TCM Prescription: Kang Bing Du Granules



Prescription Description
Prescription IDTCMF4049
Pinyin NameKang Bing Du Ke Li
Chinese Name抗病毒颗粒
English NameKang Bing Du Granules
Function Description感冒
IndicationsCommon cold disorder, Common cold
Disease ICD-11 Category SA60 [Common cold disorder (TM1), 感冒 (TM1) ];
CA00 [Acute nasopharyngitis, 急性鼻咽炎 ];
Human Tissues Associated with IndicationLung, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1714 Lonicera japonica 忍冬藤 TCMH1714 ITSAI3881-14
TCMH1814 Sophora subprostrata 山豆根 TCMH1814
TCMH2545 Houttuynia cordata 鱼腥草 TCMH2545 ITSAJ4504-14
TCMH2646 Rhizoma paridis 重楼 TCMH2646
TCMH719 Dryopteris crassirhizoma 贯众 TCMH719 GBVM2585-11
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH295 Belamcanda chinensis 川射干 TCMH295
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT575 PLA2G2A Phospholipase A2 group IIA Hydrolase P14555
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1321 Staphylococcus hominis
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 11.7112
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.7112
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AR, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, GSK3B, HSD17B2, IDO1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC, TEK, TYR 11.7112
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 11.7112
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 11.3115
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, AR, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 10.1219
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, GSK3B, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 10.0803
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 9.9773
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.70118
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 9.70118
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 9.69864
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.10489
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.86869
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.86869
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.66726
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.51575
[BP] GO:0033993 response to lipid ALPL, AR, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, IDO1, NR3C1, PTGS2, RORC, SRC, TYR 8.44948
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.44948
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC, TEK, TYR 8.43357
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.29216
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.29216
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, EGFR, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 8.20878
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AR, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.16465
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AR, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.12756
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, NR3C1, PTGS2, SMAD3, SRC, TEK 8.08402
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC 8.05017
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.96489
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.95128
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.90084
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 7.85675
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 7.64364
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, FUT7, HSPA1A, IDO1, PIK3CA, PIM1, PTGS1, PTGS2, TYR, XDH 7.60136
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, PIM1, SRC, TEK 7.36043
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AR, AXL, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GSK3B, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC 7.36043
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 7.13692
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, GSK3B, HSD11B1, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.10959
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC 7.09405
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.0883
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 7.06493
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AR, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TYR 7.02241
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.83404
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.79106
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 6.77972
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AR, AXL, CYP1B1, EGFR, ESR1, GSK3B, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 6.57409
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, NR3C1, PTGS2, SRC, TEK 6.50119
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.45072
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 6.44833
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FLT3, GSK3B, HSD11B1, HSD17B2, INSR, KDR, MMP9, PGR, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.38521
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HSD17B2, IDO1, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 6.23089
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.22659
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 6.07182
[BP] GO:0048513 animal organ development ACHE, AR, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, SMAD3, SRC, TEK, TYR 6.07027
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IDO1, IGF1R, MET, MMP12, MMP2, NUAK1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.05735
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 6.0074
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.99758
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 5.98606
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.68619
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.62139
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, DHFR, EGFR, ESR1, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.55691
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.55316
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 5.54263
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DHFR, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 5.521
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.51224
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.5056
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 5.38255
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.35824
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.34304
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.30815
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.2962
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK 5.2962
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.23323
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PTGS1, PTGS2 5.18638
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AR, AURKB, CDC25B, EGFR, ESR1, FABP3, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.18416
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AR, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIK3CB, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.14943
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.14943
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.14943
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.11723
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.04941
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.97778
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 4.94493
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GSK3B, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 4.91521
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.91296
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.91034
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.90927
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.90927
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.88382
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.85688
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GSK3B, IGF1R, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, TNKS 4.83499
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.82395
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 4.81859
[BP] GO:0051130 positive regulation of cellular component organization APP, AR, AURKB, AXL, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.81859
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.81346
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, AR, EGFR, ESR1, FLT3, GSK3B, IGF1R, INSR, MMP2, NR3C1, PTGS2, SMAD3, SRC 4.7754
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.7754
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.722
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 4.66508
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.61657
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 4.59748
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 4.57585
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GSK3B, HSPA1A, IDO1, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.55823
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.54088
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.51772
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.51126
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, AR, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.4776
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, NR3C1, PGR, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 4.47123
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, AR, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.38662
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, DHFR, EGFR, ESR1, FLT3, GSK3B, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.33493
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.2946
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.28541
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, EGFR, ESR1, GPR35, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 4.28117
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 4.27449
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC 4.23797
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 4.21135
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.20181
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.15332
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, PTPN1, SMAD3, SRC, TEK 4.11109
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.0671
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.01936
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.00261
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, IDO1, INSR, MMP2, MMP9, PGR, PTGS2, SRC 3.98627
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 3.94727
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 3.93966
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DHFR, EGFR, FABP3, FLT3, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC, TEK, TYR 3.91294
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, GSK3B, HSPA1A, IDO1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 3.85132
[BP] GO:0048545 response to steroid hormone ALPL, AR, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.8482
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PGR, PTGS2, SRC 3.81524
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.77488
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.76237
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, PIK3CB, PTGS2, TNKS, TNKS2 3.76237
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.73005
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 3.72361
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.72329
[BP] GO:0010638 positive regulation of organelle organization AURKB, GSK3B, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.72329
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD17B1, HSD17B2 3.69871
[BP] GO:0001952 regulation of cell-matrix adhesion GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 3.65886
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.65704
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 3.61851
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 3.61851
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, GPR35, GSK3B, HSPA1A, IDO1, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, TNKS2, XDH 3.61085
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, NR3C1, NR3C2, PGR, RORC, SRC 3.59814
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 3.57799
[BP] GO:0010605 negative regulation of macromolecule metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, KDR, MMP12, MMP9, NR3C1, PGR, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.57799
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3, XDH 3.57278
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, HSPA1A, IDO1 3.57278
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.56878
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.53629
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.52666
[BP] GO:0080135 regulation of cellular response to stress APP, DHFR, DUSP3, EGFR, GSK3B, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 3.52426
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, AR, CYP19A1, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.50581
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.50512
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.50512
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.50512
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, NR3C1, PGR, PIM1, RORC, SRC 3.49712
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, AR, CDC25B, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.49606
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.49217
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.47839
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.46484
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 3.46428
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.46189
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.44215
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AR, AXL, CA1, CA2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.4361
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, AR, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.42057
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GSK3B, IGF1R, INSR, PTGS2, SRC, TEK 3.40828
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.34097
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 3.3381
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.33655
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AR, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, FABP3, FABP4, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.32669
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28607
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.26979
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.25436
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.24966
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AR, AXL, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GSK3B, KDR, MET, MMP2, MMP9, PGR, PTGS2, RORC, SMAD3, SRC, TEK 3.24478
[BP] GO:0071383 None AR, EGFR, FLT3, NR3C1, SRC 3.19916
[BP] GO:0043412 macromolecule modification ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.19916
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, ESR1, FABP4, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, NR3C1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 3.19916
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.19155
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, NR3C1, PTGS2, SRC 3.19155
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 3.17728
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 3.17728
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, ESR1, GSK3B, PGR, RORC, SRC 3.17501
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.15975
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, GSK3B, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.12126
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, NR3C1, PGR, SRC 3.10998
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, PTGS2, SMAD3, TEK 3.09375
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PTGS2, SMAD3, SRC, TEK, TYR 3.07963
[BP] GO:0051128 regulation of cellular component organization APP, AR, AURKB, AXL, CSNK2A1, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 3.07886
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DHFR, EGFR, FABP3, KDR, NR3C1, PTGS2, SRC 3.07419
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PTGS1, PTGS2 3.06117
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 3.04267
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 3.04267
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.03793
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2 3.03138
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.02757
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.97641
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.94928
[BP] GO:0009968 negative regulation of signal transduction AR, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.94573
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.94083
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.94083
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.9379
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.92346
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.88885
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GSK3B, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PTGS2, PTPN1, SMAD3, SRC 2.88885
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.86949
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.86537
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.85641
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, IDO1, KDR, MET, MMP12, PTGS2, SMAD3, TEK 2.84491
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, CA2, CYP1B1, EGFR, HSPA1A, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 2.83806
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, NR3C1, PTGS2, SRC 2.8266
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS 2.82395
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, GSK3B, IGF1R, INSR, MMP2, PTGS2, SRC 2.81496
[BP] GO:0001954 positive regulation of cell-matrix adhesion GSK3B, KDR, SMAD3, TEK 2.80852
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AR, AURKB, EGFR, ESR1, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2 2.78997
[BP] GO:0050678 None AR, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.78294
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, GSK3B, IDO1, KDR, NUAK1, PIK3CA, PIK3CB, SMAD3, SRC, TEK 2.78005
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.77738
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, NR3C1, NR3C2, PGR, RORC 2.77519
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, APP, AR, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIM1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 2.77519
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.77519
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CYP1A1, EGFR, ESR1, PGR, PTGS2, SRC 2.77341
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 2.75171
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75171
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.72157
[BP] GO:0001775 cell activation ALOX5, APP, AXL, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC 2.69116
[BP] GO:0051172 None APP, AR, AURKB, CSNK2A1, DHFR, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MMP12, MMP9, NR3C1, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.68975
[BP] GO:0051098 regulation of binding APP, AURKB, GSK3B, MET, MMP9, SMAD3, SRC, TNKS 2.68975
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.68444
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, GSK3B, INSR, MMP12, PTGS2, SMAD3, SRC 2.68233
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.68233
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67261
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67261
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.67261
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.67261
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2 2.63869
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DHFR, EGFR, INSR, PTGS2, SMAD3 2.63362
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.63362
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.63283
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, CYP1B1, FABP3, HSPA1A, IDO1, PTGS2, SMAD3, XDH 2.62971
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 2.62971
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.61438
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.61192
[BP] GO:0048729 tissue morphogenesis AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.6102
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PTGS2, SMAD3, SRC, TEK 2.60583
[BP] GO:0071396 cellular response to lipid AR, AXL, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 2.60583
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.59005
[BP] GO:0060748 None AR, PGR 2.58769
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.58769
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.57795
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.56481
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.56481
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.56317
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DHFR, EGFR, SMAD3 2.55998
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PTGS2, RORC, SRC, TEK 2.55857
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS1, PTGS2, TYR 2.54382
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PTGS2, SMAD3, SRC, TEK 2.53893
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, PTGS1, PTGS2 2.51843
[BP] GO:0048608 reproductive structure development AR, AXL, CYP19A1, ESR1, HSD17B2, INSR, SRC 2.51227
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.51227
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.50131
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TNKS 2.49903
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AR, AURKB, EGFR, ESR1, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, RORC, SMAD3, SRC, TNKS, TNKS2 2.49712
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.49081
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.49081
[BP] GO:0044089 positive regulation of cellular component biogenesis ESR1, GSK3B, HSPA1A, KDR, MET, MMP1, SMAD3, SRC, TEK 2.48259
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.48259
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.47327
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.46829
[BP] GO:0010810 regulation of cell-substrate adhesion GSK3B, KDR, PIK3CB, SMAD3, SRC, TEK 2.46539
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.4606
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.4606
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.4606
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.44478
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, IDO1, KDR, MET, PTGS2, SMAD3 2.44478
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, NR3C1, SMAD3, SRC 2.44478
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, GSK3B, HSPA1A, MMP9, PTGS2, PTPN1, SMAD3, SRC 2.44249
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.42108
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CYP19A1, DUSP3, ESR1, HSPA1A, IDO1, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.39093
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PIK3CA, SRC, TNKS, TNKS2 2.39093
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, CA2, CYP1B1, EGFR, ESR1, GSK3B, IDO1, INSR, KDR, NUAK1, PIK3CA, PIM1, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, XDH 2.38755
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.38755
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.36465
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.35312
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PTGS2, SMAD3, SRC, TEK 2.34535
[BP] GO:0070213 None TNKS, TNKS2 2.34535
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.34535
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.34535
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PTGS2, SRC, TEK 2.34535
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, GSK3B, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTPN1, SMAD3 2.33173
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.33173
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.33173
[BP] GO:0048870 cell motility AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.32014
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.32014
[BP] GO:0051894 None KDR, SMAD3, TEK 2.31592
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.31592
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, IDO1, PTGS2, SRC 2.31456
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.31401
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.31025
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, NR3C1, NR3C2, PGR, RORC 2.30083
[BP] GO:0043393 regulation of protein binding APP, AURKB, GSK3B, MET, MMP9, SRC 2.30083
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.30046
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.29273
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.28495
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.28096
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.28096
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GSK3B, IGF1R, INSR, SRC 2.27431
[BP] GO:0040008 regulation of growth APP, AR, CSNK2A1, EGFR, HSPA1A, INSR, PIK3CA, PIM1, SMAD3, TNKS2 2.27416
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.26009
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.2459
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, DHFR, TYR 2.2408
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, IDO1 2.23617
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.23617
[BP] GO:1903393 None KDR, SMAD3, TEK 2.23617
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.2337
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.22607
[BP] GO:0051248 None APP, CSNK2A1, DHFR, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.22323
[BP] GO:0031349 positive regulation of defense response EGFR, FABP4, HSPA1A, IDO1, MMP12, MMP2, PTGS2, SRC 2.22323
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3 2.22323
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS1, PTGS2, TYR 2.22143
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.21695
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.21695
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 2.20925
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.20812
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.20166
[BP] GO:1904646 cellular response to amyloid-beta APP, GSK3B, IGF1R 2.20166
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.19719
[BP] GO:0031099 regeneration AXL, CSNK2A1, DHFR, EGFR, FLT3 2.19454
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, GSK3B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.1913
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.18465
[BP] GO:1900180 regulation of protein localization to nucleus APP, EGFR, GSK3B, PTGS2, SMAD3, SRC 2.16669
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, IDO1, PIM1, PTGS1, PTGS2, TYR 2.16669
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.16669
[BP] GO:0051384 response to glucocorticoid ALPL, EGFR, FLT3, NR3C1, PTGS2 2.15858
[BP] GO:0031334 positive regulation of protein complex assembly ESR1, GSK3B, HSPA1A, MET, MMP1, SRC 2.13171
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.12642
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.10926
[BP] GO:0044283 None AKR1B1, ALOX5, CYP19A1, CYP1A1, DHFR, IDO1, PTGS1, PTGS2 2.10805
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR 2.09817
[BP] GO:0035265 organ growth AR, CYP19A1, ESR1 2.089
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.089
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.089
[BP] GO:1904645 response to amyloid-beta APP, GSK3B, IGF1R 2.089
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.08093
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.07377
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.05436
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, GSK3B, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.05436
[BP] GO:1901890 None KDR, SMAD3, TEK 2.05403
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.05403
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.05403
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, CA2, CA9, CYP1B1, EGFR, ESR1, INSR, MET, MMP2, SMAD3, SRC, TEK 2.05323
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, CYP19A1, CYP1A2, GSK3B, IDO1, NQO2, XDH 2.05133
[BP] GO:0040007 None APP, AR, CYP19A1, ESR1, SMAD3, SRC, TNKS2 2.04658
[BP] GO:0008217 None ADORA1, AR, PTGS1, PTGS2, SMAD3 2.04658
[BP] GO:1990535 None APP, INSR 2.04658
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.04658
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.02741
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.02527
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, IDO1, PIK3CB 2.01463
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3 2.01463
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.01463
[BP] GO:0008286 None IGF1R, INSR, PIK3CA, PTPN1 2.01463
[BP] GO:0032870 cellular response to hormone stimulus AR, EGFR, ESR1, FLT3, INSR, NR3C1, SRC 2.01419
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, INSR, KDR, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 4.33493
[CC] GO:0005829 cytosol AKR1B1, AKR1B10, ALOX5, APP, AR, AURKB, CA1, CA2, CA7, CBR1, CDC25B, CSNK2A1, DHFR, DUSP3, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TNKS, TNKS2, TYR, XDH 3.42874
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FLT3, FUT7, GPR35, GSK3B, HSD11B1, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 3.24592
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, GSK3B, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK 2.62971
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.48465
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.33173
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.32014
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, HSD11B1, HSD17B2, NR3C2, PTGS1, PTGS2, PTPN1 2.1371
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.04658
[MF] GO:0046914 transition metal ion binding ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PIM1, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 14.0166
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 14.001
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DUSP3, EGFR, F10, FLT3, FUT7, GSK3B, HSD11B1, HSD17B1, HSD17B2, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TYR, XDH 13.9345
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1293
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PTPN1, RORC, SMAD3, TNKS 8.51575
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD11B1, HSD17B1, HSD17B2, IDO1, NQO2, PTGS1, PTGS2, TYR, XDH 7.60136
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.60136
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH 7.02428
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.83404
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, IDO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TYR, XDH 6.69162
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 6.61703
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.48028
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 6.19244
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.70719
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.62139
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.54978
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.42501
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC 5.38255
[MF] GO:0005496 steroid binding AR, ESR1, HSD17B1, NR3C1, NR3C2, PGR, RORC 5.28817
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, IDO1, PTGS1, PTGS2, SRC 5.17548
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.11723
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.00409
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, NR3C1, NR3C2, PGR, RORC 4.91148
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, HSD17B1, IDO1, NQO2, PTGS1, PTGS2, SRC, XDH 4.70983
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.27785
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.11723
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.77676
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.77488
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, DHFR, EGFR, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.74307
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.59814
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, IDO1, NQO2, XDH 3.56878
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, DHFR, EGFR, F10, FABP3, FABP4, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.49606
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, GSK3B, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 3.46659
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.42057
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.38672
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.37864
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 3.37095
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.19622
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, DHFR, EGFR, FLT3, GSK3B, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.19498
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PTPN1, SMAD3, SRC 3.15127
[MF] GO:1901363 heterocyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.03508
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.03285
[MF] GO:0008013 beta-catenin binding AR, CSNK2A1, ESR1, GSK3B, SMAD3 3.02757
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.95729
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.92084
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.88866
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, SMAD3, TEK 2.81496
[MF] GO:0097159 organic cyclic compound binding ADORA1, APP, AR, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, EGFR, ESR1, FLT3, GSK3B, HSD17B1, HSPA1A, IDO1, IGF1R, INSR, KDR, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.81496
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.80852
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PTPN1, SMAD3, SRC 2.80546
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 2.7911
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.77519
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.77519
[MF] GO:0008289 lipid binding AR, AXL, ESR1, F10, FABP3, FABP4, HSD17B1, NR3C1, NR3C2, PGR, RORC 2.75171
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PGR, RORC 2.69051
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PGR, RORC 2.69051
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, EGFR, ESR1, FLT3, GPR35, IGF1R, INSR, KDR, MET, NR3C1, NR3C2, PGR, RORC, TEK 2.65615
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSPA1A, KDR, NR3C1 2.60885
[MF] GO:0019899 enzyme binding APP, AR, AURKB, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, GSK3B, HSPA1A, MET, NR3C1, PGR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2 2.54382
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.34649
[MF] GO:0051425 None APP, INSR 2.34535
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.29395
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.26009
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GSK3B, NR3C1, PTPN1, SMAD3, SRC 2.2459
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.23617
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX5, IDO1, PTGS2 2.23617
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.20166
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX5, IDO1, PTGS2 2.20166
[MF] GO:0043559 insulin binding IGF1R, INSR 2.18355
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.17684
[MF] GO:0042802 identical protein binding ACHE, APP, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, MET, MMP9, NQO2, PGR, PTGS2, SMAD3, TYR, XDH 2.15233
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.1469
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.1421
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.12642
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.12642
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.05403
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.04658
[MF] GO:0004064 arylesterase activity CA1, CA2 2.04658
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GSK3B, NR3C1, PTPN1, SMAD3, SRC 2.03979
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.02527
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.01916
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, GSK3B, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.01463


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.2096
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2096
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, PIK3CA, MET 7.6124
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.113
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.6124
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.4977
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 7.4977
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.5812
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.1645
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, IDO1 5.7833
Focal adhesion_Homo sapiens_hsa04510 GSK3B, PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 5.3003
Prostate cancer_Homo sapiens_hsa05215 AR, GSK3B, PIK3CA, PIK3CB, EGFR, IGF1R 5.1912
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.9792
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.4195
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.7113
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.3361
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 4.8742
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.7317
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.6757
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.4947
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.3359
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.5988
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 4.4848
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.4042
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.4744
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB 3.8996
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.8508
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, PIK3CA, SRC, PIK3CB, EGFR 4.1849
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.9485
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 3.7812
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, PIK3CA, SRC, PIK3CB, ESR1 3.6417
Measles_Homo sapiens_hsa05162 GSK3B, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 3.4069
Hepatitis B_Homo sapiens_hsa05161 SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.3034
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B, PIK3CA, INSR, PIK3CB 3.3737
Endometrial cancer_Homo sapiens_hsa05213 GSK3B, PIK3CA, PIK3CB, EGFR 3.8431
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, SMAD3, PIK3CA, PIK3CB, IGF1R 3.35
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.7109
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.1625
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.534
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB, NR3C2 4.2558
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 3.0602
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1, IDO1 4.2275
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.5193
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, SMAD3, PIK3CA, PIK3CB 3.6033
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, PTGS2, PTGS1 3.6033
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.7261
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7635
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.014
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PTGS2, PTGS1 2.7462
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2982
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.6525
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.6908
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6908
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.6714
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.6338
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, PIK3CB, EGFR 2.4275
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PIK3CA, PIK3CB, EGFR 2.5427
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PIK3CA, INSR, PIK3CB 2.3745
Influenza A_Homo sapiens_hsa05164 GSK3B, PIK3CA, PIK3CB, HSPA1A 2.1682
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1367
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, PIK3CA, SRC, PIK3CB 2.0897
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.923
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.0162
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0946
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.6979
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.9914
HTLV-I infection_Homo sapiens_hsa05166 GSK3B, SMAD3, PIK3CA, PIK3CB 1.6857
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.9052
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.6562
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1, NR3C1 1.5967
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B, PIK3CA, PIK3CB 2.3352
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.9727
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.3352
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, PIK3CA, PIK3CB 1.8228
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B, PIK3CA, PIK3CB 1.9727
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3362
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3288
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3463
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.7986
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.3347
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.1516
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3354
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, SMAD3, CSNK2A1 1.6562
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.5459
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.4275
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.2895
Cell cycle_Homo sapiens_hsa04110 GSK3B, SMAD3, CDC25B 1.7943
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4208
cAMP signaling pathway_Homo sapiens_hsa04024 PIK3CA, ADORA1, PIK3CB 1.3179
Dopaminergic synapse_Homo sapiens_hsa04728 GSK3B 0.4311
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.397
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.6055
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9462
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9477
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9654
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9784
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9201
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B, SMAD3 0.9031
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B, APP 0.8536
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1 2.3855
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 1.0036
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5153
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5319
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5309
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1338
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5449
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.7462
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 1.175
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5514
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5514
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2195
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.175
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5627
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.1826
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5502
Peroxisome_Homo sapiens_hsa04146 XDH 0.5643
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2369
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2195
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2503
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5799
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6007
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5865
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5986
Bile secretion_Homo sapiens_hsa04976 CA2 0.6082
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.616
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6386
Shigellosis_Homo sapiens_hsa05131 SRC 0.6358
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4394
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6605
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4089
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5278
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6916
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4716
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4716
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.6916
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.537
Malaria_Homo sapiens_hsa05144 MET 0.7275
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.7228
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7409
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7459
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7272
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8536
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.8536
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9281
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8894
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8536
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9059
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0108
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9363
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9727
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8993
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8945
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9281
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.197
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 1.0228
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.5709
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.3737


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)