TCM Prescription: Jiang Zhi Ling Capsules



Prescription Description
Prescription IDTCMF4568
Pinyin NameJiang Zhi Ling Jiao Nang
Chinese Name降脂灵胶囊
English NameJiang Zhi Ling Capsules
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1630 Camellia sinensis var. assamica 普洱茶 TCMH1630 ITSAG2924-14
TCMH327 Eleutherococcus senticosus 刺五加 TCMH327 KR080437
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1240 Raphanus sativus 莱菔子 TCMH1240 ITSAD4259-14
TCMH825 Nelumbo nucifera 荷叶 TCMH825 ITSAI3109-14
TCMH677 Pueraria lobata 葛根 TCMH677 ITSAJ4206-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH263 Fructus leonuri 茺蔚子 TCMH263
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH1768 Panax notoginseng 三七 TCMH1768 ITSAO2360-14
TCMH938 Sophora japonica 槐花 TCMH938 ITSAN2377-14
TCMH1791 Loranthus parasiticus 桑寄生 TCMH1791
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT953 PNMT Phenylethanolamine N-methyltransferase Transferase P11086
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1310 Enterococcus hirae
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3178
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3178
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 12.9911
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 11.9704
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, FABP3, FABP4, FLT3, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 11.9704
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 11.9704
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PPARD, PTGS2, RORC, SRC, TYR 11.5802
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, MMP2, PIK3CA, PPARA, PPARD, PTGS2, RORC, SRC, TYR 11.0359
[BP] GO:0097756 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 10.2385
[BP] GO:0007187 None ADORA1, CHRM2, CNR1, CNR2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 9.09605
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HMGCR, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR, XDH 9.01074
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 9.01011
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, TOP2A, TYR 8.95657
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 8.91397
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PHF8, PPARD, PTGS1, PTGS2, TYR, XDH 8.84224
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, RORC, SRC, TYR 8.80632
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRB, FABP4, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, TYR 8.80632
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.78402
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.74903
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD2, FABP3, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 8.7297
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C, PPARD 8.63314
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, TYR 8.35061
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.17604
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, FABP3, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS1, PTGS2, SRC, XDH 8.15361
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 7.85158
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 7.76756
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARD 7.71349
[BP] GO:0003018 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 7.56672
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B 7.55164
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 7.52847
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, ALPI, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP3, FABP4, FUT7, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2 7.51747
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.47806
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TOP2A, XDH 7.46374
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TOP2A, XDH 7.46315
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 7.45467
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARD, PTGS2 7.40952
[BP] GO:0097746 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.31056
[BP] GO:0035296 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.31056
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD2, HMGCR, HTR1B, HTR1D, KDR, SRC 7.2599
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.25658
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, ALPI, CSNK2A1, CYP19A1, CYP1A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PPARD, PTGS1, PTGS2 7.25221
[BP] GO:0050880 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.069
[BP] GO:0035150 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 7.04329
[BP] GO:0050795 None ADORA1, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 7.01659
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, PPARA, PTGS2, SRC 7.01659
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.99996
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, FLT3, GLO1, HMGCR, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TOP2A, XDH 6.90525
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.78371
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, ESRRA, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.78371
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 6.75922
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 6.75773
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 6.73308
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, FLT3, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.652
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, PTGS2, SRC 6.53282
[BP] GO:0003013 None ADORA1, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2, SRC 6.47401
[BP] GO:0007188 None ADORA1, CHRM2, CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 6.45254
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.26368
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.22478
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC 6.1773
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.09899
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC 6.03637
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.98368
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, MMP2, PPARA, PTGS2, SRC 5.95289
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, XDH 5.95064
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, RORC, SRC 5.94387
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 5.91898
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.81433
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.7078
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD2, HTR1B, HTR2A, PTGS2 5.63445
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.56639
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2 5.5624
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC 5.53289
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPI, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, FLT3, HMGCR, HTR2B, HTR2C, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PPARD, PTGS2, PTPN1, SRC, TNKS, XDH 5.53289
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.50176
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM2, CNR1, CNR2, DRD2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.48065
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, HMGCR, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PPARD, PTGS2, PTPN1, SRC 5.42963
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PHF8, PIK3CA, PPARA, PPARD, SRC, TYR 5.39513
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 5.38301
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 5.25432
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.23425
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, PIK3CA, PPARD, PTGS2, RORC, SRC 5.23335
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.23335
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 5.23335
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.21051
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, FABP4, FLT3, HMGCR, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.16481
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 5.16392
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.15064
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.15064
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, RORC, SRC 5.11678
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FABP3, FABP4, FLT3, HMGCR, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 5.09402
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PPARD, PTGS1, PTGS2 5.01755
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, PPARA, PTGS2, SRC 5.00761
[BP] GO:0099536 None CHRM2, CNR1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.98334
[BP] GO:0099537 None CHRM2, CNR1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.98334
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, PPARD, RORC, SRC 4.98111
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 4.96996
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.85156
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.84701
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TYR 4.67791
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 4.59062
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, HTR1B, HTR2A, MMP9, PTGS2 4.58966
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, HMGCR, HTR1A, PPARD, TYR 4.51722
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD2, HTR1B, HTR2A, PTGS2 4.51722
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.50942
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD2, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 4.50822
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, HMGCR, HSD11B2, HTR1B, HTR2A, HTR2B, MMP2, PPARA, PPARD, PTGS2, SRC, TYR 4.50822
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 4.49189
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARD 4.49074
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.45051
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.45045
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESRRB, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.44486
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTPN1, SRC, XDH 4.42505
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.3596
[BP] GO:0051967 None ADORA1, DRD2, HTR1B, HTR2A 4.3596
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.32105
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.28944
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, HTR7, PPARA, RORC, SRC, TOP2A 4.2772
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 4.27492
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 4.26774
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.25234
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PPARD, PTGS2, SRC 4.19389
[BP] GO:0007268 None CHRM2, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.18559
[BP] GO:0098916 None CHRM2, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.18559
[BP] GO:0090066 None ADORA1, ALOX15, HMGCR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PPARD, PTGS2 4.17806
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD2, PIK3CB, PTGS2, TNKS, TNKS2 4.14691
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.14083
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, MMP9, PIK3CB, PPARA, PPARD, PTGS2, PTPN1, SRC 4.11859
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC, SRC 4.11173
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, HMGCR, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.10692
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B, HTR2A, PTGS2 4.08591
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD2, HTR1B, HTR2A, PTGS2 4.08591
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, SRC 4.08533
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.02409
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.02409
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM2, CNR1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 4.02018
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD2, ESR1, ESR2, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PPARD, PTGS2, PTPN1, SRC, XDH 3.96703
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PTGS2 3.95774
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PPARD, PTGS1, PTGS2 3.94857
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA, PPARD 3.91103
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, HTR1D, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC 3.88977
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.86395
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD, SRC 3.86075
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.85881
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.8423
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD2, HMGCR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA, PPARD, PTGS2, SRC, TYR 3.83925
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, HTR1B, MMP2, MMP9, PPARD, PTGS2 3.8221
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, PHF8, PPARA, PPARD, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A 3.78262
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.76013
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, DRD2, HMGCR, HTR1A, HTR2A, HTR2C, PPARD 3.66192
[BP] GO:0006939 None DRD2, HTR1D, HTR2A, HTR2B, HTR7 3.66192
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.65077
[BP] GO:0007200 None CHRM2, DRD2, ESR1, HTR2A, HTR2B, HTR2C 3.64785
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC 3.64225
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, SRC 3.63577
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, PIK3CB, PTPN1, SRC, XDH 3.6309
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HMGCR, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.60712
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD2, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.60103
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PPARD, PTGS2, SRC, TYR 3.5956
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 3.58041
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.57654
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARD, PTGS2, PTPN1, RORC, SRC, TOP2A 3.56301
[BP] GO:0007267 None ADORA1, CHRM2, CNR1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.56301
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.55566
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DRD2, HMGCR, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 3.55188
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PPARD, SRC 3.54529
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.51735
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CNR1, CSNK2A1, DRD2, ESR1, ESR2, ESRRA, FABP4, HMGCR, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.50687
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DRD2, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.50687
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49156
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, HTR1B, KDR, PTGS2, SRC 3.46212
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, DRD2, FABP3, PPARA, PPARD 3.44879
[BP] GO:0008217 None ADORA1, CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2 3.44361
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PPARD, PTGS2, RORC, SRC 3.42861
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, MET, MMP12, PHF8, PPARA, PPARD, PTGS2, RORC, SRC, TNKS, TNKS2, TOP2A 3.38649
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIK3CB, PIM1, PPARD, SRC, TYR 3.38643
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.35068
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 3.34391
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.33075
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC 3.32007
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PPARD, PTGS2, SRC 3.31674
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, IGF1R, KDR, MET, MMP9, PPARD, PTGS2, SRC 3.27474
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 3.26621
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPI, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DRD2, ESR1, FLT3, FUT7, GLO1, HMGCR, HTR1A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIM1, PPARA, PPARD, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.26621
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, HMGCR, KDR, MET, MMP12, PPARA, PPARD, PTGS2 3.26127
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.25323
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.25205
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC 3.24348
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.23148
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 3.22638
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, HTR2A, PTGS2 3.21051
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD2, ESR1, ESR2, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.20356
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.20356
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.20356
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD2, ESR1, ESR2, HMGCR, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, XDH 3.19297
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PPARD, SRC 3.17308
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.15303
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.15303
[BP] GO:0023052 None ADORA1, CHRM2, CNR1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.14071
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, DRD2, MMP12, PPARA, PPARD 3.11686
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 3.11686
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, FABP3, FABP4, MET, PIK3CA, PIK3CB 3.11686
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.11686
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD2, HSD11B2, HTR1A, HTR2C, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PPARD, PTGS1, PTGS2, PTPN1, SRC, TOP2A 3.11249
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, HMGCR, HSD11B2, PPARD, PTGS2, SRC, TYR 3.11249
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, PTGS2 3.11224
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.11164
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.09399
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS 3.08914
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.08391
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CNR1, CNR2, CYP19A1, DRD2, ESR1, FABP4, HMGCR, IGF1R, MET, MMP12, MMP2, PPARA, PPARD, PTGS2, PTPN1, SRC, XDH 3.04131
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 3.0163
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD2, HTR2A, MET, PIK3CA 3.0163
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 3.00142
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.00142
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.98409
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.98306
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.93594
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRM2, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARD, PTGS2, SRC, TNKS2, XDH 2.93106
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PPARD, PTGS2, SRC, TOP2A 2.92731
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CB, PTPN1, SRC 2.9176
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, HMGCR, PPARD 2.89051
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.89051
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.88654
[BP] GO:0007208 None HTR2A, HTR2C 2.85558
[BP] GO:0009115 None AOX1, XDH 2.85558
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARD 2.85558
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.84606
[BP] GO:0051952 None ADORA1, CNR1, DRD2, HTR1B, HTR2A 2.84589
[BP] GO:0007610 None BCL2, CNR1, DRD2, HMGCR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, PPARA, PTGS2 2.83825
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, HMGCR, PPARD, PTGS2, TYR 2.83442
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.83279
[BP] GO:0007566 embryo implantation MMP2, MMP9, PPARD, PTGS2 2.80778
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, PPARD 2.80778
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, DRD2, ESR1, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.80654
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80531
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, HTR1A, TYR 2.80277
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.80163
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.78057
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, HMGCR, HSD11B2, HTR2A, MMP12, PPARD, PTGS2, SRC, TYR 2.78057
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, PIK3CB, PPARD, SRC, XDH 2.77278
[BP] GO:0002791 None ACHE, ADORA1, CNR1, DRD2, HMGCR, HTR2B, HTR2C, MMP12, PPARD, SRC 2.76966
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, HMGCR, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, PPARD, PTGS2, XDH 2.76497
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD2, ESR1, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 2.76497
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.74225
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71782
[BP] GO:2000146 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARD 2.71507
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, PPARD, PTGS2, TYR 2.71445
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 2.70221
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 2.69511
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.66765
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.66718
[BP] GO:0045776 None ADORA1, CNR1, DRD2, PPARA 2.66171
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD2, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HMGCR, HTR2B, KDR, MET, MMP2, MMP9, PPARD, PTGS2, RORC, SRC, TOP2A 2.66135
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.63968
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, MET, PIK3CA, PIK3CB, SRC, XDH 2.62478
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.618
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, PTGS2, SRC 2.57158
[BP] GO:0051271 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARD 2.56301
[BP] GO:2001023 None CNR1, DRD2, HTR1B, HTR2A, MET 2.56207
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56207
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56207
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.56207
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.56207
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.56207
[BP] GO:0090087 None ACHE, ADORA1, CA2, CNR1, DRD2, HMGCR, HTR2B, HTR2C, MMP12, PPARD, PTGS2, PTPN1, SRC 2.5616
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.55258
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, ESR1, FABP4, PPARA, PPARD, PTGS2 2.54968
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.5142
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 2.49464
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.49285
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.49108
[BP] GO:0090407 organophosphate biosynthetic process ACHE, ALOX15, ALPI, CSNK2A1, HTR2B, HTR2C, PIK3CA, PIK3CB, PPARD, PTGS2 2.4909
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PPARD, PTGS2, SRC 2.48868
[BP] GO:0046110 None AOX1, XDH 2.46035
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46035
[BP] GO:0033602 None CNR1, DRD2 2.46035
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.45561
[BP] GO:0040013 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, PPARD 2.45415
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, DRD2, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.44191
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.4376
[BP] GO:0014821 None DRD2, HTR1D, HTR2B 2.42973
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PPARD, PTGS1, PTGS2, TYR 2.42879
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PPARD, PTGS2, SRC 2.42357
[BP] GO:0002683 negative regulation of immune system process ADORA1, ALOX15, AXL, CDK6, CNR1, CNR2, CYP19A1, DRD2, MMP12 2.42317
[BP] GO:0030154 cell differentiation ALPL, AXL, BCL2, CBR1, CDK6, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HMGCR, HTR2B, KDR, MMP2, MMP9, PPARD, PTGS2, RORC, TOP2A 2.42317
[BP] GO:0042752 None ADORA1, DRD2, PPARA, RORC, TOP2A 2.40225
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, MET, PIK3CA, PIK3CB, PPARD 2.40225
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DRD2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB, PTPN1, SRC 2.39847
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PTPN1, SRC 2.37213
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.36925
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.36871
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DRD2, ESR1, ESRRA, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SRC 2.36145
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.3216
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.30892
[BP] GO:0046890 None FABP3, HMGCR, HTR2A, HTR2B, HTR2C, PTGS2 2.30223
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.26181
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.24227
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.24227
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.23823
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, PPARD 2.23823
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, ALPI, CSNK2A1, DRD2, MET, PIK3CA, PIK3CB 2.23823
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTGS1, PTGS2 2.21673
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PHF8, PPARA, PPARD, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A 2.21673
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.21031
[BP] GO:0070213 None TNKS, TNKS2 2.20388
[BP] GO:0006145 None AOX1, XDH 2.20388
[BP] GO:0038171 None CNR1, CNR2 2.20388
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20388
[BP] GO:0014827 None HTR1D, HTR2B 2.20388
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.19739
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.19739
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, ESR1, ESR2, FABP4, FLT3, HMGCR, HTR2A, HTR2B, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 2.1896
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HTR2B, MMP12, PPARD, SRC 2.18923
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.18504
[BP] GO:2001251 None PHF8, SRC, TNKS, TNKS2, TOP2A 2.18177
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PIK3CA, PIK3CB, PTPN1, SRC 2.17669
[BP] GO:0045600 positive regulation of fat cell differentiation HTR2A, HTR2C, PPARD, PTGS2 2.17102
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.17102
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, PHF8 2.17102
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.1519
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.1519
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1519
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1519
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HTR2A, HTR2B, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1 2.1519
[BP] GO:0008654 phospholipid biosynthetic process ACHE, ALOX15, ALPI, CSNK2A1, PIK3CA, PIK3CB, PPARD 2.15115
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.15115
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, DRD2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.15115
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, HMGCR, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, MMP12, MMP9, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, XDH 2.14724
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.1466
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.14593
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, HTR1A 2.14241
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.14013
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.13256
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARD 2.13256
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MET, PIK3CA, PPARA 2.13256
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, PIK3CB, PTPN1, SRC 2.12451
[BP] GO:0003012 None ADORA1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.12451
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.11827
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.11537
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.11537
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.10153
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.07834
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.06685
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.06443
[BP] GO:0060402 None DRD2, HTR2A, HTR2B, HTR2C 2.06443
[BP] GO:0045598 None HTR2A, HTR2C, PPARD, PTGS2, RORC 2.06035
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.06035
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, PTGS2 2.04451
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.0424
[BP] GO:0043696 None CDK6, ESRRB 2.03504
[BP] GO:0043697 None CDK6, ESRRB 2.03504
[BP] GO:0071502 None HTR1B, HTR2B 2.03504
[BP] GO:0042321 None ADORA1, DRD2 2.03504
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02686
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.02068
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.006
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, PPARD, SRC 2.00477
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, PIK3CA, TNKS2 2.00477
[BP] GO:0015908 None DRD2, FABP3, PPARA, PPARD 2.00477
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD2, HMGCR, PPARA, PPARD 2.00477
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, HMGCR, HTR2A, HTR2C, KDR, PIK3CA, PIM1, PPARA, PPARD, PTGS2, RORC, SRC, TNKS2, XDH 2.00183
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM2, CNR1, CNR2, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.19611
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 4.90092
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TYR 4.49189
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPI, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD2, ESR1, FLT3, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SRC 4.19515
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTGS2, SRC 3.46166
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPI, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, FLT3, FUT7, HMGCR, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TYR 3.20356
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, ALPI, AOX1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTPN1, RORC, TNKS, TYR, XDH 16.3878
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3178
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.3178
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2657
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.2657
[MF] GO:0099528 None CHRM2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.9449
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 15.9449
[MF] GO:0008227 None CHRM2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.5351
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 12.4579
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 12.0632
[MF] GO:0030594 None CHRM2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.8619
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.8388
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.7603
[MF] GO:0008270 zinc ion binding ALPI, CA1, CA12, CA2, CA4, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PPARA, PPARD, PTPN1, RORC, TNKS 10.5313
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARD, RORC 9.77716
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 9.59672
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, FUT7, GLO1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 9.02408
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, CNR1, CNR2, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARD, RORC 9.01011
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARD, RORC 8.66658
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.81125
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, PPARD, RORC 7.71349
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.46476
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, SRC, TOP2A 7.02895
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.97969
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.38504
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 6.38504
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPI, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PHF8, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TOP2A, TYR, XDH 5.86889
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARD, RORC 5.86039
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1 5.83242
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.67951
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, CNR1, CNR2, DRD2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET 5.67951
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, XDH 5.25222
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.10947
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.85156
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HMGCR, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.66009
[MF] GO:0004930 None ADORA1, ADORA3, CHRM2, CNR1, CNR2, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.6405
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PHF8, PTGS1, PTGS2, TYR 4.32105
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.8221
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.62554
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.55566
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 3.38077
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.36411
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.30748
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PPARD, RORC 3.25597
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.20356
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.20356
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.20356
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HMGCR, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, MET, MMP12, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PPARD, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP2A, XDH 3.19806
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.00142
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.85558
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.85558
[MF] GO:0003845 None HSD11B1, HSD11B2 2.85558
[MF] GO:0071886 None HTR2A, HTR2C 2.85558
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.85558
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.78057
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.64862
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.58899
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.56207
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PHF8, PTGS1, PTGS2 2.55036
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.46035
[MF] GO:0004949 None CNR1, CNR2 2.46035
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.45561
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC 2.20388
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20388
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC 2.15115
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.15115
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MET, MMP9, NQO2, PTGS2, TOP2A, TYR, XDH 2.07909
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.03504
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.02686
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARD, SRC, TOP2A, XDH 2.02292


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 16.0519
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD2 13.1119
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.9531
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.1119
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, PIK3CA, HTR1E, HTR1D, ADORA1, HTR1A, HTR1B, PIK3CB, DRD2, PPARA, HTR4 8.9531
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.5756
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R, PPARD 5.7106
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, ALPI, XDH 5.6876
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.5891
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 5.6876
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.5891
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.9682
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KDR, PIK3CB, DRD2, MET, IGF1R 4.5177
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.4588
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.4399
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.8517
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB, PPARD 4.4399
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.324
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.3125
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.0649
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0553
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 3.8778
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.7655
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA, PPARD 4.1049
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.0348
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.0452
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, PIK3CA, KDR, BCL2, PIK3CB, MET, IGF1R 3.3751
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB 3.4921
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7838
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, BCL2, PIK3CB 3.3244
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2C, HTR2A, DRD2 3.7655
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.1777
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.8306
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.158
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.7129
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8374
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.8642
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.8069
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.1309
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.7129
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5753
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8877
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.504
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4166
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.4219
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.3331
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.3331
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3028
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3331
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, HMGCR, IGF1R 2.2851
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.1667
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.1242
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 1.9792
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 1.901
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8099
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.6774
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.6613
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.6038
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.8661
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.0525
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.1706
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.3786
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.305
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8049
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.5578
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2022
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4183
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.1625
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8099
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.461
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1831
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.461
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4212
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3656
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.3578
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.1625
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2662
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2752
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2845
Alcoholism_Homo sapiens_hsa05034 DRD2 0.273
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1667
Parkinson's disease_Homo sapiens_hsa05012 DRD2 0.3356
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.8517
Axon guidance_Homo sapiens_hsa04360 MET 0.3661
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.1602
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.4815
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2 0.3639
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3739
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6676
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.6755
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8102
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8324
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8239
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PPARD 0.8027
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.7975
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8661
Melanogenesis_Homo sapiens_hsa04916 TYR 0.439
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4384
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.6824
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4511
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4504
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 0.9987
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9747
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9987
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 0.9851
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4634
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4645
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.0446
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9851
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0089
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.057
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4665
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4665
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 0.9987
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4655
Peroxisome_Homo sapiens_hsa04146 XDH 0.4815
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5194
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5174
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5318
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.534
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2201
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2581
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5533
Shigellosis_Homo sapiens_hsa05131 SRC 0.5533
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5533
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2376
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.574
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR 1.2376
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2581
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2512
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3491
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4253
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3578
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6336
Malaria_Homo sapiens_hsa05144 MET 0.6459
Cocaine addiction_Homo sapiens_hsa05030 DRD2 0.6459
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6519
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.647
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.475
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.657
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5226
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.702
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7975
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8099
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7757
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6979
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8196
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6801
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7675
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8102
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8356
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8027
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.828
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9914
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8928
Folate biosynthesis_Homo sapiens_hsa00790 ALPL, ALPI 2.3331
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1309
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3578


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)