TCM Prescription: Hou Pu Wen Zhong Pills



Prescription Description
Prescription IDTCMF4658
Pinyin NameHou Pu Wen Zhong Wan
Chinese Name厚朴温中丸
English NameHou Pu Wen Zhong Pills
Function Description腹胀, 腹痛, 腹泻
IndicationsAbdominal pain disorder, Diarrhea, Dyspepsia, Enteritis
Disease ICD-11 Category SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
ME05.1 [Diarrhoea, 腹泻 ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH925 Exocarpium citri grandis 化橘红 TCMH925
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH214 Alpinia katsumadai 草豆蔻 TCMH214 KY454001
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1533 Saussurea lappa 木香 TCMH1533
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 15.1111
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.1696
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.4877
[BP] GO:0033993 response to lipid ALPL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, HSD11B2, HSD17B2, PRKCE, TYR 7.32486
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, HSD17B2, PRKCB, PRKCD, PRKCE, TYR 7.32486
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, HSD11B2, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TYR 7.31769
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.14293
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.0756
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FUT7, GBA2, TYR, XDH 6.99611
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 6.5383
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, HSD11B2, PRKCE, PRKCG, TYR 6.45649
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE 6.35728
[BP] GO:0042221 response to chemical AKR1B1, ALPL, BCL2, CA2, CA3, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP4, HSD11B2, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TYR 5.64664
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FUT7, GBA2, HSD17B1, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 5.59109
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.32491
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F2, F3, FABP4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, TNKS, TNKS2, XDH 5.22699
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 5.16823
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.05901
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.04436
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, PRKCE 4.87913
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA3, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, HSD11B2, PRKCD, PRKCE, PRKCG 4.59598
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.50587
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.48542
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.4128
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, BCL2, CA3, CNR1, CNR2, CYP1A1, CYP1B1, PRKCD, PRKCE 4.35353
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, PRKCA, PRKCB, PRKCD, TNKS 4.30493
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2, PRKCD, PRKCE 4.26502
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 4.16016
[BP] GO:0018105 peptidyl-serine phosphorylation BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TNKS 3.92331
[BP] GO:0030168 platelet activation F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 3.69939
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.69939
[BP] GO:0018209 peptidyl-serine modification BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TNKS 3.63961
[BP] GO:0010647 positive regulation of cell communication AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 3.61246
[BP] GO:0023056 positive regulation of signaling AKR1B1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 3.59509
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.41343
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09767
[BP] GO:0032844 regulation of homeostatic process BCL2, CA2, CA7, CDK6, CNR1, F2, PRKCE, TNKS, TNKS2 2.85871
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALPL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, F2, FABP4, FUT7, GBA2, HSD11B1, HSD17B2, PRKCA, PRKCD, TNKS2, TYR 2.79466
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, KCNA3, PRKCB, PRKCE 2.7891
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.78764
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.78764
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F2, F3, FABP4, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, XDH 2.73244
[BP] GO:0035408 None PRKCA, PRKCB 2.69655
[BP] GO:0009115 None AOX1, XDH 2.69655
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, HSD11B2, PRKCD, PRKCE 2.67219
[BP] GO:0048513 animal organ development ACHE, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, HSD11B1, HSD17B2, TYR 2.59454
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.50491
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.49765
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.48573
[BP] GO:0050896 response to stimulus ACHE, AKR1B1, ALPL, BCL2, CA2, CA3, CA6, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F2, F3, FABP4, HSD11B2, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TYR 2.48573
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.48573
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.45287
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.35965
[BP] GO:0080134 regulation of response to stress CDK6, CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, XDH 2.35965
[BP] GO:0046110 None AOX1, XDH 2.31472
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.31472
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.30603
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28684
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, PRKCD 2.22745
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, BCL2, CSNK2A1, CYP1B1, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, TNKS, TNKS2, XDH 2.22745
[BP] GO:0032846 positive regulation of homeostatic process CA2, CA7, CNR1, F2, TNKS, TNKS2 2.20397
[BP] GO:0002682 regulation of immune system process BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, F2, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1 2.19635
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, ESR1, F2, FABP4, PRKCB, PRKCE 2.19635
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1 2.19635
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19529
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, ESR1, F2, F3, FABP4, PRKCA, PRKCD, PRKCG 2.15667
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.14662
[BP] GO:0061041 regulation of wound healing F2, F3, PRKCA, PRKCD, PRKCE 2.11469
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, XDH 2.11024
[BP] GO:0070213 None TNKS, TNKS2 2.09596
[BP] GO:0006145 None AOX1, XDH 2.09596
[BP] GO:0038171 None CNR1, CNR2 2.09596
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09596
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AOX1, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, F2, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 2.83734
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, CA4, PRKCA, PRKCD, PRKCE, PRKCG, TNKS2, TYR 2.07409
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 1.30671
[CC] GO:0016020 membrane ACHE, ALPL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, KCNA3, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR 1.28353
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GBA2, HSD11B1, HSD11B2, HSD17B2 1.21742
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 21.3951
[MF] GO:0046914 transition metal ion binding AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, PRKCA, PRKCB, PRKCG, PTPN1, TNKS, TYR, XDH 15.1111
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 14.1696
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6679
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F2, F3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 9.99464
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, PRKCA, PRKCB, PRKCG, PTPN1, TNKS 9.6623
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 8.4877
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 7.09912
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.00559
[MF] GO:0046872 metal ion binding ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 6.66133
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, HSD17B1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, TNKS, TNKS2, TYR, XDH 6.37226
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.37226
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.5156
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.77726
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.4128
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.28486
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.75924
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58757
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.52706
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.41343
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.96786
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.85871
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.85008
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.77551
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.75476
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.72795
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69655
[MF] GO:0003845 None HSD11B1, HSD11B2 2.69655
[MF] GO:0035403 None PRKCA, PRKCB 2.69655
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.62606
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.62606
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.58062
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.35965
[MF] GO:0004949 None CNR1, CNR2 2.31472
[MF] GO:0004699 None PRKCD, PRKCE 2.31472
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, XDH 2.12627
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.09596


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 22.8294
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.9442
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PRKCB, PRKCE, PRKCD, BCL2, PRKCA, F3 5.158
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 5.158
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.1565
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, CDK6, PRKCB, PRKCE, BCL2, CYP1B1, PRKCA, CDC25B 4.768
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.6659
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, PRKCE, PRKCD, PRKCA 4.6405
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 4.3003
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 4.3776
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, PRKCB, BCL2, PRKCA 4.0975
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.5233
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.4219
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PRKCB, PRKCA 4.4255
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PRKCB, PRKCA 4.0119
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 4.242
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 4.0119
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PRKCB, PRKCA 3.8099
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PRKCB, PRKCE, BCL2, PRKCA 4.0119
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, PRKCB, BCL2, PRKCA 3.6469
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 3.6304
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 3.4962
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 3.212
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA 3.2116
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PRKCB, BCL2, PRKCA 3.1944
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 3.2637
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PRKCB, PRKCE, PRKCD 3.1148
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PRKCB, PRKCA, ESR1 2.997
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, CSNK2A1, PRKCB, PRKCA 2.721
Long-term depression_Homo sapiens_hsa04730 PRKCG, PRKCB, PRKCA 2.721
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PRKCB, PRKCA 2.721
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PRKCB, PRKCA 2.7129
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, PRKCA 2.63
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 3.2817
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, PRKCA, ESR1 2.3274
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PRKCB, PRKCA 2.3415
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA 2.3527
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, PRKCB, PRKCA 2.6373
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PRKCB, BCL2, PRKCA 2.3274
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.6445
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, PRKCA 2.3415
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, CNR1, PRKCA 2.2959
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, PRKCD, PRKCA 2.3392
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.5682
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 2.3392
Gap junction_Homo sapiens_hsa04540 PRKCG, PRKCB, PRKCA 2.3415
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, PRKCA 2.3392
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA 2.3218
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, CDK6, PRKCB, BCL2, PRKCA 2.1409
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2 2.3274
Estrogen signaling pathway_Homo sapiens_hsa04915 PRKCD, ESR1, ESR2 2.2959
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PRKCB, PRKCA 2.2959
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, PRKCB, PRKCA 2.2873
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PRKCB, PRKCA 2.2917
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, PRKCB, PRKCA, CDC25B 2.0867
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA 2.1686
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, PRKCA 2.1754
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PRKCB, PRKCA 1.8359
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PRKCB, PRKCA 2.1409
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PRKCB, PRKCA 2.0115
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, PRKCA 2.0599
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, PRKCB, PRKCA 1.6944
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PRKCB, PRKCA 1.4643
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CNR2, CNR1, F2 1.2517
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2, PRKCA 1.0661
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 1.0717
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 1.0318
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 1.1318
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PRKCD, BCL2 1.2139
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.8867
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.1935
Influenza A_Homo sapiens_hsa05164 PRKCB, PRKCA 0.9792
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 F2 0.374
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.3848
Chemokine signaling pathway_Homo sapiens_hsa04062 PRKCB, PRKCD 0.9389
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.4369
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4262
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.416
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.4257
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PRKCE 0.4375
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4897
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4897
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4881
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PRKCA 0.4866
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.5807
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.5453
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.4643
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B 0.6119
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6202
Prostate cancer_Homo sapiens_hsa05215 BCL2 0.6415
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.5223
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.5701
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6415
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.6098
Peroxisome_Homo sapiens_hsa04146 XDH 0.6611
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.7077
B cell receptor signaling pathway_Homo sapiens_hsa04662 PRKCB 0.7077
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.7106
Melanoma_Homo sapiens_hsa05218 CDK6 0.7077
Leishmaniasis_Homo sapiens_hsa05140 PRKCB 0.7077
Bile secretion_Homo sapiens_hsa04976 CA2 0.7077
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.716
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.7106
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4 0.7106
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.7275
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.7368
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4 0.7696
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1 0.7368
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.7726
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7989
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7989
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PRKCB 0.8277
Type II diabetes mellitus_Homo sapiens_hsa04930 PRKCE, PRKCD 1.8877
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.8147
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.819
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.8233
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.2111
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9682
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9863
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.3392
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 2.1228
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.1708
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.9863
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 2.1056
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 1.0176
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0067
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.1473
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.2381
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.4454
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.5701


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)