TCM Prescription: Bu Shen Pills



Prescription Description
Prescription IDTCMF3955
Pinyin NameBu Shen Wan
Chinese Name补肾丸
English NameBu Shen Pills
Function Description眩晕, 咳嗽, 遗精
IndicationsInvoluntary ejaculation disorder, Vertigo disorder, Dizziness
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Lung, Kidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2056 Cynomorium songaricum 锁阳 TCMH2056 ITSAO3649-14
TCMH746 Carapax et plastrum testudinis 龟甲 TCMH746
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT601 F2 Thrombin Unclassified P00734
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.9619
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1027
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, IGF1R, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1 8.77192
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 8.72338
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, KDR, MAOB, MET, PPARA, SRC, TRPV1, XDH 8.40035
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 8.13481
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MMP2, NR3C1, PPARA, RORC, SRC, TRPV1 8.09042
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, PDE5A, PIM1, PPARA, XDH 7.95989
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FLT3, MAOB, NR3C1, RORC, SRC, TRPV1 7.79521
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, MET, PPARA, TRPV1 7.68835
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 7.55533
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 7.25232
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1 6.85223
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA, TRPV1 6.8007
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, IGF1R, MAOB, MMP2, NR3C1, PPARA, SRC, TRPV1 6.77079
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MAOB, MMP9, SRC 6.73059
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, PPARA, SRC, TRPV1 6.68123
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, XDH 6.55196
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.49265
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CHRM1, CSNK2A1, CYP1B1, DRD2, ESR1, ESRRA, F2, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 6.28055
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRB, F10, F2, F3, FABP4, IGF1R, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1 6.25407
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, SRC, XDH 6.24034
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, MAOB, NR3C1, RORC, SRC 6.23339
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, SRC, XDH 6.22514
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, F2, KDR, SRC, TRPV1 6.11759
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.10162
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, HSD11B1, KDR, MAOB, MMP9, PIM1, PPARA, RORC, SRC 5.74252
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, RORC, SRC 5.55548
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CA3, CYP1A1, CYP1B1, DRD1, DRD2, KDR, MAOB, SRC 5.50202
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 5.36257
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 5.33053
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, KDR, MAOB, NR3C1, SRC, TRPV1 5.27986
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1 5.23089
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F2, F3, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, PPARA, SRC, TRPV1 5.12594
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, BCL2, CHRM1, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 5.06963
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 5.04913
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HSD11B1, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC 4.96601
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 4.92428
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 4.9141
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, DRD1, DRD2, F2, HCAR2, KDR, SRC, TRPV1 4.82621
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, NR3C1, RORC, SRC, TRPV1 4.77283
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, SRC, TRPV1, XDH 4.76653
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.73207
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.66795
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, DRD2, F10, F2, F3, MET, XDH 4.63911
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC, SRC 4.61846
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, F10, F2, F3, FLT3, KDR, MET, PDE5A, SRC, XDH 4.59677
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HCAR2, HSD11B1, HSD17B1 4.5563
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, MAOB 4.51859
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD17B1 4.46532
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, DRD1, DRD2, MET, TRPV1 4.45084
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA3, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MAOB, MMP2, MMP9, NR3C1, PPARA, RORC, SRC, TRPV1 4.43282
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, F2, PPARA 4.43282
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.41841
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CHRM1, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 4.3994
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F10, F3, IGF1R, KDR, MET, MMP9, SRC 4.34814
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD2 4.29743
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.29431
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESR1, F10, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, SRC, XDH 4.28655
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, NR3C1, RORC, SRC, TRPV1 4.25107
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIM1, SRC, TRPV1, XDH 4.22196
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, AXL, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, FLT3, MET, SRC, TRPV1 4.17073
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, F2, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 4.13165
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD2, FABP3, FABP4, FUT7, MET, PPARA 3.97425
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1 3.86052
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.79236
[BP] GO:0019748 secondary metabolic process AKR1B1, BCL2, CYP1A1, CYP1A2, CYP1B1 3.78314
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, PPARA, TRPV1 3.75713
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.75713
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 3.73874
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.7358
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, SRC, XDH 3.69999
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.69999
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.69999
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 3.69279
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.68344
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 3.67356
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 3.65471
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, MAOB, XDH 3.65255
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, MAOB 3.65255
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.65099
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, KDR, PPARA, SRC 3.6413
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, SRC, XDH 3.63555
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.62275
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 3.62275
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, F10, F2, F3, FLT3, KDR, MET, MMP9, PDE5A, SRC, XDH 3.60754
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, MET, PIM1, SRC 3.5874
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CHRM3, CYP1B1, DRD2, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, SRC, TRPV1 3.53686
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.52934
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 3.49669
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.4932
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.48926
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.48444
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CYP1B1, DRD2, ESR1, ESRRA, ESRRB, F2, F3, HCAR2, KDR, MET, MMP9, PDE5A, PIM1, SRC, TRPV1, XDH 3.4809
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.47915
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, IGF1R, KDR, MAOB, MET, MMP9, NR3C1, PDE5A, PPARA, RORC, SRC, TRPV1, XDH 3.46952
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, FABP4, MET, TRPV1 3.461
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 3.4269
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.40135
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.39615
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.3008
[BP] GO:0001659 None ADORA1, DRD1, DRD2, TRPV1 3.29354
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.28465
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.24288
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, ESRRA, F10, F2, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PDE5A, SRC, XDH 3.23566
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.23566
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 3.22997
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, NR3C1, SRC, TRPV1 3.21744
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21744
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, ESR1, PPARA, RORC, SRC 3.20372
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, SRC 3.20372
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.18552
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 3.13675
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.08197
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 3.07936
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, NR3C1, RORC, SRC, TRPV1 3.07936
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, MAOB 3.07936
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, F10, F3, MET, SRC, XDH 3.06856
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, MAOB, NR3C1, SRC 2.97373
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, MAOB 2.93669
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, ESR1, F2, F3, FABP4, KDR, MET, PPARA 2.93171
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CHRM5, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.92279
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, F2, HCAR2 2.89791
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CHRM5, DRD1, DRD2, ESRRB, F2, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.88254
[BP] GO:0009115 None AOX1, XDH 2.86638
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.86638
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.86638
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.86638
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PDE5A, SRC, XDH 2.8249
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, DRD1, DRD2, ESRRB, F2, FABP3, FLT3, KDR, MMP9, PDE5A, SRC, XDH 2.8249
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 2.8248
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 2.8248
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.8248
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, MAOB, NR3C1, SRC 2.8248
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1 2.8248
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD17B1 2.81263
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD1, DRD2, F2, HCAR2, SRC, TRPV1 2.78515
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.72756
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PDE5A, PPARA, SRC, XDH 2.71653
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, F10, F2, FABP3, MMP9, PPARA, SRC, TRPV1, XDH 2.70676
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HCAR2, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 2.67093
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.66804
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.66804
[BP] GO:0006939 None CHRM3, DRD1, DRD2, TRPV1 2.66403
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1 2.64387
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CYP19A1, DRD1, DRD2, ESR1, ESR2, F2, IGF1R, MET, MMP9, PPARA, SRC, XDH 2.64232
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIM1, SRC 2.62894
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CYP19A1, DRD1, DRD2, F2, HCAR2, MAOB, MMP9, PPARA, SRC, TRPV1 2.60372
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.58978
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PPARA, SRC, XDH 2.5884
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, ESR1, F10, F2, FABP3, MMP9, PPARA, SRC, TRPV1, XDH 2.5884
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.58579
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD1, DRD2, F10, F2, FABP3, MMP9, PPARA, SRC, TRPV1, XDH 2.57831
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, MAOB, NR3C1, SRC 2.53664
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, F2, FLT3, IGF1R, KDR, MET, SRC 2.53516
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.5225
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.51268
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.51268
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CHRM1, DRD1, DRD2, F2, MAOB, MMP9 2.51116
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.50199
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, MAOB 2.49917
[BP] GO:0046110 None AOX1, XDH 2.48842
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48842
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.48842
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.46236
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, DRD2, F2, PPARA 2.43459
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CSNK2A1, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, IGF1R, KDR, MET, MMP9, NR3C1, PDE5A, PPARA, RORC, SRC, XDH 2.43459
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.43459
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.43459
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.43459
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, PDE5A 2.38648
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.37442
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 2.35785
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.33491
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 2.32511
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD2, HCAR2, PDE5A, TRPV1 2.32511
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.3212
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CHRM1, CHRM3, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DRD2, ESR1, F10, F2, F3, FLT3, FUT7, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, SRC, XDH 2.31669
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, PPARA, SRC 2.29873
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.26892
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, IGF1R, KDR, MET, NR3C1, PPARA, RORC, SRC, TRPV1 2.26479
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.26479
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.26424
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1 2.25796
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD1, DRD2, FABP3, PPARA, TRPV1 2.25198
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3 2.24649
[BP] GO:0006145 None AOX1, XDH 2.24649
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24649
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD1, DRD2, ESR1, F2, FABP3, TRPV1 2.24019
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.23515
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CA3, CSNK2A1, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PDE5A, PIM1, SRC, XDH 2.13825
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.13704
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, DRD2, ESRRB, F2, FLT3, KDR, MMP9, PDE5A, SRC, XDH 2.13025
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.09535
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, FLT3, MAOB, NR3C1 2.0904
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, MMP2, PPARA, SRC, TRPV1 2.08246
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DRD2, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, SRC 2.08155
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, DRD2, MAOB, MMP9 2.0736
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.0736
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.0736
[BP] GO:0021853 None DRD1, DRD2 2.0736
[BP] GO:0046541 None CHRM1, CHRM3 2.0736
[BP] GO:0010641 None F3, SRC 2.0736
[BP] GO:0007598 None F10, F3 2.0736
[BP] GO:1904936 None DRD1, DRD2 2.0736
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.0736
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.0736
[BP] GO:0042321 None ADORA1, DRD2 2.0736
[BP] GO:0032845 None ADORA1, BCL2, DRD2, SRC, TRPV1 2.04547
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, MAOB, PDE5A, XDH 2.02154
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR2, TRPV1 2.02154
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.01837
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, DRD1, DRD2, ESR1, F10, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, PIM1, SRC, TRPV1 3.31977
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F10, F3, FLT3, IGF1R, KDR, MET, TRPV1 3.22856
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, MET, SRC, TRPV1 2.7212
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F10, F2, F3, FLT3, IGF1R, KDR, MET, SRC, TRPV1 2.54221
[CC] GO:0043679 None CHRM1, CHRM2, CHRM3, DRD2 2.483
[CC] GO:0031233 None CA4, F10, F3 2.43459
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, F10, F2, F3, FLT3, FUT7, HCAR2, HSD11B1, IGF1R, KDR, MAOB, MET, MMP2, PIM1, SRC, TRPV1 2.30038
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, SRC, TRPV1 2.15648
[CC] GO:0044306 None CHRM1, CHRM2, CHRM3, DRD2 2.13704
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2026
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, RORC, XDH 17.6022
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, SRC, TRPV1, XDH 13.6434
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.0818
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5586
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, TRPV1, XDH 9.76772
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, F10, F2, F3, FLT3, FUT7, HSD11B1, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, SRC, XDH 9.07105
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NR3C1, PPARA, RORC 8.77192
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 8.22705
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.64475
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP2, MMP9, NR3C1, PDE5A, PIM1, PPARA, RORC, TRPV1, XDH 7.38316
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, NR3C1, PPARA, RORC, TRPV1 7.3788
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 7.34892
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 7.09799
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 7.02084
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HCAR2, IGF1R, KDR, MET, NR3C1, PPARA, RORC, TRPV1 6.60867
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, RORC 6.5914
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.49265
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, RORC 6.28055
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.33053
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.27986
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.27986
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DRD2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 5.22489
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.09859
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD17B1, MAOB, XDH 4.57096
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 4.10113
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.04153
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5, DRD2 3.6187
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.54172
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2 3.52934
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.47915
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.41871
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, DRD1, DRD2, F3, FLT3, HCAR2, IGF1R, KDR, MET, TRPV1 3.41871
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.33969
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.33405
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD17B1, MAOB, SRC, XDH 3.22856
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.21744
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.05995
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.05995
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.99502
[MF] GO:0042562 hormone binding ACHE, CHRM3, HSD17B1, IGF1R, NR3C1 2.92007
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.86638
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.86638
[MF] GO:0008081 None ADORA1, CHRM1, CHRM3, CHRM5, PDE5A 2.81529
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.73135
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.50847
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.48842
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.48842
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.48842
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP2, MMP9 2.40395
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.24649
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.24649
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.24649
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.13704
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AOX1, HSD11B1, HSD17B1, XDH 2.12847
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5 2.09535
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.09535
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, DRD1, DRD2 2.08155
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.0736
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.0736


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.6276
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, TRPV1, DRD1, NR3C1, F2, DRD2 7.2943
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.3655
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.3983
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.3378
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2 4.4865
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, DRD1, DRD2, PPARA 4.2495
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.2495
Metabolic pathways_Homo sapiens_hsa01100 MAOB, ALOX15, AKR1B1, ALOX12, CYP3A4, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.1074
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.2495
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, ESR2 3.7796
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.1074
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0092
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5, F2 3.2583
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.276
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.776
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOB, CYP1A2, AOX1, CYP3A4 3.2583
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.1641
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, DRD1 2.776
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.7486
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2583
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6017
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, MET, IGF1R 2.4384
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.5491
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, ALOX12 2.6017
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET 1.9846
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1512
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9846
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12 2.3244
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 2.5764
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 1.8496
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 2.0498
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5099
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, DRD2 1.969
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.1453
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 1.5533
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6282
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4396
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.3719
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.3327
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.29
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.1023
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3719
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3327
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3719
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.29
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1131
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9755
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1104
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.29
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2457
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1104
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2712
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0413
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1023
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.29
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.211
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9755
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8592
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0896
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8592
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9755
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9755
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8592
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2712
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6702
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.7523
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7493
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5099
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3157
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3413
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3673
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3412
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4136
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.4015
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3982
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3863
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4202
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4123
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4245
Platelet activation_Homo sapiens_hsa04611 SRC 0.4384
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4391
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4245
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4384
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4384
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.4667
Axon guidance_Homo sapiens_hsa04360 MET 0.4336
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4667
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.4977
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4904
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.518
Taste transduction_Homo sapiens_hsa04742 CHRM3 0.518
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5054
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5054
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.518
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.518
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.518
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1 1.6959
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5177
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.518
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.518
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.518
Peroxisome_Homo sapiens_hsa04146 XDH 0.518
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5724
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5924
Glioma_Homo sapiens_hsa05214 IGF1R 0.5924
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5909
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5964
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5924
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5924
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5924
Shigellosis_Homo sapiens_hsa05131 SRC 0.5924
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.5983
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6515
Malaria_Homo sapiens_hsa05144 MET 0.6578
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.6546
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6645
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6611
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9935
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7196
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8058
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7978
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7523
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7899
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8085
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8422
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8058
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8324
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.8592
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.9755
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0399
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1541
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.29


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)