TCM Prescription: Nuan Wei Shu Le Tablets



Prescription Description
Prescription IDTCMF4370
Pinyin NameNuan Wei Shu Le Pian
Chinese Name暖胃舒乐片
English NameNuan Wei Shu Le Tablets
Function Description胃脘痛, 腹痛
IndicationsStomach ache disorder, Abdominal pain disorder, Dyspepsia, Enteritis
Disease ICD-11 Category SA51 [Stomach ache disorder (TM1), 胃脘痛 (TM1) ];
SA58 [Abdominal pain disorder (TM1), 腹痛 (TM1) ];
MD92 [Dyspepsia, 消化不良 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH362 NA 大红袍 TCMH362
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1029 Paederia scandens 鸡矢藤 TCMH1029 ITSAJ4469-14
TCMH72 Bletilla striata 白芨 TCMH72 ITSAJ4380-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH2175 Galla chinensis 五倍子 TCMH2175
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1405 Penicillium citrinum
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7632
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9863
[BP] GO:0042221 response to chemical ADRA1A, ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP2, MMP9, POLB, PPARA, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 11.7466
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, KDR, MET, POLA1, POLB, PPARA, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 10.9956
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, POLB, PPARA, RORC, SLC6A4, SRC, TYR 10.2119
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.60983
[BP] GO:0010033 response to organic substance ADRA1A, ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA3, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR5A, IGF1R, KDR, MMP2, POLB, PPARA, RORC, SLC6A4, SRC, TYR 9.31989
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SLC6A4, SRC, TERT, XDH 9.31989
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA3, CA9, CDK6, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD11B2, HTR2A, HTR2B, KCNH2, KDR, POLB, SLC6A2, SLC6A4, SRC 9.31989
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.26555
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 9.24146
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 9.11589
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 8.55736
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FUT7, GBA2, HTR2B, PIM1, PPARA, TYR, XDH 8.17374
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TYR 8.16813
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F10, F2, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A4, SRC, TNKS2, TYR 8.01845
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, TERT 7.98895
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC, TNKS, TNKS2 7.95876
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR5A, RORC, SLC6A4, SRC, TYR 7.86297
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HSD11B2, HTR5A, RORC, SLC6A4, SRC, TYR 7.83635
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.55194
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 7.48767
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 7.32198
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 7.29915
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 7.17039
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CES1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, SLC6A4, SRC 7.07663
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 6.87454
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, KCNH2, MET, POLA1, POLB, SRC, TERT 6.87454
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.85648
[BP] GO:0009725 response to hormone ADRA1A, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, PPARA, SLC6A4, SRC 6.84684
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, RORC, SIGMAR1, SLC6A4, SRC, TERT, TNKS2, TYR 6.56502
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56502
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56502
[BP] GO:0009719 response to endogenous stimulus ADRA1A, ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR5A, IGF1R, MMP2, PPARA, SLC6A4, SRC 6.54036
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.33362
[BP] GO:0003018 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 6.3326
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 6.07135
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 6.07135
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 6.02536
[BP] GO:0097746 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.97105
[BP] GO:0035296 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.97105
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 5.95018
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A 5.8751
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 5.86904
[BP] GO:0050880 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.75786
[BP] GO:0035150 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 5.73546
[BP] GO:0007187 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 5.70997
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.67091
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.52162
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, HTR2A, HTR2B, SRC, TNKS, TNKS2 5.46329
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F2, F3, HTR1A, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 5.38717
[BP] GO:0003013 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4, SRC 5.28065
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KCNH2, PPARA, SLC6A2, SLC6A4 5.25182
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 5.21407
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, GBA2, HTR1A, TYR 5.20007
[BP] GO:0007188 None ADORA1, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.20007
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, RORC 5.07436
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 5.04617
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.03331
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, ESR1, HTR7, PPARA, RORC, SLC6A4, SRC 5.03331
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HSD11B2, HTR2A, HTR2B, MMP2, POLB, PPARA, SLC6A4, SRC, TERT, TYR 5.02782
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 4.97613
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, POLB, PPARA, SLC6A4, SRC, TERT 4.95021
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, RORC, SRC 4.94627
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.88033
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.83343
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.8297
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC, TERT 4.74522
[BP] GO:0048878 chemical homeostasis ADRA1A, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, FABP4, HTR2A, HTR2B, KCNH2, MET 4.74147
[BP] GO:0007200 None ADRA1A, ADRA2A, DRD1, DRD2, ESR1, HTR2A, HTR2B 4.7083
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, POLB, PPARA, SRC, TYR 4.66108
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD2, FABP3, FABP4, FUT7, GBA2, MET, PPARA 4.62661
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, MMP9, PIM1, POLB, PPARA, RORC, SIGMAR1, SRC, TYR 4.57696
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.55374
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.51801
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, RORC, SIGMAR1, SRC, TNKS, TNKS2 4.50895
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.50612
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 4.49996
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, HTR2A, KCNH2, MMP9 4.49972
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.46451
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.43619
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, RORC, SLC6A4, SRC, TERT 4.436
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 4.41896
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SLC6A4, SRC, TERT 4.4075
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 4.38688
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.37117
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.37015
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, KCNH2, MMP9, SLC6A4 4.29349
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.28485
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.28485
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 4.27155
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, SLC6A4 4.27155
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.27155
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.21999
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, ADRA2A, BCL2, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SLC6A4, SRC, TERT, XDH 4.20179
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.17855
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 4.15932
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 4.13169
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, F2, TNKS, TNKS2 4.06668
[BP] GO:0032225 None DRD1, DRD2, DRD3, SLC6A4 4.06287
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, PPARA 4.06287
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, F2, HTR2B, KCNH2, MMP12, SLC6A4, SRC, TERT 4.0342
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, SLC6A4 4.00572
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, SLC6A4 4.00572
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.91639
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.91639
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.91639
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.89718
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ADRA2A, BCL2, CDK6, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, TERT, XDH 3.88931
[BP] GO:0051952 None ADORA1, ADRA2A, DRD1, DRD2, DRD3, HTR2A 3.8805
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP3, HTR2A, HTR2B, KCNH2 3.87311
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.84357
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TERT, XDH 3.82436
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.81458
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.79895
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 3.79895
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.79618
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, XDH 3.76704
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.76131
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.71868
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.71868
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.70409
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 3.6353
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.634
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.63022
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.59768
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 3.58572
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 3.55236
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC, TERT 3.55236
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F10, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, TERT, TNKS, TNKS2, XDH 3.51701
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT 3.51104
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3 3.51104
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KCNH2, KDR, MMP2, MMP9, POLA1, POLB, PTPN1, RORC, SLC6A4, SRC, TERT 3.51022
[BP] GO:0019933 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.50549
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.47806
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.46163
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.43036
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, DRD3, ESRRB, F2, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.42798
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, RORC, SLC6A4, SRC 3.41222
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 3.40564
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F10, F3, MET, SRC, XDH 3.39969
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.39969
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2, HSD11B2 3.39061
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TERT 3.34706
[BP] GO:0043266 None ADORA1, ADRA2A, DRD1, DRD2, HTR2A, KCNH2 3.34293
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.33907
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.33358
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.33358
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.33358
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.32546
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TERT, XDH 3.32328
[BP] GO:0019935 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR5A 3.30951
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.30116
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.24605
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 3.24605
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.24471
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 3.22886
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.22275
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, HTR2B, KCNH2, KDR, MET, MMP12, MMP9, PIM1, SLC6A4, SRC, TERT, TNKS2, XDH 3.22209
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, ESRRB, F2, F3, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC, TERT 3.22188
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, PPARA 3.19055
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.19055
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 3.16638
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, ESR1, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 3.16609
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, ADRA2A, CA2, DRD1, DRD2, DRD3, ESR1, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 3.13433
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, TERT, TNKS, XDH 3.13363
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC, TERT 3.13212
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.12693
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 3.12586
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1, ESR1 3.1105
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.05578
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.05578
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, TERT, TNKS, XDH 2.97778
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.97487
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, XDH 2.97487
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 2.96175
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.95589
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.95589
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, F2, PPARA 2.95116
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CA3, CDC25B, CDK6, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, POLB, PTPN1, SRC, TNKS, XDH 2.95041
[BP] GO:0002031 None DRD2, DRD3, HTR2B 2.94334
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.92747
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 2.90743
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, SLC6A2, SLC6A4 2.89988
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TERT, TNKS, XDH 2.89434
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 2.88877
[BP] GO:0007189 None ADRA1A, ADRA2A, DRD1, DRD2, DRD3 2.88877
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 2.87692
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 2.87692
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TERT 2.85776
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.84771
[BP] GO:0015872 None DRD1, SLC6A2, SLC6A4 2.84771
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TERT, TNKS 2.84771
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 2.83785
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F10, F2, FABP3, HTR2A, HTR2B, KCNH2, MMP12, MMP9, PPARA, SIGMAR1, SLC6A2, SLC6A4, SRC, TNKS, XDH 2.82588
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.81586
[BP] GO:0009115 None AOX1, XDH 2.81089
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.80288
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.80148
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, RORC, SLC6A4, SRC 2.78554
[BP] GO:0003008 None ADORA1, ADRA1A, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD1, DRD2, DRD3, HSD11B2, HTR1A, HTR2A, HTR2B, HTR7, KCNH2, SLC6A4, SRC, TYR 2.78009
[BP] GO:0035556 intracellular signal transduction ADRA1A, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KCNH2, KDR, MET, POLB, PTPN1, SRC 2.77398
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.76685
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.76685
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.76685
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.76685
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.76685
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD1, DRD2, DRD3, F2, HTR2A, KCNH2 2.76344
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 2.76344
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TYR 2.74822
[BP] GO:0007623 circadian rhythm DRD2, DRD3, HTR7, PPARA, RORC, SLC6A4 2.67995
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.67614
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.67614
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.67614
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, MMP12, PPARA, SIGMAR1, SLC6A2, SLC6A4, TNKS 2.66737
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, ADRA2A, AURKB, BCL2, CDC25B, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, TERT, TNKS, XDH 2.66459
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KCNH2, KDR, MET, PIM1, SRC, TNKS 2.66096
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, KDR, MET, MMP12, PPARA 2.65768
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KCNH2, KDR, SRC 2.65768
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.65707
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.65522
[BP] GO:0090066 None ADORA1, ADRA1A, ADRA2A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SLC6A4 2.65467
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.64212
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.63607
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.63006
[BP] GO:0043268 None ADORA1, ADRA2A, DRD1, KCNH2 2.63006
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.60489
[BP] GO:0051937 None DRD1, SLC6A2, SLC6A4 2.60489
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.60489
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 2.60392
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.59793
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.59793
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.59201
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, PTPN1, SRC, TNKS 2.59124
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.56704
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.56611
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, KCNH2 2.56611
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, MMP12, SLC6A4, SRC 2.56394
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, DRD2, ESR1, F2, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, TERT, XDH 2.53962
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.53962
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.53767
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.53767
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A, SLC6A4 2.5219
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, HSD11B2, PPARA 2.51046
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, SLC6A4, SRC, TYR 2.49088
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.48243
[BP] GO:0050433 None ADRA2A, DRD2, DRD3, HTR2A 2.4692
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.46443
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, MET, MMP12, PPARA, RORC, SRC, TERT, TNKS, TNKS2 2.4617
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.44553
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.44361
[BP] GO:0046110 None AOX1, XDH 2.4356
[BP] GO:0060160 None DRD2, DRD3 2.4356
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.4356
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.43226
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ADRA2A, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 2.43153
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.4135
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.4041
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.4041
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CYP1A1, HTR2A, POLB, TERT 2.39299
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.37303
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.36643
[BP] GO:1900542 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.36166
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9, TERT 2.35181
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP12, SLC6A4, SRC 2.35181
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.34153
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.34153
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 2.34153
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, KCNH2, MMP9 2.34153
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, TYR 2.32706
[BP] GO:0043270 None ADORA1, ADRA2A, DRD1, DRD2, F2, KCNH2, SLC6A4 2.32575
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.31696
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.31495
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.30065
[BP] GO:0006140 None ADRA2A, DRD1, DRD2, DRD3, ESRRB, HTR2A, PPARA 2.29673
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.28721
[BP] GO:0071880 None ADRA1A, ADRA2A, DRD2 2.28721
[BP] GO:0033555 multicellular organismal response to stress BCL2, DRD1, HTR1A, SLC6A2 2.27626
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA3, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, F2, HSD11B2, HTR1A, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SLC6A2, SLC6A4, SRC, TERT 2.27626
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, RORC, SLC6A4, SRC 2.2624
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, FABP4, HTR2B, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2, XDH 2.25142
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.25142
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.25142
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, F2, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.25142
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, MMP12, PPARA 2.2383
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B 2.23633
[BP] GO:0015844 None DRD1, SLC6A2, SLC6A4 2.23629
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.23629
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, HTR2A, PTPN1, SRC 2.21895
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.21722
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.21722
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC, TNKS 2.21705
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, HTR2A, IGF1R, MET, MMP12, PPARA, PTPN1, RORC, SRC, TERT, TNKS, TNKS2 2.21438
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.21228
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.20503
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.20273
[BP] GO:0070213 None TNKS, TNKS2 2.20273
[BP] GO:0006145 None AOX1, XDH 2.20273
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.20273
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD1, DRD2, DRD3, F2, KCNH2, MMP9 2.19739
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.19739
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.19739
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.19286
[BP] GO:0055065 metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, KCNH2 2.19282
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.17444
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.16766
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.16766
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B 2.14929
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.14929
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.14929
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.14929
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.14929
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.14581
[BP] GO:0019725 cellular homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, POLA1 2.13639
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.10938
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.105
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.10253
[BP] GO:0071875 None ADRA1A, ADRA2A, DRD2 2.10253
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.10253
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, ADRA2A, BCL2, DRD2, DRD3, ESR1, ESR2, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, TERT, XDH 2.10158
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.10116
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.09196
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.09196
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.05628
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.05391
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.05391
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.02889
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 2.02889
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, POLA1, PPARA, PTPN1, RORC, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.02889
[BP] GO:0021853 None DRD1, DRD2 2.02889
[BP] GO:0043696 None CDK6, ESRRB 2.02889
[BP] GO:0043697 None CDK6, ESRRB 2.02889
[BP] GO:0010641 None F3, SRC 2.02889
[BP] GO:0090325 None DRD2, DRD3 2.02889
[BP] GO:0007598 None F10, F3 2.02889
[BP] GO:1904936 None DRD1, DRD2 2.02889
[BP] GO:0042321 None ADORA1, DRD2 2.02889
[BP] GO:0010513 None HTR2A, HTR2B 2.02889
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ADRA2A, BCL2, CDC25B, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.0285
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02176
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.02176
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, SLC6A4, SRC 2.00709
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, SLC6A4, SRC, TERT 2.0054
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, KCNH2, SLC6A2 2.00494
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, SLC6A4 2.00297
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, TNKS2 2.00177
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.00177
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, TYR 2.00177
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA 2.00177
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 5.67041
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SLC6A2, SLC6A4 4.23813
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F10, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, SIGMAR1, SLC6A2, SLC6A4, SRC 3.84216
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, GBA2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A4, SRC, TERT 3.79618
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, F10, F2, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, SIGMAR1 3.6353
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR 3.51104
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, F10, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PTPN1, SIGMAR1, SLC6A2, SLC6A4, SRC, TYR 2.89024
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA3, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F10, F2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2A, HTR5A, KCNH2, KDR, MMP2, MMP9, PIM1, POLA1, PTPN1, SIGMAR1, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.76685
[CC] GO:0005783 None ADORA1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.49675
[CC] GO:0031233 None CA4, F10, F3 2.28721
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HTR2A, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SIGMAR1, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.22181
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, GBA2, HSD11B1, HSD11B2, HSD17B2, SIGMAR1 2.10253
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.8676
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 15.6106
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, SRC, TERT, TNKS, TNKS2, TYR, XDH 13.628
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 12.0777
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 11.9463
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8874
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, F10, F2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TERT, TNKS, TNKS2, TYR, XDH 10.1399
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, SLC6A4 9.15412
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 8.871
[MF] GO:0008227 None ADRA1A, ADRA2A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.63014
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 8.63014
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, CDK6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 8.16813
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 7.84656
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 7.8164
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SLC6A2, SLC6A4, TERT, TNKS, TNKS2, TYR, XDH 6.92874
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KCNH2, KDR, MET, PPARA, RORC, SIGMAR1 6.91412
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.57469
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.57469
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56502
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56502
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.41869
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.41289
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, XDH 5.10999
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SLC6A4, SRC 5.04617
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6 5.02782
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.99316
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.83442
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.83442
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 4.79416
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.75317
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.73472
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.71123
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.59317
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 4.48764
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.43619
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.36781
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, ADRA2A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 4.36781
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, HSD11B2, HSD17B1, POLA1, SRC, XDH 3.84216
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 3.8311
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.76013
[MF] GO:1901338 None ADRA2A, DRD1, DRD2, DRD3 3.71868
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, SRC 3.56943
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A4, SRC 3.34003
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, TYR 3.30116
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25917
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, ESRRB, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A4, SRC 3.16609
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.15943
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.15943
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.94334
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2C19, CYP2D6 2.91404
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.84771
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.81089
[MF] GO:0003845 None HSD11B1, HSD11B2 2.81089
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, ADRA2A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 2.79054
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.76685
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.7423
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.65282
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.56611
[MF] GO:0004935 None ADRA1A, ADRA2A, DRD2 2.53767
[MF] GO:0005330 None SLC6A2, SLC6A4 2.4356
[MF] GO:0047374 None CES1, CES2 2.4356
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.28721
[MF] GO:0004252 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.23633
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, POLA1, POLB, SRC, TERT 2.22802
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.21722
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KCNH2, KDR, MET, PIM1, SRC 2.20273
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.20273
[MF] GO:0032795 None ADORA1, ADRA2A 2.20273
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.14457
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, ESR1, ESR2, FLT3, IGF1R, KCNH2, KDR, MET, MMP9, SLC6A4, TERT, TYR, XDH 2.06954
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.02889
[MF] GO:0008236 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.00525


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 20.2587
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR2B, HTR1A, HTR2A, F2, HTR5A, ADRA1A, ADRA2A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 9.2532
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A, CYP2C19, SLC6A4 8.777
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.4399
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 7.3893
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, CYP2C19, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.2154
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 3.6897
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.5604
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 3.649
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.649
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.5604
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.2587
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 3.4747
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP2C19 3.5604
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.5604
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 2.8324
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.7802
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.7802
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP2C19 2.8324
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.2654
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8324
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.0358
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 1.9706
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.7817
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A, ADRA2A 1.6338
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.7817
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7796
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 1.8586
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH, CES2, CES1 2.2397
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5491
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5124
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.6951
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, IGF1R 1.3159
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.2952
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3159
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.1472
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.256
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1094
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.8871
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.1472
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 0.8871
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.8871
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1439
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.116
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8511
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.901
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.0903
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.7836
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8871
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8202
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.7908
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7199
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9698
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.0742
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7567
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8844
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7567
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.7567
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.7324
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1341
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.6885
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.0703
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.7324
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6849
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.6849
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, CYP2C19 1.1115
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.6849
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.2386
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.6661
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5666
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.5648
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5648
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.513
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1831
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.4893
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2629
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2864
HTLV-I infection_Homo sapiens_hsa05166 POLB, TERT 0.4364
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2628
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3038
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3148
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3325
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3325
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3311
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.3427
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3427
Platelet activation_Homo sapiens_hsa04611 SRC 0.3587
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3603
Axon guidance_Homo sapiens_hsa04360 MET 0.3513
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3587
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3831
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3603
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4059
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4058
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3958
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5491
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4173
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4296
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.417
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4168
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.5524
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.4364
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4296
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4292
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4296
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4296
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.4546
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4296
Peroxisome_Homo sapiens_hsa04146 XDH 0.4364
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4683
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4671
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.476
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.4861
Bile secretion_Homo sapiens_hsa04976 CA2 0.4747
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4861
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4861
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4893
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4774
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.4845
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4861
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5124
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.4423
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4861
Shigellosis_Homo sapiens_hsa05131 SRC 0.4861
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4861
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5103
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7093
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5376
Malaria_Homo sapiens_hsa05144 MET 0.5487
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5556
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5521
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5556
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6055
DNA replication_Homo sapiens_hsa03030 POLA1 0.6326
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6778
Base excision repair_Homo sapiens_hsa03410 POLB 0.6627
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6849
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7058
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6849
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.6959
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.803
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.8844
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8324
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1341


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)