroRNAs in cancer_Homo sapiens_hsa05206 | PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B | 3.8735 |
| Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.8589 |
| Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R | 3.7742 |
| Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9 | 4.3513 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.8589 |
| Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET | 3.6415 |
| Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, IGF1R | 3.5815 |
| Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1 | 3.5761 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, PIM1, PIK3CB | 3.0852 |
| Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 3.1205 |
| PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.6112 |
| Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 3.4572 |
| cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA | 3.015 |
| TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.9987 |
| Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, PIK3CB, PPARA | 3.0007 |
| Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.8401 |
| Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.8768 |
| Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1 | 2.908 |
| Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.908 |
| Hepatitis B_Homo sapiens_hsa05161 | PIK3CA, SRC, PIK3CB, MMP9 | 2.6054 |
| Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.8925 |
| Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2 | 2.5394 |
| cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, ADORA1, PIK3CB | 2.4598 |
| PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, KDR, PIK3CB, MET, IGF1R | 2.1972 |
| Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 2.3492 |
| Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, IGF1R | 2.5984 |
| Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, PIK3CB, IGF1R | 2.5984 |
| ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB | 2.2989 |
| Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET | 2.5892 |
| Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, PIK3CB, IGF1R | 2.2879 |
| Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 3.0767 |
| Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, PIK3CB, IGF1R | 2.2286 |
| Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, PIK3CB, PTGS2 | 2.3043 |
| Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, PIK3CB | 2.064 |
| HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, PIK3CB, IGF1R | 2.1322 |
| Retinol metabolism_Homo sapiens_hsa00830 | CYP1A2, CYP1A1, CYP3A4 | 2.5984 |
| Endocytosis_Homo sapiens_hsa04144 | SRC, KDR, MET, IGF1R | 1.9024 |
| Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2D6, CYP1A2, CYP3A4 | 2.5429 |
| Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, PIK3CB | 1.997 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.9516 |
| FoxO signaling pathway_Homo sapiens_hsa04068 | PIK3CA, PIK3CB, IGF1R | 1.8952 |
| Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | ADORA3, ADORA1, TRPV1, NR3C1 | 1.8502 |
| Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB | 1.8752 |
| Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA | 1.8952 |
| Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, PIK3CB | 1.8557 |
| Linoleic acid metabolism_Homo sapiens_hsa00591 | ALOX15, CYP1A2, CYP3A4 | 3.4372 |
| Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | PIK3CA, PIK3CB, IGF1R | 1.8502 |
| Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, PIK3CB, PPARA | 1.7948 |
| Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, PIM1, PIK3CB | 1.7533 |
| Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.5929 |
| Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, PIK3CB | 1.5382 |
| Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.5264 |
| Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB | 1.4825 |
| MAPK signaling pathway_Homo sapiens_hsa04010 | CDC25B | 0.2952 |
| Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.4046 |
| Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.3942 |
| Tuberculosis_Homo sapiens_hsa05152 | SRC | 0.404 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.4173 |
| HTLV-I infection_Homo sapiens_hsa05166 | PIK3CA, PIK3CB | 0.7106 |
| Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET | 1.2912 |
| Wnt signaling pathway_Homo sapiens_hsa04310 | CSNK2A1 | 0.4728 |
| Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.5151 |
| Cell cycle_Homo sapiens_hsa04110 | CDC25B | 0.5151 |
| Axon guidance_Homo sapiens_hsa04360 | MET | 0.5096 |
| Apoptosis_Homo sapiens_hsa04210 | PIK3CA, PIK3CB | 1.1198 |
| Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB | 0.9678 |
| Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 1.1211 |
| Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 1.1393 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, PIK3CB | 1.0856 |
| Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, PIK3CB | 1.1024 |
| Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 1.1524 |
| Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, PIK3CB | 1.2222 |
| Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.5847 |
| Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.5847 |
| Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 1.3111 |
| GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2 | 1.3961 |
| Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB | 1.336 |
| Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.5943 |
| Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.3881 |
| Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.5847 |
| Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.5938 |
| Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | PIK3CA, PIK3CB | 1.3218 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.3393 |
| Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.6073 |
| T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 1.3218 |
| Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1 | 0.608 |
| Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.3509 |
| GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.6096 |
| Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.6096 |
| Gap junction_Homo sapiens_hsa04540 | SRC | 0.6096 |
| Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.6089 |
| NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, PTGS2 | 1.3881 |
| Peroxisome_Homo sapiens_hsa04146 | XDH | 0.6214 |
| Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.6641 |
| B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.5553 |
| Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.6625 |
| Chronic myeloid leukemia_Homo sapiens_hsa05220 | PIK3CA, PIK3CB | 1.5553 |
| Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.5929 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.677 |
| Pancreatic cancer_Homo sapiens_hsa05212 | PIK3CA, PIK3CB | 1.6014 |
| Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.5678 |
| mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB | 1.6692 |
| Bile secretion_Homo sapiens_hsa04976 | CA2, CYP3A4 | 1.5678 |
| Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.7049 |
| Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET | 1.5929 |
| Shigellosis_Homo sapiens_hsa05131 | SRC | 0.7025 |
| Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.7228 |
| Colorectal cancer_Homo sapiens_hsa05210 | PIK3CA, PIK3CB | 1.6474 |
| Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB | 1.7151 |
| Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.6774 |
| Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB | 1.7652 |
| Malaria_Homo sapiens_hsa05144 | MET | 0.8008 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, PIK3CB | 1.93 |
| Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | PIK3CA, PIK3CB | 1.8502 |
| Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, PIK3CB | 1.8204 |
| Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.8136 |
| Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP3A4, XDH | 1.8502 |
| Galactose metabolism_Homo sapiens_hsa00052 | AKR1B10, AKR1B1 | 2.1096 |
| Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 2.064 |
| Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.9838 |
| Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.9307 |
| Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.2982 |
| Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 1.0309 |
| Caffeine metabolism_Homo sapiens_hsa00232 | CYP1A2, XDH | 3.42 |
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples