TCM Prescription: Jin Gu Zhi Tong Ointment



Prescription Description
Prescription IDTCMF4308
Pinyin NameJin Gu Zhi Tong Gao
Chinese Name筋骨止痛膏
English NameJin Gu Zhi Tong Ointment
Function Description痹病, 跌打损伤
IndicationsArthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病,未特指的 ];
Human Tissues Associated with IndicationSkeletalMuscle, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH945 Sophora japonica 槐枝 TCMH945 ITSAN2377-14
TCMH1798 Morus alba 桑枝 TCMH1798 ITSAL1073-14
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
TCMH333 Bulbus allii fistulosi TCMH333
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH486 Syzygium aromaticum 丁香 TCMH486 GBVI185-11
TCMH2333 Cynanchum paniculatum 徐长卿 TCMH2333
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
TCMH2585 Cinnamomum camphora 樟脑 TCMH2585 SDH069-14
TCMH2036 NA 松枝 TCMH2036
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT124 FUCA1 Alpha-L-fucosidase I Hydrolase P04066
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT347 MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Hydrolase Q9UKM7
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 14.168
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, POLB, PPARA, PRKCD, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 14.1614
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, GBA, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCD, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 14.1101
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 14.0769
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, POLB, PPARA, PRKCD, PTGES, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, TYR 13.5011
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MIF, MTNR1B, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 11.7075
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, MIF, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR, XDH 11.357
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP9, PRKCD, PTGES, PTGS2, SRC, TERT 10.6757
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TRPV1 10.6747
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HSD17B2, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TRPV1 10.4839
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.4622
[BP] GO:0010941 regulation of cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 10.4164
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PIK3CA, POLA1, POLB, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 10.4164
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.4164
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 10.3887
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, IGF1R, INSR, MMP2, PPARA, PRKCD, PTGS2, SMAD3, SRC, TEK, TRPV1 10.0912
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 10.0492
[BP] GO:0043067 regulation of programmed cell death AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.79597
[BP] GO:0042127 regulation of cell proliferation AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, FABP3, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH 9.79597
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PRKCD, PTGS2, RORC, SMAD3, SRC, TRPV1 9.77621
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 9.66233
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 9.63405
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.5633
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 9.41578
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, GBA, PTGES, PTGS2, RORC, SRC, TEK, TRPV1, TYR 9.35302
[BP] GO:0042981 regulation of apoptotic process AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 9.23664
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 9.22866
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 8.79749
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.75948
[BP] GO:0042592 homeostatic process AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, MET, MTNR1B, PIK3CA, PIK3CB, POLA1, POLB, SMAD3, SRC, TERT, TRPV1 8.74939
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, GBA, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR 8.71564
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GBA, HSD17B2, PTGES, PTGS2, RORC, SRC, TYR 8.55188
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.50291
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.47154
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 8.35689
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 8.10626
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 8.08079
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 7.96325
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.88315
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 7.8039
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.67818
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GBA, HIF1A, INSR, KDR, MIF, MMP9, MTNR1A, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.67818
[BP] GO:0031325 positive regulation of cellular metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.43447
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 7.41311
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 7.39738
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 7.33953
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 7.33953
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.20547
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.13765
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MIF, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.13765
[BP] GO:0009893 positive regulation of metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 7.10909
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, POLB, PPARA, SMAD3, SRC, TEK, TYR 7.10423
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.94743
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 6.9075
[BP] GO:2000145 regulation of cell motility APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.86516
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.6948
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.6948
[BP] GO:0048523 negative regulation of cellular process ACHE, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 6.6948
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCD, PTGS2, RORC, SRC, TRPV1 6.6948
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.65906
[BP] GO:0018212 peptidyl-tyrosine modification AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.65063
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.57957
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 6.56634
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.56513
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, GAA, GBA, HIF1A, HSD17B2, IGF1R, INSR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 6.56172
[BP] GO:0030334 regulation of cell migration APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.56172
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.51696
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 6.40856
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.38452
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGES, PTGS2, TERT 6.38452
[BP] GO:0040012 regulation of locomotion APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.37398
[BP] GO:0051270 regulation of cellular component movement APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.35705
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, MIF, PTGES, PTGS1, PTGS2, TBXAS1 6.35705
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, GAA, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.34755
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.33297
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TYR, XDH 6.26427
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.26138
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, F10, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.25298
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.20835
[BP] GO:0006950 response to stress ACHE, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1 6.16403
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, GBA, KDR, POLB, PRKCD, PTGS2, SRC, TRPV1 6.13936
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.08424
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 6.08309
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TYR 6.08309
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCD, SRC, TEK 6.08079
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HIF1A, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 6.06658
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, MET, MTNR1B, PIK3CA, PIK3CB, SMAD3, TRPV1 6.02664
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, RORC, SRC, TOP2A 6.01105
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 5.99632
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, RORC, SMAD3, SRC, TRPV1 5.9274
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.92646
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.90495
[BP] GO:0048519 negative regulation of biological process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PTGES, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 5.84161
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 5.83391
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESRRA, ESRRB, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 5.8324
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, HIF1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 5.73408
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 5.73408
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.67261
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HSPA1A, MMP2, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, TYR 5.64252
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MAOA, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 5.61975
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 5.60852
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 5.60852
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2, TBXAS1 5.57884
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HIF1A, HSPA1A, INSR, MIF, MMP12, MMP9, MTNR1B, PIK3CB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, TRPV1 5.51436
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.42348
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK 5.38268
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, EGFR, HIF1A, HSPA1A, IGF1R, MET, MIF, NUAK1, PRKCD, PTGS2, PTPN1, TERT, XDH 5.37788
[BP] GO:0032787 None ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, HIF1A, MIF, PPARA, PTGES, PTGS1, PTGS2, TBXAS1 5.37788
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 5.37078
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 5.34206
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 5.3263
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MIF, MMP9, NUAK1, POLA1, POLB, PRKCD, PTGS2, PTPN1, SRC, TERT, TOP2A, TRPV1 5.28186
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.26131
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HSPA1A, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.26131
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, HIF1A, MAOA, TYR 5.25111
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1, TYR 5.25111
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 5.22146
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 5.19887
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 5.14656
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, PRKCD, PTGS2, SRC, TRPV1 5.12553
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 5.12553
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 5.09128
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HIF1A, MMP2, POLB, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 5.00007
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.93224
[BP] GO:0065009 regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.89535
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, KDR, MIF, PIK3CB, PRKCD, PTPN1, SRC, TEK, XDH 4.8589
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1, TYR 4.82535
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 4.82259
[BP] GO:0019371 None PTGES, PTGS1, PTGS2, TBXAS1 4.78879
[BP] GO:0009892 negative regulation of metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.759
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, GBA, HSD17B2, MIF, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 4.70735
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 4.69296
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SRC, TEK, XDH 4.68766
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PRKCD, SMAD3, SRC, TEK 4.67502
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PIK3CA, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.65224
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGES, PTGS1, PTGS2 4.65224
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, EGFR, HIF1A, KDR, MIF, PIK3CB, PTGS2, SRC, TRPV1 4.64571
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.63908
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 4.62607
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A 4.59923
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HIF1A, INSR, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC, TERT, TRPV1 4.59923
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 4.59314
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 4.59314
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.54599
[BP] GO:0001516 None MIF, PTGES, PTGS1, PTGS2 4.50771
[BP] GO:0046457 None MIF, PTGES, PTGS1, PTGS2 4.50771
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.49301
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT 4.4387
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PRKCD, PTGS2, SMAD3, SRC, TRPV1 4.42684
[BP] GO:0043405 regulation of MAP kinase activity DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC 4.41606
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC, TERT 4.41459
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.40038
[BP] GO:0050790 regulation of catalytic activity APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.36673
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 4.35696
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HIF1A, HSPA1A, INSR, MET, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.35629
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC, TERT 4.32521
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PRKCD, PTGS2, SRC, TRPV1 4.32451
[BP] GO:0009894 regulation of catabolic process APEX1, BCL2, CSNK2A1, EGFR, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCD, PTPN1, SMAD3 4.25883
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 4.24175
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 4.23886
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.23579
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 4.22135
[BP] GO:0019222 regulation of metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.20429
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, GBA, HIF1A, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1 4.13945
[BP] GO:0080090 regulation of primary metabolic process ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 4.12646
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC, TERT, TOP2A 4.12376
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 4.0964
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC, TERT 4.09511
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HIF1A, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 4.09351
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 4.06948
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, POLB, PRKCD, PTGS2, TERT 4.03713
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH 4.02695
[BP] GO:0051239 regulation of multicellular organismal process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GAA, GBA, GPR35, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PRKCD, PTGS2, SMAD3, SRC, TEK, TERT, TRPV1, XDH 4.02495
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.01855
[BP] GO:2001233 regulation of apoptotic signaling pathway BCL2, HIF1A, HSPA1A, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 3.99763
[BP] GO:0051171 regulation of nitrogen compound metabolic process ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.99763
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.98675
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.98675
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, GLO1, HIF1A, MIF, PIM1, PPARA, PTGES, PTGS1, PTGS2, TBXAS1, TYR 3.98172
[BP] GO:0016137 None AKR1B1, AKR1B10, FUCA1, GBA 3.9737
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.9584
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.95547
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.94461
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, MTNR1A, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 3.93002
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, MTNR1A, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.91216
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PRKCD, PTGS2, SRC, TEK 3.91163
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.8987
[BP] GO:0010634 positive regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 3.86832
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCD, SMAD3, SRC, TEK 3.86208
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK, TOP2A 3.85947
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGES, PTGS1, PTGS2 3.84572
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B2 3.8373
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, INSR, MMP2, MMP9, MTNR1A, PTGS2, SRC, TOP2A 3.82187
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, PTGS2, SRC 3.80831
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, KDR, POLB, PRKCD, SRC 3.80831
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, HIF1A, KDR, MET, MIF, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.78404
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 3.77451
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.77451
[BP] GO:0031347 regulation of defense response CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK 3.76718
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.75769
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.75724
[BP] GO:0051172 None APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GBA, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TRPV1, XDH 3.75652
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.73569
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, IGF1R, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.73369
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HIF1A, HSD17B2, INSR, PTGS2, SRC 3.67541
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 3.66977
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HIF1A, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCD, PTPN1, SMAD3, SRC 3.65013
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, EGFR, FLT3, INSR, KDR, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 3.63393
[BP] GO:0032268 regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.63393
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC, TERT 3.59687
[BP] GO:0044092 negative regulation of molecular function APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCD, PTGS2, PTPN1, SRC 3.56705
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, XDH 3.55201
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.53513
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 3.514
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.51334
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.48792
[BP] GO:0043434 None APEX1, FABP3, INSR, PPARA, PRKCD, PTGS2, SRC, TEK, TRPV1 3.46781
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MIF, MMP9, PRKCD, RORC, SMAD3, TRPV1 3.45524
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.44284
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PTPN1 3.43655
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 3.42569
[BP] GO:0006693 None MIF, PTGES, PTGS1, PTGS2 3.38589
[BP] GO:0006692 None MIF, PTGES, PTGS1, PTGS2 3.38589
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 3.37466
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.36193
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.34313
[BP] GO:0065007 biological regulation ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.33653
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2, SRC 3.32974
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTGS2, SRC 3.32713
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.29753
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.28124
[BP] GO:0007165 signal transduction AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HIF1A, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PRKCD, PTGES, PTPN1, RORC, SMAD3, SRC, TEK, TRPV1 3.24366
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 3.23267
[BP] GO:0044236 multicellular organism metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9, TRPV1 3.22326
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, PIK3CB, SMAD3, TRPV1 3.21734
[BP] GO:0050727 regulation of inflammatory response CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.18252
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 3.18252
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, GBA, HIF1A, PTGES, PTGS2, SRC, TRPV1 3.18191
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, EGFR, ESR1, FABP4, GBA, KDR, MET, MIF, MMP12, PPARA, PRKCD, PTGS2, SMAD3, TEK 3.17412
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCD, PTPN1 3.17412
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, ESR1, GAA, GPR35, HIF1A, PIK3CA, PIK3CB, POLA1, SMAD3, TRPV1 3.15836
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, HIF1A, KDR, POLB, TEK, TYR 3.14784
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.14784
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, POLB, PPARA, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.14781
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.13783
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.13783
[BP] GO:0031331 positive regulation of cellular catabolic process ESRRB, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PRKCD, PTPN1 3.13474
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MET, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.12603
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MAOA, MGAM, PIK3CB, SRC, XDH 3.12422
[BP] GO:0031348 negative regulation of defense response CYP19A1, GBA, MMP12, PPARA, PRKCD, SMAD3, TEK 3.09668
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.08161
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.07675
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.07172
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.06113
[BP] GO:0050728 negative regulation of inflammatory response CYP19A1, GBA, PPARA, PRKCD, SMAD3, TEK 3.05965
[BP] GO:1901575 None ACHE, AKR1B10, AOX1, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MAOA, MGAM, XDH 3.05965
[BP] GO:0045913 None ESRRB, HIF1A, INSR, PPARA, SRC 3.04484
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 3.04423
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GAA, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 3.0347
[BP] GO:1902893 None HIF1A, PPARA, SMAD3, TERT 3.03159
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.03159
[BP] GO:0071900 regulation of protein serine/threonine kinase activity DUSP3, EGFR, FLT3, GBA, IGF1R, INSR, MIF, PIK3CB, PRKCD, PTPN1, SRC 3.01783
[BP] GO:0051246 regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.01199
[BP] GO:0009611 response to wounding ACHE, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 2.9898
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD 2.97003
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA, MAOA 2.94844
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, MIF, TERT 2.94493
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 2.94465
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.94465
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, POLB, SMAD3, SRC, TEK 2.94302
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HIF1A, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 2.94019
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOA, PTGS2, SMAD3, TRPV1 2.9281
[BP] GO:0001525 angiogenesis CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.91717
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B2 2.91439
[BP] GO:1901215 negative regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.90142
[BP] GO:0009115 None AOX1, XDH 2.90142
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.90142
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.87938
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F10, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, POLB, PRKCD, PTPN1, SMAD3, SRC, TEK, TOP2A 2.87938
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, PTGS2, SRC, TRPV1, TYR 2.86125
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, HSPA1A, MAOA 2.86071
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, HIF1A, INSR, KDR, MIF, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TRPV1, XDH 2.85481
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.84554
[BP] GO:0006954 inflammatory response ALOX15, AXL, MIF, PIK3CA, PIK3CB, POLB, PTGES, PTGS1, PTGS2, TRPV1 2.84055
[BP] GO:0002376 immune system process ALOX5, APP, AXL, BCL2, FLT3, FUCA1, FUT7, GAA, HIF1A, HSPA1A, IGF1R, MGAM, MIF, MMP1, MMP9, PIK3CA, PIK3CB, POLB, PRKCD, RORC, SMAD3, SRC, TEK, TRPV1 2.82872
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.81157
[BP] GO:0060249 None AKR1B1, APEX1, BCL2, GAA, HIF1A, POLA1, SRC, TERT 2.81157
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, GBA, MIF, PTGES, PTGS1, PTGS2 2.81157
[BP] GO:0018958 None AKR1B1, BCL2, DAO, MAOA, TYR 2.80803
[BP] GO:0033135 regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, MIF, PIK3CA, PTGS2 2.79719
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, SMAD3, TRPV1 2.78633
[BP] GO:0050794 regulation of cellular process ACHE, AKR1B1, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GBA, GLO1, GPR35, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, XDH 2.78633
[BP] GO:0016042 lipid catabolic process AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.78408
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, KDR, MIF, SRC, TEK 2.77135
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.76396
[BP] GO:0002252 None ALOX5, APP, BCL2, FUCA1, FUT7, GAA, HSPA1A, MGAM, MIF, MMP9, PIK3CA, PIK3CB, PRKCD, RORC, SRC 2.75521
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, TRPV1 2.75521
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.74932
[BP] GO:0032963 collagen metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.7417
[BP] GO:0033674 positive regulation of kinase activity CDC25B, EGFR, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.73699
[BP] GO:0007623 circadian rhythm DYRK1A, EGFR, MTNR1A, MTNR1B, PPARA, RORC 2.72293
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, MIF, PIK3CB 2.72293
[BP] GO:0044070 regulation of anion transport ABCB1, CA2, CA7, MIF, PRKCD 2.72293
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.72293
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.72293
[BP] GO:0009268 None CA2, GBA, SRC, TRPV1 2.72083
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ESR1, ESR2, ESRRA, ESRRB, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.72083
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, PPARA, PRKCD, PTGS2, RORC, SRC, TEK 2.70602
[BP] GO:0001816 cytokine production APP, FABP4, HIF1A, PRKCD, PTGS2 2.70324
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, PIK3CA, PIK3CB, POLB, PRKCD, PTPN1, SRC, TEK 2.70236
[BP] GO:0051248 None APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, GBA, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 2.69676
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.68267
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, GBA, PTGS2 2.68262
[BP] GO:0010595 positive regulation of endothelial cell migration HIF1A, KDR, MET, PTGS2, TEK 2.66013
[BP] GO:0001961 None AXL, HIF1A, HSPA1A, MMP12 2.64993
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PRKCD, SRC 2.64983
[BP] GO:0006633 None ALOX15, MIF, PTGES, PTGS1, PTGS2 2.64125
[BP] GO:0044259 multicellular organismal macromolecule metabolic process HIF1A, MMP1, MMP12, MMP2, MMP9 2.64125
[BP] GO:0009888 tissue development ALOX15, ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 2.63457
[BP] GO:0032880 regulation of protein localization ACHE, APP, BCL2, CSNK2A1, EGFR, HIF1A, MIF, MMP12, MTNR1B, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TERT 2.60252
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.60252
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.60252
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.60252
[BP] GO:0070920 None EGFR, ESR1, TERT 2.60252
[BP] GO:0048546 None BCL2, EGFR, HIF1A 2.60252
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.60252
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, PRKCD, SRC 2.5998
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.58982
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, TEK, TRPV1, TYR 2.58516
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC 2.58056
[BP] GO:0010632 regulation of epithelial cell migration HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK 2.58056
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, EGFR, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 2.57003
[BP] GO:0090342 None CDK6, MIF, NUAK1, TERT 2.56175
[BP] GO:0007166 cell surface receptor signaling pathway APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PIK3CA, PIK3CB, PRKCD, PTPN1, SMAD3, SRC, TEK, TRPV1 2.56175
[BP] GO:0072330 monocarboxylic acid biosynthetic process ALOX15, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.56175
[BP] GO:0046903 None ALOX5, APP, AXL, CA2, CA9, FUCA1, GAA, HIF1A, HSPA1A, MGAM, MIF, MMP9, PRKCD, TRPV1, XDH 2.55049
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, HIF1A, MIF, MMP12, PRKCD, PTGS2, SMAD3, SRC 2.54337
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.53668
[BP] GO:2000107 negative regulation of leukocyte apoptotic process AURKB, AXL, HIF1A, MIF 2.53054
[BP] GO:0060760 None AXL, HIF1A, HSPA1A, MMP12 2.53054
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC, TERT 2.52349
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.52349
[BP] GO:0000023 None GAA, MGAM 2.52349
[BP] GO:0046110 None AOX1, XDH 2.52349
[BP] GO:0023021 None GBA, PRKCD 2.52349
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52349
[BP] GO:0090087 None ACHE, APP, CA2, EGFR, HIF1A, MIF, MMP12, MTNR1B, PRKCD, PTGS2, PTPN1, SMAD3, SRC 2.51003
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.48424
[BP] GO:0045821 None ESRRB, HIF1A, INSR 2.47633
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HIF1A, PIK3CB, PTGS2 2.4718
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.45961
[BP] GO:0070201 None ACHE, APP, BCL2, EGFR, HIF1A, MIF, MMP12, MTNR1B, PRKCD, PTGS2, PTPN1, SMAD3, SRC 2.45256
[BP] GO:0010468 regulation of gene expression APEX1, APP, AURKB, BCL2, CA9, CDK6, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HIF1A, HSPA1A, INSR, KDR, MET, MIF, MMP12, PIK3CA, PIK3CB, PIM1, POLA1, PPARA, PRKCD, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1, XDH 2.44728
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.4199
[BP] GO:0050730 None APP, EGFR, FLT3, MIF, PRKCD, PTPN1, SRC 2.41713
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.41359
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, PRKCD, SMAD3, SRC, TEK, TOP2A 2.4131
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.41303
[BP] GO:0051197 None ESRRB, HIF1A, INSR 2.41303
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.41075
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, GBA, PTGS2, SRC, TRPV1, TYR 2.41032
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.40713
[BP] GO:1904591 positive regulation of protein import APP, EGFR, PRKCD, PTGS2, SMAD3 2.38699
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.38684
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, DAO, GBA, TYR 2.38121
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.38121
[BP] GO:0010629 None APP, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HIF1A, HSPA1A, KDR, MIF, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TRPV1, XDH 2.38101
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.38062
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HIF1A, HSD17B2, MTNR1B 2.37737
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.37609
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.37609
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.37609
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.37609
[BP] GO:0048146 positive regulation of fibroblast proliferation CDK6, EGFR, ESR1, MIF 2.36384
[BP] GO:0001892 None EGFR, ESRRB, HIF1A 2.36118
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.3605
[BP] GO:0045860 positive regulation of protein kinase activity CDC25B, EGFR, FLT3, INSR, MIF, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.35281
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.34036
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.34036
[BP] GO:0071456 cellular response to hypoxia BCL2, HIF1A, PTGS2, SRC, TERT 2.32613
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, SMAD3, TRPV1 2.30498
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.30498
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.30498
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.29075
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.29075
[BP] GO:0050678 None CDK6, EGFR, HIF1A, KDR, MMP12, SMAD3, TEK, XDH 2.29075
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, PTGS2, SRC, TEK 2.28678
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.28663
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CYP1A1, DYRK1A, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, POLA1, PRKCD, SMAD3, SRC 2.28099
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.27825
[BP] GO:0098908 None GBA, GPR35 2.27825
[BP] GO:0006145 None AOX1, XDH 2.27825
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27825
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.26465
[BP] GO:0044242 None AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA 2.26169
[BP] GO:0090344 None CDK6, MIF, TERT 2.26169
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.26169
[BP] GO:1902895 None HIF1A, SMAD3, TERT 2.26169
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.26169
[BP] GO:0051194 None ESRRB, HIF1A, INSR 2.26169
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.26169
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HIF1A, INSR, PPARA, RORC, SRC 2.25032
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT 2.23759
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCD, SRC 2.23547
[BP] GO:0036294 cellular response to decreased oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.21872
[BP] GO:0051253 None APEX1, AURKB, DNMT1, DYRK1A, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TRPV1 2.21709
[BP] GO:0007610 None APP, BCL2, EGFR, GAA, HIF1A, INSR, MTNR1A, PPARA, PTGS2, TRPV1 2.21114
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.21114
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21114
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, GBA, SRC 2.20512
[BP] GO:0040008 regulation of growth APP, BCL2, CSNK2A1, EGFR, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, SMAD3 2.18848
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CA, PIK3CB, SMAD3, TRPV1 2.18848
[BP] GO:1901987 None APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, EGFR, TERT 2.18
[BP] GO:0051894 None KDR, SMAD3, TEK 2.16313
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B2 2.16313
[BP] GO:0061900 None APP, EGFR, TRPV1 2.16313
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.16313
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.15564
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, DUSP3, ESR1, HSPA1A, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PRKCD, PTPN1, SMAD3, SRC 2.15073
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 2.15071
[BP] GO:0048872 homeostasis of number of cells AXL, BCL2, FLT3, HIF1A, POLB 2.14604
[BP] GO:0050900 leukocyte migration FUT7, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.14555
[BP] GO:0043406 positive regulation of MAP kinase activity EGFR, FLT3, INSR, MIF, PIK3CB, PTPN1, SRC 2.13104
[BP] GO:0051223 None ACHE, APP, EGFR, HIF1A, MIF, MMP12, MTNR1B, PRKCD, PTGS2, PTPN1, SMAD3, SRC 2.12748
[BP] GO:0051093 None APP, BCL2, CDK6, EGFR, ESRRB, HIF1A, MIF, PPARA, SMAD3, TEK, TERT, TRPV1, XDH 2.1225
[BP] GO:0048871 multicellular organismal homeostasis AKR1B1, GBA, MET, PIK3CA, TRPV1 2.11797
[BP] GO:0046394 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.11675
[BP] GO:0016053 None ALOX15, ALOX5, CYP1A1, MIF, PTGES, PTGS1, PTGS2 2.11006
[BP] GO:0009889 regulation of biosynthetic process APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, PIM1, POLA1, PPARA, PRKCD, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.10342
[BP] GO:0043696 None CDK6, ESRRB 2.10288
[BP] GO:0043697 None CDK6, ESRRB 2.10288
[BP] GO:0098501 polynucleotide dephosphorylation APEX1, POLB 2.10288
[BP] GO:0008150 biological_process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.09284
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.08995
[BP] GO:0007569 cell aging BCL2, MIF, PRKCD, TERT 2.08995
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.08928
[BP] GO:0046466 None CYP1B1, FUCA1, GBA 2.0849
[BP] GO:1903393 None KDR, SMAD3, TEK 2.0849
[BP] GO:0050806 positive regulation of synaptic transmission APP, CA2, CA7, EGFR, PTGS2 2.0849
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.0849
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CB, SMAD3, TRPV1 2.07846
[BP] GO:0043467 regulation of generation of precursor metabolites and energy ESRRB, HIF1A, INSR, PIK3CA, PPARA 2.07062
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process APEX1, APP, AURKB, CA9, CSNK2A1, CYP1B1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, MTNR1A, PIK3CA, PIM1, POLA1, PPARA, PRKCD, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TRPV1 2.06872
[BP] GO:0090068 positive regulation of cell cycle process APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, TERT 2.05822
[BP] GO:0007584 response to nutrient ALPL, CYP1A1, EGFR, PTGS2, TRPV1, TYR 2.05645
[BP] GO:0014910 regulation of smooth muscle cell migration APEX1, BCL2, SRC, TERT 2.05168
[BP] GO:0006110 None ESRRB, HIF1A, INSR, PPARA 2.05168
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCD, PTPN1, SRC 2.05168
[BP] GO:0010575 positive regulation of vascular endothelial growth factor production CYP1B1, HIF1A, PTGS2 2.0464
[BP] GO:0032069 None HSPA1A, PRKCD, PTPN1 2.0464
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2 2.04636
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, PTGES, PTGS2, SRC 2.03721
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.03169
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, MMP12, PRKCD, PTGES, PTGS2, SMAD3, SRC 2.03148
[BP] GO:1901214 regulation of neuron death AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT 2.03001
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, GBA, MIF, PPARA, PRKCD, SMAD3, TEK 2.02282
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, MIF, PTGS2, SMAD3 2.02282
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC, TRPV1 2.02282
[BP] GO:0032269 None APP, CSNK2A1, DNMT1, DUSP3, FABP4, GBA, HSPA1A, IGF1R, MIF, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 2.01391
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.01391
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, ESR1, GPR35, HIF1A, PIK3CB, SMAD3, TRPV1 2.0138
[BP] GO:0051254 None APP, EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A 2.01159
[BP] GO:0033032 regulation of myeloid cell apoptotic process BCL2, MIF, PIK3CB 2.01159
[BP] GO:0071634 None HIF1A, PTGS2, SMAD3 2.01159
[BP] GO:0071453 cellular response to oxygen levels BCL2, HIF1A, PTGS2, SRC, TERT 2.01112
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MGAM, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 4.35657
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSD17B2, HSPA1A, INSR, KDR, MAOA, MGAM, MIF, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 3.7391
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, PTGES 3.41523
[CC] GO:0043226 organelle ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MAOA, MGAM, MIF, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 3.37858
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, MIF, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, RORC, SMAD3, SRC, TERT, TOP2A 3.1635
[CC] GO:0044446 intracellular organelle part AKR1B1, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUCA1, FUT7, GAA, GBA, HIF1A, HSD17B2, HSPA1A, INSR, MAOA, MGAM, MIF, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR 3.13783
[CC] GO:0044422 organelle part AKR1B1, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUCA1, FUT7, GAA, GBA, HIF1A, HSD17B2, HSPA1A, INSR, MAOA, MGAM, MIF, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TYR 3.13044
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GAA, GLO1, GPR35, IGF1R, INSR, KDR, MET, MGAM, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCD, PTPN1, SMAD3, SRC, TEK, TERT, TRPV1 3.05027
[CC] GO:0044428 nuclear part AKR1B1, ALOX5, AOX1, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, HSPA1A, INSR, MIF, NQO2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, RORC, SMAD3, SRC, TERT, TOP2A 2.89886
[CC] GO:0031974 None ALOX5, APP, BACE1, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PRKCD, PTGES, PTGS2 2.89886
[CC] GO:0043233 None ALOX5, APP, BACE1, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PRKCD, PTGES, PTGS2 2.89886
[CC] GO:0070013 None ALOX5, APP, BACE1, DAO, EGFR, F10, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MIF, MMP9, PRKCD, PTGES, PTGS2 2.89886
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, EGFR, ESR1, F10, FLT3, FUT7, GAA, GBA, GLO1, GPR35, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MGAM, MMP2, MTNR1A, MTNR1B, PIK3CA, PIK3CB, PIM1, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TBXAS1, TEK, TERT, TRPV1, TYR 2.70602
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.58243
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.56697
[CC] GO:0044464 cell part ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.50495
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GLO1, HIF1A, HSPA1A, IGF1R, KDR, MAOA, MMP12, MMP2, NUAK1, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH 2.35915
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCD, PTGES, SRC, TYR 2.22064
[CC] GO:0009986 cell surface ABCB1, ACHE, APP, AXL, BACE1, CA4, EGFR, MET, MIF, TEK 2.20032
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, HSD17B2, PTGES, PTGS1, PTGS2, PTPN1, TBXAS1 2.15071
[CC] GO:0070062 None ABCB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PRKCD, PTGS1, SRC 2.14357
[CC] GO:0098589 membrane region APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.12454
[CC] GO:0044421 None ABCB1, ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, DUSP3, EGFR, ESRRA, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, PRKCD, PTGS1, SRC, XDH 2.11364
[CC] GO:1903561 None ABCB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PRKCD, PTGS1, SRC 2.11324
[CC] GO:0043230 None ABCB1, AKR1B1, AKR1B10, ALPL, AOX1, APP, AXL, CA1, CA2, CA4, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MIF, MMP9, NQO2, PRKCD, PTGS1, SRC 2.112
[CC] GO:0061695 transferase complex, transferring phosphorus-containing groups CDK6, INSR, PIK3CA, PIK3CB, POLA1, TERT 2.05645
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, F10, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, SRC, TBXAS1, TEK, TERT, TOP2A, TYR, XDH 17.1844
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 15.0402
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 14.8223
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.79597
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 8.43269
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TBXAS1, TERT, TOP2A, TRPV1, TYR, XDH 8.15794
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 7.70205
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.69747
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCD, SRC, TEK, TOP2A, TRPV1 7.26942
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.96616
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 6.9008
[MF] GO:0004713 protein tyrosine kinase activity AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 6.80745
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.67213
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.26427
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PRKCD, SRC, TEK, TERT 6.25298
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCD, SRC, TEK 6.08424
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.01476
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK 5.77452
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1, POLB 5.75921
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, NQO2, POLA1, PTGES, PTGS1, PTGS2, SRC, TBXAS1, XDH 5.34206
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK 5.25958
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 5.21327
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 5.08824
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 5.08679
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.94159
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.94159
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, DAO, DYRK1A, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, PTGES, SRC, TEK, TOP2A, TRPV1, XDH 4.91923
[MF] GO:0036094 small molecule binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1, XDH 4.89869
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.84103
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MTNR1A, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 4.68742
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC, TBXAS1 4.62607
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.5212
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, XDH 4.44908
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 4.40038
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TRPV1, TYR, XDH 4.29854
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TBXAS1, TYR 4.29854
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 4.24996
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 4.2122
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, HIF1A, HSPA1A, MET, MIF, POLA1, POLB, PPARA, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 3.79066
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR, MTNR1A, NQO2 3.71964
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58228
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.46252
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.38589
[MF] GO:0044877 macromolecular complex binding ACHE, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.28723
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.26282
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCD, PTPN1, SRC, TEK 3.24388
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.18252
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 3.1348
[MF] GO:0032403 protein complex binding ACHE, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.12957
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 3.00304
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.96307
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.95347
[MF] GO:0097367 carbohydrate derivative binding ABCB1, APP, AURKB, AXL, CDK6, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, PRKCD, SRC, TEK, TOP2A, TRPV1 2.94465
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.90142
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.90142
[MF] GO:0038023 signaling receptor activity AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 2.75524
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, HIF1A, POLA1, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.70155
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, RORC 2.64125
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.61673
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, PPARA, RORC, TRPV1 2.60797
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.58982
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, HIF1A, POLA1, PRKCD, PTPN1, SMAD3, SRC, TOP2A 2.57077
[MF] GO:0008502 None MTNR1A, MTNR1B 2.52349
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.52349
[MF] GO:0032450 None GAA, MGAM 2.52349
[MF] GO:0008134 transcription factor binding APEX1, BCL2, ESR1, ESRRB, FLT3, HIF1A, PIM1, PPARA, SMAD3, SRC, TERT 2.51138
[MF] GO:0060089 molecular transducer activity AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 2.47921
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.36118
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.36118
[MF] GO:0005488 binding ABCB1, ACHE, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GAA, GBA, GLO1, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.34036
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.27825
[MF] GO:0051425 None APP, INSR 2.27825
[MF] GO:0004558 None GAA, MGAM 2.27825
[MF] GO:0004872 receptor activity AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, TEK, TRPV1 2.21114
[MF] GO:0004871 signal transducer activity AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, RORC, SMAD3, TEK, TRPV1 2.16791
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.12707
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CSNK2A1, DYRK1A, EGFR, NUAK1, PIK3CA, PIM1, PRKCD 2.11675
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.10288
[MF] GO:0043559 insulin binding IGF1R, INSR 2.10288
[MF] GO:0003674 molecular_function ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HIF1A, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MGAM, MIF, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGES, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.09284
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.0849
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.07065
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.0464
[MF] GO:0140097 None APEX1, DNMT1, POLA1, POLB, TERT, TOP2A 2.02006
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.01391
[MF] GO:0005515 protein binding ABCB1, ACHE, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PRKCD, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TRPV1, TYR, XDH 2.0138


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 8.8948
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.64
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.1523
Metabolic pathways_Homo sapiens_hsa01100 MGAM, DNMT1, MAOA, GAA, ALOX15, GBA, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, POLA1, FUT7, DAO, AKR1B10, ALOX5, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 7.9598
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 7.4338
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R 7.4769
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4769
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 6.9314
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R 6.5508
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PRKCD, BCL2, PIM1, PIK3CB 5.4023
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, PIK3CB, PTGS2, PTGS1 5.5914
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.3734
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, TBXAS1, PTGS2, PTGES, PTGS1 5.4023
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.6968
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.1453
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR 5.2662
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.6245
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.5514
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.3136
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0731
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0444
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PRKCD, PIK3CB, PPARA 4.2556
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.3052
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, ALOX15, PTGS2, PTGS1 4.254
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.254
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2552
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 4.3748
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.2365
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.8864
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.0654
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.6722
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCD, PIK3CB, TRPV1 3.4965
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.2404
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.7312
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.1816
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1, HIF1A 3.1816
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.134
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.9527
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.326
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.8841
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.3073
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.7055
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.7055
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1868
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.9821
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCD, PIK3CB 3.5664
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET, HIF1A 3.1324
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.2552
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.7352
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.5879
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCD, EGFR 2.6936
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8897
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.3171
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.6482
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.4157
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, HIF1A, EGFR 2.5498
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.4231
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, PIK3CA, SRC, PIK3CB 2.2957
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0672
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, PTGS2 2.8245
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 2.3171
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.3317
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.2792
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 4.0653
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.1875
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.1364
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.0987
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 2.0363
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, PIK3CA, TERT, PIK3CB 1.9512
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8008
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.5797
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PRKCD, PIK3CB 1.7537
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2588
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.2642
Alcoholism_Homo sapiens_hsa05034 MAOA 0.2642
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3077
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3665
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3469
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.3905
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 MTNR1A, GPR35, MTNR1B, TRPV1 1.2736
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3302
Axon guidance_Homo sapiens_hsa04360 MET 0.3592
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCD 1.3942
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA 0.3566
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCD, PIK3CB 1.8008
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3671
Lysosome_Homo sapiens_hsa04142 FUCA1, GAA, GBA 1.5198
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.3455
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCD 0.3728
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, BCL2, PIK3CB 1.5436
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.6914
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6726
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.6515
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.5151
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6501
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6735
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4154
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, INSR, PIK3CB 1.2369
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4262
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4262
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, PIK3CB, PPARA 1.0726
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8008
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.2019
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7752
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.4262
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4371
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.436
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7994
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8122
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4589
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4589
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4702
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4575
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.9555
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9662
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB, HIF1A 2.2483
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9923
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0038
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.4897
Circadian entrainment_Homo sapiens_hsa04713 MTNR1A, MTNR1B 1.0238
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4963
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5105
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.0594
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.3879
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5082
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0577
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5233
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.1295
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.0712
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1 2.1172
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1734
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5258
Amphetamine addiction_Homo sapiens_hsa05031 MAOA 0.534
Peroxisome_Homo sapiens_hsa04146 DAO, XDH 1.1087
Shigellosis_Homo sapiens_hsa05131 SRC 0.5424
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2019
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5699
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.2415
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2193
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2193
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6003
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM, PIK3CA, PIK3CB 2.5498
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 2.6949
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2734
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6267
Malaria_Homo sapiens_hsa05144 MET 0.6394
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.6394
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3386
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6467
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6415
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.3665
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.649
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA 0.6467
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6542
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6515
Arginine and proline metabolism_Homo sapiens_hsa00330 DAO, MAOA 1.4423
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6824
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7293
DNA replication_Homo sapiens_hsa03030 POLA1 0.7212
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8122
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7752
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 DAO, MAOA 1.6031
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7924
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8199
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.782
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7655
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8283
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.7496
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6863
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8122
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8492
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0156
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.2199
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0526
Other glycan degradation_Homo sapiens_hsa00511 FUCA1, GBA 2.1822
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3493
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.134


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)