TCM Prescription: Hu Gan Tablets



Prescription Description
Prescription IDTCMF4778
Pinyin NameHu Gan Pian
Chinese Name护肝片
English NameHu Gan Tablets
Function Description胁痛, 黄疸
IndicationsHypochondrium pain disorder, Jaundice disorder, Jaundice
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2695 NA 猪胆 TCMH2695
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2, XDH 9.6146
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, HSD11B1, KIT, MET, PPARA, PTGS2, TRPV1 9.6146
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, KDR, KIT, MET, PPARA, PTGS2, SRC, TRPV1, XDH 9.6146
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 8.34675
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CYP1A1, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 8.33272
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 8.33272
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, PTGS2, SRC, TOP1, TRPV1 8.29952
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.75619
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 7.36785
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, GSK3B, IDO1, IGF1R, MMP2, MMP9, NR3C1, PPARA, PTGS2, SRC, TRPV1 7.36635
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1, XDH 7.31053
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TRPV1, XDH 7.13306
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 7.13306
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, F10, FABP3, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 6.98765
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, GSK3B, HSD11B1, IDO1, PTGS2, XDH 6.93772
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, NR3C1, PTGS2, SRC, TRPV1 6.93591
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 6.63459
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 6.62671
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC 6.62671
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, SRC, TRPV1 6.53117
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, APP, CA2, CA9, FABP3, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PPARA, PTGS2, SRC, TRPV1 6.45031
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC 6.22477
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, CYP1B1, FABP3, FLT3, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 5.90247
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 5.90247
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR 5.76363
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS2 5.7239
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1B1, PTGS2 5.71733
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, KIT, MET, PPARA, PTGS2 5.69761
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, ALOX12, AURKB, AXL, CYP1B1, FLT3, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC, TRPV1, XDH 5.67862
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1B1, F10, FLT3, KDR, KIT, MET, PTGS2, SRC, XDH 5.67862
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PTGS2, SRC, TRPV1 5.67862
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 5.67862
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1B1, F10, FABP4, IDO1, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1 5.65146
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, IDO1, PTGS2 5.65146
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS2 5.65146
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1 5.58247
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, FABP3, KDR, NR3C1, PTGS2, SRC, TOP1, TRPV1 5.35317
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 5.33349
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 5.32876
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1 5.32876
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, XDH 5.26991
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CYP1B1, GSK3B, IGF1R, MMP2, MMP9, NR3C1, PTGS2, SRC, TRPV1 5.26923
[BP] GO:0046777 protein autophosphorylation AURKB, FLT3, GSK3B, IGF1R, KDR, KIT, PIM1, SRC 5.15618
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MMP2, MMP9, NR3C1, PPARA, PTGS2, SRC, TOP1, TRPV1 5.05929
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PPARA, PTGS2, SRC, TRPV1 5.04138
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, PPARA, PTGS2 5.00552
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1B1, F10, FLT3, GSK3B, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 4.98431
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, CA2, CA9, FABP3, FLT3, KIT, NR3C1, PPARA, PTGS2, SRC, TRPV1 4.97448
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CYP1B1, F10, FABP4, FLT3, GSK3B, IDO1, KDR, KIT, MET, MMP2, MMP9, PTGS2, SRC, XDH 4.97448
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.874
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, FLT3, GSK3B, IGF1R, KIT, MMP2, NR3C1, PTGS2, SRC, TRPV1 4.83646
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 4.80054
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, CA2, CYP1A1, FABP4, KIT, MMP9, PTGS2 4.78631
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, GSK3B, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, SRC 4.7241
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CYP1B1, F10, FLT3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 4.68414
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.68414
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, PTGS2 4.64728
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, GSK3B, IDO1, MMP1, MMP2, MMP9, SRC, XDH 4.64728
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 4.64728
[BP] GO:0014070 response to organic cyclic compound AKR1C3, APP, CA2, CA9, CYP1A1, CYP1B1, DHFR, FLT3, NR3C1, PTGS2, SRC, TRPV1 4.60139
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.56887
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP3A4, DHFR 4.54176
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, PPARA, PTGS2, SRC, TRPV1 4.5114
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, APP, CYP1A1, CYP1B1, FLT3, NR3C1, PTGS2, SRC, TRPV1 4.49572
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.47756
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX12, ALOX15, CYP1A1, CYP1B1, PTGS2 4.46402
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1B1 4.46402
[BP] GO:0032787 None AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, FABP3, IDO1, PPARA, PTGS2 4.42795
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1 4.42795
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, F10, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP2, MMP9, PPARA, PTGS2, SRC, XDH 4.41853
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CYP19A1, CYP1B1, DHFR, FABP3, FABP4, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 4.41853
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CYP1A1, FABP3, FLT3, KIT, PPARA, PTGS2, SRC 4.41282
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, F10, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 4.37526
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4 4.31319
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 4.31319
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1B1, DHFR, GSK3B, IDO1, KIT, MMP2, MMP9, PPARA, PTGS2, SRC, TRPV1 4.31319
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1B1, CYP3A4, FABP3, FABP4 4.29976
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 4.25268
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.23082
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.19238
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTGS2, SRC, TRPV1 4.19138
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1 4.1567
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, FABP3, FLT3, GSK3B, IGF1R, MMP2, PPARA, PTGS2, SRC, TRPV1 4.15073
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1, XDH 4.12409
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC 4.03968
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 4.02777
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 4.01712
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 3.99088
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.9711
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX12, ALOX15, CYP19A1, CYP1A1, CYP3A4, HSD11B1, PTGS2 3.9711
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA7, CYP19A1, CYP1B1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 3.95086
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, IDO1 3.93067
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC, XDH 3.92582
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.88763
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.88763
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.88763
[BP] GO:0033993 response to lipid AKR1C3, AXL, CA2, CA9, CYP1A1, FABP3, FLT3, IDO1, NR3C1, PTGS2, SRC 3.86573
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, APP, CYP19A1, DHFR, FABP4, GSK3B, IDO1, IGF1R, MET, MMP2, PPARA, PTGS2, SRC, XDH 3.83754
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, DHFR, FABP3, KDR, MMP2, PTGS2, SRC 3.82989
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AXL, CA2, CYP19A1, CYP1A1, CYP1B1, DHFR, FLT3, GSK3B, HSD11B1, KDR, KIT, MMP9, PIM1, PPARA, PTGS2, SRC 3.78603
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP19A1, CYP1A1, CYP1B1, DHFR, FABP4, FLT3, GSK3B, HSD11B1, KDR, KIT, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC 3.73522
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.7338
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC, TOP1, XDH 3.67563
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, CYP1B1, MMP9, PTGS2, SRC 3.64207
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 3.64207
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.63407
[BP] GO:0001816 cytokine production APP, FABP4, IDO1, KIT, PTGS2 3.58635
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F10, KIT, MET, SRC 3.58635
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.58635
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS2 3.54812
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1, XDH 3.52537
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX12, ALOX15, ALOX5, CYP1A1, CYP1B1, DHFR, FABP3, IDO1, PIM1, PPARA, PTGS2 3.52537
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MET, SRC, TRPV1 3.4982
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CYP1B1, FABP4, GSK3B, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 3.47224
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 3.4571
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PTGS2, SRC, TOP1, XDH 3.45073
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1 3.39875
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, KIT, MMP2, PPARA, PTGS2, SRC, TRPV1 3.37607
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, DHFR, PTGS2, TRPV1, XDH 3.3675
[BP] GO:0046394 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 3.36155
[BP] GO:0016053 None ALOX12, ALOX15, ALOX5, CYP1A1, DHFR, IDO1, PTGS2 3.35466
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, FABP4, MMP9, PTGS2 3.33502
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 3.32979
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.31174
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1B1, CYP3A4, DHFR, IDO1 3.29769
[BP] GO:0006066 None AKR1B1, AKR1B10, AKR1C3, APP, CYP1B1, CYP3A4, DHFR 3.27918
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC, TRPV1 3.27918
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DHFR, PPARA 3.25795
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, SRC, TOP1 3.16025
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP2, MMP9, TRPV1 3.15395
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1B1, CYP3A4 3.15341
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, ALOX12, FLT3, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 3.15341
[BP] GO:0016488 None AKR1B10, AKR1C3 3.15341
[BP] GO:0016487 None AKR1B10, AKR1C3 3.15341
[BP] GO:0016107 None AKR1B10, AKR1C3 3.15341
[BP] GO:0006714 None AKR1B10, AKR1C3 3.15341
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 3.15341
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 3.15341
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 3.15341
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.09845
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 3.08691
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, KIT, PTGS2 3.08691
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GSK3B, IGF1R, MMP2, PTGS2, SRC, TRPV1 3.07818
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CYP1B1, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TRPV1 2.99963
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.97204
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.94233
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, GSK3B, IDO1, XDH 2.94233
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, PTGS2 2.92611
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.92195
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.88085
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1B1, CYP3A4 2.86882
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.86882
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.86882
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.85695
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1 2.85695
[BP] GO:0048545 response to steroid hormone AKR1C3, CA2, FLT3, NR3C1, PTGS2, SRC 2.83622
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, GSK3B, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC 2.80667
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, KDR, PTGS2, SRC, TRPV1 2.78477
[BP] GO:0034097 response to cytokine ALOX15, AXL, FABP4, FLT3, GSK3B, PTGS2, SRC, TRPV1 2.7673
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, PPARA, SRC 2.76078
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, CA2, CYP19A1, CYP1A1, FLT3, HSD11B1, KDR, KIT, PPARA, SRC 2.76032
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.74892
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.74892
[BP] GO:0016095 None AKR1B10, AKR1C3 2.74892
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1, XDH 2.67473
[BP] GO:0010942 positive regulation of cell death AKR1C3, CYP1B1, GSK3B, IDO1, MMP9, PTGS2, SRC, TRPV1, XDH 2.64058
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, DHFR, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TRPV1, XDH 2.59799
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, KDR, KIT, SRC, XDH 2.59779
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC 2.58231
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC 2.58011
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX12, ALOX15, CYP1A1, IDO1, PTGS2 2.57514
[BP] GO:0071383 None AKR1C3, FLT3, NR3C1, SRC 2.53909
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AURKB, FABP3, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, NR3C1, PPARA, PTGS2, SRC, TRPV1, XDH 2.51815
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, PTGS2 2.4993
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.49077
[BP] GO:0031960 response to corticosteroid AKR1C3, FLT3, NR3C1, PTGS2, SRC 2.49077
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.4878
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 2.4878
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.4878
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 2.4878
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.46569
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, FABP3, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PPARA, PTGS2, SRC, XDH 2.45563
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, CYP1B1, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC, XDH 2.45445
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, FLT3, KIT 2.45236
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.43698
[BP] GO:0070542 None AKR1C3, FABP3, PTGS2, SRC 2.43698
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS2 2.43698
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, CA2, CA9, CYP1B1, DHFR, GSK3B, MMP9, PTGS2, SRC, TRPV1 2.43698
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, IGF1R, KDR, KIT, SRC, XDH 2.41109
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AURKB, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, GSK3B, IDO1, SRC, XDH 2.41109
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.4058
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, FABP3, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.4058
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS2 2.39297
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.35337
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC 2.35337
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.35337
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, CA2, CYP1B1, GSK3B, IDO1, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC, TRPV1, XDH 2.35001
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP2, MMP9 2.33316
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.31833
[BP] GO:0048511 rhythmic process AXL, GSK3B, KIT, PPARA, SRC, TOP1 2.31833
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.31833
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.31833
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.31833
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.31833
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4 2.31833
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, APP, AXL, CYP19A1, CYP1A1, IDO1, KIT, MMP2, MMP9, PTGS2, SRC 2.30037
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, KDR, KIT, PTGS2 2.29978
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.29239
[BP] GO:0001523 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.28015
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, PTGS2, TRPV1, XDH 2.28015
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, FABP3, FABP4, MET, TRPV1 2.27962
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SRC 2.27825
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.27528
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC 2.26182
[BP] GO:0006810 None ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, F10, FABP3, KIT, MMP9, PPARA, SRC, TRPV1, XDH 2.25043
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, FABP4, FLT3, IGF1R, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.24655
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, GSK3B, MMP9, PPARA, PTGS2, SRC, TRPV1 2.24009
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, PTGS2, TRPV1 2.23926
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, GSK3B, PTGS2, SRC, TRPV1 2.22387
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, FABP4, IDO1, KDR, MET, PPARA, PTGS2 2.18098
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.18098
[BP] GO:0016115 None AKR1B10, AKR1C3 2.18098
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1 2.18098
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.16823
[BP] GO:0032091 negative regulation of protein binding AURKB, GSK3B, MET, PPARA 2.1668
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP2, MMP9 2.16363
[BP] GO:0051234 None ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, F10, FABP3, KIT, MMP9, PPARA, SRC, TRPV1, XDH 2.15515
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, MMP9, SRC, TRPV1 2.14676
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, FLT3, KDR, KIT, MMP9, PTGS2, SRC, XDH 2.14676
[BP] GO:0034405 response to fluid shear stress CA2, PTGS2, SRC 2.14324
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CYP1A1, CYP3A4, DHFR, F10, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTGS2, SRC, TOP1, XDH 2.12248
[BP] GO:0007566 embryo implantation MMP2, MMP9, PTGS2 2.11133
[BP] GO:0061515 None APP, KIT, SRC 2.05176
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CYP1B1, DHFR, FABP4, FLT3, GSK3B, IGF1R, KIT, MET, MMP9, PIM1, PPARA, PTGS2, SRC, TRPV1, XDH 2.04256
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, CYP1B1, SRC 2.02696
[BP] GO:0009268 None CA2, SRC, TRPV1 2.02696
[BP] GO:0046173 None AKR1B1, CYP3A4, DHFR 2.02696
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, KDR, KIT, PTGS2, XDH 2.02588
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, SRC 2.01244
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD11B1, IDO1, KDR, KIT, MMP2, MMP9, NR3C1, PIM1, PTGS2, SRC, TOP1, TRPV1, XDH 2.69155
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, F10, FLT3, GSK3B, IGF1R, KDR, KIT, MET, MMP2, PIM1, SRC, TRPV1 2.31795
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, F10, FLT3, IGF1R, KDR, KIT, MET, PTGS2, SRC, TRPV1 2.20841
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP 1.95968
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, F10, FLT3, IGF1R, KDR, MET, TRPV1 1.52609
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.4296
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, XDH 10.1598
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, SRC, TOP1, TRPV1, XDH 10.0768
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, F10, FLT3, GSK3B, HSD11B1, IDO1, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIM1, PTGS2, SRC, TOP1, XDH 9.65213
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.16567
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, HSD11B1, IDO1, PTGS2, XDH 7.10635
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.43371
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, F10, IDO1, KIT, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 5.86627
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1B1, CYP3A4, XDH 5.67862
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.67862
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, PPARA, SRC, TOP1, TRPV1 5.65901
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, IDO1, PTGS2 5.65146
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1B1, CYP3A4, F10, IDO1, KIT, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTGS2, TRPV1, XDH 5.50657
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 5.50179
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 5.11293
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.97357
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.94273
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 4.29328
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1B1, CYP3A4 4.26213
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.25382
[MF] GO:0004672 protein kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 4.21591
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1B1, CYP3A4 4.07998
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.55109
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, IDO1, PTGS2, SRC, XDH 3.55109
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, PTGS2 3.54833
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, IDO1, PTGS2 3.44995
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, NR3C1, PPARA 3.4422
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.35466
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 3.29769
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1B1, CYP3A4 3.2664
[MF] GO:0016301 kinase activity AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 3.25795
[MF] GO:0045550 None AKR1B10, AKR1C3 3.15341
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 3.15341
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, DHFR, F10, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TRPV1, XDH 3.1282
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.74892
[MF] GO:0047718 None AKR1B10, AKR1C3 2.74892
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.74892
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.74892
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.74892
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, HSD11B1, XDH 2.72937
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1 2.68927
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, DHFR, FABP3, FABP4, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TRPV1, XDH 2.62443
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, F10, FABP3, FABP4, NR3C1, PPARA, TRPV1 2.57628
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.50047
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.31833
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.2323
[MF] GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen AKR1C3, CYP1A1, CYP3A4 2.2323
[MF] GO:0004064 arylesterase activity CA1, CA2 2.18098
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.05685
[MF] GO:0001758 None AKR1B10, AKR1C3 2.05685
[MF] GO:0004032 None AKR1B1, AKR1C3 2.05685
[MF] GO:0001609 None ADORA1, ADORA3 2.05685
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, IDO1, XDH 2.02696
[MF] GO:0005524 ATP binding AURKB, AXL, FLT3, GSK3B, IGF1R, KDR, KIT, MET, PIM1, SRC, TOP1, TRPV1 2.02238


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 12.3044
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9194
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, CYP1A1, AKR1C3, CYP1B1, CYP3A4, CYP19A1 6.7956
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, FLT3, MMP1, MMP2, KIT, PTGS2, MMP9, MET, IGF1R 5.1292
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, ALOX12, PTGS2 5.1292
Metabolic pathways_Homo sapiens_hsa01100 ALOX15, AKR1C3, AKR1B1, ALOX12, PTGS2, CYP3A4, CYP19A1, DHFR, HSD11B1, AKR1B10, ALOX5, CYP1A1, XDH, IDO1 5.0652
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 4.0787
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A1, CYP1B1, PTGS2, CYP3A4 4.6651
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.4458
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12, PTGS2 4.105
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A1, CYP1B1, CYP3A4 3.6139
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.6733
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, MET, IGF1R 3.0331
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KIT, KDR, MET, IGF1R 3.0063
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.6722
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A1, CYP1B1, IDO1 3.031
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 2.6722
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.6722
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET 2.4678
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.6169
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, KIT, KDR, MET, IGF1R 2.2565
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET 2.5191
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.3848
Adherens junction_Homo sapiens_hsa04520 SRC, MET, IGF1R 2.434
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.1566
Ras signaling pathway_Homo sapiens_hsa04014 KIT, KDR, MET, IGF1R 2.0983
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 2.1566
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.9266
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, TRPV1, NR3C1 1.871
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4603
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.4574
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.2457
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC 1.4563
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 1.3212
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5553
Prostate cancer_Homo sapiens_hsa05215 GSK3B, IGF1R 1.3212
Retinol metabolism_Homo sapiens_hsa00830 CYP1A1, CYP3A4 1.4862
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.3124
Melanogenesis_Homo sapiens_hsa04916 GSK3B, KIT 1.2457
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 1.1942
Insulin resistance_Homo sapiens_hsa04931 GSK3B, PPARA 1.1942
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.4002
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.3212
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.4574
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC 1.1547
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.1547
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.1494
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 1.0348
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 1.0914
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, IGF1R 1.0474
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 1.0214
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.1202
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.9931
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.9598
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.7533
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.9598
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.8918
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.8533
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0526
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP3A4 2.0672
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9266
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.3467
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B 0.417
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.4046
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.4157
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4577
Platelet activation_Homo sapiens_hsa04611 SRC 0.5432
Influenza A_Homo sapiens_hsa05164 GSK3B 0.4577
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.586
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4574
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B 0.5432
Measles_Homo sapiens_hsa05162 GSK3B 0.5207
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4889
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5602
Insulin signaling pathway_Homo sapiens_hsa04910 GSK3B 0.5204
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5834
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5432
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.4968
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.5251
Tight junction_Homo sapiens_hsa04530 SRC 0.5204
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5896
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B 0.5164
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5809
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.5151
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.5432
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5918
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.5432
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5918
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.5324
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5952
Cell cycle_Homo sapiens_hsa04110 GSK3B 0.5432
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.5809
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5896
NF-kappa B signaling pathway_Homo sapiens_hsa04064 PTGS2 0.5896
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5834
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.5952
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.6388
Gap junction_Homo sapiens_hsa04540 SRC 0.5952
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2043
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5896
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.0111
Peroxisome_Homo sapiens_hsa04146 XDH 0.6033
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6386
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.6586
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6388
Glioma_Homo sapiens_hsa05214 IGF1R 0.6586
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6178
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6451
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6621
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.658
Colorectal cancer_Homo sapiens_hsa05210 GSK3B 0.6586
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6586
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP3A4 0.6455
Shigellosis_Homo sapiens_hsa05131 SRC 0.6586
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.7084
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6914
Malaria_Homo sapiens_hsa05144 MET 0.7203
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7183
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8533
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9427
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 1.0348
Folate biosynthesis_Homo sapiens_hsa00790 DHFR 1.1489
Caffeine metabolism_Homo sapiens_hsa00232 XDH 1.4574


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)