TCM Prescription: Ku Dan Pills



Prescription Description
Prescription IDTCMF4512
Pinyin NameKu Dan Wan
Chinese Name苦胆丸
English NameKu Dan Pills
Function Description黄疸
IndicationsJaundice disorder, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH419 NA 胆汁膏 TCMH419
TCMH1307 Massa medicata fermentata 六神曲 TCMH1307
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MAOA, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 17.557
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, TYR 16.044
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.044
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.044
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 15.8296
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 15.8091
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGES, PTGS2, RELA, SRC, TEK, TYR 15.77
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, TYR 15.6946
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 15.4818
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, AR, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 15.2178
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 14.1705
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.963
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 13.9021
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TEK, TYR 13.9021
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 13.7612
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, EGFR, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.7116
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGES, PTGS2, RELA, SRC, TYR 12.9973
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 12.6301
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 12.3575
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 12.099
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, PPARA, PTGS2, RELA, SRC, TEK 11.923
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MAP2K1, PIK3CA, PPARA, RELA, SMAD3, SRC, TEK, TYR 11.5387
[BP] GO:0050896 response to stimulus ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR 11.3848
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, RELA, TEK 11.0461
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, KIT, MMP9, PTGES, PTGS2, RELA, SRC 10.9069
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 10.6806
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 10.4598
[BP] GO:0048583 regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 10.3785
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK, XDH 10.3785
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C 10.2023
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, AR, BCL2, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.83091
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, AR, BCL2, DRD1, DRD2, EGFR, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 9.83091
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 9.71912
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 9.70494
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 9.63845
[BP] GO:0032879 regulation of localization ACHE, ADORA3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SMAD3, SRC, TEK 9.54944
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, RELA, SMAD3, SRC, TEK 9.38025
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, AR, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC, TEK, XDH 9.20889
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HSD17B3, HSPA1A, HTR2B, HTR2C, MIF, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 9.15516
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 8.98107
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MAP2K1, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 8.90391
[BP] GO:0048518 positive regulation of biological process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.87885
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.7419
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 8.66212
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 8.65199
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, AR, DRD2, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC, TEK, XDH 8.5429
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 8.5429
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, RELA, SMAD3, SRC 8.50855
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, AR, BCL2, DRD2, EGFR, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 8.45166
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, SRC, TEK, XDH 8.39275
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 8.3918
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, RELA, SRC 8.38198
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, EGFR, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 8.36245
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 8.26472
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, INSR, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 8.23956
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PTGS2, RELA, SMAD3, SRC 8.21037
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 8.18759
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3 8.07199
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, AR, BCL2, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 8.05904
[BP] GO:0060548 negative regulation of cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 8.02315
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 8.02315
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 7.95674
[BP] GO:0007187 None CNR1, CNR2, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 7.93577
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 7.92927
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, MIF, PIK3CB, PTGS2, SRC 7.91461
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 7.83615
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, HSD17B3, HTR1A, MAOA, TYR 7.81783
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2, HSD17B3 7.78396
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 7.73784
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.73784
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.73319
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR 7.6283
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 7.61924
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MIF, SRC, TEK 7.61924
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESRRB, F3, HSPA1A, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 7.57778
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, AR, BCL2, DRD1, DRD2, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SRC, TEK, XDH 7.55838
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 7.556
[BP] GO:0003018 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.54843
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 7.42675
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, RELA, SRC, TEK, TYR 7.38134
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.36326
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2 7.36326
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK 7.30187
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 7.30187
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 7.29054
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.2311
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, XDH 7.22398
[BP] GO:0065009 regulation of molecular function ADORA3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.17407
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, RELA, SMAD3, SRC 7.1699
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 7.1647
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, MIF, SRC, TEK 7.15263
[BP] GO:0051049 regulation of transport ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, DRD1, DRD2, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MAP2K1, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, SMAD3, SRC 7.12722
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 7.11687
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 7.11529
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, HTR1B, HTR1D, KDR, RELA, SRC 7.11376
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, DRD1, DRD2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 7.09899
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.08049
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 7.07857
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 7.05565
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK 7.02718
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 7.00788
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SMAD3, SRC, TEK, XDH 6.98932
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, DRD1, DRD2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PTGS2, RELA, SRC, TEK, TYR 6.90764
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.9047
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK 6.89581
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR 6.84943
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.84943
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 6.83517
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, SRC, TEK, XDH 6.82062
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 6.76767
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 6.74336
[BP] GO:0080134 regulation of response to stress APP, CNR1, CNR2, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.74336
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, HTR2A, KIT, PTGS2 6.74336
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, HTR2A, KIT, PTGS2 6.74336
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC, TEK 6.6844
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AR, AURKB, BCL2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.65852
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 6.64724
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.63555
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 6.62744
[BP] GO:0010648 negative regulation of cell communication ACHE, AR, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, RELA, SMAD3, SRC, XDH 6.48297
[BP] GO:0032101 regulation of response to external stimulus CNR1, CNR2, CYP19A1, DRD1, DRD2, EGFR, ESR1, F3, FABP4, KDR, MAP2K1, MET, MIF, MMP12, PPARA, PTGS2, RELA, SMAD3, TEK 6.48018
[BP] GO:0023057 negative regulation of signaling ACHE, AR, BCL2, CNR2, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, RELA, SMAD3, SRC, XDH 6.46462
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2 6.46462
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.44554
[BP] GO:0003013 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.44179
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGES, PTGS2, RELA, SMAD3, SRC, TEK, XDH 6.4245
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, HTR2A, HTR2B, HTR2C, KDR, SRC 6.38372
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.32528
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.3001
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, AR, BCL2, DRD2, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK, XDH 6.28935
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, SRC 6.2796
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 6.17357
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC 6.16876
[BP] GO:0097746 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.13924
[BP] GO:0035296 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 6.13924
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, RELA, SRC 6.13508
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 6.13508
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, DRD1, EGFR, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.12103
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.09048
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 6.09048
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, DRD2, HTR1B 6.09048
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CNR1, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC 6.0827
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, MAP3K7, PIM1, PPARA, RELA, SRC 6.01996
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.9974
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.98365
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 5.96131
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, DRD1, DRD2, EGFR, HTR1B, HTR2A, PTGS2 5.93824
[BP] GO:0050880 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.93404
[BP] GO:0044093 positive regulation of molecular function APP, AR, AURKB, BCL2, DRD2, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP9, PIK3CA, PIK3CB, RELA, SMAD3, SRC, TEK, XDH 5.91717
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, PIK3CA, PTGS2, SRC, TEK, TYR 5.91717
[BP] GO:0035150 None DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.91222
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 5.89397
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.89397
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC, TEK 5.88539
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, AR, DRD1, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, KIT, MMP2, PTGS2, RELA, SMAD3, SRC 5.84963
[BP] GO:0007154 None AKR1C3, AR, AXL, BCL2, CACNA1C, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2, TEK 5.84688
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, PTGS2, SRC 5.82621
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 5.81206
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, DRD1, DRD2, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, NUAK1, PIK3CA, PIK3CB, RELA, SRC, TEK 5.79574
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, PIK3CA, RELA, SMAD3, TYR 5.78916
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 5.73776
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, DRD1, DRD2, HTR1B, HTR2A, PTGS2 5.7244
[BP] GO:0050795 None CNR1, DRD2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.7244
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.67917
[BP] GO:0007610 None APP, BCL2, CNR1, DRD1, DRD2, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PTGS2 5.60187
[BP] GO:0065007 biological regulation ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.4494
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 5.43344
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, MMP9, RELA, SRC 5.42591
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC 5.42425
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.38032
[BP] GO:0007188 None CNR1, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.35927
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SMAD3, SRC, TEK 5.3431
[BP] GO:0015701 bicarbonate transport CA12, CA14, CA2, CA4, CA7, CA9 5.29816
[BP] GO:0043549 regulation of kinase activity APP, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC, TEK 5.28143
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.28143
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AR, AXL, CYP1B1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RELA, SRC 5.2793
[BP] GO:0007193 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 5.23853
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, DRD2, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, SMAD3, SRC, TEK 5.23395
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 5.23395
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, SRC, TEK 5.20991
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, SMAD3, SRC, TEK 5.18298
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, HTR1A, MAOA, TYR 5.17117
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, AR, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, SRC 5.1583
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 5.11044
[BP] GO:0006939 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7 5.09761
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, AR, BCL2, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 5.08955
[BP] GO:0031347 regulation of defense response CNR1, CNR2, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 5.03663
[BP] GO:0045859 regulation of protein kinase activity APP, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC 5.02275
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, EGFR, MMP9, RELA, SRC 5.00034
[BP] GO:0043269 regulation of ion transport APP, BCL2, CA2, CA7, CACNA1C, CNR1, DRD1, DRD2, GPR35, HTR1A, HTR1B, HTR2A, MIF, MMP9, PTGS2 4.99162
[BP] GO:0006693 None AKR1C3, MIF, PTGES, PTGS1, PTGS2 4.99162
[BP] GO:0006692 None AKR1C3, MIF, PTGES, PTGS1, PTGS2 4.99162
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 4.99162
[BP] GO:0099536 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.94545
[BP] GO:0099537 None CNR1, DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.94545
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, HSPA1A, MAOA 4.94545
[BP] GO:0019371 None AKR1C3, PTGES, PTGS1, PTGS2 4.92434
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 4.91659
[BP] GO:0051338 regulation of transferase activity APP, AURKB, DRD2, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC, TEK 4.88852
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD1, DRD2, HTR1A, MAOA 4.86021
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.83329
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.81968
[BP] GO:0033674 positive regulation of kinase activity DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC, TEK 4.76775
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES, PTGS1, PTGS2 4.7672
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, DRD1, DRD2, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 4.73207
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, MIF, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.70612
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.68693
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, RELA, SRC 4.65299
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, EGFR, HTR1A, INSR, MAOA, PTGS2, SMAD3 4.64486
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, EGFR, HSPA1A, MMP9, RELA, SRC 4.64486
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.63986
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 4.63986
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.63968
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, DRD2, GPR35, HTR1B, HTR2A, MMP9, PTGS2 4.63937
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.63621
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HSPA1A, KIT, MAP3K7, MIF, MMP12, MMP2, PIK3CA, PIK3CB, RELA, SMAD3, SRC 4.63332
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.63332
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.63332
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.61962
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.60198
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, RELA, SMAD3, SRC, XDH 4.59124
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, DRD2, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SMAD3, SRC, TEK, XDH 4.56255
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.53133
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, SMAD3, SRC 4.5278
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.51156
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.50299
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.50019
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.49447
[BP] GO:0008217 None AR, CNR1, DRD2, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 4.48243
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC 4.42363
[BP] GO:0080090 regulation of primary metabolic process ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.42363
[BP] GO:0051347 positive regulation of transferase activity AURKB, DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC, TEK 4.41386
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.39536
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CA9, CNR1, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.36183
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.36183
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PTGS2, RELA, SRC, TEK 4.35777
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 4.34082
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.34082
[BP] GO:0006730 one-carbon metabolic process CA12, CA2, CA4, CA7, CA9 4.34082
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CB, SRC 4.33916
[BP] GO:0045860 positive regulation of protein kinase activity DRD2, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MIF, PIK3CA, PIK3CB, SRC 4.33277
[BP] GO:0023052 None AR, CACNA1C, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 4.32576
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TYR 4.31356
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.31353
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, RELA, SRC, XDH 4.31012
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, HTR1B, KDR, PTGS2, RELA, SRC 4.30693
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA 4.28901
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.28465
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, EGFR, ESR1, HTR7, KIT, PPARA, SRC 4.28465
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, DRD1, DRD2, EGFR, KIT, PTGS2, RELA, TYR 4.27216
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HSD17B3, MIF, PTGES, PTGS1, PTGS2 4.25279
[BP] GO:0009894 regulation of catabolic process BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, RELA, SMAD3 4.24143
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 4.19555
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.18893
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.18893
[BP] GO:0007268 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.18754
[BP] GO:0098916 None DRD1, DRD2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 4.18754
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.18464
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, EGFR, PIK3CB, PTGS2 4.1719
[BP] GO:0007267 None AR, CNR1, DRD1, DRD2, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, TEK 4.16477
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 4.13945
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PTGS2, RELA, SMAD3, SRC 4.13277
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 4.12147
[BP] GO:0007568 aging AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, MIF, PTGS2, RELA 4.09969
[BP] GO:0014821 None DRD1, DRD2, HTR1D, HTR2B 4.08661
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 4.08624
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD2, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, SRC 4.08624
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.07187
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 4.04784
[BP] GO:0007611 None APP, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, KIT, PTGS2 4.04716
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 4.02862
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, ESR2, HSPA1A, KIT, MAP3K7, PIM1, RELA 3.96447
[BP] GO:0050727 regulation of inflammatory response CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, RELA, SMAD3, TEK 3.96447
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 3.94017
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 3.92645
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2 3.89952
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, RELA, SRC 3.89952
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, DRD2, HSPA1A, HTR2B, MAP3K7, MIF, MMP12, PTGS2, RELA, SMAD3, SRC 3.89952
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, RELA, TYR 3.87084
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, SMAD3 3.84794
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.83752
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, SRC, TEK 3.83529
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.81727
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 3.81264
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TYR 3.80355
[BP] GO:1903530 regulation of secretion by cell ACHE, CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC 3.76947
[BP] GO:0019725 cellular homeostasis APP, BCL2, CA2, CA7, CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, SMAD3 3.74924
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.73224
[BP] GO:0007200 None DRD1, DRD2, ESR1, HTR2A, HTR2B, HTR2C 3.73224
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, EGFR, PTGS2, RELA, TYR 3.73072
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.70074
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, DRD1, HTR1A, HTR2C, KIT, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, SRC 3.68746
[BP] GO:0009895 negative regulation of catabolic process BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, RELA, SMAD3 3.68053
[BP] GO:2001023 None CNR1, DRD1, DRD2, HTR1B, HTR2A, MET 3.68053
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.65457
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DRD2, DUSP3, ESR1, HSPA1A, KIT, MAP3K7, MIF, MMP12, MMP2, PIK3CA, PIK3CB, RELA, SMAD3, SRC 3.6383
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.60302
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, HTR1B, IGF1R, INSR, MMP2, PTGS2, RELA, SRC 3.59077
[BP] GO:0050890 None APP, CNR1, DRD1, DRD2, EGFR, HTR2A, INSR, KIT, PTGS2 3.56886
[BP] GO:0032845 None BCL2, DRD2, HTR2A, HTR2B, HTR2C, MIF, SRC 3.56646
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.53612
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.53486
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, EGFR, HTR1B, RELA 3.53039
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 3.52837
[BP] GO:0009987 cellular process ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA2, CA4, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 3.52656
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.5206
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.5206
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.5206
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, MIF, PTGS2, SMAD3 3.49231
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTGS2, RELA, SRC 3.47214
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9 3.47214
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.45935
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DRD2, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PTGS2, RELA, SMAD3, SRC, XDH 3.44428
[BP] GO:0051046 None ACHE, CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MIF, MMP12, SRC 3.43958
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 3.43937
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DRD2, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, RELA, SMAD3, SRC, XDH 3.43278
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C, SMAD3 3.42865
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 3.42865
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.39695
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.39695
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.39695
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.39695
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, DRD2, EGFR, ESR1, HTR2B, INSR, MET, MMP2, RELA, SMAD3, SRC, TEK 3.37803
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.37507
[BP] GO:0090066 None ALOX15, DRD1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.37507
[BP] GO:0051050 positive regulation of transport ACHE, APP, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, EGFR, HTR2B, INSR, MIF, MMP12, PTGS2, SMAD3, SRC 3.37442
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.36956
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1, HSD17B3 3.36416
[BP] GO:0014059 None CNR1, DRD2, HTR1B, HTR2A 3.36416
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.35763
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, DRD1, EGFR, ESR1, KIT, PTGS2, SRC 3.3548
[BP] GO:0050794 regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.33444
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.31593
[BP] GO:0007613 None CNR1, DRD1, DRD2, HTR2A, INSR, PTGS2 3.31593
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.28246
[BP] GO:0007166 cell surface receptor signaling pathway ADORA3, APP, AXL, BCL2, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, RELA, SMAD3, SRC, TEK 3.27863
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, CYP3A4, HSD17B3, TYR 3.27724
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.25714
[BP] GO:0002209 None BCL2, DRD1, HTR1A, HTR2C 3.25714
[BP] GO:0001662 None BCL2, DRD1, HTR1A, HTR2C 3.25714
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.25714
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, RELA, SRC 3.25714
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT 3.25714
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.23849
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.22905
[BP] GO:0060402 None CACNA1C, DRD2, HTR2A, HTR2B, HTR2C 3.22905
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.22905
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 3.2209
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.20884
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, EGFR, ESR1, ESRRA, F3, INSR, KDR, KIT, MAP2K1, PIM1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 3.20884
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TEK, TYR 3.20884
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.20884
[BP] GO:1900542 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA 3.19559
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.15878
[BP] GO:0042596 None BCL2, DRD1, HTR1A, HTR2C 3.15878
[BP] GO:0051282 None CACNA1C, DRD1, DRD2, HTR2A, HTR2B, HTR2C 3.15878
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, DRD2, HTR2A, HTR2C, KDR, KIT, MAP2K1, PTGS2, RELA, SMAD3 3.1551
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCL2, CYP1A1, DRD1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, HTR2B, KDR, KIT, MAP2K1, MET, MIF, MMP2, MMP9, PTGS2, SMAD3, SRC, TEK 3.1501
[BP] GO:0031348 negative regulation of defense response CNR2, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 3.1501
[BP] GO:0032147 activation of protein kinase activity DRD2, EGFR, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, SRC 3.14303
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, NQO2, PTGS1 3.1419
[BP] GO:0002031 None DRD2, HTR1B, HTR2B 3.12293
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.12293
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.12293
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.11868
[BP] GO:0006140 None DRD1, DRD2, ESRRB, HTR1B, HTR1E, HTR2A, INSR, PPARA 3.11749
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 3.11749
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.11749
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, TEK 3.09599
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, ESR2, HSPA1A, KIT, MAP3K7, RELA 3.09599
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, HSD17B3 3.0954
[BP] GO:0009605 response to external stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, MMP12, PTGES, PTGS2, RELA, SMAD3, SRC, TYR 3.07599
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, DRD1, DRD2, HTR2A, MET, PIK3CA 3.07015
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, RELA, SRC 3.05396
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration CACNA1C, DRD1, DRD2, ESR1, GPR35, HTR2A, HTR2B, HTR2C 3.04179
[BP] GO:0008285 negative regulation of cell proliferation ADORA3, APP, AR, BCL2, CYP1B1, DRD2, FABP3, HSPA1A, MAP2K1, PTGES, PTGS2, SMAD3, XDH 3.02859
[BP] GO:0090087 None ACHE, APP, CA2, CACNA1C, CNR1, DRD2, EGFR, HTR2B, HTR2C, MIF, MMP12, PTGS2, SMAD3, SRC 3.01879
[BP] GO:0045759 None CNR1, CNR2, GPR35 3.01879
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.01644
[BP] GO:0007208 None HTR2A, HTR2C 3.013
[BP] GO:0016488 None AKR1B10, AKR1C3 3.013
[BP] GO:0016487 None AKR1B10, AKR1C3 3.013
[BP] GO:0016107 None AKR1B10, AKR1C3 3.013
[BP] GO:0009115 None AOX1, XDH 3.013
[BP] GO:0006714 None AKR1B10, AKR1C3 3.013
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 3.00777
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PTGS2, RELA, SRC 2.98631
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, SRC 2.97232
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 2.97213
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, DRD2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.95557
[BP] GO:0009314 response to radiation APP, AURKB, BCL2, DRD1, DRD2, EGFR, KIT, PTGS2, RELA, TYR 2.95557
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.95509
[BP] GO:0006650 glycerophospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, KIT, MET, PIK3CA, PIK3CB 2.95353
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 2.92909
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.92753
[BP] GO:0001817 regulation of cytokine production AXL, CYP1B1, DRD2, HSPA1A, HTR2B, MAP3K7, MIF, MMP12, PTGS2, RELA, SMAD3, SRC 2.92572
[BP] GO:0051952 None CNR1, DRD1, DRD2, HTR1B, HTR2A 2.92499
[BP] GO:0060401 None CACNA1C, DRD2, HTR2A, HTR2B, HTR2C 2.92499
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.90817
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 2.90402
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC 2.90007
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, AR, EGFR, ESR1, FLT3, INSR, KIT, RELA, SRC 2.89141
[BP] GO:0046883 regulation of hormone secretion CACNA1C, CNR1, CYP19A1, DRD2, EGFR, HTR1A, HTR2A, HTR2C 2.89059
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MIF, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.86267
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.85256
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8358
[BP] GO:0051967 None DRD2, HTR1B, HTR2A 2.8358
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, RELA, TYR 2.81813
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.81567
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.79034
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.79034
[BP] GO:0035094 response to nicotine BCL2, CNR1, DRD2, RELA 2.79034
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.79034
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.78806
[BP] GO:0050673 epithelial cell proliferation ESR1, KIT, MAP2K1, PIK3CB, TEK 2.78261
[BP] GO:0007612 None APP, DRD1, DRD2, INSR, KIT, PTGS2 2.77235
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.75185
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.7516
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MIF, NUAK1, PTGS2, XDH 2.74192
[BP] GO:0043434 None FABP3, HSD11B2, INSR, PPARA, PTGS2, RELA, SRC, TEK 2.73701
[BP] GO:0002791 None ACHE, CACNA1C, CNR1, DRD2, EGFR, HTR2B, HTR2C, MIF, MMP12, SRC 2.73198
[BP] GO:0032102 negative regulation of response to external stimulus CNR2, CYP19A1, DRD1, DRD2, MIF, PPARA, SMAD3, TEK 2.7277
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC 2.72603
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.72603
[BP] GO:0040008 regulation of growth APP, AR, BCL2, CSNK2A1, DRD2, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.72196
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD2, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CB, SMAD3, SRC, TEK 2.72196
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.72196
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOA 2.72196
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOA 2.72196
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.72196
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.7209
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.71131
[BP] GO:0006633 None ALOX15, MIF, PTGES, PTGS1, PTGS2 2.6997
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.6997
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.68708
[BP] GO:0050789 regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.68515
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.68292
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.68292
[BP] GO:0070920 None EGFR, ESR1, MAP2K1 2.68292
[BP] GO:0032225 None DRD1, DRD2, PTGS2 2.68292
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.68292
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CYP1A1, DRD2, DUSP3, EGFR, INSR, MIF, SRC 2.66574
[BP] GO:0019637 organophosphate metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, HSPA1A, HTR2B, HTR2C, KIT, MET, PIK3CA, PIK3CB, PTGS2, XDH 2.66286
[BP] GO:0060359 None CNR1, DRD1, DRD2, HTR1B, RELA 2.66162
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, HTR2C 2.65878
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, HTR2C 2.65878
[BP] GO:0006936 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.62141
[BP] GO:0051588 None DRD1, DRD2, HTR1A, HTR1B, HTR2C 2.61804
[BP] GO:0023014 signal transduction by protein phosphorylation EGFR, HTR2B, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, TEK 2.61775
[BP] GO:0031329 regulation of cellular catabolic process BCL2, CNR1, ESRRB, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA 2.61484
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.61185
[BP] GO:0033590 None EGFR, RELA 2.60887
[BP] GO:0046110 None AOX1, XDH 2.60887
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.60887
[BP] GO:0033602 None CNR1, DRD2 2.60887
[BP] GO:0002520 None CACNA1C, SMAD3 2.60887
[BP] GO:0016095 None AKR1B10, AKR1C3 2.60887
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, XDH 2.60887
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.60887
[BP] GO:0050433 None CNR1, DRD2, HTR1B, HTR2A 2.59873
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MIF, MMP9, PTGS2, RELA, SMAD3, SRC 2.59597
[BP] GO:0008584 None AKR1C3, BCL2, ESR1, INSR, KIT 2.58736
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CNR1, CSNK2A1, DRD2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.57643
[BP] GO:0008542 None APP, DRD1, DRD2, KIT 2.56557
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.5493
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.54923
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.54923
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, DRD2, EGFR, ESRRA, ESRRB, HTR2A, HTR2C, KDR, KIT, MAP2K1, PPARA, PTGS2, RELA, SMAD3, XDH 2.52978
[BP] GO:0007631 None APP, DRD1, DRD2, HTR1B, HTR2C 2.52777
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CSNK2A1, CYP1A1, DRD2, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, MIF, PIM1, PTGS2, SMAD3, SRC 2.52007
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.51746
[BP] GO:0003014 None AKR1B1, AKR1C3, BCL2, DRD2, HSD11B2 2.50839
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, RELA, SMAD3, SRC 2.5004
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.48925
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.48925
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.4844
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.4844
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA3, ALOX15, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.48389
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTGS2, SRC 2.46841
[BP] GO:0051051 negative regulation of transport APP, BCL2, CNR1, DRD2, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PTGS2 2.45216
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.45216
[BP] GO:0042391 None APP, BCL2, CACNA1C, CNR1, CNR2, DRD1, GPR35, KDR, SRC 2.45216
[BP] GO:0050730 None APP, EGFR, FLT3, HTR2A, KIT, MIF, SRC 2.44714
[BP] GO:0032989 cellular component morphogenesis APP, AR, AXL, BCL2, DRD2, EGFR, MET, SRC, TEK 2.44714
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.44714
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.44714
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.44714
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 2.44499
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, KIT, MMP9, NUAK1, PTGS2, SMAD3, SRC, XDH 2.43944
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.43761
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CNR1, DRD2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.42855
[BP] GO:0048148 None DRD1, DRD2, HTR2A 2.42641
[BP] GO:0098900 None CACNA1C, CNR1, CNR2, GPR35 2.42044
[BP] GO:0007632 None APP, DRD1, DRD2, KIT 2.42044
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.42044
[BP] GO:0002683 negative regulation of immune system process ALOX15, AXL, CNR1, CNR2, CYP19A1, DRD2, DUSP3, MIF, MMP12 2.41345
[BP] GO:0019932 second-messenger-mediated signaling CACNA1C, DRD1, DRD2, EGFR, HTR2B, HTR5A, KDR 2.41107
[BP] GO:0050714 None ACHE, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.41107
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.40489
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.40489
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.40489
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.4025
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.39649
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, HTR2C 2.39649
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.39649
[BP] GO:0006644 phospholipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, EGFR, KIT, MET, PIK3CA, PIK3CB 2.39649
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC 2.38916
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.37463
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.37463
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.37463
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.37463
[BP] GO:0031623 None ACHE, DRD2, HTR1B, HTR2B 2.37024
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.37024
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.3655
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.36232
[BP] GO:0001889 liver development CSNK2A1, EGFR, PIK3CA, RELA, SMAD3 2.36032
[BP] GO:0006145 None AOX1, XDH 2.36032
[BP] GO:0038171 None CNR1, CNR2 2.36032
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.36032
[BP] GO:0014827 None HTR1D, HTR2B 2.36032
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PTGES, PTGS2, RELA, SMAD3, SRC 2.35505
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.34506
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.3442
[BP] GO:0030258 lipid modification CYP1A1, CYP3A4, EGFR, KIT, MET, PIK3CA, PIK3CB 2.3442
[BP] GO:0015711 organic anion transport CA12, CA14, CA2, CA4, CA7, CA9, DRD2, FABP3, PPARA 2.34344
[BP] GO:0044057 None ADORA3, CACNA1C, DRD2, EGFR, GPR35, HTR2A, HTR2C, KIT, PTGS2, SMAD3 2.33051
[BP] GO:0002694 regulation of leukocyte activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, MAP3K7, MIF, PIK3CA, SRC 2.33051
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.33051
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.33051
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.33051
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.32958
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, HTR2C 2.32958
[BP] GO:0072347 None CNR1, DRD2, HTR1B, RELA 2.32958
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.32958
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.32958
[BP] GO:0050708 None ACHE, CACNA1C, CNR1, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.30444
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.27668
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.27668
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PTGS2, TEK 2.27334
[BP] GO:0035295 tube development AKR1B1, AR, CYP1A1, EGFR, KIT, SMAD3 2.27334
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, RELA, SMAD3, SRC, TEK 2.27318
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.26519
[BP] GO:0000165 MAPK cascade EGFR, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, TEK 2.26144
[BP] GO:0050715 None DRD2, HTR2B, MIF, MMP12, SRC 2.24826
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, RELA, SMAD3, SRC 2.23734
[BP] GO:0002793 None ACHE, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.23006
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MAP2K1, MET, MMP1, MMP12, RELA, SMAD3, SRC 2.2288
[BP] GO:0051894 None KDR, SMAD3, TEK 2.2288
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.2288
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.2288
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.2288
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, AXL, CYP1B1, RELA 2.22608
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.22426
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MIF, MMP9, NUAK1, PTGS2, RELA, SRC 2.22197
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.21715
[BP] GO:0050728 negative regulation of inflammatory response CNR2, CYP19A1, PPARA, SMAD3, TEK 2.20245
[BP] GO:1901222 None APP, EGFR, MAP3K7, RELA 2.20192
[BP] GO:0050920 regulation of chemotaxis CYP19A1, F3, KDR, MET, MIF, SMAD3 2.19275
[BP] GO:0007423 None BCL2, CACNA1C, CYP1A1, EGFR, KIT 2.18684
[BP] GO:0050927 None F3, KDR, SMAD3 2.18128
[BP] GO:0048169 None APP, DRD2, KIT 2.18128
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, HSPA1A, MAP3K7, MIF, MMP12, MMP2, PIK3CA, PIK3CB, RELA, SRC 2.17577
[BP] GO:0021853 None DRD1, DRD2 2.17577
[BP] GO:0010641 None F3, SRC 2.17577
[BP] GO:0071502 None HTR1B, HTR2B 2.17577
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.17577
[BP] GO:1904936 None DRD1, DRD2 2.17577
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, HSPA1A, HTR2A, INSR, KDR, MAP3K7, PIK3CB, PPARA 2.17214
[BP] GO:0003012 None DRD1, DRD2, HTR1D, HTR2A, HTR2B, HTR7, PIK3CA 2.15609
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, SMAD3 2.15052
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.14293
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.14293
[BP] GO:0050926 None F3, KDR, SMAD3 2.14293
[BP] GO:1903393 None KDR, SMAD3, TEK 2.14293
[BP] GO:0001975 None CNR2, DRD1, DRD2 2.14293
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.1418
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.14095
[BP] GO:0051926 negative regulation of calcium ion transport BCL2, DRD2, GPR35, PTGS2 2.14095
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, RELA 2.14095
[BP] GO:0009889 regulation of biosynthetic process ADORA3, AKR1C3, APP, AR, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, PIM1, PPARA, PTGS2, RELA, SMAD3, SRC 2.13903
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, RELA 2.13672
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.13563
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HTR2B, MIF, MMP12, SRC 2.13063
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, EGFR, ESR1, FLT3, RELA, SRC 2.13063
[BP] GO:0050865 regulation of cell activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, MAP3K7, MIF, PIK3CA, SRC 2.12345
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling FLT3, KDR, KIT, TEK 2.11968
[BP] GO:0051223 None ACHE, APP, CACNA1C, CNR1, DRD2, EGFR, HTR2B, MIF, MMP12, PTGS2, SMAD3, SRC 2.11432
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, HTR2A, INSR, PIK3CA, PPARA 2.1077
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, DRD2, PIK3CA 2.09756
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.09756
[BP] GO:0009612 None EGFR, HTR2A, KIT, PTGS2, RELA, SRC 2.05971
[BP] GO:0051482 None DRD1, GPR35, HTR2C 2.05971
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.05971
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, MIF, PIK3CB 2.05971
[BP] GO:0042417 None DRD1, DRD2, MAOA 2.05971
[BP] GO:0070371 None HTR2B, KDR, MAP2K1 2.05971
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC 2.03124
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.03124
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.03124
[BP] GO:0021843 None DRD1, DRD2 2.03124
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.03124
[BP] GO:0046113 None AOX1, XDH 2.03124
[BP] GO:1990535 None APP, INSR 2.03124
[BP] GO:0021830 None DRD1, DRD2 2.03124
[BP] GO:0014831 None HTR1D, HTR2B 2.03124
[BP] GO:0032229 None CNR2, HTR1B 2.03124
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.03124
[BP] GO:0021826 None DRD1, DRD2 2.03124
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.03124
[BP] GO:0016115 None AKR1B10, AKR1C3 2.03124
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.03124
[BP] GO:0042181 None AKR1C3, CYP19A1, HSD17B3 2.02517
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.02517
[BP] GO:1900543 None DRD2, HTR1B, HTR1E, PPARA 2.01933
[BP] GO:0008306 None APP, DRD1, DRD2, KIT 2.01933
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MET, PIK3CA 2.01933
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.00236
[BP] GO:0046683 response to organophosphorus APP, PTGS2, RELA, TEK, TYR 2.00236
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CNR1, CNR2, DRD1, DRD2, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 7.3168
[CC] GO:0005886 plasma membrane ACHE, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, DRD1, DRD2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, SMAD3, SRC, TEK 7.28337
[CC] GO:0044459 plasma membrane part ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DRD1, DRD2, DUSP3, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PTGS2, SRC, TEK 7.0345
[CC] GO:0016020 membrane ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TYR 7.00579
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CNR1, CNR2, DRD1, DRD2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, TEK 6.43045
[CC] GO:0044425 membrane part ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, SRC, TEK, TYR 6.27296
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.5206
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.34884
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.32728
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 3.04572
[CC] GO:0031224 None ACHE, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, TEK, TYR 3.04332
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.79326
[CC] GO:0016021 None ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CNR1, CNR2, CYP3A4, DRD1, DRD2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, TEK, TYR 2.66823
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, AR, AURKB, BCL2, CA2, CA4, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TYR, XDH 2.55024
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2 2.53997
[CC] GO:0044464 cell part ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 2.02157
[CC] GO:0005901 caveola HTR2A, INSR, PTGS2, SRC 2.01933
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.044
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.044
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0375
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.0375
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, TYR, XDH 15.7182
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.9021
[MF] GO:0008227 None DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.6201
[MF] GO:0038023 signaling receptor activity ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 12.359
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 12.3163
[MF] GO:0004871 signal transducer activity ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, SMAD3, TEK 12.1508
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, AR, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, SMAD3, TYR, XDH 11.7979
[MF] GO:0030594 None DRD1, DRD2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.7375
[MF] GO:0004872 receptor activity ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 10.9847
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.714
[MF] GO:0060089 molecular transducer activity ADORA3, AR, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, TEK 10.6372
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK 10.5369
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 9.25898
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 9.17286
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 8.65989
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, DRD1, DRD2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK 8.65989
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.48918
[MF] GO:0003824 catalytic activity ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DUSP3, EGFR, F3, FLT3, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, PTGS1, PTGS2, SRC, TEK, TYR, XDH 8.15485
[MF] GO:0004089 carbonate dehydratase activity CA12, CA14, CA2, CA4, CA7, CA9 7.99492
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.64939
[MF] GO:0005496 steroid binding AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, SHBG 7.36326
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.9504
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, SRC, TEK 6.94179
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.49694
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.32528
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, SHBG 6.16472
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 6.09742
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.76972
[MF] GO:0097159 organic cyclic compound binding AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SHBG, SMAD3, SRC, TEK, XDH 5.51205
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, TYR 5.38032
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 5.35927
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.28143
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.2793
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.23853
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.23395
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.13974
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.04809
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 5.04809
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.99162
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 4.92464
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.92434
[MF] GO:0008270 zinc ion binding AR, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, SMAD3 4.87962
[MF] GO:0016836 hydro-lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.7784
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS1, PTGS2, SRC 4.69639
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.64439
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PPARA 4.62449
[MF] GO:0004930 None ADORA3, CNR1, CNR2, DRD1, DRD2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 4.49729
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, SHBG 4.48039
[MF] GO:1901363 heterocyclic compound binding AOX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 4.465
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.30596
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DRD2, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MIF, MMP9, NQO2, PTGS2, RELA, SMAD3, TYR, XDH 4.2204
[MF] GO:0016835 carbon-oxygen lyase activity CA12, CA14, CA2, CA4, CA7, CA9 4.07932
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, MAP2K1, MAP3K7, SMAD3 4.00587
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.94733
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.92114
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.90287
[MF] GO:0043168 anion binding ALOX15, AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGES, RELA, SRC, TEK, XDH 3.6575
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, SMAD3, TYR, XDH 3.47214
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.36956
[MF] GO:0044877 macromolecular complex binding ACHE, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, RELA, SMAD3, SRC 3.25715
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.25714
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.17038
[MF] GO:0032403 protein complex binding ACHE, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, RELA, SMAD3, SRC 3.11749
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 3.0954
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.04332
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.04179
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 3.013
[MF] GO:0045550 None AKR1B10, AKR1C3 3.013
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.013
[MF] GO:0003845 None HSD11B1, HSD11B2 3.013
[MF] GO:0071886 None HTR2A, HTR2C 3.013
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.97232
[MF] GO:0036094 small molecule binding AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.86267
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.81567
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.6997
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.66823
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.60887
[MF] GO:0047718 None AKR1B10, AKR1C3 2.60887
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.60887
[MF] GO:0004949 None CNR1, CNR2 2.60887
[MF] GO:0047045 None AKR1C3, HSD17B3 2.60887
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.36032
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.36032
[MF] GO:0005497 None AR, SHBG 2.36032
[MF] GO:0051425 None APP, INSR 2.36032
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.36032
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCL2, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KIT, MET, MIF, PPARA, PTGS2, RELA, SMAD3, SRC, TEK 2.34873
[MF] GO:0003674 molecular_function ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AR, AURKB, AXL, BCL2, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGES, PTGS1, PTGS2, RELA, SHBG, SMAD3, SRC, TEK, TYR, XDH 2.3442
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.17821
[MF] GO:0016829 lyase activity CA12, CA14, CA2, CA4, CA7, CA9 2.17577
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.17577
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.17577
[MF] GO:0043559 insulin binding IGF1R, INSR 2.17577
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.14293
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.14293
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.10196
[MF] GO:0042803 protein homodimerization activity ACHE, AOX1, BCL2, DRD2, FLT3, KIT, NQO2, PTGS2, RELA, SMAD3, TYR, XDH 2.06218
[MF] GO:0043546 None AOX1, XDH 2.03124
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.02517
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.00236


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAP2K1, HTR1E, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 22.3019
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, DRD1, DRD2 12.5318
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 12.1338
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP3A4, CYP19A1 12.901
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HTR6, PIK3CA, DRD1, DRD2, PPARA 11.0683
Pathways in cancer_Homo sapiens_hsa05200 MAP2K1, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 9.3306
Rap1 signaling pathway_Homo sapiens_hsa04015 MAP2K1, SRC, INSR, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KIT, KDR, TEK, DRD2, MET 9.5325
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 9.3306
Ras signaling pathway_Homo sapiens_hsa04014 MAP2K1, HTR7, PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 8.1627
Proteoglycans in cancer_Homo sapiens_hsa05205 MAP2K1, PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.6358
HIF-1 signaling pathway_Homo sapiens_hsa04066 MAP2K1, PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, RELA, IGF1R 7.8722
Adherens junction_Homo sapiens_hsa04520 SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 7.6951
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, EGFR, RELA, IGF1R 7.1635
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, CACNA1C, HTR2A, DRD1, HTR5A, HTR4, EGFR 7.0949
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3, RELA 6.8047
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP3A4, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 6.8047
Gap junction_Homo sapiens_hsa04540 MAP2K1, SRC, HTR2B, HTR2C, HTR2A, DRD1, DRD2, EGFR 7.1635
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 7.1635
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, PIK3CA, INSR, KIT, KDR, BCL2, TEK, PIK3CB, MET, EGFR, RELA, IGF1R 6.5378
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 6.759
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, ESR2, RELA 6.5792
Hepatitis B_Homo sapiens_hsa05161 MAP2K1, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9, RELA 5.6938
Focal adhesion_Homo sapiens_hsa04510 MAP2K1, PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 5.6938
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.8681
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.4388
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.6453
VEGF signaling pathway_Homo sapiens_hsa04370 MAP2K1, PIK3CA, SRC, KDR, PIK3CB, PTGS2 5.6938
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA2, CA4, CA7, CA9, CA14 8.8005
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 5.2734
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, PIK3CA, PIK3CB, EGFR, RELA 5.5187
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.3577
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, AKR1C3, PTGS2, PTGES, PTGS1 5.667
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.9496
Oxytocin signaling pathway_Homo sapiens_hsa04921 MAP2K1, PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 4.4777
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.5981
MicroRNAs in cancer_Homo sapiens_hsa05206 MAP2K1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR 4.4726
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, MAP2K1, PIK3CA, BCL2, CACNA1C, PIK3CB 4.3427
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.0265
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 4.1025
Sphingolipid signaling pathway_Homo sapiens_hsa04071 MAP2K1, PIK3CA, ADORA3, BCL2, PIK3CB, RELA 4.1688
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 3.9172
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 3.9176
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.3548
Glioma_Homo sapiens_hsa05214 MAP2K1, PIK3CA, PIK3CB, EGFR, IGF1R 4.3427
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, PIK3CA, BCL2, PIK3CB 4.412
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, PIK3CA, PIK3CB, RELA 4.1346
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 3.8462
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, INSR, KIT, PIK3CB, EGFR 3.8283
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.9083
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1346
ErbB signaling pathway_Homo sapiens_hsa04012 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 3.8345
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, SRC, MMP2, CACNA1C, EGFR 3.7565
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, INSR, CACNA1C, PIK3CB 3.5302
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.8462
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.2853
MAPK signaling pathway_Homo sapiens_hsa04010 MAP2K1, DUSP3, CACNA1C, MAP3K7, EGFR, RELA, HSPA1A 3.4088
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, RELA, IGF1R 3.7118
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.5302
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.4989
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2, MAP3K7, RELA 3.719
Insulin resistance_Homo sapiens_hsa04931 PIK3CA, INSR, PIK3CB, PPARA, RELA 3.4551
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1 3.3063
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.2847
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, MAP3K7, IGF1R 3.2366
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 3.0423
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.1395
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA, RELA 2.8989
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.815
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR, RELA 3.1354
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2633
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PIK3CB, RELA, HSPA1A 2.6313
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3022
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.341
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.5869
Axon guidance_Homo sapiens_hsa04360 MET 0.3559
Cell cycle_Homo sapiens_hsa04110 SMAD3 0.3612
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 2.2867
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, SRC, PIK3CB, RELA 2.5184
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3865
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, IGF1R 2.6836
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.93
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3672
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4252
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6772
Choline metabolism in cancer_Homo sapiens_hsa05231 MAP2K1, PIK3CA, PIK3CB, EGFR 2.64
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4415
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4403
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6784
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4415
Insulin signaling pathway_Homo sapiens_hsa04910 MAP2K1, PIK3CA, INSR, PIK3CB 2.1891
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, CACNA1C, PIK3CB 2.102
Morphine addiction_Homo sapiens_hsa05032 DRD1 0.4516
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA, DRD1, DRD2 1.8389
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C, DRD1, DRD2 2.2887
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.7878
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB, RELA 2.6028
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.797
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.453
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4153
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4674
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.6668
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4544
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4641
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4657
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB, RELA 1.3743
Peroxisome_Homo sapiens_hsa04146 XDH 0.469
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4726
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, MAP3K7 1.4058
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.469
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.169
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 MAP2K1, PIK3CA, PIK3CB 1.4552
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.481
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.479
Pertussis_Homo sapiens_hsa05133 RELA 0.4899
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4829
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4921
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.2068
Vascular smooth muscle contraction_Homo sapiens_hsa04270 MAP2K1, CACNA1C 0.8841
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.5535
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4921
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PIK3CB, RELA 3.1362
Melanogenesis_Homo sapiens_hsa04916 MAP2K1, KIT, TYR 1.7708
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB, RELA 1.7708
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 MAP2K1, PIK3CA, PIK3CB 1.8404
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.2646
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB, EGFR 3.5972
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0309
Renin secretion_Homo sapiens_hsa04924 CACNA1C 0.5406
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, CACNA1C, PTGS2 1.763
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5406
Non-small cell lung cancer_Homo sapiens_hsa05223 MAP2K1, PIK3CA, PIK3CB, EGFR 3.4983
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.0423
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0924
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1032
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.9914
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.2842
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1032
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.2264
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 3.2135
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2135
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.7129
Leishmaniasis_Homo sapiens_hsa05140 PTGS2, MAP3K7, RELA 2.1067
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PIK3CB 2.1891
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.2615
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6218
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1, DRD2, RELA 3.6921
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.6267
Malaria_Homo sapiens_hsa05144 MET 0.6317
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.257
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.257
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C, DRD1 2.1984
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.2615
Long-term potentiation_Homo sapiens_hsa04720 MAP2K1, CACNA1C 1.3014
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.1439
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6423
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.637
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.3101
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.3671
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RELA 1.3101
Long-term depression_Homo sapiens_hsa04730 MAP2K1, IGF1R 1.3671
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3943
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3736
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.4122
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.697
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.8147
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5608
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7934
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5504
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8147
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8502
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.758
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8377
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8595
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.9404
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8173
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8801
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7383
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1673
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0733
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0924
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.2996
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.395
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2884


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)