TCM Prescription: Jiang Ya Dai Pao Tea



Prescription Description
Prescription IDTCMF4517
Pinyin NameJiang Ya Dai Pao Cha
Chinese Name降压袋泡茶
English NameJiang Ya Dai Pao Tea
Function Description头痛, 眩晕, 牙痛
IndicationsVertigo disorder, Hypertension
Disease ICD-11 Category SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
BA2Z [Hypotension, unspecified, 低血压，未特指的 ];
Human Tissues Associated with IndicationBrain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2244 Prunella vulgaris 夏枯草 TCMH2244 ITSAH2424-14
TCMH1199 Cassia tora 决明子 TCMH1199 GENG109-13
TCMH263 Fructus leonuri 茺蔚子 TCMH263
TCMH695 Uncaria rhynchophylla 钩藤 TCMH695 ITSAM939-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH226 Camellia sinensis 茶叶 TCMH226 ITSAG2924-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.2004
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4042
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.87971
[BP] GO:0023056 positive regulation of signaling ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, FLT3, HCAR2, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 8.87971
[BP] GO:0042221 response to chemical ABCB1, ADORA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EPHX2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TERT 8.12929
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 7.86048
[BP] GO:0044281 small molecule metabolic process ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PIM1, PPARA, XDH 7.73671
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.73671
[BP] GO:0015711 organic anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.42061
[BP] GO:0010033 response to organic substance ADORA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP2, PPARA, RORC, SRC 7.24758
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.06981
[BP] GO:0044237 cellular metabolic process ACHE, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 7.00072
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, FABP3, IGF1R, MMP2, MMP9, PPARA, RORC, SRC 6.94259
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ADORA2A, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 6.71002
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 6.69802
[BP] GO:0009636 response to toxic substance ADORA2A, AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, KDR, SRC 6.67725
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, EPHX2, FABP3, FABP4, FLT3, HCAR2, HSD17B1, KDR, MET, PPARA, SRC, TERT, TNKS, TNKS2, XDH 6.67017
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, FABP3, FABP4, HSD17B1, MET, PPARA 6.64726
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.59986
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 6.47686
[BP] GO:0006793 phosphorus metabolic process ACHE, ADORA2A, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, PIM1, PTPN1, PTPRS, SRC, TNKS, XDH 6.42157
[BP] GO:0006820 anion transport ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 6.19733
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA2A, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, DRD2, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, TERT, XDH 6.02256
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, DRD1, DRD2, HCAR2, KDR, SRC, TNKS, TNKS2 5.91541
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FLT3, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 5.84433
[BP] GO:0014070 response to organic cyclic compound ADORA2A, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, RORC, SRC 5.59307
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, RORC, SRC, TERT 5.21147
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1 5.17995
[BP] GO:2000021 regulation of ion homeostasis ADORA1, ADORA2A, BCL2, CA2, CA7, DRD1, DRD2, KDR, SRC 5.07559
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 5.06036
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 5.01388
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 4.98223
[BP] GO:0060548 negative regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 4.96683
[BP] GO:0032846 positive regulation of homeostatic process ADORA2A, AURKB, CA2, CA7, DRD1, DRD2, HCAR2, TNKS, TNKS2 4.81611
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 4.80545
[BP] GO:0032502 developmental process ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPRS, RORC, SRC, TERT, TNKS2 4.80545
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 4.80545
[BP] GO:0042493 response to drug ABCB1, ADORA2A, AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, SRC 4.73072
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EPHX2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TERT 4.73072
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 4.70633
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADORA2A, CA2, CA7, DRD2 4.70633
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, TERT 4.70049
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, FABP4, FLT3, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.67228
[BP] GO:0010941 regulation of cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, XDH 4.66926
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA2A, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC, TERT 4.6006
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC, TERT 4.52651
[BP] GO:0043067 regulation of programmed cell death ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT, XDH 4.47388
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADORA2A, APP, CA2, CA7, DRD1, DRD2 4.45596
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADORA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.43976
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SRC 4.4194
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.39153
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.36818
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.29227
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, PIM1, SRC 4.26956
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 4.26956
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADORA2A, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.26403
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC, TERT 4.26403
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, HCAR2, MMP12, SRC, TERT 4.24941
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EPHX2, FABP3, FABP4, MET, PPARA 4.24941
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 4.15724
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FABP4, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.10127
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 4.09706
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ADORA2A, APP, CYP19A1, DRD2, DYRK1A, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 4.09706
[BP] GO:0032501 multicellular organismal process ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, FABP4, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TNKS2 4.07252
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA 4.0491
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADORA2A, ALOX15, BCL2, CYP19A1, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, PTPRS, SRC, TERT, XDH 4.01406
[BP] GO:0044092 negative regulation of molecular function ADORA2A, ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DRD2, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 4.01406
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, DRD1, DRD2 4.01406
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADORA2A, APP, BACE1, CA2, CA7, DRD1, DRD2 4.01406
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADORA2A, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP3, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.01406
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC, TERT 3.98009
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.97917
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ADORA2A, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, HCAR2, MMP12, MMP9, PPARA, PTPN1, SRC, TERT 3.9718
[BP] GO:0042981 regulation of apoptotic process ADORA1, ADORA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT, XDH 3.9718
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, IGF1R, KDR, MET, MMP9, SRC, TERT 3.93246
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.91184
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.89768
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, FABP3, FABP4, FLT3, MET, SRC, TERT 3.89588
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2 3.88564
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.80579
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1 3.67127
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 3.65436
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, KDR, MMP9, PTPN1, SRC, XDH 3.65436
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT, TNKS 3.63264
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADORA2A, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, KDR, MMP9, PIM1, PPARA, PTPRS, RORC, SRC 3.63264
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, DRD2, FLT3, KDR, MET, PTPN1, SRC, XDH 3.55213
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.55213
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.55034
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.53892
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.50805
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.49743
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.48219
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, EPHX2, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.4777
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 3.47545
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.47545
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, RORC, SRC 3.45317
[BP] GO:0009966 regulation of signal transduction ADORA1, ADORA2A, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DYRK1A, FLT3, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, XDH 3.44601
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.44063
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.41056
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, DRD2, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 3.40718
[BP] GO:0001973 None ADORA1, ADORA2A, ADORA3 3.37515
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 3.34197
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DYRK1A, PPARA, RORC, SRC 3.33871
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADORA2A, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, FABP4, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 3.32382
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC, TERT 3.26733
[BP] GO:0010243 response to organonitrogen compound ADORA2A, AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 3.26257
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.26257
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.25719
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2, MMP2, MMP9, PPARA, PTPN1, SRC, TERT 3.25594
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.25542
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.25542
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADORA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HCAR2, HSD17B1 3.25239
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DRD1, DRD2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.22432
[BP] GO:0031399 regulation of protein modification process ADORA1, ADORA2A, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD1, DRD2, DYRK1A, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.16133
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EPHX2 3.1244
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 3.09527
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, ADORA2A, CA2, CA7 3.06323
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TNKS, TNKS2 3.06323
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 3.00331
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DRD2, DYRK1A, IGF1R, MET, MMP12, MMP9, PTPN1, PTPRS, SRC, TERT, XDH 2.99005
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HCAR2, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 2.97883
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.97883
[BP] GO:1901698 response to nitrogen compound ADORA2A, AKR1B1, APP, DNMT1, DRD1, DRD2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.97751
[BP] GO:0006811 None ABCB1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 2.94143
[BP] GO:0060134 None ADORA2A, DRD1, DRD2 2.93081
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADORA2A, CA2, CA7 2.93081
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.91437
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, MMP2, PPARA, SRC, TERT 2.83369
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CA3, CYP1B1, MMP9, SRC 2.82266
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.79948
[BP] GO:0003014 None ADORA1, ADORA2A, AKR1B1, BCL2, DRD2 2.77002
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.76867
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, FLT3, RORC, SRC 2.76425
[BP] GO:0001963 None ADORA2A, DRD1, DRD2 2.75948
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.75948
[BP] GO:0051179 None ABCB1, ACHE, ADORA1, ADORA2A, ALOX15, ALOX5, APP, AURKB, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, MMP9, PPARA, SRC, TERT, TNKS, TNKS2, XDH 2.75706
[BP] GO:0042752 None ADORA1, ADORA2A, DRD2, PPARA, RORC 2.74566
[BP] GO:0002793 None ACHE, ADORA1, ADORA2A, DRD2, HCAR2, MMP12, SRC 2.73569
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.73569
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.73569
[BP] GO:0031348 negative regulation of defense response ADORA1, ADORA2A, CYP19A1, DRD2, MMP12, PPARA 2.70758
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD2, DYRK1A, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.69248
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, PPARA 2.68811
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.68218
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.67996
[BP] GO:0043269 regulation of ion transport ABCB1, ADORA1, ADORA2A, APP, BCL2, CA2, CA7, DRD1, DRD2, MMP9 2.67996
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, DNMT1, DRD1, IGF1R, MMP2, MMP9, RORC, SRC 2.64229
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, KDR, MET, MMP9, SRC, TNKS, TNKS2 2.64229
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, IGF1R, KDR, MET, MMP9, SRC, TERT 2.63938
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.63129
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.61106
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2 2.58919
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.58919
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.58919
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.58919
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.58015
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.58009
[BP] GO:0051234 None ABCB1, ACHE, ADORA1, ADORA2A, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, MMP9, PPARA, SRC, TERT, TNKS, XDH 2.57598
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, DYRK1A, SRC, TNKS 2.57477
[BP] GO:0051047 None ACHE, ADORA1, ADORA2A, CYP19A1, DRD2, HCAR2, MMP12, SRC 2.57382
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1 2.56619
[BP] GO:0071702 None ABCB1, ADORA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, PPARA, TNKS 2.55437
[BP] GO:0048869 cellular developmental process ACHE, ADORA2A, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, DRD1, DRD2, FABP4, FLT3, KDR, MET, MMP2, MMP9, PTPRS, RORC, SRC, TERT 2.55063
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ADORA2A, CYP19A1, DRD1, DRD2, PPARA, PTPRS 2.55063
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ADORA2A, CYP19A1, DRD1, DRD2, FABP4, KDR, MET, MMP12, PPARA, PTPRS 2.52884
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, KDR, PTPN1, SRC, XDH 2.5224
[BP] GO:0045187 None ADORA1, ADORA2A, DRD2 2.52205
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.52205
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, ADORA2A, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.52205
[BP] GO:0031324 negative regulation of cellular metabolic process ADORA2A, APP, AURKB, BCL2, CSNK2A1, DNMT1, DRD2, DYRK1A, FABP4, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.52205
[BP] GO:0031347 regulation of defense response ADORA1, ADORA2A, CYP19A1, DRD2, FABP4, MMP12, MMP2, PPARA, PTPN1, PTPRS, SRC 2.52205
[BP] GO:0016311 None ALPL, BCL2, CA3, CDC25B, EPHX2, PTPN1, PTPRS 2.51936
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.51936
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX2, RORC 2.51936
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.51704
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51704
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, DRD1, DRD2, EPHX2, FABP3, FABP4, MET 2.51704
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DYRK1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.5134
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.51227
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA2A, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.49105
[BP] GO:0035588 None ADORA1, ADORA2A, ADORA3 2.49102
[BP] GO:0035809 None ADORA2A, AKR1B1, DRD2 2.49102
[BP] GO:0035813 None ADORA1, ADORA2A, DRD2 2.49102
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, MET 2.47475
[BP] GO:0034502 protein localization to chromosome AURKB, TERT, TNKS, TNKS2 2.46494
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, ADORA2A, DRD1, DRD2 2.46494
[BP] GO:0002683 negative regulation of immune system process ADORA1, ADORA2A, ALOX15, AXL, CYP19A1, DRD2, MMP12, PTPRS 2.45059
[BP] GO:0006909 phagocytosis ADORA1, ADORA2A, ALOX15, AXL 2.44203
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.44203
[BP] GO:0042749 None ADORA1, ADORA2A, DRD2 2.43921
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA2A, ADORA3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.42457
[BP] GO:0006810 None ABCB1, ACHE, ADORA1, ADORA2A, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, MMP12, MMP9, PPARA, SRC, TNKS, XDH 2.40596
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 2.39868
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA2A, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FABP4, FLT3, IGF1R, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.38714
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.38635
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD2, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.36257
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.35485
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.35449
[BP] GO:0051881 regulation of mitochondrial membrane potential ADORA2A, BCL2, KDR, SRC 2.35449
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.35449
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.35356
[BP] GO:0040013 None ADORA1, ADORA2A, ADORA3, BCL2, CYP19A1, CYP1B1, DRD2 2.34752
[BP] GO:0044062 None ADORA1, ADORA2A, DRD2 2.34752
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34752
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.33915
[BP] GO:0002682 regulation of immune system process ADORA1, ADORA2A, ALOX15, APP, AXL, BCL2, CA2, CYP19A1, DRD2, HCAR2, MMP12, MMP2, PTPN1, PTPRS, SRC 2.33185
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, IGF1R, SRC, TNKS, TNKS2 2.3286
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADORA2A, APP, AURKB, DNMT1, DRD1, DRD2, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.32847
[BP] GO:0051240 positive regulation of multicellular organismal process ADORA2A, APP, AXL, BCL2, CA2, CYP1B1, DRD2, HCAR2, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 2.31928
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.30509
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30509
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, TNKS2 2.30181
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA2A, ADORA3, APP, BCL2, CYP1B1, DRD2, FABP3, TERT, XDH 2.29937
[BP] GO:0070213 None TNKS, TNKS2 2.29937
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.29937
[BP] GO:0019538 protein metabolic process ACHE, ADORA2A, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, SRC, TNKS, TNKS2 2.29604
[BP] GO:0051338 regulation of transferase activity ADORA1, ADORA2A, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, IGF1R, PTPN1, SRC, TNKS 2.29604
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, KDR, PPARA, PTPRS, SRC 2.28801
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PTPN1, SRC 2.28479
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA2A, ADORA3, APP, AXL, BCL2, CSNK2A1, DRD2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 2.2506
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.24794
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DRD2, FLT3, IGF1R, KDR, PTPN1, SRC, XDH 2.24358
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.22773
[BP] GO:0001975 None ADORA2A, DRD1, DRD2 2.22773
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.18658
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.18254
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.14077
[BP] GO:0050714 None ACHE, ADORA2A, DRD2, HCAR2, MMP12, SRC 2.1393
[BP] GO:0035587 None ADORA1, ADORA2A, ADORA3 2.13923
[BP] GO:0051952 None ADORA1, ADORA2A, DRD1, DRD2 2.12804
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, MMP2, MMP9, TERT 2.12804
[BP] GO:0009891 positive regulation of biosynthetic process ADORA2A, APP, AURKB, DRD1, DRD2, FABP3, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 2.12374
[BP] GO:0021853 None DRD1, DRD2 2.12043
[BP] GO:1904936 None DRD1, DRD2 2.12043
[BP] GO:0042321 None ADORA1, DRD2 2.12043
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.1143
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD2, DYRK1A, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.10937
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, DYRK1A, TNKS 2.09842
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.09842
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2 2.09842
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.07999
[BP] GO:1903532 None ACHE, ADORA2A, CYP19A1, DRD2, HCAR2, MMP12, SRC 2.0522
[BP] GO:0048167 None ADORA1, ADORA2A, APP, DRD1, DRD2 2.0456
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.04239
[BP] GO:0003018 None ADORA1, ADORA2A, DRD1, EPHX2, SRC 2.03632
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.03632
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.03632
[BP] GO:0051172 None ADORA2A, APP, AURKB, CSNK2A1, DNMT1, DRD2, DYRK1A, FABP4, IGF1R, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.01145
[CC] GO:0099055 None ADORA1, ADORA2A, PTPRS 3.37515
[CC] GO:0099699 None ADORA1, ADORA2A, PTPRS 3.37515
[CC] GO:0099240 None ADORA1, ADORA2A, PTPRS 3.37515
[CC] GO:0098936 None ADORA1, ADORA2A, PTPRS 3.37515
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA2A, ADORA3, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, PTPRS, SRC, TERT 2.6912
[CC] GO:0099056 None ADORA1, ADORA2A 2.51704
[CC] GO:0098889 None ADORA1, ADORA2A 2.51704
[CC] GO:0031253 None ADORA1, ADORA2A, CA4, CA9, DRD1, DRD2, SRC 2.31928
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, ADORA2A, AKR1B1, AKR1B10, ALOX15, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 2.25707
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APP, AURKB, AXL, BACE1, BCL2, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 2.20224
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA2A, ADORA3, APP, AXL, BACE1, CA4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PTPRS 2.00989
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 17.6107
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, XDH 13.8376
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, AXL, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, DYRK1A, EPHX2, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, PTPRS, RORC, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 11.9433
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, BACE1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EPHX2, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, PTPRS, SRC, TERT, TNKS, TNKS2, TUBB3, XDH 11.7162
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.4412
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.1343
[MF] GO:0008270 zinc ion binding CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 7.44082
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DRD2, EPHX2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 6.74504
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.67725
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APP, AURKB, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EPHX2, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TERT, TNKS, TNKS2, XDH 5.17472
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.82306
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.82306
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.77772
[MF] GO:0001609 None ADORA1, ADORA2A, ADORA3 3.65385
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58481
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.53975
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, FLT3, IGF1R, KDR, MET, SRC 3.53054
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.13184
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.7901
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, XDH 2.74668
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, DYRK1A, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.49789
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.36915
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.34752
[MF] GO:0035586 None ADORA1, ADORA2A, ADORA3 2.26639
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, XDH 2.25677
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.23347
[MF] GO:0042802 identical protein binding ACHE, ADORA2A, APP, BCL2, CSNK2A1, DRD2, DYRK1A, EPHX2, FLT3, IGF1R, KDR, MET, MMP9, TERT, XDH 2.0946
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03632


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.183
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.2859
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.45
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 4.1418
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1418
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.8371
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.2926
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA2A, ADORA1, DRD1, DRD2, PPARA 3.2926
Rap1 signaling pathway_Homo sapiens_hsa04015 ADORA2A, SRC, KDR, DRD2, MET, IGF1R 3.2908
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, EPHX2, ALOX15 3.2926
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, EPHX2, ALOX15, AKR1B1, CYP19A1, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, ALPL, XDH 3.1765
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.8684
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1727
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1963
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, DRD1, DRD2 2.9465
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6299
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0376
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA2A, ADORA3, ADORA1, DRD1, DRD2 2.0349
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7783
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9027
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7501
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7501
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15 1.6735
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5035
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6202
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4408
Parkinson's disease_Homo sapiens_hsa05012 ADORA2A, DRD1, DRD2 1.4473
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, BCL2, MET, IGF1R 1.2613
Alcoholism_Homo sapiens_hsa05034 ADORA2A, DRD1, DRD2 1.2744
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3475
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3451
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3125
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1124
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2683
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3284
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1124
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4408
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1124
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2744
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2613
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2666
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.073
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0001
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1124
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 1.0066
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1944
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0418
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0131
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2613
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.7501
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1536
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1063
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7457
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9813
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2 0.9197
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.7875
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9813
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.87
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.762
Calcium signaling pathway_Homo sapiens_hsa04020 ADORA2A, DRD1 0.7245
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6507
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.762
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7261
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6373
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9027
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7069
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2662
HTLV-I infection_Homo sapiens_hsa05166 TERT 0.2662
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3155
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3255
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3513
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3741
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3642
Platelet activation_Homo sapiens_hsa04611 SRC 0.4323
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4323
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4467
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4153
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4323
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4153
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4192
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4323
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4153
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4046
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3513
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4014
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4153
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4323
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4192
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4153
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADORA2A 0.4323
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3932
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3984
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4323
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.495
Axon guidance_Homo sapiens_hsa04360 MET 0.4277
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.474
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4808
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4843
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4843
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.495
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4843
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.495
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.495
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.495
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.495
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5476
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5418
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5622
Glioma_Homo sapiens_hsa05214 IGF1R 0.5622
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5622
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5536
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5615
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5622
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5622
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5607
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5542
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5622
Shigellosis_Homo sapiens_hsa05131 SRC 0.5622
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5902
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6149
Malaria_Homo sapiens_hsa05144 MET 0.6251
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6447
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6507
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6476
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7698
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8002
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0945
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0182


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)