TCM Prescription: Ji Zhong Ding



Prescription Description
Prescription IDTCMF4677
Pinyin NameJi Zhong Ding
Chinese Name济众酊
English NameJi Zhong Ding
Function Description中暑
IndicationsSunstroke
Disease ICD-11 Category NF01.0 [Heat stroke, 中暑 ];
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH189 Mentholum 薄荷脑 TCMH189
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1228 Capsicum frutescens 辣椒 TCMH1228 ITSAL4555-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH728 Pogostemon cablin 广藿香 TCMH728 ITSAJ4146-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH2295 fructus foeniculi 小茴香 TCMH2295
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8053
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8053
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MAOA, MET, MTNR1B, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS1, PTGS2, SRC, TRPV1, XDH 14.457
[BP] GO:0042221 response to chemical ABCG2, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCD, PTGES, PTGS2, SRC, TRPV1, TYR 13.1771
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PRKCD, PTGES, PTGS2, SRC, TRPV1, TYR 12.691
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 12.4566
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, PPARA, PRKCD, PTGES, PTGS2, SRC, TRPV1, TYR 11.1066
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, SRC, TYR 10.6387
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.5751
[BP] GO:0042493 response to drug ABCG2, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PRKCD, PTGS2, SRC, TRPV1 10.5079
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 9.67485
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HMGCR, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.83689
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TRPV1, TYR 8.35089
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, MTNR1B 8.3119
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, FABP4, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, SRC, TRPV1, TYR 8.01081
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, SRC, TRPV1, TYR 7.83141
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGES, PTGS1, PTGS2, SRC, XDH 7.82714
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TRPV1 7.78044
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 7.78044
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.76296
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 7.76296
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PRKCD, PTGS2, SRC, TRPV1 7.65117
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 7.29353
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.22572
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 7.16205
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.13196
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 7.10014
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PRKCD, PTGES, PTGS2, SRC 7.06949
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.0634
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.0252
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 7.00125
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 6.96902
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.919
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HMGCR, HTR1B, HTR1D, KDR, PRKCD, SRC 6.89293
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 6.86725
[BP] GO:0003018 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 6.85047
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.79112
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1 6.79112
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC, TRPV1 6.75175
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 6.6809
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.59916
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 6.54805
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.52595
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.509
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PTGS2, SRC 6.50125
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, MTNR1B, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.48833
[BP] GO:0097746 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.48833
[BP] GO:0035296 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.48833
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PRKCD, PTGS2, SRC 6.48564
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.47482
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 6.4444
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.4175
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B, PIK3CA, PIK3CB, SRC 6.37795
[BP] GO:0050880 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.29768
[BP] GO:0035150 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.2739
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC 6.27025
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.26352
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B 6.26352
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 6.1509
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 6.0876
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SRC 6.0876
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.06523
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 6.06523
[BP] GO:0042592 homeostatic process ABCG2, ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, MTNR1B, PIK3CA, PIK3CB, SRC, TRPV1 6.01212
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.99011
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.97967
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.96968
[BP] GO:0003013 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 5.88604
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC, TRPV1 5.82993
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.76907
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PRKCD, SRC 5.62571
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1 5.62571
[BP] GO:0048878 chemical homeostasis ABCG2, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, MTNR1B, PIK3CA, PIK3CB, TRPV1 5.58087
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.57455
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.57455
[BP] GO:0008152 metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 5.49578
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.49181
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 5.49181
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HMGCR, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SRC 5.44521
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 5.43454
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PRKCD, PTGS2, SRC, TRPV1 5.42361
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, SRC, TRPV1 5.40197
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.33106
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 5.32653
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTPN1, SRC, TRPV1 5.17243
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.9411
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, HTR2A, HTR2B, HTR2C, SRC, TRPV1 4.85938
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, SRC, TYR 4.83443
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.7055
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, HTR1B, KDR, PRKCD, PTGS2, SRC, TRPV1 4.68936
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.6836
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 4.65517
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.61447
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, XDH 4.61342
[BP] GO:0090066 None ADORA1, ALOX15, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PTGS2 4.60131
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.60059
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC, TRPV1, TYR 4.5893
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, HTR1B, HTR2A, PTGS2 4.58685
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.58685
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SRC, TRPV1, TYR 4.53728
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.53642
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 4.50237
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 4.50237
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.48127
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 4.36253
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC 4.34224
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SRC, XDH 4.28677
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.28384
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PRKCD, PTGS2, SRC, TRPV1, TYR 4.20447
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP4, FLT3, HMGCR, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 4.18036
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTGS2 4.18036
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, HMGCR, HTR1A, MAOA, TYR 4.16194
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PRKCD, PTPN1, SRC, XDH 4.14729
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 4.14354
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTPN1, SRC, XDH 4.14136
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.12814
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.12814
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.12814
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC, TRPV1 4.04975
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 4.04251
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 4.00498
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, TRPV1 3.97818
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PTGS2, SRC, TRPV1, TYR 3.96767
[BP] GO:0007154 None ADORA1, AXL, BCL2, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B, PTGS2, TRPV1 3.93567
[BP] GO:0007610 None BCL2, CNR1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MTNR1A, PPARA, PTGS2, TRPV1 3.91589
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, HTR2A, MMP12, PRKCD, PTGES, PTGS2, SRC, TRPV1, TYR 3.90987
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR, XDH 3.89095
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.85512
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.85405
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, PRKCD, SRC, TYR 3.85405
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 3.85008
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 3.83889
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGES, PTGS2, PTPN1, SRC, TRPV1, XDH 3.77406
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, MTNR1A, MTNR1B, PPARA, SRC 3.76797
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TRPV1, XDH 3.71181
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 3.68021
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 3.68021
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MTNR1B, SRC 3.67701
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.64584
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.64342
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 3.64342
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, SRC, TYR 3.64342
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.64104
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TRPV1 3.64104
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 3.63511
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63511
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.60703
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.60305
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, PTGS2 3.60305
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCD, SRC 3.60073
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 3.59179
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, PTPN1, SRC, TRPV1 3.56134
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, PRKCD, PTGS2 3.50432
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.48934
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 3.48527
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, HTR1B, HTR2A, PTGS2 3.47652
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TRPV1, TYR 3.46097
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGES, PTGS2 3.42712
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.42712
[BP] GO:0046890 None FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 3.42712
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.42121
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 3.42121
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.42121
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, FABP3, FABP4, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGES, PTGS2, PTPN1, SRC, TRPV1, XDH 3.41271
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.37174
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.36459
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.35269
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.33398
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, SRC 3.33398
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, AXL, BCL2, CNR2, HTR1A, HTR2C, PIK3CA, PIK3CB, PRKCD, PTGES, PTGS1, PTGS2, SRC, TRPV1 3.32683
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, SRC, TRPV1 3.28788
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, ESR1, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.26449
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 3.26196
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, ESR1, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 3.25047
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 3.23137
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 3.2295
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PRKCD, PTGS1, PTGS2, SRC 3.21507
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21507
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.2046
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 3.2046
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.17449
[BP] GO:1901652 response to peptide AKR1B1, FABP3, HSD11B2, IGF1R, PPARA, PRKCD, PTGS2, SRC, TRPV1 3.16916
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, HMGCR, HTR1A, HTR2A, HTR2C, MTNR1B 3.16598
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.15826
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 3.15699
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PRKCD, PTGS2 3.14147
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.14005
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.12976
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.12976
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, MMP12, MMP2, PPARA, PRKCD, PTGS2, PTPN1, SRC 3.12681
[BP] GO:0050801 ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 3.12425
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.11858
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC 3.10596
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PTGS2, TRPV1, TYR 3.09494
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 3.07584
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTGS2 3.074
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 3.06316
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.05824
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, HMGCR, HTR2A, HTR2B, HTR2C, KDR, SRC 3.04557
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PRKCD, PTGES, PTGS2, SRC 3.02235
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, HMGCR, HTR2B, HTR2C, MMP12, MTNR1B, PRKCD, PTGS2, PTPN1, SRC 3.00128
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.98158
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.96767
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 2.94349
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.93618
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 2.92488
[BP] GO:0007208 None HTR2A, HTR2C 2.92455
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.91359
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.91359
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.91359
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.90569
[BP] GO:0006082 organic acid metabolic process ABCG2, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.89747
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 2.87137
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PRKCD, PTGS2 2.86752
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, XDH 2.86674
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PRKCD, PTGES, PTGS2, SRC 2.86219
[BP] GO:0009987 cellular process ABCG2, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 2.84134
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.83454
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 2.83347
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TRPV1, XDH 2.83062
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.83062
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.83062
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PRKCD, PTGS2 2.82746
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TRPV1, XDH 2.79774
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.79357
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CB, PRKCD, PTPN1, SRC 2.79302
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.77649
[BP] GO:0008217 None ADORA1, CNR1, HSD11B2, PPARA, PTGS1, PTGS2 2.76146
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.74954
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.74954
[BP] GO:0009266 None ADORA1, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 2.74954
[BP] GO:0007267 None ADORA1, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 2.72754
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.72476
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, TRPV1 2.71564
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, TRPV1 2.71564
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.69723
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.67579
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.67579
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.67579
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, HTR1D, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.6532
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC 2.64333
[BP] GO:0098771 inorganic ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.64333
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.64281
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 2.60515
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.60124
[BP] GO:0055082 cellular chemical homeostasis ABCG2, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, TRPV1 2.58187
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCD, PTPN1 2.54388
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, HMGCR, MMP9, PIK3CB, PRKCD, PTGS2, SRC, TRPV1, XDH 2.53672
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.53367
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52495
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.5219
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, HMGCR, PTGES, PTGS1, PTGS2 2.51548
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, HSD11B2, HSD17B2, MMP2, MMP9, MTNR1A, PTGS2, SRC 2.50772
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, PRKCD, PTGS2, TRPV1, XDH 2.49989
[BP] GO:0050994 None ADORA1, CNR1, PPARA, PRKCD 2.49883
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.49745
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.47812
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD 2.47679
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.4759
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.4759
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.46668
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, MMP12, MMP2, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.45882
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TYR 2.45882
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.44841
[BP] GO:0002791 None ACHE, ADORA1, CNR1, HMGCR, HTR2B, HTR2C, MMP12, MTNR1B, SRC 2.43501
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.42679
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, FABP4, HMGCR, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 2.42181
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC, TRPV1 2.42181
[BP] GO:0030003 cellular cation homeostasis ABCG2, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.42181
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 2.41873
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.38474
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCD, SRC 2.38328
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.37954
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.37369
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, TRPV1 2.36855
[BP] GO:0023052 None ADORA1, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, MTNR1B 2.36841
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, PIK3CB, PTPN1, SRC 2.36841
[BP] GO:0003012 None ADORA1, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.36841
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.36787
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.36787
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, HTR1A, MAOA 2.35741
[BP] GO:0006873 cellular ion homeostasis ABCG2, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.35136
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.32456
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.32456
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.31594
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.31285
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD 2.31024
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.28944
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PTGES, PTGS2, SRC, TRPV1 2.28179
[BP] GO:0038171 None CNR1, CNR2 2.28161
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.28161
[BP] GO:0014827 None HTR1D, HTR2B 2.28161
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, PRKCD 2.27611
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.26905
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26905
[BP] GO:0043434 None FABP3, HSD11B2, PPARA, PRKCD, PTGS2, SRC, TRPV1 2.25485
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, PRKCD 2.24068
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, MMP9, PRKCD, SRC 2.23108
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.21932
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.21932
[BP] GO:0060402 None HTR2A, HTR2B, HTR2C, TRPV1 2.2086
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, FLT3, FUT7, HMGCR, HTR1A, HTR2B, HTR2C, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TYR, XDH 2.20831
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.18521
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, SRC, TRPV1, XDH 2.17835
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR 2.1686
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.1686
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC, TRPV1, XDH 2.1265
[BP] GO:0006693 None PTGES, PTGS1, PTGS2 2.1256
[BP] GO:0006692 None PTGES, PTGS1, PTGS2 2.1256
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, HTR1B, IGF1R, MMP2, PRKCD, PTGS2, SRC, TRPV1 2.1251
[BP] GO:0055080 cation homeostasis ABCG2, BCL2, CA2, CA7, ESR1, HTR2A, HTR2B, HTR2C, PIK3CB, TRPV1 2.11024
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR 2.09637
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.09637
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, XDH 2.0677
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.06478
[BP] GO:0051896 regulation of protein kinase B signaling AXL, MET, PIK3CA, PIK3CB, SRC, XDH 2.05674
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.05559
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, MMP12 2.05455
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.04321
[BP] GO:0014059 None CNR1, HTR1B, HTR2A 2.04321
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.04132
[BP] GO:0006936 None HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, TRPV1 2.03112
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.01647
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.00133
[CC] GO:0016020 membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR 7.74452
[CC] GO:0044425 membrane part ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR 7.29353
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 6.75175
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCD, PTPN1, SRC, TRPV1 6.4444
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 6.43211
[CC] GO:0044459 plasma membrane part ABCG2, ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PTGS2, SRC, TRPV1 5.54732
[CC] GO:0031224 None ABCG2, ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA4, CA9, CNR1, CNR2, ESR1, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TRPV1, TYR 3.54746
[CC] GO:0016021 None ABCG2, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA9, CNR1, CNR2, ESR1, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MAOA, MET, MTNR1A, MTNR1B, PTGES, TBXAS1, TRPV1, TYR 2.94211
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS1, PTGS2, TBXAS1 2.52859
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 2.24068
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8053
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.8053
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6717
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.6717
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.4414
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.4566
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 11.6057
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.1066
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1862
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.69442
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.46968
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 9.19418
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.68726
[MF] GO:0003824 catalytic activity ABCG2, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TYR, XDH 8.45071
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 7.83959
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, SRC, TRPV1 7.37481
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 7.3249
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 7.18455
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, TRPV1 7.18455
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 6.96629
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, TBXAS1, TRPV1, TYR, XDH 6.919
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.36452
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CNR1, CNR2, ESR1, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MTNR1A, MTNR1B, PPARA, TRPV1 6.27025
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.06523
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.52276
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, MTNR1A, MTNR1B 5.34295
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 5.23668
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.03818
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.99239
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB, PRKCD 4.9411
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.63266
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 4.55257
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.27226
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.68423
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.68021
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1 3.60776
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50977
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.45449
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADORA1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, MTNR1A, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, XDH 3.41271
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.3922
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.35269
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, PRKCD, SRC 3.23307
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCD, SRC 3.2046
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.20152
[MF] GO:1901363 heterocyclic compound binding ABCG2, ADORA1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TRPV1, XDH 3.18825
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 3.13917
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.95787
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.92455
[MF] GO:0003845 None HSD11B1, HSD11B2 2.92455
[MF] GO:0071886 None HTR2A, HTR2C 2.92455
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, MTNR1A, NQO2 2.83454
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 2.80112
[MF] GO:0036094 small molecule binding ABCG2, ADORA1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TRPV1, XDH 2.74326
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.71564
[MF] GO:0008502 None MTNR1A, MTNR1B 2.52495
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.52495
[MF] GO:0004949 None CNR1, CNR2 2.52495
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.41873
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, TBXAS1, TRPV1, TYR, XDH 2.30411
[MF] GO:0000166 nucleotide binding ABCG2, AURKB, AXL, CDK6, CSNK2A1, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TRPV1, XDH 2.27565
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.27516
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AURKB, AXL, CDK6, CSNK2A1, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TRPV1, XDH 2.27516
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCD, SRC 2.18521
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.1256
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.08128
[MF] GO:0043168 anion binding ABCG2, ALOX15, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCD, PTGES, SRC, TRPV1, XDH 2.06169
[MF] GO:0051721 None BCL2, HMGCR, PTPN1 2.04321


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.6026
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, HTR5A, HTR4, HTR6, MTNR1A, HTR7, CNR2, CNR1, MTNR1B, ADORA3, ADORA1 15.2373
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.3511
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.9055
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1515
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCD, HTR2B, HTR2C, PIK3CB, TRPV1, HTR2A 7.1504
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 7.1504
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 6.5561
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.0243
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 5.5656
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.0243
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1 5.9363
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGES, PTGS1 5.8435
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PRKCD, BCL2, PIM1, PIK3CB 4.6757
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.7781
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.3684
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.5197
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.1107
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.2431
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, MET, IGF1R 4.0227
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1779
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.9905
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.9905
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.0227
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCD, PIK3CB, PPARA 3.5137
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.3265
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.3458
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 3.08
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.4791
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.299
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 2.978
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 4.0088
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9905
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.2614
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.1786
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.9867
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.9031
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2249
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1675
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.764
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0796
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5979
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6005
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A 2.9112
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.6919
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.5249
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.5249
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.5063
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.5249
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.4652
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.3377
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 2.1521
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.1521
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.0794
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9767
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PRKCD, PIK3CB 1.9539
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.856
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.8395
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD 1.9638
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.1867
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.0054
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCD, PIK3CB 1.9539
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5445
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2975
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3209
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9539
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3451
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.5501
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.594
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.212
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2975
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.9539
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.5533
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.594
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.4652
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.5533
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.5445
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, ABCG2 2.214
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4881
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3001
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3098
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.5063
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3196
Alcoholism_Homo sapiens_hsa05034 MAOA 0.3074
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1437
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PRKCD, PIK3CB 2.6005
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3728
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9666
Axon guidance_Homo sapiens_hsa04360 MET 0.4046
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.4022
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5479
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4127
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.4183
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7445
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.739
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.8755
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9115
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.8286
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4768
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4761
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9241
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.959
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4893
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4885
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0907
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.502
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0658
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5031
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.1168
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0907
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0764
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5051
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5051
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0764
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1014
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0907
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.504
Peroxisome_Homo sapiens_hsa04146 XDH 0.5206
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5592
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5574
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.572
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5743
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.5824
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3159
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5933
Shigellosis_Homo sapiens_hsa05131 SRC 0.5906
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3593
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6149
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3337
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3593
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.352
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3865
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4467
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6753
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4557
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6796
Malaria_Homo sapiens_hsa05144 MET 0.6842
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6842
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.5445
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.694
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.699
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.7133
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6229
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.7445
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.841
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9307
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.8228
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8817
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9539
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8044
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9024
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8904
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0958
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.9241
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9566
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 1.0528
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1016
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2054


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)