TCM Prescription: Huang Dan Yin Chen Infusion



Prescription Description
Prescription IDTCMF4019
Pinyin NameHuang Dan Yin Chen Chong Ji
Chinese Name黄疸茵陈蒿冲剂
English NameHuang Dan Yin Chen Infusion
Function Description黄疸
IndicationsJaundice disorder, Jaundice
Disease ICD-11 Category SA01 [Jaundice disorder (TM1), 黄疸 (TM1) ];
ME10.1 [Unspecified jaundice, 未特指的黄疸 ];
Human Tissues Associated with IndicationLiver
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, KDR, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 13.2287
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 12.1658
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.7788
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TYR 11.1387
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PTGS2, SRC, TYR 11.1219
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, KDR, KIT, MMP2, PIK3CA, PPARA, PTGS2, SRC, TYR 10.3202
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.97521
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 8.95092
[BP] GO:0010647 positive regulation of cell communication AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.6024
[BP] GO:0023056 positive regulation of signaling AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 8.57444
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APP, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, HTR1B, HTR5A, PTGS2, SRC, TYR 8.28829
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, KIT, PPARA, PTGS2, SRC 8.08924
[BP] GO:0042127 regulation of cell proliferation ADORA3, AKR1B1, AKR1C3, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS1, PTGS2, SRC, XDH 7.98538
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SRC, TNKS2, TYR 7.82457
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 7.80058
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.76614
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, KIT, MMP2, PPARA, PTGS2, SRC 7.76614
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, KIT, MMP9, PTGS2, SRC 7.62615
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 7.58861
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 7.52993
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PTGS2, SRC 7.40631
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 7.39975
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.29515
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.15025
[BP] GO:0032502 developmental process ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS2, TYR 7.15025
[BP] GO:0097756 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 7.06854
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 7.06315
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.03923
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.02914
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, KDR, KIT, MMP2, MMP9, PIM1, PTGS2 7.02191
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.98712
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.94462
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 6.84025
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 6.8212
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.76174
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESRRA, F3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, HTR6, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.76174
[BP] GO:0032844 regulation of homeostatic process AURKB, BCL2, CA2, CA7, CDK6, CNR1, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 6.63555
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC, TYR 6.57574
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.55925
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 6.51698
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 6.46664
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, KIT, PIK3CA, PPARA, PTPRS, SRC, TYR 6.46525
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 6.2808
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, AKR1C3, CNR1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2C 6.2808
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 6.28024
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 6.18417
[BP] GO:0010941 regulation of cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 6.04123
[BP] GO:0007187 None CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.0033
[BP] GO:0007165 signal transduction ADORA3, AKR1B1, AKR1C3, APP, AXL, BCL2, CA1, CA2, CDK6, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 5.99106
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 5.99106
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.85435
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.85435
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.74883
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.72452
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 5.6314
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, PIK3CA, PTGS2, SRC 5.60099
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, SRC 5.51203
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 5.49621
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 5.49621
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, SRC 5.40584
[BP] GO:0019216 regulation of lipid metabolic process AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2, SRC 5.26272
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 5.25643
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, ESR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, PIK3CA, PIK3CB, SRC 5.23396
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS1, PTGS2 5.19049
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.16418
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA3, ALOX15, APP, AXL, BCL2, CA2, CA7, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1B1, F3, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 5.03227
[BP] GO:0019220 regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.99306
[BP] GO:0051174 regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.9311
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.91944
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, APP, BCL2, CDC25B, ESRRB, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.91944
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, XDH 4.90213
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, ESRRB, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.90213
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, FABP4, KIT, MMP9, PTGS2 4.90213
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, SRC 4.84423
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AKR1C3, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.82472
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HTR5A, KDR, KIT, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TYR 4.80726
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 4.80726
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HTR1A, TYR 4.72384
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA3, AKR1B1, AKR1C3, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.60918
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.56128
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC, TNKS 4.5409
[BP] GO:0032228 regulation of synaptic transmission, GABAergic CA2, CA7, CNR1, CNR2, HTR1B 4.49623
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC, XDH 4.4923
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, F3, KIT, MET, PIK3CA, PIK3CB, SRC 4.48998
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 4.48995
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 4.46462
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCL2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.44571
[BP] GO:0003018 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 4.44571
[BP] GO:0050795 None CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 4.42307
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, BCL2, CA2, FLT3, HSD11B2, HTR1B, PTGS2, SRC 4.38669
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37348
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 4.28204
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, HTR1A, KIT, MET, PIK3CB, PIM1, SRC, TYR 4.28204
[BP] GO:0042325 regulation of phosphorylation ALOX15, APP, BCL2, CDC25B, ESRRB, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 4.24904
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.24036
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, APP, CA2, CA7, CNR1, CNR2, HTR1B, HTR2A, KIT, PTGS2 4.24036
[BP] GO:0009966 regulation of signal transduction AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.19404
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.16692
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PPARA, PTGS1, PTGS2 4.13835
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, HTR2B, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS 4.04321
[BP] GO:0007193 None HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.02003
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.0182
[BP] GO:0097746 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.98704
[BP] GO:0035296 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.98704
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.98232
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.97484
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3, GBA2 3.97431
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.95181
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.94659
[BP] GO:0043410 positive regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 3.88652
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB 3.86844
[BP] GO:0031325 positive regulation of cellular metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.83808
[BP] GO:0050880 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.83808
[BP] GO:0035150 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 3.81876
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APP, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 3.79166
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, KIT, PIM1, SRC 3.77124
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, KIT, MMP2, MMP9, PTGS2, SRC 3.73291
[BP] GO:0042592 homeostatic process AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CNR1, ESR1, FABP3, FABP4, FLT3, HTR2A, HTR2B, HTR2C, MET, PIK3CA, PIK3CB, SRC 3.71918
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.67482
[BP] GO:0003013 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC 3.64628
[BP] GO:0001932 regulation of protein phosphorylation ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.64269
[BP] GO:0032845 None BCL2, HTR2A, HTR2B, HTR2C, SRC, TNKS, TNKS2 3.61894
[BP] GO:0003008 None AKR1B1, AKR1C3, APP, BCL2, CNR1, CNR2, CYP1B1, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, KIT, PIK3CA, PTGS2, SRC, TYR 3.61522
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.61248
[BP] GO:2000021 regulation of ion homeostasis BCL2, CA2, CA7, HTR2A, HTR2B, HTR2C, KDR, SRC 3.61187
[BP] GO:0009628 response to abiotic stimulus AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, HSD11B2, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PTGS2, SRC, TYR 3.58053
[BP] GO:0009893 positive regulation of metabolic process AKR1C3, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.58053
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.57104
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HTR1B, IGF1R, KDR, KIT, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, SRC 3.57104
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.56188
[BP] GO:0040012 regulation of locomotion ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, HTR1D, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.54138
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.53146
[BP] GO:0007188 None CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.41937
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.41895
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 3.41895
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 3.40226
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.39722
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.39722
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.39722
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, PIK3CB, PTGS2, TNKS, TNKS2 3.38698
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.28129
[BP] GO:0051247 positive regulation of protein metabolic process ALOX15, APP, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.28129
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, CNR1, CNR2, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.28129
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, KIT, PTGS2, SRC 3.27358
[BP] GO:2000145 regulation of cell motility ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 3.27358
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 3.27102
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.24709
[BP] GO:0010604 positive regulation of macromolecule metabolic process ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.24709
[BP] GO:0031401 positive regulation of protein modification process ALOX15, APP, BCL2, CDC25B, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.24709
[BP] GO:0043408 regulation of MAPK cascade ALOX15, APP, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, PIK3CB, PTPN1, SRC, XDH 3.22398
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 3.2188
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, CNR2, HTR1B, HTR2A, PTGS2 3.2043
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PTGS2 3.2043
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.2043
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 3.19701
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, AXL, BCL2, CYP1B1, MMP9, SRC 3.16611
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.15253
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.15253
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.12214
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.12214
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.12214
[BP] GO:0050790 regulation of catalytic activity ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, ESR1, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, XDH 3.12214
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.10143
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 3.09311
[BP] GO:0032270 positive regulation of cellular protein metabolic process ALOX15, APP, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, HTR2C, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.09311
[BP] GO:0007154 None AKR1C3, AXL, BCL2, CNR1, ESR2, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PTGS2 3.05245
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 3.04757
[BP] GO:0010863 positive regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 3.04703
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APP, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, SRC 3.03918
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ALOX15, APP, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 3.0147
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.0147
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 3.0147
[BP] GO:0007610 None APP, BCL2, CNR1, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, PPARA, PTGS2 3.00338
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.999
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.98218
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 2.97842
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APP, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, SRC 2.96309
[BP] GO:0030334 regulation of cell migration ADORA3, APP, BCL2, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.94599
[BP] GO:0051270 regulation of cellular component movement ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.9459
[BP] GO:1900274 regulation of phospholipase C activity ESR1, HTR2A, HTR2B, KIT 2.92269
[BP] GO:0048608 reproductive structure development AKR1C3, AXL, BCL2, CYP19A1, ESR1, HSD17B2, KIT, SRC 2.92269
[BP] GO:0016042 lipid catabolic process AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.92269
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA3, APP, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, ESR1, ESR2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 2.90565
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.90565
[BP] GO:0044093 positive regulation of molecular function ABCB1, APP, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, HTR2A, HTR2B, KIT, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.89777
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.89777
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.89072
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, PTPN1, SRC 2.89072
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, SRC 2.89029
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.88117
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, CNR1, ESR1, IGF1R, KDR, KIT, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.88117
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.87851
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.87851
[BP] GO:0007208 None HTR2A, HTR2C 2.87851
[BP] GO:0016488 None AKR1B10, AKR1C3 2.87851
[BP] GO:0016487 None AKR1B10, AKR1C3 2.87851
[BP] GO:0016107 None AKR1B10, AKR1C3 2.87851
[BP] GO:0009115 None AOX1, XDH 2.87851
[BP] GO:0006714 None AKR1B10, AKR1C3 2.87851
[BP] GO:0080134 regulation of response to stress ABCB1, APP, CDK6, CNR1, CNR2, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.86905
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.84475
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, HTR1B, KDR, PTGS2, SRC 2.83422
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, F3, FLT3, FUT7, GBA2, HTR1A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR, XDH 2.83186
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, HTR7, KIT, PPARA, SRC 2.81538
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 2.81523
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.81294
[BP] GO:0006950 response to stress ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HTR1A, HTR2C, KIT, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SRC 2.75248
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.75248
[BP] GO:0043271 negative regulation of ion transport BCL2, CNR1, HTR1B, HTR2A, MMP9, PTGS2 2.74731
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.73997
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7 2.73997
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 2.72789
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC 2.7024
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, F3, IGF1R, KDR, KIT, MET, MMP9, PTGS2, SRC 2.69544
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.66558
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 2.65051
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA3, AKR1B1, AKR1C3, ALOX15, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.65051
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.65016
[BP] GO:0002682 regulation of immune system process ALOX15, APP, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESRRA, KIT, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SRC 2.64382
[BP] GO:0043269 regulation of ion transport ABCB1, APP, BCL2, CA2, CA7, CNR1, HTR1A, HTR1B, HTR2A, MMP9, PTGS2 2.61629
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.59397
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.59397
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.59397
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, HTR2B, KDR, KIT, MET, MMP2, MMP9, PTGS2, PTPRS, SRC 2.58936
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.57737
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCL2, CNR1, CYP1A1, HSD11B2, PTGS2, SRC, TYR 2.57049
[BP] GO:0051239 regulation of multicellular organismal process ADORA3, APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2B, HTR2C, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SRC, TNKS2, XDH 2.56715
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.522
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.52121
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7 2.5177
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA3, AKR1C3, ALOX15, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.51417
[BP] GO:0010518 positive regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.48493
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.47572
[BP] GO:0046110 None AOX1, XDH 2.46925
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46925
[BP] GO:0016095 None AKR1B10, AKR1C3 2.46925
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.46034
[BP] GO:0051338 regulation of transferase activity APP, AURKB, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.45117
[BP] GO:0009892 negative regulation of metabolic process AKR1C3, APP, AURKB, BCL2, CNR1, CNR2, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.44345
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MET, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.41259
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.39512
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.39512
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PTGS2 2.39512
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.3819
[BP] GO:0031399 regulation of protein modification process ALOX15, APP, BCL2, CDC25B, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.37846
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.37486
[BP] GO:0006954 inflammatory response ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2 2.36731
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.34909
[BP] GO:0043405 regulation of MAP kinase activity FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CB, PTPN1, SRC 2.33771
[BP] GO:0044242 None AKR1B10, AKR1C3, CYP1B1, FABP3, FABP4, GBA2 2.31955
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.31379
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.31379
[BP] GO:0045859 regulation of protein kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.30789
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.30789
[BP] GO:0048585 negative regulation of response to stimulus ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.30256
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, ESR1, FABP3, HTR2A, HTR2B, HTR2C, PIK3CB 2.30248
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.30248
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, KIT 2.30248
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, KIT, MMP9 2.29773
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28429
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.28429
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, PTGS2, SRC 2.27576
[BP] GO:0001666 response to hypoxia BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.26343
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC 2.26108
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.25738
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APP, ESR1, FLT3, HTR1B, IGF1R, KIT, MMP2, PTGS2, SRC 2.23458
[BP] GO:0050793 regulation of developmental process APP, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, ESR1, ESRRA, ESRRB, F3, HTR2A, HTR2C, KDR, KIT, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, SRC, TNKS2, XDH 2.23458
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APP, AURKB, BCL2, CNR1, CSNK2A1, ESR1, ESR2, ESRRA, FABP4, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 2.23424
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.2334
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.2334
[BP] GO:0051347 positive regulation of transferase activity AURKB, CDC25B, FLT3, HTR2A, HTR2B, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS 2.23085
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, CSNK2A1, HTR1A 2.23085
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.23085
[BP] GO:0010517 regulation of phospholipase activity ESR1, HTR2A, HTR2B, KIT 2.23085
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic CNR1, HTR1B, HTR2A, PTGS2 2.23085
[BP] GO:0043406 positive regulation of MAP kinase activity FLT3, HTR2A, HTR2B, KIT, PIK3CB, PTPN1, SRC 2.23085
[BP] GO:0070213 None TNKS, TNKS2 2.23085
[BP] GO:0006145 None AOX1, XDH 2.23085
[BP] GO:0038171 None CNR1, CNR2 2.23085
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.23085
[BP] GO:0014827 None HTR1D, HTR2B 2.23085
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.22382
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1 2.22382
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.2126
[BP] GO:0036293 response to decreased oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.20972
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.19611
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.19611
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2B, KDR, KIT, MET, MMP9, PIM1, PTGS2, SRC 2.17584
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TUBB3 2.1731
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.17232
[BP] GO:0060193 positive regulation of lipase activity ESR1, HTR2A, HTR2B, KIT 2.16523
[BP] GO:0090066 None ALOX15, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 2.1477
[BP] GO:0032098 None HTR2C, HTR4, PPARA 2.1477
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.1477
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.117
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, CNR1, CYP1A1, PTGS2, TYR 2.117
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, AXL, CYP1B1, MMP9, SRC 2.10591
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HTR2A, HTR2C, KDR, KIT, PIM1, PTGS2, SRC 2.08121
[BP] GO:0032355 response to estradiol CYP1A2, ESR1, ESRRA, HTR5A, PTGS2 2.0707
[BP] GO:0043549 regulation of kinase activity APP, CDC25B, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KIT, PIK3CA, PIK3CB, PTPN1, SRC 2.06824
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1 2.05896
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.05896
[BP] GO:0043085 positive regulation of catalytic activity APP, AURKB, BCL2, CDC25B, ESR1, F3, FLT3, HTR2A, HTR2B, KIT, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.05877
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.05877
[BP] GO:0006693 None AKR1C3, PTGS1, PTGS2 2.05877
[BP] GO:0006692 None AKR1C3, PTGS1, PTGS2 2.05877
[BP] GO:0040014 regulation of multicellular organism growth APP, BCL2, PIK3CA, TNKS2 2.05585
[BP] GO:0006952 defense response ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PTGS1, PTGS2, SRC 2.05308
[BP] GO:0043696 None CDK6, ESRRB 2.05308
[BP] GO:0043697 None CDK6, ESRRB 2.05308
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1 2.05308
[BP] GO:0010641 None F3, SRC 2.05308
[BP] GO:0071502 None HTR1B, HTR2B 2.05308
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.05308
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, XDH 2.04644
[BP] GO:0045913 None ESRRB, HTR2A, PPARA, SRC 2.04198
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HTR1B, MMP2, MMP9, PTGS2 2.03091
[BP] GO:0010648 negative regulation of cell communication ACHE, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, PTPRS, SRC, XDH 2.02968
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.02552
[BP] GO:0070482 response to oxygen levels BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.025
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1 2.025
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PTGS2, SRC, XDH 2.0225
[BP] GO:0023057 negative regulation of signaling ACHE, BCL2, CNR2, ESR1, ESR2, HTR1B, HTR2A, IGF1R, MET, MMP9, PTGS2, PTPN1, PTPRS, SRC, XDH 2.0225
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.00103
[CC] GO:0031226 intrinsic component of plasma membrane ADORA3, APP, AXL, CA4, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 5.60099
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, ESR1, F3, FLT3, GBA2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SRC 5.51257
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA3, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR 5.31854
[CC] GO:0044459 plasma membrane part ABCB1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PTGS2, PTPRS, SRC 4.91928
[CC] GO:0005887 integral component of plasma membrane ADORA3, APP, AXL, CNR1, CNR2, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPRS 4.67321
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TYR 4.64504
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 16.5366
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 16.4544
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 14.1159
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 13.8651
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 12.1529
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 12.1359
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.9241
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.99656
[MF] GO:0070405 ammonium ion binding ACHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 9.43389
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 9.16665
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, KIT, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TUBB3, TYR, XDH 9.05218
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 8.28829
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.27169
[MF] GO:0038023 signaling receptor activity ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 8.08924
[MF] GO:0060089 molecular transducer activity ADORA3, AXL, CDK6, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 7.50294
[MF] GO:0004872 receptor activity ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 7.09581
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 7.07067
[MF] GO:0004871 signal transducer activity ADORA3, AXL, CNR1, CNR2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET, PPARA 6.32922
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC 6.28019
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.14357
[MF] GO:0099600 transmembrane receptor activity ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.41953
[MF] GO:0004888 transmembrane signaling receptor activity ADORA3, AXL, CNR1, CNR2, F3, FLT3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, KDR, KIT, MET 5.41953
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, TNKS 5.32293
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.29511
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.21206
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.84423
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.69901
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 4.48921
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 4.44571
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 4.35335
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 4.10318
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET 3.94659
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.91421
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.88996
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.75589
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.72452
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68773
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68773
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.58979
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.55
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.39762
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.34539
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTGS1, PTGS2, PTPN1, TNKS, TNKS2, TYR, XDH 3.29508
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.27102
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, KIT, MET, SRC 3.07411
[MF] GO:0004930 None ADORA3, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.04703
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.03918
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 3.0147
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIM1, SRC 2.97104
[MF] GO:1901363 heterocyclic compound binding ABCB1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TUBB3, XDH 2.91015
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.89309
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.87851
[MF] GO:0045550 None AKR1B10, AKR1C3 2.87851
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.87851
[MF] GO:0003845 None HSD11B1, HSD11B2 2.87851
[MF] GO:0071886 None HTR2A, HTR2C 2.87851
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA 2.87533
[MF] GO:0097159 organic cyclic compound binding ABCB1, AOX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SRC, TUBB3, XDH 2.73607
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.61341
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, KIT, MET, PIK3CA, PIK3CB, PIM1, SRC 2.5682
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.46925
[MF] GO:0047718 None AKR1B10, AKR1C3 2.46925
[MF] GO:0004949 None CNR1, CNR2 2.46925
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CSNK2A1, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, KIT, MET, NQO2, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TUBB3, XDH 2.46114
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.23085
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity KIT, MET, PIK3CA, PIK3CB 2.06983
[MF] GO:0004033 None AKR1B1, AKR1B10, AKR1C3 2.05877
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.05877
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.05308
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.02552
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity KIT, MET, PIK3CA, PIK3CB 2.025


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR1E, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 18.2139
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 10.8339
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3 10.0074
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AKR1C3, CYP1B1, CYP19A1 10.3412
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.8339
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, KIT, BCL2, PIK3CB, PTGS2, MMP9, MET, IGF1R 6.0312
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1C3, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.0312
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 5.7873
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PIK3CA, HTR1E, HTR1D, HTR1A, HTR1B, PIK3CB, PPARA, HTR4 5.8102
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 5.7464
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 5.5272
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 5.6792
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, CNR1, KIT, KDR, PIK3CB, MET, IGF1R 4.7352
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, HTR2B, HTR2C, PIK3CB, HTR2A 4.6286
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 4.6158
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.023
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.6158
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2C, HTR2A, HTR5A, HTR4 4.3176
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.6158
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.492
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET 4.3176
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.2288
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, IGF1R 4.0839
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.2181
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PIK3CB, MMP9 3.9326
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, PIK3CA, KIT, KDR, PIK3CB, MET, IGF1R 3.848
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.1958
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 4.2071
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KIT, KDR, BCL2, PIK3CB, MET, IGF1R 3.5935
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.9412
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, HTR2B, HTR2C, HTR2A 3.9215
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, IGF1R 3.2612
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.8202
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B 2.8989
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 2.8055
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.668
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9714
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.991
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9987
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.5046
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PIK3CB, IGF1R 2.5969
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.5096
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.5147
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.185
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.4333
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.4333
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.3971
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.4333
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, PIK3CB 2.415
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.251
Endocytosis_Homo sapiens_hsa04144 SRC, KIT, KDR, MET, IGF1R 2.0697
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.219
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.0697
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8935
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.7577
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.7479
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 1.9389
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.1257
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.8719
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.251
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.2745
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.6245
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.2357
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.4872
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB 2.3939
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.5921
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.8784
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET 1.4423
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.5331
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.2357
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.5331
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.4877
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1985
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, KIT, PIK3CB 1.4632
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.4245
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.4423
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.2395
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2842
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2964
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3059
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3059
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, PIK3CB 1.3311
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3292
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3523
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PIK3CB 2.752
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.1115
Axon guidance_Homo sapiens_hsa04360 MET 0.3864
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3942
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.2388
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5267
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7138
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.7219
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4597
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8739
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.8877
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.8965
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4755
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4747
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9389
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4919
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4939
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.1115
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 1.0736
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1205
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.493
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.0487
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.0736
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.0736
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.0592
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.0803
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.0592
Peroxisome_Homo sapiens_hsa04146 XDH 0.5123
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1, PTGS2 1.0736
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.1422
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5267
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5474
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5455
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.56
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5621
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.2805
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.3189
Shigellosis_Homo sapiens_hsa05131 SRC 0.5815
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.2982
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6091
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.2982
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3189
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.3118
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.4016
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.6394
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.4872
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4095
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6657
Malaria_Homo sapiens_hsa05144 MET 0.678
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6876
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.5331
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6828
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.5738
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6893
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6876
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7033
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8671
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8342
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.755
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8784
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8184
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.743
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8579
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8881
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8798
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0552
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.0295
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.099
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.185
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.4016


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)