TCM Prescription: Li Yan Ning Tablets



Prescription Description
Prescription IDTCMF4087
Pinyin NameLi Yan Ning Pian
Chinese Name痢炎宁片
English NameLi Yan Ning Tablets
Function Description痢疾
IndicationsDysentery disorder, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1396 Portulaca oleracea 马齿苋 TCMH1396 ITSAK4834-14
TCMH2113 Herba acalyphae 铁苋菜 TCMH2113
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH109 Pulsatilla chinensis 白头翁 TCMH109 ITSAJ4425-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT303 KCNA3 Voltage-gated potassium channel subunit Kv1.3 Ion channel P22001
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT572 EPHX1 Epoxide hydrolase 1 Hydrolase P07099
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042221 response to chemical ABCG2, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 13.0858
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 12.7934
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, ESRRA, FLT3, RORC, SLC6A3, SRC, TEK, TYR 11.5873
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SLC6A3, SRC, TEK, TYR 11.0737
[BP] GO:0065008 regulation of biological quality ABCG2, ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, MIF, PPARA, SLC6A2, SLC6A3, SMAD3, SRC, TEK, XDH 9.43744
[BP] GO:0010647 positive regulation of cell communication ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.4075
[BP] GO:0023056 positive regulation of signaling ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 9.40642
[BP] GO:0044237 cellular metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP2, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 9.01596
[BP] GO:0048518 positive regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 8.86643
[BP] GO:0042127 regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, XDH 8.79424
[BP] GO:0048522 positive regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 8.79424
[BP] GO:0008152 metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 8.69587
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, PPARA, SRC, TEK 8.64886
[BP] GO:1902531 regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 8.6207
[BP] GO:0050896 response to stimulus ABCG2, ACHE, ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, EPHX2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 8.48609
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 8.43126
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, SLC6A3, SRC 8.07544
[BP] GO:0009967 positive regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 8.07544
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.93518
[BP] GO:0032501 multicellular organismal process ADRA2A, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESRRB, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 7.93518
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EPHX1, EPHX2, KDR, SLC6A3, SRC 7.89766
[BP] GO:0044281 small molecule metabolic process ABCG2, AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX1, EPHX2, FABP3, FUT7, GLO1, HSPA1A, MIF, PIM1, PPARA, TYR, XDH 7.7433
[BP] GO:1902533 positive regulation of intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, DRD2, DRD4, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, PTPN1, SRC, TEK, XDH 7.71058
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, AKR1C3, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, PIM1, TEK 7.58807
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.44101
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.38359
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 7.31649
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 7.11017
[BP] GO:0048584 positive regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESRRA, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 7.03591
[BP] GO:0010646 regulation of cell communication ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 7.03057
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD17B2, INSR, KDR, MET, MIF, MMP2, MMP9, PIM1, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR 7.03057
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, EPHX2, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, MIF, PPARA 7.01638
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.92323
[BP] GO:0023051 regulation of signaling ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 6.91386
[BP] GO:0042592 homeostatic process ABCG2, ADRA2A, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 6.8669
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 6.81122
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, RORC, SRC, TOP2A 6.66313
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX2, HSPA1A, SLC6A3 6.53771
[BP] GO:0048523 negative regulation of cellular process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.47654
[BP] GO:0048878 chemical homeostasis ABCG2, ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 6.4424
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.40198
[BP] GO:0042493 response to drug ABCG2, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, KDR, SLC6A2, SLC6A3, SRC 6.40198
[BP] GO:0019220 regulation of phosphate metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.37428
[BP] GO:0051174 regulation of phosphorus metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.31766
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 6.2349
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MET, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.21511
[BP] GO:0048583 regulation of response to stimulus ADRA2A, ADRA2C, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 6.18096
[BP] GO:0009893 positive regulation of metabolic process ADRA2A, ADRA2C, AKR1C3, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.17502
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.05279
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC, TOP2A 5.97271
[BP] GO:0032879 regulation of localization ACHE, ADRA2A, ADRA2C, APEX1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, GPR35, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.97176
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.91815
[BP] GO:0010648 negative regulation of cell communication ACHE, ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 5.90716
[BP] GO:0023057 negative regulation of signaling ACHE, ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 5.88982
[BP] GO:0048519 negative regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 5.81349
[BP] GO:0031325 positive regulation of cellular metabolic process ADRA2A, ADRA2C, AKR1C3, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.79755
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, DRD2, DRD3, EGFR, INSR, MET, SRC, TEK, XDH 5.79755
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.75328
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.75328
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 5.75328
[BP] GO:0071704 organic substance metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 5.73412
[BP] GO:0009966 regulation of signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 5.68057
[BP] GO:0048585 negative regulation of response to stimulus ADRA2A, BCL2, CYP19A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, XDH 5.60465
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 5.60465
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, AKR1C3, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 5.60465
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.59253
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.54233
[BP] GO:0045937 positive regulation of phosphate metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 5.54233
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 5.49857
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 5.43888
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 5.4361
[BP] GO:0030334 regulation of cell migration ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.4184
[BP] GO:0040012 regulation of locomotion ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.3805
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALPL, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 5.32027
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 5.29068
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD17B1, HSD17B2 5.27898
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.25656
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.24069
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.18492
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, INSR, SLC6A2, SLC6A3, SMAD3 5.17925
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, SLC6A3, TYR 5.155
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SLC6A3, SRC, TEK, TYR 5.12078
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA 5.12078
[BP] GO:0010817 regulation of hormone levels ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HSD17B1, HSD17B2 5.12078
[BP] GO:2000145 regulation of cell motility ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 5.11635
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 5.11635
[BP] GO:0043410 positive regulation of MAPK cascade ADRA2A, ADRA2C, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.11307
[BP] GO:0043408 regulation of MAPK cascade ADRA2A, ADRA2C, DRD2, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MIF, PTPN1, SRC, TEK, XDH 5.0813
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTPN1, SRC, XDH 5.06175
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, EPHX2, FABP3, FABP4, FUT7, MET, MIF, PPARA 4.97175
[BP] GO:0042325 regulation of phosphorylation ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PPARA, PTPN1, SRC, TEK, XDH 4.94043
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.9375
[BP] GO:1901564 organonitrogen compound metabolic process ABCG2, ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.91987
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 4.90218
[BP] GO:0042327 positive regulation of phosphorylation ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.83446
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX1, EPHX2, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SLC6A3, SRC, XDH 4.82802
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, HSPA1A, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A3, SMAD3, SRC, TEK 4.82242
[BP] GO:0019216 regulation of lipid metabolic process ADRA2A, AKR1C3, CYP1A1, DRD3, EPHX2, FABP3, FLT3, PPARA, RORC, SRC, TEK 4.82242
[BP] GO:0051049 regulation of transport ACHE, ADRA2A, ADRA2C, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, HSPA1A, INSR, KCNA3, MIF, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.73914
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, MIF, SRC 4.73757
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 4.72529
[BP] GO:0051270 regulation of cellular component movement ADRA2A, APEX1, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, IGF1R, INSR, KDR, MET, MIF, MMP9, SMAD3, SRC, TEK 4.69822
[BP] GO:0050801 ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, FABP3, GPR35, SMAD3 4.67836
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD2, DUSP3, EGFR, EPHX2, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, XDH 4.6178
[BP] GO:0044092 negative regulation of molecular function ADRA2A, AURKB, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.59153
[BP] GO:0080134 regulation of response to stress ADRA2A, CYP19A1, DRD2, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.51143
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.50746
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 4.50584
[BP] GO:0065009 regulation of molecular function ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MIF, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.44682
[BP] GO:0010038 response to metal ion AKR1C3, BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, SLC6A3 4.4036
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.4036
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.39884
[BP] GO:0001934 positive regulation of protein phosphorylation ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.39884
[BP] GO:0080090 regulation of primary metabolic process ADRA2A, ADRA2C, AKR1C3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 4.3551
[BP] GO:0050790 regulation of catalytic activity ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 4.3551
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.29873
[BP] GO:0043549 regulation of kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 4.25585
[BP] GO:0001932 regulation of protein phosphorylation ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 4.25585
[BP] GO:0043405 regulation of MAP kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 4.17715
[BP] GO:0009987 cellular process ABCG2, ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 4.15373
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.14817
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.14305
[BP] GO:0019222 regulation of metabolic process ACHE, ADRA2A, ADRA2C, AKR1C3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 4.14305
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.14305
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 4.14305
[BP] GO:0098771 inorganic ion homeostasis ABCG2, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 4.11638
[BP] GO:0009892 negative regulation of metabolic process ADRA2A, AKR1C3, APEX1, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 4.08791
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.08498
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, RORC, SRC 4.08498
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.08498
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 4.08498
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA 4.06382
[BP] GO:0051338 regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC, TEK 4.05739
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, MIF, PIM1, SRC, TEK, TYR 4.05336
[BP] GO:0033674 positive regulation of kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 4.05202
[BP] GO:0044093 positive regulation of molecular function ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, MET, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 4.03327
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TOP2A 4.02676
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.99168
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, SMAD3, SRC, TOP2A 3.98254
[BP] GO:0032101 regulation of response to external stimulus CYP19A1, DRD2, DRD3, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, SLC6A3, SMAD3, TEK 3.97356
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.97327
[BP] GO:0043271 negative regulation of ion transport ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 3.96739
[BP] GO:0031399 regulation of protein modification process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.9485
[BP] GO:0045859 regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 3.94431
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.94011
[BP] GO:0051247 positive regulation of protein metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.93327
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, EPHX2 3.93173
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR, XDH 3.90685
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.87413
[BP] GO:0051347 positive regulation of transferase activity ADRA2A, ADRA2C, AURKB, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, MIF, PTPN1, SRC, TEK 3.87383
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AKR1C3, APEX1, AURKB, BCL2, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 3.85755
[BP] GO:0032844 regulation of homeostatic process ADRA2A, AURKB, BCL2, CA2, CA7, DRD2, DRD3, EGFR, KDR, MIF, SRC 3.8455
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.8283
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.82508
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 3.80994
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, MIF, PPARA 3.80994
[BP] GO:0051239 regulation of multicellular organismal process ADRA2A, ADRA2C, AXL, BCL2, CA2, CHRM2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, GPR35, HSPA1A, INSR, KDR, MET, MIF, MMP12, MMP9, PIM1, SLC6A3, SMAD3, SRC, TEK, XDH 3.80056
[BP] GO:0022414 reproductive process ADRA2C, AKR1B1, AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, MMP2, MMP9, SRC, TOP2A 3.7985
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADRA2A, ADRA2C, AKR1C3, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.7985
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, INSR, MET, SRC, TEK 3.79558
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.7568
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EPHX2 3.74922
[BP] GO:0042752 None DRD2, DRD3, DRD4, PPARA, RORC, TOP2A 3.74922
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, MIF 3.74766
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.73228
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 3.7212
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MIF, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.71027
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.71027
[BP] GO:0051050 positive regulation of transport ACHE, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, INSR, MIF, MMP12, SMAD3, SRC 3.71027
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.70504
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, EPHX2 3.66678
[BP] GO:0045860 positive regulation of protein kinase activity ADRA2A, ADRA2C, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, MIF, PTPN1, SRC 3.5763
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.5763
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.5763
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.5763
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.5763
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.5763
[BP] GO:0006950 response to stress ACHE, AKR1B1, AKR1C3, APEX1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, EPHX2, HSPA1A, MIF, MMP2, MMP9, NUAK1, PPARA, PTPN1, SLC6A2, SMAD3, SRC, TEK, TOP2A 3.5763
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.57374
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.57195
[BP] GO:0043085 positive regulation of catalytic activity ADRA2A, ADRA2C, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, FLT3, HSPA1A, INSR, MIF, PTPN1, SMAD3, SRC, TEK, XDH 3.57057
[BP] GO:0055080 cation homeostasis ABCG2, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 3.55432
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.55432
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 3.5493
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 3.54076
[BP] GO:0009628 response to abiotic stimulus AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 3.53797
[BP] GO:0007165 signal transduction ADRA2A, ADRA2C, AKR1B1, AKR1C3, AXL, BCL2, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK 3.51657
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.51352
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.51352
[BP] GO:0050708 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 3.50794
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP1A1, DRD2, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, MET, MIF, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TOP2A 3.45155
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.43876
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, EPHX1, EPHX2, RORC 3.43876
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.43634
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.42779
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, DRD4, GPR35 3.42779
[BP] GO:0009611 response to wounding ACHE, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.41245
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.41174
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADRA2A, ADRA2C, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.38785
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 3.36966
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADRA2A, ADRA2C, APEX1, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP12, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, XDH 3.36869
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.36362
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 3.36176
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 3.36176
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 3.36176
[BP] GO:0051172 None ADRA2A, APEX1, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 3.35837
[BP] GO:0031347 regulation of defense response CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.34219
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1 3.32228
[BP] GO:0043406 positive regulation of MAP kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, MIF, PTPN1, SRC 3.31693
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, DRD4 3.31693
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.31693
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.31693
[BP] GO:0002791 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 3.30932
[BP] GO:0065007 biological regulation ABCG2, ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 3.30497
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.29272
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, DRD4, PPARA 3.27679
[BP] GO:0031401 positive regulation of protein modification process ADRA2A, ADRA2C, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, INSR, KDR, MIF, MMP9, PTPN1, SRC, TEK, XDH 3.27679
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.27587
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC 3.26389
[BP] GO:0030003 cellular cation homeostasis ABCG2, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.26276
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 3.26178
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, AKR1C3, APEX1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 3.26011
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, DRD4, PPARA 3.25788
[BP] GO:0032148 None ADRA2A, ADRA2C, INSR, SRC 3.23425
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, DRD4 3.23425
[BP] GO:0090087 None ACHE, ADRA2A, ADRA2C, CA2, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, PTPN1, SMAD3, SRC 3.2319
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DRD2, DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 3.2319
[BP] GO:0035556 intracellular signal transduction ADRA2A, ADRA2C, AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD3, EGFR, IGF1R, INSR, KDR, MET, MIF, NUAK1, PTPN1, SRC, TEK 3.22627
[BP] GO:0034776 None DRD2, DRD3, DRD4 3.21079
[BP] GO:0006873 cellular ion homeostasis ABCG2, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 3.18097
[BP] GO:0032102 negative regulation of response to external stimulus CYP19A1, DRD2, DRD3, MIF, PPARA, SLC6A3, SMAD3, TEK 3.18097
[BP] GO:0070201 None ACHE, ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, PTPN1, SMAD3, SRC 3.17242
[BP] GO:0007193 None ADRA2A, CHRM2, DRD2, DRD3, DRD4 3.16291
[BP] GO:0051952 None ADRA2A, ADRA2C, DRD2, DRD3, DRD4 3.16291
[BP] GO:0001775 cell activation ADRA2A, ADRA2C, ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MIF, MMP9, RORC, SMAD3, SRC 3.15902
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.15654
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, DRD4 3.155
[BP] GO:0032787 None AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PPARA 3.13263
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A 3.1184
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.11113
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, MIF 3.07048
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 3.06964
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, DRD2, MMP2, PPARA, SMAD3, SRC, TEK 3.06964
[BP] GO:0050793 regulation of developmental process ADRA2C, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, INSR, KDR, MIF, NUAK1, PIM1, PPARA, RORC, SLC6A3, SMAD3, SRC, TEK, XDH 3.03395
[BP] GO:1901020 None ADRA2A, DRD2, DRD4, GPR35 3.0303
[BP] GO:0043269 regulation of ion transport ADRA2A, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, KCNA3, MIF, MMP9 3.02037
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.02037
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 3.02037
[BP] GO:0033604 None ADRA2A, ADRA2C, DRD2 3.02037
[BP] GO:0016488 None AKR1B10, AKR1C3 3.02037
[BP] GO:0016487 None AKR1B10, AKR1C3 3.02037
[BP] GO:0016107 None AKR1B10, AKR1C3 3.02037
[BP] GO:0009115 None AOX1, XDH 3.02037
[BP] GO:0006714 None AKR1B10, AKR1C3 3.02037
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.99099
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADRA2A, DRD4, DUSP3, EGFR, FLT3, IGF1R, INSR, MIF, PTPN1, SRC 2.98408
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.97697
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.95543
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.95215
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.95004
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A 2.93583
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.93435
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.93435
[BP] GO:0071248 cellular response to metal ion AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.92187
[BP] GO:0006807 nitrogen compound metabolic process ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 2.9144
[BP] GO:0032268 regulation of cellular protein metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.90745
[BP] GO:1903170 None ADRA2A, DRD2, DRD4, GPR35 2.90002
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.90002
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, ADRA2C, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, PTPN1, SMAD3, SRC 2.88283
[BP] GO:0032147 activation of protein kinase activity ADRA2A, ADRA2C, DRD2, DRD4, EGFR, INSR, PTPN1, SRC 2.88111
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.8733
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, SMAD3, XDH 2.87166
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, DRD4 2.86725
[BP] GO:0022898 None ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 2.86725
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 2.84116
[BP] GO:0050730 None ADRA2A, ADRA2C, EGFR, FLT3, MIF, PTPN1, SRC 2.83393
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD4 2.83393
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, EGFR, FLT3, SRC 2.83223
[BP] GO:0003018 None ADRA2A, ADRA2C, EGFR, EPHX2, SRC, TEK 2.83223
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.82063
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.82034
[BP] GO:0007188 None ADRA2A, ADRA2C, CHRM2, DRD2, DRD3, DRD4 2.82034
[BP] GO:1900542 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 2.80917
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, DRD4 2.806
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIM1, SLC6A3, SMAD3 2.80028
[BP] GO:0055082 cellular chemical homeostasis ABCG2, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.80028
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.79677
[BP] GO:0009894 regulation of catabolic process ADRA2A, APEX1, BCL2, CSNK2A1, EGFR, ESRRB, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.79158
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.79158
[BP] GO:0032225 None DRD2, DRD3, DRD4 2.79158
[BP] GO:0051223 None ACHE, ADRA2A, ADRA2C, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, PTPN1, SMAD3, SRC 2.78879
[BP] GO:0050433 None ADRA2A, ADRA2C, DRD2, DRD3 2.7812
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.77474
[BP] GO:0019725 cellular homeostasis ABCG2, APEX1, BCL2, CA2, CA7, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.77083
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.77047
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.75202
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, DRD4 2.75202
[BP] GO:0055065 metal ion homeostasis ABCG2, BCL2, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, GPR35, SMAD3 2.7515
[BP] GO:0006140 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, INSR, PPARA 2.75098
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.74192
[BP] GO:0032409 None ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, MMP9 2.74192
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.72472
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, DRD4 2.72472
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, DRD4 2.72472
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EPHX1, EPHX2, FABP3, FABP4, HSPA1A, SLC6A3, SRC, XDH 2.71954
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD2, DRD3, DRD4, GPR35, KCNA3, MMP9 2.71954
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, CYP1A1, CYP1A2, CYP1B1, EPHX2 2.70064
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, DRD4 2.69448
[BP] GO:0051704 multi-organism process ADRA2C, AXL, BCL2, CHRM2, CYP1A1, DRD3, DRD4, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC 2.69214
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.68691
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.68691
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.68691
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.68691
[BP] GO:0032870 cellular response to hormone stimulus ADRA2A, AKR1C3, APEX1, EGFR, ESR1, FLT3, INSR, SRC 2.66887
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.66844
[BP] GO:1903530 regulation of secretion by cell ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 2.6668
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.66407
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.65175
[BP] GO:0031348 negative regulation of defense response CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.65024
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.65024
[BP] GO:1900673 olefin metabolic process CYP1A1, EPHX2 2.65024
[BP] GO:0051944 None DRD2, DRD4 2.65024
[BP] GO:0046110 None AOX1, XDH 2.65024
[BP] GO:0060160 None DRD2, DRD3 2.65024
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.65024
[BP] GO:0051586 None DRD2, DRD4 2.65024
[BP] GO:0016095 None AKR1B10, AKR1C3 2.65024
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.64428
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.63895
[BP] GO:0045927 positive regulation of growth BCL2, CSNK2A1, DRD2, EGFR, INSR, PIM1, SLC6A3 2.63768
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADRA2A, ADRA2C, FLT3, MIF, PTPN1, SRC 2.63685
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.62799
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADRA2A, DRD4, EGFR, FLT3, INSR, MIF, PTPN1, SRC 2.62631
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.61861
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.61861
[BP] GO:0006082 organic acid metabolic process ABCG2, AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.61164
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.60445
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.60445
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.60026
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.58845
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR 2.58845
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.58218
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.57927
[BP] GO:0045934 None ADRA2A, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC 2.57389
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.56307
[BP] GO:0071880 None ADRA2A, ADRA2C, DRD2 2.56307
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.5525
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.52436
[BP] GO:0007187 None ADRA2A, ADRA2C, CHRM2, DRD2, DRD3, DRD4 2.52436
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.52193
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, IGF1R, PPARA, PTPN1, XDH 2.51337
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.50933
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, IGF1R, PPARA, PTPN1, XDH 2.50933
[BP] GO:0051128 regulation of cellular component organization AURKB, AXL, BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK, TOP2A 2.4898
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.47967
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, DRD4, FABP3, KCNA3, PPARA, SLC6A2, SLC6A3 2.47513
[BP] GO:0090068 positive regulation of cell cycle process APEX1, AURKB, CDC25B, CYP1A1, DRD2, DRD3, INSR 2.47453
[BP] GO:0006875 cellular metal ion homeostasis ABCG2, BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.45413
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.45024
[BP] GO:0051046 None ACHE, ADRA2A, ADRA2C, CYP19A1, DRD2, DRD3, DRD4, EGFR, MIF, MMP12, SRC 2.43989
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.42646
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD4 2.42646
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.4164
[BP] GO:0051254 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.4163
[BP] GO:0051047 None ACHE, CYP19A1, DRD2, DRD3, EGFR, MIF, MMP12, SRC 2.4163
[BP] GO:0051246 regulation of protein metabolic process ADRA2A, ADRA2C, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.4163
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, SRC 2.4163
[BP] GO:0031327 None ADRA2A, AKR1C3, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC 2.4163
[BP] GO:0035625 None ADRA2A, ADRA2C 2.4163
[BP] GO:0032811 None ADRA2A, ADRA2C 2.4163
[BP] GO:0006145 None AOX1, XDH 2.4163
[BP] GO:0097176 epoxide metabolic process EPHX1, EPHX2 2.4163
[BP] GO:0051582 None DRD2, DRD4 2.4163
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.4163
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD4 2.4163
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.4163
[BP] GO:0051953 None ADRA2A, ADRA2C, DRD2 2.4163
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.4163
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.4163
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.4163
[BP] GO:0051051 negative regulation of transport ADRA2A, ADRA2C, BCL2, DRD2, DRD3, DRD4, GPR35, HSPA1A, MMP9 2.40725
[BP] GO:0016311 None ALPL, APEX1, BCL2, CDC25B, DUSP3, EPHX2, PTPN1 2.40652
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MET, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.40614
[BP] GO:0050806 positive regulation of synaptic transmission CA2, CA7, DRD2, DRD4, EGFR 2.40532
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.40532
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade DRD2, EGFR, KDR, MIF, SRC, TEK 2.39171
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.37442
[BP] GO:0051894 None KDR, SMAD3, TEK 2.37078
[BP] GO:0071875 None ADRA2A, ADRA2C, DRD2 2.37078
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37078
[BP] GO:0009890 None ADRA2A, AKR1C3, APEX1, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC 2.37034
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.35535
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.35373
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1 2.35373
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.34965
[BP] GO:0001819 positive regulation of cytokine production ADRA2A, CYP1B1, DRD2, HSPA1A, MIF, MMP12, SMAD3, SRC 2.34377
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD17B1, HSD17B2 2.33513
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, EPHX2, ESR1, GPR35, SMAD3 2.32378
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.31236
[BP] GO:0003013 None ADRA2A, ADRA2C, EGFR, EPHX2, SRC, TEK 2.31236
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.31236
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, SLC6A3 2.31047
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MIF, MMP9, NUAK1, PTPN1, SRC, TOP2A 2.30879
[BP] GO:0045913 None ESRRB, INSR, PPARA, SRC 2.28895
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.28895
[BP] GO:0032309 None DRD2, DRD3, DRD4 2.28464
[BP] GO:1903393 None KDR, SMAD3, TEK 2.28464
[BP] GO:0001975 None DRD2, DRD3, DRD4 2.28464
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR 2.28148
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, CA2, CA7, DRD2, DRD3, DRD4, EGFR 2.28148
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MIF, MMP1, MMP12, MMP9, SRC, TEK 2.27086
[BP] GO:0015718 None DRD2, DRD3, DRD4, FABP3, PPARA 2.25716
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MIF, MMP9, PTPN1, SRC 2.25716
[BP] GO:0003008 None ADRA2A, ADRA2C, AKR1B1, AKR1C3, BCL2, CYP1B1, DRD2, DRD3, EGFR, EPHX2, INSR, SLC6A3, SRC, TEK, TYR 2.24217
[BP] GO:0035624 None ADRA2A, ADRA2C 2.24217
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.24217
[BP] GO:0090325 None DRD2, DRD3 2.24217
[BP] GO:0014060 None ADRA2A, ADRA2C 2.24217
[BP] GO:1901575 None ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, FABP4, FUT7, HSPA1A, SLC6A3, XDH 2.23611
[BP] GO:0035239 tube morphogenesis BCL2, EGFR, ESR1, MET, SMAD3, SRC 2.2222
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.21327
[BP] GO:0007189 None ADRA2A, ADRA2C, DRD2, DRD3 2.21327
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.21081
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC 2.21081
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.1934
[BP] GO:0071383 None AKR1C3, EGFR, FLT3, SRC 2.17385
[BP] GO:0045893 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.17221
[BP] GO:1903508 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.17221
[BP] GO:1902680 None DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TOP2A 2.17089
[BP] GO:0071715 None DRD2, DRD3, DRD4 2.17089
[BP] GO:1901571 None DRD2, DRD3, DRD4 2.17089
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX5, CYP1A1, CYP1A2, CYP1B1, EPHX2, FABP3, GLO1, MIF, PIM1, PPARA, TYR 2.16433
[BP] GO:0032412 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 2.16418
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.13977
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.13977
[BP] GO:0051094 positive regulation of developmental process ADRA2C, AXL, BCL2, CA2, CYP1B1, DRD2, ESRRB, INSR, KDR, PIM1, SLC6A3, SMAD3, SRC, TEK 2.13615
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.13449
[BP] GO:1901661 None AKR1B1, AKR1B10, AKR1C3 2.13449
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.13449
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.13449
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CYP1A1, EGFR, SRC, TYR 2.13111
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB 2.13111
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR 2.13111
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, MIF 2.12367
[BP] GO:0032845 None ADRA2A, BCL2, DRD2, MIF, SRC 2.11988
[BP] GO:0010605 negative regulation of macromolecule metabolic process APEX1, AURKB, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MIF, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, XDH 2.11362
[BP] GO:0010760 negative regulation of macrophage chemotaxis CYP19A1, MIF 2.11362
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.11362
[BP] GO:0046113 None AOX1, XDH 2.11362
[BP] GO:0032415 None DRD3, DRD4 2.11362
[BP] GO:0051934 None SLC6A2, SLC6A3 2.11362
[BP] GO:0021984 None DRD2, SLC6A3 2.11362
[BP] GO:0090494 None SLC6A2, SLC6A3 2.11362
[BP] GO:0090493 None SLC6A2, SLC6A3 2.11362
[BP] GO:0051583 None SLC6A2, SLC6A3 2.11362
[BP] GO:0016115 None AKR1B10, AKR1C3 2.11362
[BP] GO:0042220 None DRD2, DRD3, SLC6A3 2.11362
[BP] GO:1901890 None KDR, SMAD3, TEK 2.11362
[BP] GO:0009410 None DRD2, DRD3, DRD4, EGFR, SLC6A3 2.10976
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.1026
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CYP1A1, MIF, SLC6A3 2.10178
[BP] GO:0009889 regulation of biosynthetic process ADRA2A, AKR1C3, APEX1, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, RORC, SMAD3, SRC, TOP2A 2.07663
[BP] GO:0040018 None BCL2, DRD2, SLC6A3 2.07663
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, DRD2 2.07663
[BP] GO:0008217 None DRD2, DRD3, EPHX2, PPARA, SMAD3 2.07404
[BP] GO:0009896 positive regulation of catabolic process ADRA2A, CSNK2A1, ESRRB, HSPA1A, INSR, KDR, PPARA, PTPN1 2.07115
[BP] GO:0007166 cell surface receptor signaling pathway AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MIF, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.06912
[BP] GO:0019932 second-messenger-mediated signaling ADRA2A, ADRA2C, DRD2, DRD3, EGFR, KDR 2.06912
[BP] GO:0050714 None ACHE, DRD2, EGFR, MIF, MMP12, SRC 2.06912
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.06912
[BP] GO:0001763 morphogenesis of a branching structure BCL2, DRD2, ESR1, MET, SRC 2.0651
[BP] GO:0050789 regulation of biological process ACHE, ADRA2A, ADRA2C, AKR1B1, AKR1C3, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, IGF1R, INSR, KCNA3, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.05989
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.05161
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.05161
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.0462
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, EPHX2, HSPA1A, SLC6A3, XDH 2.0207
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3 2.01511
[BP] GO:0051098 regulation of binding AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 2.00958
[CC] GO:0005886 plasma membrane ABCG2, ACHE, ADRA2A, ADRA2C, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, FLT3, GLO1, GPR35, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A3, SMAD3, SRC, TEK 3.51657
[CC] GO:0045121 membrane raft EGFR, INSR, KCNA3, KDR, SLC6A2, SLC6A3, SRC, TEK 3.04958
[CC] GO:0098857 membrane microdomain EGFR, INSR, KCNA3, KDR, SLC6A2, SLC6A3, SRC, TEK 3.03119
[CC] GO:0044459 plasma membrane part ABCG2, ADRA2A, ADRA2C, AXL, CA2, CA4, CA9, CHRM2, DRD2, DRD3, DRD4, DUSP3, EGFR, FLT3, GPR35, IGF1R, INSR, KCNA3, KDR, MET, SLC6A2, SLC6A3, SRC, TEK 2.95004
[CC] GO:0031226 intrinsic component of plasma membrane ADRA2A, ADRA2C, AXL, CA4, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, TEK 2.91669
[CC] GO:0005887 integral component of plasma membrane ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, FLT3, GPR35, IGF1R, INSR, KDR, MET, SLC6A2, SLC6A3, TEK 2.64323
[CC] GO:0098589 membrane region EGFR, INSR, KCNA3, KDR, SLC6A2, SLC6A3, SRC, TEK 2.60567
[CC] GO:0016323 basolateral plasma membrane ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.49033
[CC] GO:0009986 cell surface ACHE, AXL, CA4, EGFR, MET, MIF, SLC6A2, SLC6A3, TEK 2.17221
[CC] GO:0043227 membrane-bounded organelle ABCG2, ACHE, ADRA2C, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DUSP3, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HSPA1A, IGF1R, INSR, KDR, MIF, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TOP2A, TYR, XDH 2.12187
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.11362
[CC] GO:0098590 plasma membrane region ABCG2, ADRA2A, CA2, CA4, CA9, CHRM2, DRD2, EGFR, INSR, MET, SRC, TEK 2.07426
[CC] GO:0016020 membrane ABCG2, ACHE, ADRA2A, ADRA2C, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX1, ESR1, FLT3, FUT7, GLO1, GPR35, HSD17B2, IGF1R, INSR, KCNA3, KDR, MET, MMP2, PIM1, PTPN1, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TYR 2.04648
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH 12.7934
[MF] GO:0043167 ion binding ABCG2, ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, EPHX2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, SRC, TEK, TOP2A, TYR, XDH 11.6699
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.88338
[MF] GO:0003824 catalytic activity ABCG2, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, EPHX1, EPHX2, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MIF, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP2A, TYR, XDH 8.79424
[MF] GO:0008144 drug binding ABCG2, ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SLC6A3, SRC, TEK, TOP2A 7.71058
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, TOP2A, TYR, XDH 7.43552
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.38359
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 7.38359
[MF] GO:1901338 None ADRA2A, ADRA2C, DRD2, DRD3, DRD4, SLC6A3 7.33713
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.82694
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.66313
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.33031
[MF] GO:0042802 identical protein binding ABCG2, ACHE, ADRA2A, ADRA2C, AOX1, BCL2, CSNK2A1, DRD2, DRD4, EGFR, EPHX2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MIF, MMP9, SMAD3, TOP2A, TYR, XDH 5.60465
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EPHX2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A2, SLC6A3, SMAD3, TOP2A, TYR, XDH 5.53529
[MF] GO:0044877 macromolecular complex binding ACHE, ADRA2A, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SMAD3, SRC 5.50021
[MF] GO:0038023 signaling receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.50001
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.3067
[MF] GO:0032403 protein complex binding ACHE, ADRA2A, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SMAD3, SRC 5.27981
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.26345
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.25896
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.25896
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.84105
[MF] GO:0004872 receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.74631
[MF] GO:0004871 signal transducer activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 4.71279
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.69822
[MF] GO:0060089 molecular transducer activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 4.54796
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 4.27375
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 4.09758
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 4.05739
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, HSD17B1, HSD17B2, XDH 4.05202
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.01727
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.80994
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.79689
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.67072
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.60561
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SLC6A3, SMAD3 3.60561
[MF] GO:0051379 None ADRA2A, ADRA2C, DRD4 3.5763
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.5763
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.43634
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.35837
[MF] GO:0042803 protein homodimerization activity ABCG2, ACHE, ADRA2A, ADRA2C, AOX1, BCL2, DRD2, EPHX2, FLT3, SMAD3, TOP2A, TYR, XDH 3.31693
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3 3.23319
[MF] GO:0005102 receptor binding ADRA2A, ADRA2C, DRD2, DRD3, EGFR, EPHX2, ESR1, ESR2, FLT3, HSPA1A, IGF1R, INSR, KDR, MIF, PTPN1, SLC6A3, SMAD3, SRC 3.16401
[MF] GO:0004952 None DRD2, DRD3, DRD4 3.10727
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.02037
[MF] GO:0045550 None AKR1B10, AKR1C3 3.02037
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 3.02037
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.96921
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.83393
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.83223
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, ESR2, ESRRB, HSPA1A, MET, MIF, PPARA, PTPN1, SLC6A3, SMAD3, SRC, TEK, TOP2A 2.80538
[MF] GO:0004935 None ADRA2A, ADRA2C, DRD2 2.79158
[MF] GO:0097159 organic cyclic compound binding ABCG2, ADRA2A, ADRA2C, AOX1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PPARA, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TOP2A, XDH 2.75202
[MF] GO:0047718 None AKR1B10, AKR1C3 2.65024
[MF] GO:0004938 None ADRA2A, ADRA2C 2.65024
[MF] GO:0005330 None SLC6A2, SLC6A3 2.65024
[MF] GO:0099600 transmembrane receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.63895
[MF] GO:0004888 transmembrane signaling receptor activity ADRA2A, ADRA2C, AXL, CHRM2, DRD2, DRD3, DRD4, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 2.63895
[MF] GO:0046983 protein dimerization activity ABCG2, ACHE, ADRA2A, ADRA2C, AOX1, AXL, BCL2, DRD2, EGFR, EPHX2, FLT3, SMAD3, TOP2A, TYR, XDH 2.62458
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.58845
[MF] GO:0008227 None ADRA2A, ADRA2C, CHRM2, DRD2 2.52436
[MF] GO:0005524 ATP binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.43989
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.43678
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, MET, PTPN1, SLC6A3 2.42981
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, HSD17B1, HSD17B2 2.4164
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.4163
[MF] GO:0046982 protein heterodimerization activity ADRA2A, ADRA2C, AXL, BCL2, DRD2, EGFR, SMAD3, TOP2A, TYR 2.40532
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.39762
[MF] GO:0032559 adenyl ribonucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.35643
[MF] GO:0030554 adenyl nucleotide binding ABCG2, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A 2.32917
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.30921
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.28464
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.28464
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD17B1, HSD17B2 2.24217
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.24217
[MF] GO:0043559 insulin binding IGF1R, INSR 2.24217
[MF] GO:0051380 None ADRA2A, DRD4 2.24217
[MF] GO:0019900 None ADRA2A, AURKB, CDC25B, DUSP3, EGFR, ESR1, PTPN1, SMAD3, SRC, TOP2A 2.21327
[MF] GO:0051721 None BCL2, PTPN1, SLC6A3 2.20626
[MF] GO:0000166 nucleotide binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.19226
[MF] GO:1901265 nucleoside phosphate binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.19038
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.18533
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD17B1, HSD17B2 2.17089
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.17089
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HSD17B1, PPARA, RORC 2.13977
[MF] GO:0036094 small molecule binding ABCG2, AOX1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 2.11988
[MF] GO:0005329 None SLC6A2, SLC6A3 2.11362
[MF] GO:0004936 None ADRA2A, ADRA2C 2.11362
[MF] GO:0004064 arylesterase activity CA1, CA2 2.11362
[MF] GO:0043546 None AOX1, XDH 2.11362
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2 2.11362
[MF] GO:0004301 None EPHX1, EPHX2 2.11362
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.11362
[MF] GO:0019901 None ADRA2A, CDC25B, DUSP3, EGFR, ESR1, PTPN1, SMAD3, SRC, TOP2A 2.01615


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, CYP19A1, IGF1R 11.0555
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.0555
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.9813
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 7.2934
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.7455
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.8911
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.8222
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.0844
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 3.744
Metabolic pathways_Homo sapiens_hsa01100 EPHX2, AKR1C3, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.49
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.4667
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.744
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.4052
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.4267
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, ADRA2C, DRD2, DRD3, DRD4, ADRA2A 3.2504
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 3.1183
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.115
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.959
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1 2.545
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 EPHX1, CYP1A2, CYP1A1, CYP1B1 3.0075
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0572
Chemical carcinogenesis_Homo sapiens_hsa05204 EPHX1, CYP1A2, CYP1A1, CYP1B1 2.8533
Dopaminergic synapse_Homo sapiens_hsa04728 DRD2, DRD3, SLC6A3, DRD4 2.1643
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.1323
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, MMP9 2.0716
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.0894
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, EPHX2, AKR1C3 2.1135
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.0716
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.0852
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.0441
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.0716
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.0393
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8254
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, MIF, TYR 2.776
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.8254
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.8091
Bile secretion_Homo sapiens_hsa04976 CA2, EPHX1, ABCG2 2.0441
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6202
Gap junction_Homo sapiens_hsa04540 SRC, DRD2, EGFR 1.8254
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.6227
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.3901
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.5575
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.3603
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.368
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.2876
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 INSR, ADRA2C, ADRA2A 1.2557
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.1003
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, DRD2, PPARA 1.1034
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.0558
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR 1.3062
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0077
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.0697
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.269
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3001
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8044
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.0341
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.8623
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8156
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8884
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8884
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.2551
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8044
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.8044
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1295
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0558
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.8623
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8044
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0363
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.8044
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.2635
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2876
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.8038
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.2499
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.7852
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2198
Peroxisome_Homo sapiens_hsa04146 EPHX2, XDH 1.1003
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.7305
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.765
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2816
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.221
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, EGFR 0.708
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.708
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2551
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.708
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3066
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3191
Cocaine addiction_Homo sapiens_hsa05030 DRD2, SLC6A3 1.3901
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.3191
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3063
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.358
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3659
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3813
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3931
Platelet activation_Homo sapiens_hsa04611 SRC 0.4162
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4185
Sphingolipid signaling pathway_Homo sapiens_hsa04071 BCL2 0.4185
Axon guidance_Homo sapiens_hsa04360 MET 0.4084
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4162
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4395
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4363
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4636
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.4563
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4636
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4636
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4645
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4689
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4685
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4901
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4968
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4901
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4916
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4895
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5388
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5373
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5259
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5511
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5664
Amphetamine addiction_Homo sapiens_hsa05031 SLC6A3 0.5643
Shigellosis_Homo sapiens_hsa05131 SRC 0.5685
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7347
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5957
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6189
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.622
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6402
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6902
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6202
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.644
Malaria_Homo sapiens_hsa05144 MET 0.6558
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.66
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6602
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.66
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9066
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6647
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.708
ABC transporters_Homo sapiens_hsa02010 ABCG2 0.6784
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7404
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.708
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8044
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7762
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7897
Base excision repair_Homo sapiens_hsa03410 APEX1 0.76
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7897
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8044
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7852
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8044
Phenylalanine metabolism_Homo sapiens_hsa00360 MIF 0.9274
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0036
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0143
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2581


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)