TCM Prescription: Ning Shen Bu Xin Tablets



Prescription Description
Prescription IDTCMF4891
Pinyin NameNing Shen Bu Xin Pian
Chinese Name宁神补心片
English NameNing Shen Bu Xin Tablets
Function Description眩晕, 耳鸣, 心悸, 健忘, 不寐
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Palpitations, Dizziness
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
MC81.2 [Palpitations, 心悸 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH2610 Concha margaritifera usta;Margarita 珍珠母 TCMH2610
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1963 Caulis polygoni multiflori 首乌藤 TCMH1963
TCMH816 Albizzia julibrissin 合欢皮 TCMH816 KT972683
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 11.0654
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MCL1, MET, PPARA, PTAFR, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 9.53304
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALOX15, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MMP2, MMP9, NR3C1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 9.01315
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 8.83701
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CBR1, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FUT7, HMGCR, PIM1, PPARA, PTAFR, TYR, XDH 7.8187
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MCL1, MMP2, NR3C1, PPARA, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 7.8187
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 7.56742
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 7.04264
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 6.90626
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 6.68251
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 6.61705
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, RORC, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 6.57851
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.57851
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KCNH2, KDR, MMP2, MMP9, NR3C1, PTAFR, RORC, SLC6A4, SRC, TERT, TRPV1 6.48517
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.40489
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, KCNH2, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTAFR, RORC, SLC6A2, SLC6A4, SRC, TRPV1, TYR 6.3378
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 6.13496
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 6.08144
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1, HSD17B2 5.94065
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, CYP1B1, ESR1, ESRRA, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, SLC6A4, SRC, TERT, XDH 5.81975
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19 5.43728
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.415
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTAFR, RORC, SLC6A4, SRC, TYR 5.38547
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CES1, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 5.31483
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, RORC 5.27323
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALOX15, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 5.22083
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TRPV1, XDH 5.17896
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, ALOX12, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, KCNH2, MCL1, MET, SRC, TERT, TRPV1 5.17896
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.17896
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PTAFR, SLC6A4, SRC, TRPV1 5.16718
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, CA2, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, NR3C1, PPARA, PTAFR, SLC6A4, SRC, TRPV1 5.12938
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.11542
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 5.11542
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KCNH2, KDR, MCL1, MMP2, MMP9, NR3C1, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1 5.07576
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.05787
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 5.05787
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 5.02462
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.98911
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 4.92228
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 4.92029
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.90435
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.90435
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, CES1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, PTAFR, TYR 4.8942
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 4.85975
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.85605
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.76006
[BP] GO:0014070 response to organic cyclic compound CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1, TYR 4.74579
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.65456
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CA2, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 4.65429
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TERT, TRPV1, XDH 4.64453
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 4.63947
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HMGCR, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT, TRPV1 4.59999
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.59923
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 4.59904
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 4.5837
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.58031
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 4.56546
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.52437
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, ALOX12, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTAFR, TERT 4.48817
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC, TERT 4.48666
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 4.38102
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A4 4.38102
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.36933
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PPARA 4.33757
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.32103
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.28802
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 4.23224
[BP] GO:0007193 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 4.06231
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 4.06231
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR 4.03722
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.03722
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, HMGCR, KCNH2, KDR, NR3C1, PTAFR, SLC6A2, SLC6A4, SRC, TRPV1 3.9899
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.98461
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TERT 3.98461
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.97497
[BP] GO:0071407 cellular response to organic cyclic compound CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC, TRPV1 3.85795
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, TRPV1, XDH 3.82191
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.77565
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.77565
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.72541
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.72541
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP3A4 3.72541
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KCNH2, KDR, NR3C1, PTAFR, SRC, TRPV1 3.72125
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.72125
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SLC6A4, SRC, TERT, TYR, XDH 3.68292
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, CA2, CBR1, CDC25B, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SLC6A4, SRC, TERT, TYR 3.5806
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, ALOX12, ALOX15, CYP19A1, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.5806
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, ALOX12, CA12, CA2, CA7, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, KCNH2, MET, TRPV1 3.52039
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.51152
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SRC, TERT, TRPV1, XDH 3.5036
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 3.4879
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TRPV1 3.4676
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, ALOX15, AURKB, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PPARA, PTAFR, PTPN1, RORC, SLC6A4, SRC, TERT, XDH 3.4676
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.43695
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, ESRRA, FABP4, FLT3, GRM1, HMGCR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PTAFR, PTPN1, SRC, TERT, XDH 3.43198
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 3.42101
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 3.42101
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, ALOX15, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, HMGCR, KCNH2, MMP12, MMP9, PPARA, PTAFR, PTPN1, SLC6A4, SRC, TERT, TRPV1 3.39179
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MCL1, MET, PTPN1, SRC, XDH 3.38582
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.38388
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 3.3503
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 3.3503
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 3.3079
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 3.30657
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, SLC6A4, SRC, TERT, TRPV1, TYR 3.28065
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 3.27155
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SLC6A4, SRC, TERT, XDH 3.25631
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.16214
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 3.15818
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, ALOX12, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MCL1, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 3.15609
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CES1, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR 3.15417
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.09468
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESR1, ESRRA, ESRRB, GRM1, HMGCR, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PTAFR, PTPRS, SLC1A1, SLC6A4, SRC, TERT, TRPV1, XDH 3.04725
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MCL1, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, RORC, SRC, TRPV1 3.04545
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, GRM1, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.01776
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.01351
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TRPV1, TYR, XDH 2.99649
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, ESR1, FLT3, GRM5, IGF1R, MMP2, NR3C1, PTAFR, SLC6A4, SRC, TRPV1 2.99346
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, FABP3, FLT3, HMGCR, PPARA, RORC, SRC 2.98484
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR, TERT 2.97239
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.96597
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.92665
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.90235
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2C19, CYP3A4 2.86962
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 2.85188
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, FABP3, PIM1, PPARA, TYR 2.85188
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 2.79008
[BP] GO:0009115 None AOX1, XDH 2.79008
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.79008
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.79008
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.79008
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78849
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SRC, TERT, TRPV1, TYR, XDH 2.78152
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.76132
[BP] GO:0042391 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC, TRPV1 2.70267
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.6965
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CES1, CYP1A1, CYP1B1, HMGCR, KDR, SLC6A4, SRC 2.69012
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.66792
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.66049
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.6572
[BP] GO:0046165 None AKR1B1, CES1, CYP3A4, HMGCR, PTAFR 2.64371
[BP] GO:0010243 response to organonitrogen compound AKR1B1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TRPV1, TYR 2.60186
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.60186
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, ALOX12, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.58879
[BP] GO:0003018 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4, SRC 2.57459
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 2.56624
[BP] GO:0007188 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 2.5653
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, SLC6A4, SRC 2.55838
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.54685
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.54685
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, FABP4, FLT3, GRM1, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP2, MMP9, PPARA, PTAFR, PTPN1, PTPRS, SRC, TERT, XDH 2.51473
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.50981
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A4 2.47205
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 2.47034
[BP] GO:0030335 positive regulation of cell migration ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.41451
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ALOX12, AXL, CA2, CYP1B1, ESRRB, HMGCR, KDR, MET, MMP12, MMP9, PIM1, PTAFR, SLC1A1, SRC, TERT, TRPV1 2.41328
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.41328
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MCL1, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.41189
[BP] GO:0099566 None GRM1, GRM5 2.40137
[BP] GO:0046110 None AOX1, XDH 2.40137
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.40137
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.39332
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, ALOX15, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTPN1, SRC, XDH 2.38665
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALOX12, ALOX15, AURKB, AXL, CA1, CA12, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, XDH 2.37913
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC 2.3655
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, GRIK5, SLC1A1, SLC6A2, SLC6A4, TRPV1 2.36435
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.35467
[BP] GO:1901698 response to nitrogen compound AKR1B1, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SLC6A4, SRC, TRPV1, TYR 2.34835
[BP] GO:2000147 positive regulation of cell motility ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.33751
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.33277
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, CA2, CYP19A1, KCNH2, MMP12, PTAFR, SLC6A4, SRC, TERT, TRPV1 2.32685
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.32685
[BP] GO:0071396 cellular response to lipid AXL, ESR1, FLT3, NR3C1, PTAFR, RORC, SLC6A4, SRC 2.32019
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.31453
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.26571
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.26373
[BP] GO:0007187 None ADORA1, ADRA2A, GRM1, GRM3, GRM5, GRM8 2.26253
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, CA2, CA7, HMGCR, KDR, SRC, TRPV1 2.2408
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, ALOX15, FLT3, GRM1, HMGCR, IGF1R, KDR, PTPN1, SRC, XDH 2.2327
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.23036
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.20375
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.20375
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.19707
[BP] GO:0006066 None AKR1B1, AKR1B10, CES1, CYP1B1, CYP3A4, HMGCR, PTAFR 2.19268
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.17409
[BP] GO:0040017 positive regulation of locomotion ADRA2A, ALOX12, IGF1R, KDR, MET, MMP9, PTAFR, SRC, TERT 2.17409
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, GRIK5, HMGCR, MMP12, PTAFR, SLC6A4, SRC, TRPV1 2.17409
[BP] GO:0006145 None AOX1, XDH 2.17409
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.17409
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.17409
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, NR3C1, PPARA, PTPN1, RORC, SRC, TERT, TRPV1, XDH 2.17085
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, MCL1, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TYR 2.17085
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17085
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, MMP12, PTAFR, SLC6A4, SRC, TRPV1 2.15746
[BP] GO:0010675 None ESRRB, PPARA, PTAFR, RORC, SRC 2.14645
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SLC6A4, SRC 2.14313
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.12175
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.12175
[BP] GO:0097746 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.10721
[BP] GO:0035296 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.10721
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.10414
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, SLC6A4, SRC, TERT 2.09142
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, ESR1, ESR2, HMGCR, IGF1R, MCL1, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.08677
[BP] GO:0007268 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.08677
[BP] GO:0098916 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.08677
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, GRM5, IGF1R, MMP2, PTAFR, SLC6A4, SRC, TRPV1 2.08183
[BP] GO:0003013 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4, SRC 2.05744
[BP] GO:0043393 regulation of protein binding AURKB, MET, MMP9, PPARA, SRC, TERT 2.05744
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.04321
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.04321
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.04321
[BP] GO:0099536 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.03799
[BP] GO:0099537 None GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.03799
[BP] GO:1902532 negative regulation of intracellular signal transduction ESR1, HMGCR, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 2.03483
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.03483
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.02846
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, CDC25B, CSNK2A1, CYP1B1, ESR1, ESR2, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TERT, TRPV1, XDH 2.02582
[BP] GO:0050880 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.01213
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.01213
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.01213
[BP] GO:0035150 None ADORA1, ADRA2A, HMGCR, PTAFR, SLC6A4 2.00556
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TRPV1 4.22607
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, AXL, CA12, CA14, CA2, CA4, CSNK2A1, ESR1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1 3.92431
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, TRPV1 3.89323
[CC] GO:0044456 None ACHE, ADORA1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PTPRS, SLC6A4, SRC, TRPV1 3.55681
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA2, CA4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, PTAFR, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1 3.51152
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 3.3844
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX12, ALOX15, ALOX5, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, MMP2, PIM1, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR 3.38388
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.29724
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.85188
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALOX15, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KCNH2, KDR, MCL1, MET, PTAFR, PTPN1, PTPRS, SLC1A1, SLC6A2, SLC6A4, SRC, TRPV1, TYR 2.73799
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KCNH2, KDR, MCL1, MMP2, MMP9, NR3C1, PIM1, PTAFR, PTPN1, PTPRS, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 2.56546
[CC] GO:0043005 None ADORA1, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTPRS, SLC6A2, SLC6A4, SRC 2.45139
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.12175
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.12175
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, TYR, XDH 14.2768
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.77261
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 7.63815
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 7.63815
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, PTPN1, PTPRS, RORC, SLC1A1, SLC6A2, SLC6A4, SRC, TERT, TRPV1, TYR, XDH 7.61739
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 7.61739
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, XDH 7.56711
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.75688
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.57741
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CDC25B, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TYR, XDH 6.40489
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.09347
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, ESR1, ESR2, ESRRA, ESRRB, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KCNH2, KDR, MET, NR3C1, PPARA, PTAFR, RORC, TRPV1 6.09347
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 5.88761
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 5.84451
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PPARA, PTPN1, RORC 5.47983
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 5.32869
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4 5.13697
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, PIM1, PPARA, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A4, TERT, TRPV1, TYR, XDH 5.11542
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.07801
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PTAFR, RORC, TRPV1 5.04986
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.00608
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.00608
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.8942
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.7651
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 4.71902
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.1606
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.08771
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, SRC 3.98461
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, SRC 3.78798
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, CSNK2A1, ESR1, ESR2, FLT3, GRIK5, HMGCR, IGF1R, KCNH2, KDR, MCL1, MET, MMP9, SLC6A4, TERT, TRPV1, TYR, XDH 3.62206
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, HMGCR, HSD17B1, SRC, XDH 3.53657
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, TYR 3.51152
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 3.3844
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 3.3844
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.3503
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.29724
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.23059
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, KCNH2, TRPV1 3.20943
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.04621
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP3A4 2.9983
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.85188
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SLC6A4, SRC, TRPV1 2.80479
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.79008
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.79008
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.62148
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.4979
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.40137
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.40137
[MF] GO:0005330 None SLC6A2, SLC6A4 2.40137
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.40137
[MF] GO:0099583 None GRM1, GRM5 2.40137
[MF] GO:0047374 None CES1, CES2 2.40137
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.36383
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.36383
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.32685
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.31453
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.31453
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.28372
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.25116
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.17409
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.17409
[MF] GO:0004971 None GRIA2, GRIA4 2.17409
[MF] GO:0032795 None ADORA1, ADRA2A 2.17409
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.17409
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, CDC25B, CYP1A1, CYP1A2, CYP2C19, CYP3A4, ESR1, ESR2, ESRRB, GRM5, HMGCR, KCNH2, MET, NR3C1, PPARA, PTAFR, PTPN1, SLC6A4, SRC 2.10414
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.08475
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.04321
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.01213
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.01213
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.01213
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.01213


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GRIK5, PTAFR, TRPV1, NR3C1, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, GRIA4 8.8567
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.8567
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.768
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP2C19, CYP19A1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, XDH, CES1 6.7303
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 8.8567
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.7303
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP2C19 6.4702
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.3853
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.6501
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12, CYP2C19 4.4142
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.064
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1118
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9154
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, ALOX12, CYP2C19, SLC6A4 3.3886
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4, CYP2C19 4.3829
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.902
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH, CES2, CES1 3.7286
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.1843
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4, CYP2C19 3.1286
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.5334
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 2.3925
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1286
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.0324
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 1.8649
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1353
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0335
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.9743
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.7731
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 1.6607
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.6811
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 1.9759
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.66
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.7731
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.6171
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3568
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1, MCL1 1.2606
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA2A 1.2248
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.1822
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, MCL1, IGF1R 1.0936
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.9743
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.2799
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 0.9578
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2752
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.01
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2478
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9743
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8542
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9838
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2064
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9062
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.1822
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2064
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2606
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8595
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8595
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.8542
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1166
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.8416
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.8248
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.808
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2027
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.769
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.7836
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7873
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.3699
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2161
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2161
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.2715
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2612
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2704
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2962
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2817
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2879
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2961
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2879
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3381
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3269
Apoptosis_Homo sapiens_hsa04210 MCL1 0.356
Measles_Homo sapiens_hsa05162 CSNK2A1 0.3584
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.356
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3549
Platelet activation_Homo sapiens_hsa04611 SRC 0.3788
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3623
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4021
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3788
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4371
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.3788
Axon guidance_Homo sapiens_hsa04360 MET 0.3743
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4021
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6811
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.3845
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4209
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4371
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4371
Melanogenesis_Homo sapiens_hsa04916 TYR 0.424
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.424
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4371
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4371
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4343
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4371
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4371
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4343
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4343
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4371
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4343
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.5287
Peroxisome_Homo sapiens_hsa04146 XDH 0.4371
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4371
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4695
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.486
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5049
Glioma_Homo sapiens_hsa05214 IGF1R 0.5049
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5038
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5049
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6171
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5049
Shigellosis_Homo sapiens_hsa05131 SRC 0.5049
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.5378
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6607
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5694
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6066
Malaria_Homo sapiens_hsa05144 MET 0.58
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8649
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5859
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5829
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7491
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7655
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7873
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.757
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7836
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8324
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0949
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2357


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)