Prescription ID | TCMF3867 |
Pinyin Name | Bu Nao An Shen Pian |
Chinese Name | 补脑安神片 |
English Name | Bu Nao An Shen Tablets |
Function Description | 眩晕, 头痛, 心悸, 不寐, 健忘 |
Indications | Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Headache, Palpitations, Dizziness |
Disease ICD-11 Category |
SD22 [Vertigo disorder (TM1), 眩晕 (TM1)
]; SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ]; SD84 [Insomnia disorder (TM1), 不寐 (TM1) ]; 7A0Z [Insomnia disorders, unspecified, 失眠障碍,未特指的 ]; MB6Y [Other specified symptoms or signs involving the nervous system, 其他特指的累及神经系统的症状或体征 ]; MC81.2 [Palpitations, 心悸 ]; MB48 [Dizziness and giddiness, 头晕和眩晕 ]; |
Human Tissues Associated with Indication | Heart, Brain |
Reference | CFDA |
Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
---|---|---|---|---|
TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
TCMH819 | Polygonum multiflorum | 何首乌 | TCMH819 | ITSAL419-14 |
TCMH1597 | Ligustrum lucidum | 女贞子 | TCMH1597 | ITSAM2109-14 |
TCMH2052 | Ziziphus jujuba var. spinosa | 酸枣仁 | TCMH2052 | ITSAM943-14 |
TCMH967 | Polygonatum sibiricum | 黄精 | TCMH967 | ITSAH4762-14 |
TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
TCMH816 | Albizzia julibrissin | 合欢皮 | TCMH816 | KT972683 |
TCMH1503 | Eclipta prostrata | 墨旱莲 | TCMH1503 | ITSAP4516-14 |
TCMH2682 | Cinnabaris | 朱砂 | TCMH2682 | |
TCMH2554 | Polygala tenuifolia | 远志 | TCMH2554 | MF096619 |
TCMH1797 | Morus alba | 桑叶 | TCMH1797 | ITSAL1073-14 |
Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
---|---|---|---|---|
TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
TCMT11 | HIF1A | Hypoxia-inducible factor 1 alpha | Transcription factor | Q16665 |
TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
TCMT118 | MGAM | Maltase-glucoamylase | Hydrolase | O43451 |
TCMT124 | FUCA1 | Alpha-L-fucosidase I | Hydrolase | P04066 |
TCMT125 | GBA | Beta-glucocerebrosidase | Hydrolase | P04062 |
TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
TCMT164 | PTGS1 | Cyclooxygenase-1 | Oxidoreductase | P23219 |
TCMT18 | GAA | Lysosomal alpha-glucosidase | Hydrolase | P10253 |
TCMT189 | DUSP3 | Dual specificity protein phosphatase 3 | Hydrolase | P51452 |
TCMT190 | PTPN2 | T-cell protein-tyrosine phosphatase | Hydrolase | P17706 |
TCMT197 | PDE4D | Phosphodiesterase 4D | Hydrolase | Q08499 |
TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
TCMT207 | BACE1 | Beta-secretase 1 | Protease | P56817 |
TCMT212 | SRC | Tyrosine-protein kinase SRC | Kinase | P12931 |
TCMT215 | CYP1A1 | Cytochrome P450 1A1 | Oxidoreductase | P04798 |
TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
TCMT23 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Hydrolase | P05186 |
TCMT232 | ABCB1 | P-glycoprotein 1 | Transporter | P08183 |
TCMT236 | ESR2 | Estrogen receptor beta | Nuclear receptor | Q92731 |
TCMT239 | PIM1 | Serine/threonine-protein kinase PIM1 | Kinase | P11309 |
TCMT240 | AMY1A | Salivary alpha-amylase | Unclassified | P04745 |
TCMT254 | CBR1 | Carbonyl reductase [NADPH] 1 | Oxidoreductase | P16152 |
TCMT257 | CYP1B1 | Cytochrome P450 1B1 | Oxidoreductase | Q16678 |
TCMT260 | FLT3 | Tyrosine-protein kinase receptor FLT3 | Kinase | P36888 |
TCMT261 | DAPK1 | Death-associated protein kinase 1 | Kinase | P53355 |
TCMT268 | CYP2A13 | Cytochrome P450 2A13 | Oxidoreductase | Q16696 |
TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
TCMT281 | DPP4 | Dipeptidyl peptidase IV | Unclassified | P27487 |
TCMT283 | PTPRS | Receptor-type tyrosine-protein phosphatase S | Hydrolase | Q13332 |
TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
TCMT298 | FABP3 | Fatty acid binding protein muscle | Hydrolase | P05413 |
TCMT30 | PTGS2 | Cyclooxygenase-2 | Oxidoreductase | P35354 |
TCMT302 | HMGCR | HMG-CoA reductase | Oxidoreductase | P04035 |
TCMT304 | MMP14 | Matrix metalloproteinase 14 | Hydrolase | P50281 |
TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
TCMT322 | MMP13 | Matrix metalloproteinase 13 | Hydrolase | P45452 |
TCMT329 | NQO2 | Quinone reductase 2 | Oxidoreductase | P16083 |
TCMT347 | MAN1B1 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | Hydrolase | Q9UKM7 |
TCMT354 | AURKA | Serine/threonine-protein kinase Aurora-A | Kinase | O14965 |
TCMT369 | IGF1R | Insulin-like growth factor I receptor | Kinase | P08069 |
TCMT370 | KDR | Vascular endothelial growth factor receptor 2 | Kinase | P35968 |
TCMT374 | AURKB | Serine/threonine-protein kinase Aurora-B | Kinase | Q96GD4 |
TCMT377 | INSR | Insulin receptor | Kinase | P06213 |
TCMT384 | GRK6 | G protein-coupled receptor kinase 6 | Kinase | P43250 |
TCMT388 | AXL | Tyrosine-protein kinase receptor UFO | Kinase | P30530 |
TCMT401 | MET | Hepatocyte growth factor receptor | Kinase | P08581 |
TCMT418 | EPHB4 | Ephrin type-B receptor 4 | Kinase | P54760 |
TCMT422 | CAMK2B | CaM kinase II beta | Kinase | Q13554 |
TCMT423 | EGFR | Epidermal growth factor receptor erbB1 | Kinase | P00533 |
TCMT436 | NUAK1 | NUAK family SNF1-like kinase 1 | Kinase | O60285 |
TCMT44 | GLO1 | Glyoxalase I | Lyase | Q04760 |
TCMT445 | NEK2 | Serine/threonine-protein kinase NEK2 | Kinase | P51955 |
TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
TCMT457 | FLT4 | Vascular endothelial growth factor receptor 3 | Kinase | P35916 |
TCMT462 | NEK6 | Serine/threonine-protein kinase NEK6 | Kinase | Q9HC98 |
TCMT47 | BCL2 | Apoptosis regulator Bcl-2 | Ion channel | P10415 |
TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
TCMT484 | PLK1 | Serine/threonine-protein kinase PLK1 | Kinase | P53350 |
TCMT502 | TEK | Tyrosine-protein kinase TIE-2 | Kinase | Q02763 |
TCMT536 | PDGFRB | Platelet-derived growth factor receptor beta | Kinase | P09619 |
TCMT558 | TOP2A | DNA topoisomerase II alpha | Isomerase | P11388 |
TCMT563 | CDC25B | Dual specificity phosphatase Cdc25B | Hydrolase | P30305 |
TCMT567 | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | Transferase | P26358 |
TCMT588 | DAO | D-amino-acid oxidase | Oxidoreductase | P14920 |
TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
TCMT597 | SLC28A3 | Solute carrier family 28 member 3 | Transporter | Q9HAS3 |
TCMT599 | UBE2N | Ubiquitin-conjugating enzyme E2 N | Transferase | P61088 |
TCMT61 | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Unclassified | Q07820 |
TCMT614 | EGLN1 | Egl nine homolog 1 | Oxidoreductase | Q9GZT9 |
TCMT626 | BRAF | Serine/threonine-protein kinase B-raf | Kinase | P15056 |
TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
TCMT65 | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | Oxidoreductase | P14061 |
TCMT66 | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | Oxidoreductase | P37059 |
TCMT690 | HDAC3 | Histone deacetylase 3 | Hydrolase | O15379 |
TCMT698 | PDE4B | Phosphodiesterase 4B | Hydrolase | Q07343 |
TCMT709 | SLC28A2 | Sodium/nucleoside cotransporter 2 | Transporter | O43868 |
TCMT710 | SLC28A1 | Sodium/nucleoside cotransporter 1 | Transporter | O00337 |
TCMT718 | TXN2 | Thioredoxin, mitochondrial | Unclassified | Q99757 |
TCMT719 | TXN | Thioredoxin | Unclassified | P10599 |
TCMT721 | HSPA1A | Heat shock 70 kDa protein 1 | Unclassified | P0DMV8 |
TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
TCMT734 | MMP12 | Matrix metalloproteinase 12 | Hydrolase | P39900 |
TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
TCMT739 | GPR35 | G-protein coupled receptor 35 | GPCR | Q9HC97 |
TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
TCMT751 | DYRK1A | Dual-specificity tyrosine-phosphorylation regulated kinase 1A | Kinase | Q13627 |
TCMT752 | CSNK2A1 | Casein kinase II alpha | Kinase | P68400 |
TCMT753 | SMAD3 | Mothers against decapentaplegic homolog 3 | Unclassified | P84022 |
TCMT755 | PLK4 | Serine/threonine-protein kinase PLK4 | Kinase | O00444 |
TCMT756 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Kinase | P41279 |
TCMT784 | AVPR2 | Vasopressin V2 receptor | GPCR | P30518 |
TCMT785 | CXCR1 | Interleukin-8 receptor A | GPCR | P25024 |
TCMT786 | CCR4 | C-C chemokine receptor type 4 | GPCR | P51679 |
TCMT791 | PKN1 | Protein kinase N1 | Kinase | Q16512 |
TCMT793 | PYGL | Liver glycogen phosphorylase | Transferase | P06737 |
TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
TCMT807 | SLC22A12 | Solute carrier family 22 member 12 | Transporter | Q96S37 |
TCMT808 | FABP5 | Fatty acid binding protein epidermal | Unclassified | Q01469 |
TCMT809 | FABP2 | Fatty acid binding protein intestinal | Unclassified | P12104 |
TCMT810 | TLR2 | Toll-like receptor 2 | Unclassified | O60603 |
TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
TCMT822 | FUT7 | Alpha-(1,3)-fucosyltransferase 7 | Transferase | Q11130 |
TCMT83 | CD38 | Lymphocyte differentiation antigen CD38 | Unclassified | P28907 |
Target ID | Target Name |
---|---|
TCMT1170 | Enterobacter cloacae |
TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
TCMT1175 | Human immunodeficiency virus |
TCMT1176 | Streptococcus pneumoniae |
TCMT1178 | Actinomyces viscosus |
TCMT1179 | Escherichia coli ATCC 8739 |
TCMT1180 | Human herpesvirus 2 |
TCMT1181 | Mycobacterium tuberculosis H37Ra |
TCMT1182 | Streptococcus sanguinis |
TCMT1189 | Pseudomonas fluorescens |
TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
TCMT1208 | Escherichia coli K12 |
TCMT1209 | Staphylococcus haemolyticus |
TCMT1212 | Verticillium dahliae |
TCMT1213 | Neisseria gonorrhoeae |
TCMT1215 | Pseudomonas aeruginosa PAO1 |
TCMT1218 | Staphylococcus aureus |
TCMT1221 | Human herpesvirus 4 |
TCMT1222 | Plasmodium falciparum D6 |
TCMT1223 | Staphylococcus epidermidis |
TCMT1226 | Klebsiella pneumoniae |
TCMT1229 | Enterococcus faecalis |
TCMT1231 | Human herpesvirus 1 strain KOS |
TCMT1232 | Pseudomonas aeruginosa |
TCMT1243 | Aspergillus flavus |
TCMT1245 | Phytophthora cactorum |
TCMT1246 | Escherichia coli |
TCMT1247 | Human herpesvirus 1 |
TCMT1248 | Hepatitis C virus |
TCMT1249 | Dengue virus 2 |
TCMT1251 | Candida albicans |
TCMT1253 | Penicillium chrysogenum |
TCMT1255 | Human immunodeficiency virus 1 |
TCMT1282 | Colletotrichum orbiculare |
TCMT1286 | Bacillus cereus |
TCMT1289 | Shigella dysenteriae |
TCMT1294 | Human parainfluenza virus 3 |
TCMT1346 | Helicobacter pylori |
TCMT1349 | Helicobacter pylori SS1 |
TCMT1361 | Neisseria meningitidis |
TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
TCMT1390 | Human herpesvirus 2 strain G |
TCMT1408 | Colletotrichum gloeosporioides |
TCMT1412 | Salmonella typhimurium |
TCMT1438 | Plasmodium falciparum |
TCMT1439 | Mycobacterium smegmatis |
TCMT1442 | Leishmania donovani |
TCMT1443 | Leishmania amazonensis |
TCMT1444 | Fusarium oxysporum |
TCMT1447 | Respiratory syncytial virus |
TCMT1448 | Enterobacter aerogenes |
TCMT1449 | Influenza A virus |
TCMT1450 | Plasmodium falciparum 3D7 |
TCMT1454 | Bacillus subtilis |
TCMT1455 | Mycobacterium tuberculosis H37Rv |
TCMT1458 | Filobasidiella neoformans |
TCMT1462 | Streptococcus mutans |
TCMT1463 | Mycobacterium tuberculosis |
TCMT1464 | Hepatitis B virus |
TCMT1465 | Entamoeba histolytica |
GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
---|---|---|---|
[BP] GO:0044281 | small molecule metabolic process | AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH | 13.3483 |
[BP] GO:0008152 | metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 12.411 |
[BP] GO:0044237 | cellular metabolic process | ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 12.1705 |
[BP] GO:0006629 | lipid metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 11.6693 |
[BP] GO:0010941 | regulation of cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GBA, GLO1, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 11.5984 |
[BP] GO:0015701 | bicarbonate transport | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 11.2306 |
[BP] GO:0043067 | regulation of programmed cell death | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 10.8692 |
[BP] GO:0010033 | response to organic substance | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 10.8363 |
[BP] GO:0010647 | positive regulation of cell communication | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 10.8298 |
[BP] GO:0023056 | positive regulation of signaling | ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 10.8091 |
[BP] GO:0060548 | negative regulation of cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT | 10.7364 |
[BP] GO:0006730 | one-carbon metabolic process | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.4716 |
[BP] GO:0042221 | response to chemical | ABCB1, AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TERT, TYR | 10.4716 |
[BP] GO:1901700 | response to oxygen-containing compound | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, GBA, HMGCR, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR | 10.4716 |
[BP] GO:0042981 | regulation of apoptotic process | ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, GLO1, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 10.3988 |
[BP] GO:0043069 | negative regulation of programmed cell death | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT | 9.87989 |
[BP] GO:0042127 | regulation of cell proliferation | ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FLT3, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH | 9.48125 |
[BP] GO:0065008 | regulation of biological quality | ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TERT, XDH | 9.15275 |
[BP] GO:0043066 | negative regulation of apoptotic process | ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT | 9.15275 |
[BP] GO:0019748 | secondary metabolic process | AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 9.15275 |
[BP] GO:1902531 | regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 9.11407 |
[BP] GO:0010646 | regulation of cell communication | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 9.05972 |
[BP] GO:0023051 | regulation of signaling | ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 8.89185 |
[BP] GO:0080134 | regulation of response to stress | ABCB1, ADORA1, APP, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 8.38509 |
[BP] GO:0032502 | developmental process | ACHE, ADORA1, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B2, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR | 8.29083 |
[BP] GO:0070887 | cellular response to chemical stimulus | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SMAD3, SRC, TERT | 8.26308 |
[BP] GO:0048522 | positive regulation of cellular process | ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 8.26308 |
[BP] GO:0010035 | response to inorganic substance | AKR1B1, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, HIF1A, KDR, MMP9, PTGS2, SRC, TERT | 8.22485 |
[BP] GO:0044255 | cellular lipid metabolic process | ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUCA1, FUT7, GBA, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 | 8.22485 |
[BP] GO:0009967 | positive regulation of signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 8.10096 |
[BP] GO:0009719 | response to endogenous stimulus | AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, EGFR, ESR1, FABP3, FLT3, GBA, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK | 8.07745 |
[BP] GO:0042592 | homeostatic process | ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GAA, GBA, GPR35, HIF1A, INSR, MCL1, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT | 7.62595 |
[BP] GO:0048518 | positive regulation of biological process | ABCB1, ACHE, ADORA1, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 7.44414 |
[BP] GO:0019369 | arachidonic acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 7.4326 |
[BP] GO:0010648 | negative regulation of cell communication | ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH | 7.40844 |
[BP] GO:0023057 | negative regulation of signaling | ACHE, ADORA1, BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH | 7.38952 |
[BP] GO:1902533 | positive regulation of intracellular signal transduction | ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HMGCR, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 7.36156 |
[BP] GO:0044238 | primary metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 7.30848 |
[BP] GO:0055114 | oxidation-reduction process | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, GAA, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 7.22888 |
[BP] GO:0051716 | cellular response to stimulus | AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A | 7.15103 |
[BP] GO:0071310 | cellular response to organic substance | AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CYP1A1, CYP1B1, DNMT1, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SMAD3, SRC | 7.15103 |
[BP] GO:0014070 | response to organic cyclic compound | ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, GBA, PTGS2, RORC, SRC, TEK, TYR | 7.10904 |
[BP] GO:0009725 | response to hormone | AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, INSR, PPARA, PTGS2, SRC, TEK | 6.90835 |
[BP] GO:0048585 | negative regulation of response to stimulus | ADORA1, BCL2, CYP19A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 6.90549 |
[BP] GO:0033559 | unsaturated fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 6.87535 |
[BP] GO:0030334 | regulation of cell migration | ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 6.69279 |
[BP] GO:1902532 | negative regulation of intracellular signal transduction | BCL2, DUSP3, DYRK1A, ESR1, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP9, PTGS2, PTPN1, SRC, XDH | 6.68102 |
[BP] GO:0050896 | response to stimulus | ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, EGFR, ESR1, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR | 6.65301 |
[BP] GO:0006690 | icosanoid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 6.63733 |
[BP] GO:0008202 | steroid metabolic process | AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HMGCR, HSD17B1, HSD17B2 | 6.63733 |
[BP] GO:0009966 | regulation of signal transduction | ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 6.59769 |
[BP] GO:0046777 | protein autophosphorylation | AURKB, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK | 6.57536 |
[BP] GO:0006796 | phosphate-containing compound metabolic process | ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, XDH | 6.43343 |
[BP] GO:0033993 | response to lipid | ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, GBA, HSD17B2, PTGS2, RORC, SRC, TYR | 6.3747 |
[BP] GO:0071704 | organic substance metabolic process | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 6.35252 |
[BP] GO:2000145 | regulation of cell motility | ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 6.3167 |
[BP] GO:0048523 | negative regulation of cellular process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 6.19244 |
[BP] GO:0048583 | regulation of response to stimulus | ABCB1, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 6.12616 |
[BP] GO:0048584 | positive regulation of response to stimulus | ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HIF1A, HMGCR, HSPA1A, INSR, KDR, MCL1, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 6.10455 |
[BP] GO:0006793 | phosphorus metabolic process | ACHE, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, XDH | 6.03597 |
[BP] GO:0032879 | regulation of localization | ABCB1, ACHE, ADORA1, ADORA3, APEX1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT | 6.01528 |
[BP] GO:0009968 | negative regulation of signal transduction | BCL2, DUSP3, DYRK1A, EGFR, ESR1, ESR2, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, XDH | 6.00058 |
[BP] GO:0048513 | animal organ development | ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HIF1A, HSD17B2, INSR, KDR, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR | 5.99281 |
[BP] GO:0032501 | multicellular organismal process | ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, GAA, GBA, HIF1A, HMGCR, HSD17B2, IGF1R, INSR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR | 5.91026 |
[BP] GO:0008284 | positive regulation of cell proliferation | AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT | 5.87089 |
[BP] GO:0010562 | positive regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.85395 |
[BP] GO:0045937 | positive regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, GBA, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.85395 |
[BP] GO:0030335 | positive regulation of cell migration | APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.85395 |
[BP] GO:0040012 | regulation of locomotion | ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.85395 |
[BP] GO:0009056 | catabolic process | ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH | 5.85395 |
[BP] GO:0051270 | regulation of cellular component movement | ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.84091 |
[BP] GO:0009628 | response to abiotic stimulus | ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, GBA, HIF1A, HMGCR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT, TYR | 5.80496 |
[BP] GO:0018108 | peptidyl-tyrosine phosphorylation | AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.76381 |
[BP] GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC | 5.75224 |
[BP] GO:0018212 | peptidyl-tyrosine modification | AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.71133 |
[BP] GO:0019220 | regulation of phosphate metabolic process | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.70903 |
[BP] GO:2000147 | positive regulation of cell motility | APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.70232 |
[BP] GO:0051174 | regulation of phosphorus metabolic process | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.64586 |
[BP] GO:0001676 | long-chain fatty acid metabolic process | CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 5.60252 |
[BP] GO:0051272 | positive regulation of cellular component movement | APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.56237 |
[BP] GO:0051173 | positive regulation of nitrogen compound metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 5.55771 |
[BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT | 5.51503 |
[BP] GO:0080135 | regulation of cellular response to stress | APP, DUSP3, DYRK1A, EGFR, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, NUAK1, PTGS2, PTPN1, PTPRS, TERT, XDH | 5.51067 |
[BP] GO:0036293 | response to decreased oxygen levels | ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT | 5.39811 |
[BP] GO:0040017 | positive regulation of locomotion | APP, BCL2, EGFR, HIF1A, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT | 5.39811 |
[BP] GO:0048519 | negative regulation of biological process | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, GBA, GLO1, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 5.39811 |
[BP] GO:0009987 | cellular process | ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 5.39811 |
[BP] GO:1901568 | fatty acid derivative metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 | 5.36018 |
[BP] GO:0019373 | epoxygenase P450 pathway | CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 5.3057 |
[BP] GO:0006979 | response to oxidative stress | AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC | 5.3057 |
[BP] GO:0015711 | organic anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 5.3057 |
[BP] GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 5.3057 |
[BP] GO:0065009 | regulation of molecular function | ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GPR35, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 5.24393 |
[BP] GO:0031325 | positive regulation of cellular metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 5.20296 |
[BP] GO:0048856 | anatomical structure development | ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, GAA, HIF1A, HSD17B2, INSR, KDR, MCL1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR | 5.17191 |
[BP] GO:0048661 | positive regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT | 5.17043 |
[BP] GO:0010604 | positive regulation of macromolecule metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 5.15656 |
[BP] GO:0050790 | regulation of catalytic activity | ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 5.13327 |
[BP] GO:0051247 | positive regulation of protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 5.08057 |
[BP] GO:0070482 | response to oxygen levels | ADORA1, BCL2, CYP1A1, HIF1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TERT | 5.08057 |
[BP] GO:0009892 | negative regulation of metabolic process | ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 5.08057 |
[BP] GO:0009894 | regulation of catabolic process | ADORA1, APEX1, BCL2, CSNK2A1, EGFR, GBA, HCAR2, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 | 5.04219 |
[BP] GO:0042325 | regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HIF1A, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH | 5.02255 |
[BP] GO:0006631 | fatty acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS1, PTGS2 | 5.01755 |
[BP] GO:0031399 | regulation of protein modification process | ADORA1, APP, BCL2, CDC25B, DNMT1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 5.00913 |
[BP] GO:0009893 | positive regulation of metabolic process | ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FLT3, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 4.95982 |
[BP] GO:1901564 | organonitrogen compound metabolic process | ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DAO, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A, TYR, XDH | 4.91786 |
[BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK | 4.90747 |
[BP] GO:0032270 | positive regulation of cellular protein metabolic process | ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, FLT3, GBA, HMGCR, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 4.90193 |
[BP] GO:0048878 | chemical homeostasis | AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GBA, GPR35, HIF1A, INSR, MET, PIK3CA, PIK3CB, SMAD3 | 4.85874 |
[BP] GO:0032844 | regulation of homeostatic process | ADORA1, AURKB, BCL2, CA2, CA7, EGFR, HCAR2, HIF1A, HMGCR, KDR, PIK3CB, PTGS2, SRC | 4.73911 |
[BP] GO:1901701 | cellular response to oxygen-containing compound | AKR1B1, APEX1, APP, AXL, CYP1B1, DNMT1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC | 4.73911 |
[BP] GO:0010038 | response to metal ion | APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, HIF1A, MMP9, PTGS2, TERT | 4.72835 |
[BP] GO:0032787 | None | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, HIF1A, PPARA, PTGS1, PTGS2 | 4.70803 |
[BP] GO:0031401 | positive regulation of protein modification process | ADORA1, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, GBA, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.65793 |
[BP] GO:0051049 | regulation of transport | ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TERT | 4.6504 |
[BP] GO:0007167 | enzyme linked receptor protein signaling pathway | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK | 4.60021 |
[BP] GO:0042327 | positive regulation of phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HIF1A, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.59245 |
[BP] GO:1901615 | organic hydroxy compound metabolic process | AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, DAO, GBA, HIF1A, HMGCR, TYR | 4.5296 |
[BP] GO:0031347 | regulation of defense response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK | 4.51239 |
[BP] GO:0006950 | response to stress | ACHE, ADORA1, ADORA3, AKR1B1, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MCL1, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A | 4.48404 |
[BP] GO:0043405 | regulation of MAP kinase activity | ADORA1, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CB, PTPN1, SRC | 4.48404 |
[BP] GO:0010817 | regulation of hormone levels | ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HIF1A, HMGCR, HSD17B1, HSD17B2 | 4.43869 |
[BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.42797 |
[BP] GO:0051897 | positive regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK | 4.37469 |
[BP] GO:0051896 | regulation of protein kinase B signaling | AXL, EGFR, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH | 4.36623 |
[BP] GO:2001234 | negative regulation of apoptotic signaling pathway | BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC, TERT | 4.36623 |
[BP] GO:0032847 | regulation of cellular pH reduction | BCL2, CA2, CA7 | 4.36623 |
[BP] GO:0071407 | cellular response to organic cyclic compound | ALPL, APEX1, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC | 4.36623 |
[BP] GO:0016310 | phosphorylation | APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.33949 |
[BP] GO:0043408 | regulation of MAPK cascade | ADORA1, APP, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 4.29602 |
[BP] GO:0048511 | rhythmic process | AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, PPARA, RORC, SRC, TOP2A | 4.27996 |
[BP] GO:2001242 | regulation of intrinsic apoptotic signaling pathway | BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SRC | 4.27046 |
[BP] GO:0044092 | negative regulation of molecular function | ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GBA, GPR35, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC | 4.27046 |
[BP] GO:0034754 | cellular hormone metabolic process | AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 4.25773 |
[BP] GO:0034614 | cellular response to reactive oxygen species | AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC | 4.25773 |
[BP] GO:0019216 | regulation of lipid metabolic process | ADORA1, CYP1A1, FABP3, FLT3, HCAR2, HMGCR, PPARA, PTGS2, RORC, SRC, TEK | 4.24318 |
[BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HMGCR, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH | 4.20991 |
[BP] GO:0042493 | response to drug | ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, GBA, HMGCR, KDR, PTGS2, SRC | 4.18407 |
[BP] GO:0006820 | anion transport | ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA | 4.15405 |
[BP] GO:2000811 | negative regulation of anoikis | BCL2, MCL1, PIK3CA, SRC | 4.146 |
[BP] GO:0001775 | cell activation | ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUCA1, FUT7, GAA, HSPA1A, MGAM, MMP9, PIK3CA, PIK3CB, RORC, SMAD3, SRC | 4.14121 |
[BP] GO:0043549 | regulation of kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 4.14121 |
[BP] GO:0006805 | xenobiotic metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC | 4.12373 |
[BP] GO:0051050 | positive regulation of transport | ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HCAR2, HIF1A, INSR, MMP12, PTGS2, SMAD3, SRC, TERT | 4.12302 |
[BP] GO:0008610 | lipid biosynthetic process | ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, GBA, HMGCR, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 | 4.098 |
[BP] GO:2000377 | regulation of reactive oxygen species metabolic process | BCL2, CYP1B1, EGFR, HIF1A, INSR, PTGS2, SMAD3, XDH | 4.09011 |
[BP] GO:0019752 | carboxylic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR | 4.08893 |
[BP] GO:0008283 | cell proliferation | ABCB1, ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR | 4.06669 |
[BP] GO:0010243 | response to organonitrogen compound | AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 4.03669 |
[BP] GO:0044093 | positive regulation of molecular function | ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, FLT3, HIF1A, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 4.03646 |
[BP] GO:0007346 | regulation of mitotic cell cycle | APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TOP2A | 4.03646 |
[BP] GO:0048869 | cellular developmental process | ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, HMGCR, KDR, MCL1, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A | 4.03646 |
[BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC | 4.0135 |
[BP] GO:0031324 | negative regulation of cellular metabolic process | APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, ESR1, ESR2, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, MCL1, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 3.97921 |
[BP] GO:0016137 | None | AKR1B1, AKR1B10, FUCA1, GBA | 3.96482 |
[BP] GO:0032101 | regulation of response to external stimulus | ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, HMGCR, KDR, MET, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK | 3.89398 |
[BP] GO:0010634 | positive regulation of epithelial cell migration | HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK | 3.89378 |
[BP] GO:0045859 | regulation of protein kinase activity | ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC | 3.85965 |
[BP] GO:0051338 | regulation of transferase activity | ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 3.85379 |
[BP] GO:0051239 | regulation of multicellular organismal process | ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, GAA, GBA, GPR35, HCAR2, HIF1A, HMGCR, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TERT, XDH | 3.83937 |
[BP] GO:0042445 | hormone metabolic process | ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 | 3.83797 |
[BP] GO:0048660 | regulation of smooth muscle cell proliferation | AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTGS2, TERT | 3.83797 |
[BP] GO:0051240 | positive regulation of multicellular organismal process | APP, AXL, BCL2, CA2, CYP1B1, EGFR, GBA, HCAR2, HIF1A, HMGCR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK, TERT | 3.79503 |
[BP] GO:0038083 | peptidyl-tyrosine autophosphorylation | EGFR, IGF1R, INSR, KDR, SRC | 3.72596 |
[BP] GO:0043410 | positive regulation of MAPK cascade | ADORA1, APP, EGFR, FLT3, HMGCR, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH | 3.70808 |
[BP] GO:0034599 | cellular response to oxidative stress | AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC | 3.70079 |
[BP] GO:0009895 | negative regulation of catabolic process | ADORA1, BCL2, EGFR, HCAR2, MCL1, MET, PIK3CA, PPARA, SMAD3 | 3.68949 |
[BP] GO:0051130 | positive regulation of cellular component organization | APP, AURKB, AXL, BCL2, DNMT1, ESR1, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK | 3.68477 |
[BP] GO:1901698 | response to nitrogen compound | AKR1B1, APEX1, APP, DNMT1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR | 3.68118 |
[BP] GO:0010638 | positive regulation of organelle organization | AURKB, BCL2, DNMT1, GBA, HIF1A, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK | 3.65384 |
[BP] GO:0016042 | lipid catabolic process | ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, FUCA1, GBA | 3.60629 |
[BP] GO:0043436 | oxoacid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.59857 |
[BP] GO:1901652 | response to peptide | AKR1B1, APEX1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK | 3.59511 |
[BP] GO:2000209 | regulation of anoikis | BCL2, MCL1, PIK3CA, SRC | 3.5701 |
[BP] GO:0009698 | phenylpropanoid metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.5701 |
[BP] GO:0009804 | coumarin metabolic process | CYP1A1, CYP2A13, CYP2A6 | 3.5701 |
[BP] GO:0043393 | regulation of protein binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT | 3.54719 |
[BP] GO:0045931 | positive regulation of mitotic cell cycle | APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT | 3.54008 |
[BP] GO:0006082 | organic acid metabolic process | ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, FABP3, GLO1, HIF1A, PIM1, PPARA, PTGS1, PTGS2, TYR | 3.5137 |
[BP] GO:0008210 | estrogen metabolic process | CYP19A1, CYP1B1, HSD17B1, HSD17B2 | 3.50164 |
[BP] GO:0002009 | morphogenesis of an epithelium | BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC | 3.47215 |
[BP] GO:0032268 | regulation of cellular protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 3.41292 |
[BP] GO:0045787 | positive regulation of cell cycle | APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT | 3.38334 |
[BP] GO:0048545 | response to steroid hormone | ALPL, BCL2, CA2, EGFR, FLT3, GBA, PTGS2, SRC | 3.35263 |
[BP] GO:0031960 | response to corticosteroid | ALPL, BCL2, EGFR, FLT3, GBA, PTGS2, SRC | 3.34585 |
[BP] GO:0051701 | interaction with host | AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC | 3.29284 |
[BP] GO:2001233 | regulation of apoptotic signaling pathway | BCL2, HIF1A, HSPA1A, MCL1, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT | 3.2897 |
[BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, KDR, PIK3CB, SMAD3, SRC, TEK | 3.2897 |
[BP] GO:0032846 | positive regulation of homeostatic process | AURKB, CA2, CA7, EGFR, HCAR2, HIF1A, PIK3CB, PTGS2 | 3.26166 |
[BP] GO:0050727 | regulation of inflammatory response | ADORA1, CYP19A1, EGFR, ESR1, FABP4, GBA, PPARA, PTGS2, SMAD3, TEK | 3.22579 |
[BP] GO:0071495 | cellular response to endogenous stimulus | AKR1B1, APEX1, APP, DNMT1, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC | 3.20595 |
[BP] GO:1901575 | None | ACHE, ADORA1, AKR1B10, AURKB, BACE1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUCA1, FUT7, GAA, GBA, HSPA1A, MGAM, XDH | 3.18554 |
[BP] GO:0042542 | response to hydrogen peroxide | AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC | 3.18554 |
[BP] GO:0043085 | positive regulation of catalytic activity | ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, FLT3, HIF1A, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, XDH | 3.17404 |
[BP] GO:0071417 | cellular response to organonitrogen compound | AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC | 3.17404 |
[BP] GO:0051726 | regulation of cell cycle | APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC, TERT, TOP2A | 3.13789 |
[BP] GO:0019222 | regulation of metabolic process | ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.12994 |
[BP] GO:0009636 | response to toxic substance | AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, HMGCR, KDR, SRC | 3.11462 |
[BP] GO:0031348 | negative regulation of defense response | ADORA1, CYP19A1, GBA, MMP12, PPARA, SMAD3, TEK | 3.10245 |
[BP] GO:2001225 | regulation of chloride transport | ABCB1, CA2, CA7 | 3.10132 |
[BP] GO:0097267 | omega-hydroxylase P450 pathway | CYP1A1, CYP1A2, CYP1B1 | 3.10132 |
[BP] GO:0051128 | regulation of cellular component organization | APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, GBA, HIF1A, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A | 3.09281 |
[BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, PTGS2, SRC | 3.08695 |
[BP] GO:0048732 | gland development | BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR | 3.0825 |
[BP] GO:0001503 | ossification | ALPL, BCL2, EGFR, MMP2, MMP9, TEK | 3.07703 |
[BP] GO:0001101 | response to acid chemical | AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC | 3.0678 |
[BP] GO:0071900 | regulation of protein serine/threonine kinase activity | ADORA1, DUSP3, EGFR, FLT3, GBA, HMGCR, IGF1R, INSR, PIK3CB, PTPN1, SRC | 3.06726 |
[BP] GO:0050728 | negative regulation of inflammatory response | ADORA1, CYP19A1, GBA, PPARA, SMAD3, TEK | 3.0604 |
[BP] GO:0043065 | positive regulation of apoptotic process | BCL2, CYP1B1, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH | 3.03961 |
[BP] GO:0042180 | None | AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR | 3.00202 |
[BP] GO:0043068 | positive regulation of programmed cell death | BCL2, CYP1B1, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH | 3.00202 |
[BP] GO:1902893 | None | HIF1A, PPARA, SMAD3, TERT | 3.00202 |
[BP] GO:0009611 | response to wounding | ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 | 2.9971 |
[BP] GO:0019371 | None | CBR1, PTGS1, PTGS2 | 2.98873 |
[BP] GO:2001240 | None | BCL2, HSPA1A, MCL1, TERT | 2.96071 |
[BP] GO:1901099 | None | BCL2, HSPA1A, MCL1, TERT | 2.96071 |
[BP] GO:0050806 | positive regulation of synaptic transmission | ADORA1, APP, CA2, CA7, EGFR, PTGS2 | 2.95391 |
[BP] GO:0001525 | angiogenesis | CYP1B1, HIF1A, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK | 2.9339 |
[BP] GO:0048010 | vascular endothelial growth factor receptor signaling pathway | AXL, KDR, PIK3CA, PIK3CB, SRC | 2.92951 |
[BP] GO:1901699 | cellular response to nitrogen compound | AKR1B1, APEX1, APP, DNMT1, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC | 2.9227 |
[BP] GO:0022414 | reproductive process | AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HIF1A, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC, TOP2A | 2.92134 |
[BP] GO:0045834 | positive regulation of lipid metabolic process | FABP3, FLT3, PPARA, PTGS2, SRC, TEK | 2.92134 |
[BP] GO:0080090 | regulation of primary metabolic process | ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HCAR2, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.91856 |
[BP] GO:1901215 | negative regulation of neuron death | AXL, BCL2, GBA, HIF1A, PIK3CA, PPARA, TERT | 2.91185 |
[BP] GO:0017144 | drug metabolic process | ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, EGFR, HSPA1A | 2.90703 |
[BP] GO:0010605 | negative regulation of macromolecule metabolic process | APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 2.9015 |
[BP] GO:0009991 | response to extracellular stimulus | ALPL, AXL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR | 2.90062 |
[BP] GO:0006720 | isoprenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR, HMGCR | 2.89364 |
[BP] GO:0051098 | regulation of binding | APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT | 2.89364 |
[BP] GO:0031323 | regulation of cellular metabolic process | ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.86057 |
[BP] GO:0051246 | regulation of protein metabolic process | ADORA1, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FABP4, FLT3, GBA, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH | 2.81717 |
[BP] GO:0033554 | cellular response to stress | AKR1B1, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, GBA, HIF1A, HSPA1A, MCL1, MMP9, NUAK1, PTGS2, PTPN1, SRC, TERT, TOP2A | 2.81588 |
[BP] GO:1900182 | positive regulation of protein localization to nucleus | APP, EGFR, PTGS2, SMAD3, SRC, TERT | 2.81097 |
[BP] GO:0002682 | regulation of immune system process | ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, ESR1, HCAR2, HIF1A, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC | 2.81096 |
[BP] GO:0018193 | peptidyl-amino acid modification | AURKB, AXL, BCL2, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP2A | 2.80097 |
[BP] GO:0006703 | estrogen biosynthetic process | CYP19A1, HSD17B1, HSD17B2 | 2.80087 |
[BP] GO:0048729 | tissue morphogenesis | BCL2, CA2, CA9, EGFR, ESR1, HIF1A, MET, SMAD3, SRC | 2.79698 |
[BP] GO:0040008 | regulation of growth | APP, BCL2, CSNK2A1, EGFR, ESR2, HIF1A, HSPA1A, INSR, PIK3CA, PIM1, PTPRS, SMAD3 | 2.7883 |
[BP] GO:0044248 | cellular catabolic process | ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, DAO, FABP3, FABP4, FUCA1, GAA, GBA, HSPA1A, MGAM, PIK3CB, SRC, XDH | 2.7883 |
[BP] GO:0070372 | regulation of ERK1 and ERK2 cascade | APP, DUSP3, EGFR, HMGCR, KDR, PTPN1, SRC, TEK | 2.76644 |
[BP] GO:0010942 | positive regulation of cell death | BCL2, CYP1B1, HCAR2, HMGCR, MCL1, MMP9, PIK3CB, PTGS2, SMAD3, SRC, TOP2A, XDH | 2.73944 |
[BP] GO:0032963 | collagen metabolic process | HIF1A, MMP1, MMP12, MMP2, MMP9 | 2.72598 |
[BP] GO:1901214 | regulation of neuron death | AXL, BCL2, GBA, HIF1A, MCL1, PIK3CA, PPARA, TERT | 2.72583 |
[BP] GO:0032102 | negative regulation of response to external stimulus | ADORA1, CYP19A1, GBA, HMGCR, PPARA, PTPRS, SMAD3, TEK | 2.71614 |
[BP] GO:0060065 | uterus development | CYP19A1, ESR1, SRC | 2.71067 |
[BP] GO:2000106 | regulation of leukocyte apoptotic process | AURKB, AXL, HCAR2, HIF1A, PIK3CB | 2.70734 |
[BP] GO:0033273 | response to vitamin | ALPL, CYP1A1, EGFR, PTGS2, TYR | 2.70734 |
[BP] GO:0050801 | ion homeostasis | APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, HIF1A, PIK3CB, SMAD3 | 2.69848 |
[BP] GO:0007166 | cell surface receptor signaling pathway | ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MCL1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK | 2.69848 |
[BP] GO:1904407 | positive regulation of nitric oxide metabolic process | EGFR, INSR, PTGS2, SMAD3 | 2.69592 |
[BP] GO:0045429 | positive regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.69592 |
[BP] GO:0031329 | regulation of cellular catabolic process | APEX1, BCL2, GBA, HIF1A, HSPA1A, INSR, KDR, MCL1, MET, PIK3CA, PIK3CB, PPARA, PTPN1 | 2.69592 |
[BP] GO:0035690 | cellular response to drug | AKR1B1, APEX1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC | 2.69585 |
[BP] GO:0019725 | cellular homeostasis | APEX1, APP, BCL2, CA2, CA7, ESR1, GAA, GPR35, HIF1A, MCL1, PIK3CA, PIK3CB, SMAD3 | 2.68152 |
[BP] GO:0051384 | response to glucocorticoid | ALPL, BCL2, EGFR, FLT3, GBA, PTGS2 | 2.6799 |
[BP] GO:1901989 | None | APEX1, APP, CDC25B, CYP1A1, TERT | 2.66933 |
[BP] GO:0009416 | response to light stimulus | APP, AURKB, BCL2, EGFR, HIF1A, HMGCR, PTGS2, TYR | 2.66872 |
[BP] GO:0010595 | positive regulation of endothelial cell migration | HIF1A, KDR, MET, PTGS2, TEK | 2.64862 |
[BP] GO:0044259 | multicellular organismal macromolecule metabolic process | HIF1A, MMP1, MMP12, MMP2, MMP9 | 2.62897 |
[BP] GO:0001961 | None | AXL, HIF1A, HSPA1A, MMP12 | 2.62897 |
[BP] GO:1903727 | positive regulation of phospholipid metabolic process | FABP3, FLT3, SRC, TEK | 2.62897 |
[BP] GO:0035239 | tube morphogenesis | BCL2, EGFR, ESR1, HIF1A, MET, SMAD3, SRC | 2.58099 |
[BP] GO:0010632 | regulation of epithelial cell migration | HIF1A, KDR, MET, MMP9, PTGS2, SRC, TEK | 2.58099 |
[BP] GO:0032872 | regulation of stress-activated MAPK cascade | APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH | 2.58099 |
[BP] GO:0009653 | anatomical structure morphogenesis | APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, ESR1, GAA, GBA, HIF1A, INSR, MET, MMP2, SMAD3, SRC, TEK | 2.57704 |
[BP] GO:0070302 | regulation of stress-activated protein kinase signaling cascade | APP, DUSP3, EGFR, HMGCR, IGF1R, PTPN1, XDH | 2.57219 |
[BP] GO:0051172 | None | APEX1, APP, AURKB, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, XDH | 2.56736 |
[BP] GO:0030540 | female genitalia development | AXL, CYP19A1, ESR1 | 2.56622 |
[BP] GO:0070920 | None | EGFR, ESR1, TERT | 2.56622 |
[BP] GO:0048546 | None | BCL2, EGFR, HIF1A | 2.56622 |
[BP] GO:0090087 | None | ACHE, ADORA1, APP, CA2, EGFR, HCAR2, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC | 2.56423 |
[BP] GO:0071248 | cellular response to metal ion | CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 2.5552 |
[BP] GO:2000379 | positive regulation of reactive oxygen species metabolic process | EGFR, INSR, PTGS2, SMAD3, XDH | 2.55298 |
[BP] GO:0051171 | regulation of nitrogen compound metabolic process | ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.55084 |
[BP] GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | BCL2, HSPA1A, MCL1, TERT | 2.53315 |
[BP] GO:0050804 | modulation of chemical synaptic transmission | ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, PTGS2 | 2.53275 |
[BP] GO:0099177 | regulation of trans-synaptic signaling | ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, PTGS2 | 2.53275 |
[BP] GO:0060255 | regulation of macromolecule metabolic process | ACHE, ADORA1, ADORA3, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 2.52076 |
[BP] GO:0060760 | None | AXL, HIF1A, HSPA1A, MMP12 | 2.50492 |
[BP] GO:0010506 | regulation of autophagy | BCL2, GBA, HIF1A, KDR, MCL1, MET, PIK3CA, PIK3CB | 2.48004 |
[BP] GO:0045766 | positive regulation of angiogenesis | CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT | 2.47419 |
[BP] GO:0000023 | None | GAA, MGAM | 2.46539 |
[BP] GO:0032849 | positive regulation of cellular pH reduction | CA2, CA7 | 2.46539 |
[BP] GO:0003018 | None | ADORA1, EGFR, HMGCR, PTGS2, SRC, TEK | 2.46355 |
[BP] GO:0016477 | cell migration | AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK | 2.4632 |
[BP] GO:0031667 | response to nutrient levels | ALPL, BCL2, CYP1A1, EGFR, GBA, HMGCR, PTGS2, SRC, TYR | 2.43257 |
[BP] GO:0007568 | aging | APEX1, AURKB, BCL2, CYP1A1, HMGCR, PTGS2, TERT | 2.42348 |
[BP] GO:0009891 | positive regulation of biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A | 2.41215 |
[BP] GO:0033138 | positive regulation of peptidyl-serine phosphorylation | APP, BCL2, EGFR, PIK3CA, PTGS2 | 2.3836 |
[BP] GO:0044267 | cellular protein metabolic process | ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A | 2.37236 |
[BP] GO:1901617 | organic hydroxy compound biosynthetic process | AKR1B1, CYP19A1, DAO, GBA, HMGCR, TYR | 2.36925 |
[BP] GO:0051900 | regulation of mitochondrial depolarization | BCL2, KDR, SRC | 2.36876 |
[BP] GO:1904951 | positive regulation of establishment of protein localization | ACHE, APP, BCL2, EGFR, HCAR2, HIF1A, MMP12, PTGS2, SMAD3, SRC | 2.36876 |
[BP] GO:1903428 | positive regulation of reactive oxygen species biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.35427 |
[BP] GO:0051828 | entry into other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.35303 |
[BP] GO:0051806 | entry into cell of other organism involved in symbiotic interaction | AXL, EGFR, HSPA1A, MET, SRC | 2.35303 |
[BP] GO:0030260 | entry into host cell | AXL, EGFR, HSPA1A, MET, SRC | 2.35303 |
[BP] GO:0044409 | entry into host | AXL, EGFR, HSPA1A, MET, SRC | 2.35303 |
[BP] GO:0072593 | reactive oxygen species metabolic process | BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.33385 |
[BP] GO:0019538 | protein metabolic process | ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A | 2.31958 |
[BP] GO:0051248 | None | APP, CSNK2A1, DNMT1, DUSP3, EGFR, FABP4, GBA, HMGCR, HSPA1A, IGF1R, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH | 2.31759 |
[BP] GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | BCL2, HSPA1A, MCL1, SRC, TERT | 2.31724 |
[BP] GO:0048534 | hematopoietic or lymphoid organ development | BCL2, FLT3, HIF1A, KDR, TEK, TYR | 2.3117 |
[BP] GO:0051893 | regulation of focal adhesion assembly | KDR, SMAD3, SRC, TEK | 2.3038 |
[BP] GO:0090109 | regulation of cell-substrate junction assembly | KDR, SMAD3, SRC, TEK | 2.3038 |
[BP] GO:0071456 | cellular response to hypoxia | BCL2, HIF1A, PTGS2, SRC, TERT | 2.30314 |
[BP] GO:0098771 | inorganic ion homeostasis | APP, BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, HIF1A, PIK3CB, SMAD3 | 2.26735 |
[BP] GO:0044236 | multicellular organism metabolic process | HIF1A, MMP1, MMP12, MMP2, MMP9 | 2.26735 |
[BP] GO:0071498 | cellular response to fluid shear stress | CA2, PTGS2, SRC | 2.25628 |
[BP] GO:0071241 | cellular response to inorganic substance | CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 | 2.25147 |
[BP] GO:0006721 | terpenoid metabolic process | AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR | 2.25147 |
[BP] GO:0046686 | response to cadmium ion | CYP1A2, EGFR, MMP9, TERT | 2.25087 |
[BP] GO:0044242 | None | AKR1B10, CYP1B1, FABP3, FABP4, FUCA1, GBA | 2.23991 |
[BP] GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | APP, AURKB, DNMT1, EGFR, ESR1, ESR2, HIF1A, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A | 2.23169 |
[BP] GO:1903391 | regulation of adherens junction organization | KDR, SMAD3, SRC, TEK | 2.22635 |
[BP] GO:0045428 | regulation of nitric oxide biosynthetic process | EGFR, INSR, PTGS2, SMAD3 | 2.22635 |
[BP] GO:1904018 | positive regulation of vasculature development | CYP1B1, HIF1A, KDR, PTGS2, TEK, TERT | 2.22184 |
[BP] GO:0030522 | intracellular receptor signaling pathway | ESR1, ESR2, PIM1, PPARA, RORC, SRC | 2.22184 |
[BP] GO:0098908 | None | GBA, GPR35 | 2.22184 |
[BP] GO:0033031 | positive regulation of neutrophil apoptotic process | HCAR2, PIK3CB | 2.22184 |
[BP] GO:0018894 | dibenzo-p-dioxin metabolic process | CYP1A1, CYP1A2 | 2.22184 |
[BP] GO:1902895 | None | HIF1A, SMAD3, TERT | 2.21744 |
[BP] GO:1904707 | positive regulation of vascular smooth muscle cell proliferation | MMP2, MMP9, TERT | 2.21744 |
[BP] GO:0030520 | intracellular estrogen receptor signaling pathway | ESR1, ESR2, SRC | 2.21744 |
[BP] GO:0040011 | locomotion | AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK | 2.21286 |
[BP] GO:0002793 | None | ACHE, ADORA1, EGFR, HCAR2, HIF1A, MMP12, SRC | 2.20918 |
[BP] GO:0036294 | cellular response to decreased oxygen levels | BCL2, HIF1A, PTGS2, SRC, TERT | 2.20053 |
[BP] GO:0032880 | regulation of protein localization | ACHE, APP, BCL2, CSNK2A1, EGFR, HCAR2, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT | 2.20045 |
[BP] GO:0033674 | positive regulation of kinase activity | ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 2.19951 |
[BP] GO:1901654 | None | AKR1B1, CA9, CSNK2A1, EGFR, GBA, SRC | 2.19951 |
[BP] GO:0009896 | positive regulation of catabolic process | CSNK2A1, GBA, HIF1A, HSPA1A, INSR, KDR, PIK3CB, PPARA, PTPN1 | 2.18612 |
[BP] GO:0009404 | toxin metabolic process | CYP1A1, CYP1A2, CYP1B1 | 2.17096 |
[BP] GO:0043412 | macromolecule modification | ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, FLT3, FUT7, HIF1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TOP2A | 2.1594 |
[BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.1594 |
[BP] GO:0097164 | None | ACHE, AKR1B1, AKR1B10, CSNK2A1, DAO, GBA | 2.15515 |
[BP] GO:0030155 | regulation of cell adhesion | BCL2, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK | 2.15284 |
[BP] GO:0070301 | cellular response to hydrogen peroxide | AKR1B1, APEX1, AXL, CYP1B1 | 2.14566 |
[BP] GO:0042446 | hormone biosynthetic process | AKR1B1, CYP19A1, HSD17B1, HSD17B2 | 2.14566 |
[BP] GO:0043406 | positive regulation of MAP kinase activity | ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC | 2.13707 |
[BP] GO:0048870 | cell motility | AXL, CYP1B1, EGFR, FUT7, HIF1A, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK | 2.13262 |
[BP] GO:0051894 | None | KDR, SMAD3, TEK | 2.12886 |
[BP] GO:1903409 | reactive oxygen species biosynthetic process | CYP1A1, CYP1A2, CYP1B1 | 2.12886 |
[BP] GO:0060249 | None | AKR1B1, APEX1, BCL2, GAA, HIF1A, SRC, TERT | 2.11294 |
[BP] GO:0009888 | tissue development | ALPL, CYP1B1, GAA, INSR, KDR, PIK3CA, PPARA, PTGS2, RORC, SMAD3 | 2.10716 |
[BP] GO:0048871 | multicellular organismal homeostasis | ADORA1, AKR1B1, GBA, MET, PIK3CA | 2.10478 |
[BP] GO:0010810 | regulation of cell-substrate adhesion | BCL2, KDR, PIK3CB, SMAD3, SRC, TEK | 2.09577 |
[BP] GO:0031328 | positive regulation of cellular biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, FABP3, GBA, HIF1A, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TOP2A | 2.09462 |
[BP] GO:0048608 | reproductive structure development | AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, SRC | 2.09013 |
[BP] GO:0051347 | positive regulation of transferase activity | ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK | 2.08274 |
[BP] GO:0097237 | cellular response to toxic substance | AKR1B1, APEX1, AXL, CYP1B1, KDR | 2.07658 |
[BP] GO:0050890 | None | ADORA1, APP, EGFR, HIF1A, HMGCR, INSR, PTGS2 | 2.07342 |
[BP] GO:0030574 | collagen catabolic process | MMP1, MMP12, MMP2, MMP9 | 2.05856 |
[BP] GO:0090068 | positive regulation of cell cycle process | APEX1, APP, AURKB, CDC25B, CYP1A1, INSR, TERT | 2.05587 |
[BP] GO:0007584 | response to nutrient | ALPL, CYP1A1, EGFR, HMGCR, PTGS2, TYR | 2.04477 |
[BP] GO:0046466 | None | CYP1B1, FUCA1, GBA | 2.04373 |
[BP] GO:1903393 | None | KDR, SMAD3, TEK | 2.04373 |
[BP] GO:0043523 | regulation of neuron apoptotic process | AXL, BCL2, HIF1A, MCL1, PIK3CA, TERT | 2.03748 |
[BP] GO:0030154 | cell differentiation | ALPL, AXL, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HIF1A, HMGCR, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A | 2.03163 |
[BP] GO:0043434 | None | APEX1, FABP3, INSR, PPARA, PTGS2, SRC, TEK | 2.02804 |
[BP] GO:0014910 | regulation of smooth muscle cell migration | APEX1, BCL2, SRC, TERT | 2.0202 |
[BP] GO:0050793 | regulation of developmental process | APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESR1, HIF1A, HMGCR, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TERT, XDH | 2.01744 |
[BP] GO:0070201 | None | ACHE, APP, BCL2, EGFR, HCAR2, HIF1A, HMGCR, MMP12, PTGS2, PTPN1, SMAD3, SRC | 2.00814 |
[BP] GO:0070374 | positive regulation of ERK1 and ERK2 cascade | APP, EGFR, HMGCR, KDR, SRC, TEK | 2.00814 |
[BP] GO:0006807 | nitrogen compound metabolic process | ACHE, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FLT3, FUCA1, FUT7, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 2.0076 |
[BP] GO:0010557 | positive regulation of macromolecule biosynthetic process | APP, AURKB, EGFR, ESR1, ESR2, GBA, HIF1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TOP2A | 2.0076 |
[BP] GO:0008285 | negative regulation of cell proliferation | ADORA1, ADORA3, APP, BCL2, CYP1B1, FABP3, HSPA1A, PTGS2, SMAD3, TERT, XDH | 2.0076 |
[BP] GO:0010575 | positive regulation of vascular endothelial growth factor production | CYP1B1, HIF1A, PTGS2 | 2.00641 |
[BP] GO:0045913 | None | HIF1A, INSR, PPARA, SRC | 2.00463 |
[BP] GO:0034097 | response to cytokine | AXL, BCL2, FABP4, FLT3, GBA, HIF1A, MCL1, PTGS2, SRC | 2.00463 |
[BP] GO:0006694 | steroid biosynthetic process | AKR1B1, CYP19A1, HMGCR, HSD17B1, HSD17B2 | 2.00275 |
[CC] GO:0043227 | membrane-bounded organelle | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH | 4.73911 |
[CC] GO:0044444 | cytoplasmic part | ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DUSP3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MCL1, MGAM, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TERT, TOP2A, TYR, XDH | 4.06763 |
[CC] GO:0043226 | organelle | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, INSR, KDR, MCL1, MGAM, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH | 3.44163 |
[CC] GO:0016020 | membrane | ABCB1, ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, EGFR, ESR1, FLT3, FUT7, GAA, GBA, GLO1, GPR35, HCAR2, HMGCR, HSD17B2, IGF1R, INSR, KDR, MCL1, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT, TYR | 2.91075 |
[CC] GO:0005886 | plasma membrane | ABCB1, ACHE, ADORA1, ADORA3, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, FLT3, GAA, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MGAM, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TERT | 2.65024 |
[CC] GO:0045121 | membrane raft | APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.59297 |
[CC] GO:0098857 | membrane microdomain | APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.57744 |
[CC] GO:0031974 | None | ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 | 2.51425 |
[CC] GO:0043233 | None | ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 | 2.51425 |
[CC] GO:0070013 | None | ALOX5, APP, BACE1, CA5A, CA5B, DAO, EGFR, FLT3, FUCA1, GAA, GBA, HSPA1A, INSR, MCL1, MMP9, PTGS2 | 2.51425 |
[CC] GO:0044432 | endoplasmic reticulum part | APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, HMGCR, HSD17B2, PTGS1, PTGS2, PTPN1 | 2.22184 |
[CC] GO:0070062 | None | ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SRC | 2.21834 |
[CC] GO:1903561 | None | ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SRC | 2.20045 |
[CC] GO:0043230 | None | ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, CA1, CA2, CA4, CA6, CBR1, DUSP3, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, MGAM, MMP9, NQO2, PTGS1, PTPRS, SRC | 2.20045 |
[CC] GO:0043231 | intracellular membrane-bounded organelle | ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CA5A, CA5B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DAO, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, FABP4, FLT3, FUT7, GAA, GLO1, HIF1A, HMGCR, HSPA1A, IGF1R, KDR, MCL1, MMP12, MMP2, NUAK1, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A, TYR, XDH | 2.19822 |
[CC] GO:0031982 | None | ABCB1, AKR1B1, AKR1B10, ALPL, APP, AXL, BACE1, CA1, CA2, CA4, CA6, CBR1, DUSP3, EGFR, FABP3, FABP4, FUCA1, GAA, GBA, GLO1, HSPA1A, INSR, KDR, MGAM, MMP9, NQO2, PTGS1, PTPN1, PTPRS, SRC, TYR | 2.15827 |
[CC] GO:0098589 | membrane region | APP, BACE1, EGFR, INSR, KDR, PTGS2, SRC, TEK | 2.13829 |
[CC] GO:0016323 | basolateral plasma membrane | ADORA1, CA2, CA4, CA9, EGFR, TEK | 2.11499 |
[CC] GO:0005783 | None | ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HMGCR, HSPA1A, KDR, PTGS2, PTPN1, XDH | 2.04437 |
[MF] GO:0003824 | catalytic activity | ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DUSP3, DYRK1A, EGFR, FLT3, FUCA1, FUT7, GAA, GBA, GLO1, HMGCR, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TERT, TOP2A, TYR, XDH | 17.9208 |
[MF] GO:0004089 | carbonate dehydratase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 16.4054 |
[MF] GO:0046914 | transition metal ion binding | ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TYR, XDH | 15.7867 |
[MF] GO:0043167 | ion binding | ABCB1, ACHE, ALOX5, ALPL, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, GLO1, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR, XDH | 12.9757 |
[MF] GO:0016835 | carbon-oxygen lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.6061 |
[MF] GO:0016836 | hydro-lyase activity | CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 | 10.4716 |
[MF] GO:0008270 | zinc ion binding | CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3 | 8.74554 |
[MF] GO:0016829 | lyase activity | APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 | 7.93247 |
[MF] GO:0016491 | oxidoreductase activity | AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, HMGCR, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH | 7.88783 |
[MF] GO:0004714 | transmembrane receptor protein tyrosine kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 7.01532 |
[MF] GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 6.41677 |
[MF] GO:0008144 | drug binding | ABCB1, ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A | 6.31836 |
[MF] GO:0019199 | transmembrane receptor protein kinase activity | AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK | 6.27631 |
[MF] GO:0043169 | cation binding | ACHE, ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH | 6.02807 |
[MF] GO:0020037 | heme binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC | 5.94854 |
[MF] GO:0004713 | protein tyrosine kinase activity | AXL, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK | 5.85395 |
[MF] GO:0046872 | metal ion binding | ALOX5, ALPL, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DNMT1, ESR1, ESR2, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TERT, TOP2A, TYR, XDH | 5.84091 |
[MF] GO:0046906 | tetrapyrrole binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC | 5.73199 |
[MF] GO:0048037 | cofactor binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, HMGCR, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH | 5.44233 |
[MF] GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, TYR | 5.36018 |
[MF] GO:0070330 | aromatase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 5.12423 |
[MF] GO:0043560 | insulin receptor substrate binding | IGF1R, INSR, PIK3CA, PIK3CB | 4.77313 |
[MF] GO:0004672 | protein kinase activity | AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK | 4.75209 |
[MF] GO:0004497 | monooxygenase activity | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR | 4.58607 |
[MF] GO:0016773 | phosphotransferase activity, alcohol group as acceptor | AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.5296 |
[MF] GO:0005506 | iron ion binding | ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH | 4.24023 |
[MF] GO:0036094 | small molecule binding | ABCB1, ADORA1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH | 4.16978 |
[MF] GO:0016301 | kinase activity | AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK | 4.09737 |
[MF] GO:0042802 | identical protein binding | ACHE, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HMGCR, IGF1R, KDR, MCL1, MET, MMP9, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH | 3.96392 |
[MF] GO:0016772 | transferase activity, transferring phosphorus-containing groups | AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT | 3.8727 |
[MF] GO:0019825 | oxygen binding | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 | 3.81309 |
[MF] GO:0000166 | nucleotide binding | ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH | 3.80001 |
[MF] GO:1901265 | nucleoside phosphate binding | ABCB1, AURKB, AXL, CSNK2A1, DAO, DNMT1, DYRK1A, EGFR, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, XDH | 3.7984 |
[MF] GO:0042562 | hormone binding | ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 | 3.72272 |
[MF] GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors | AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2, XDH | 3.68477 |
[MF] GO:0044877 | macromolecular complex binding | ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC | 3.39858 |
[MF] GO:0004716 | signal transducer, downstream of receptor, with protein tyrosine kinase activity | EGFR, INSR, KDR | 3.22579 |
[MF] GO:0032403 | protein complex binding | ACHE, ADORA1, APEX1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC | 3.20144 |
[MF] GO:0019902 | phosphatase binding | BCL2, EGFR, HMGCR, MET, PPARA, PTPN1, SMAD3 | 3.20144 |
[MF] GO:1901363 | heterocyclic compound binding | ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.18011 |
[MF] GO:0043168 | anion binding | ABCB1, APP, AURKB, AXL, CSNK2A1, DAO, DYRK1A, EGFR, FABP3, FABP4, FLT3, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, XDH | 3.13077 |
[MF] GO:0097159 | organic cyclic compound binding | ABCB1, ADORA1, APEX1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DAO, DNMT1, DYRK1A, EGFR, ESR1, ESR2, FLT3, HIF1A, HMGCR, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, XDH | 3.11325 |
[MF] GO:0005524 | ATP binding | ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.98873 |
[MF] GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | AKR1B1, AKR1B10, CBR1, HMGCR, HSD17B1, HSD17B2 | 2.98873 |
[MF] GO:0008395 | steroid hydroxylase activity | CYP19A1, CYP1A1, CYP2A13, CYP2A6 | 2.96071 |
[MF] GO:0032559 | adenyl ribonucleotide binding | ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.87721 |
[MF] GO:0004666 | prostaglandin-endoperoxide synthase activity | PTGS1, PTGS2 | 2.85428 |
[MF] GO:0038052 | RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | ESR1, ESR2 | 2.85428 |
[MF] GO:0008389 | None | CYP2A13, CYP2A6 | 2.85428 |
[MF] GO:0030554 | adenyl nucleotide binding | ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.84472 |
[MF] GO:0046983 | protein dimerization activity | ACHE, ADORA1, AXL, BCL2, DAO, EGFR, FLT3, HIF1A, HMGCR, MCL1, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH | 2.80143 |
[MF] GO:0019899 | enzyme binding | APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, DUSP3, EGFR, ESR1, ESR2, HIF1A, HMGCR, HSPA1A, MET, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A | 2.64693 |
[MF] GO:0032450 | None | GAA, MGAM | 2.46539 |
[MF] GO:0140096 | catalytic activity, acting on a protein | AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK | 2.45604 |
[MF] GO:0098531 | transcription factor activity, direct ligand regulated sequence-specific DNA binding | ESR1, ESR2, PPARA, RORC | 2.4455 |
[MF] GO:0004879 | nuclear receptor activity | ESR1, ESR2, PPARA, RORC | 2.4455 |
[MF] GO:0001223 | transcription coactivator binding | ESR1, PPARA, TERT | 2.31259 |
[MF] GO:0031072 | heat shock protein binding | ADORA1, CSNK2A1, HIF1A, HSPA1A, KDR | 2.28457 |
[MF] GO:0009055 | electron transfer activity | AKR1B1, CYP19A1, CYP1A2, NQO2, XDH | 2.23575 |
[MF] GO:0034056 | estrogen response element binding | ESR1, ESR2 | 2.22184 |
[MF] GO:0051425 | None | APP, INSR | 2.22184 |
[MF] GO:0004558 | None | GAA, MGAM | 2.22184 |
[MF] GO:0003707 | steroid hormone receptor activity | ESR1, ESR2, PPARA, RORC | 2.1928 |
[MF] GO:0097367 | carbohydrate derivative binding | ABCB1, ADORA1, APP, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A | 2.14295 |
[MF] GO:0042803 | protein homodimerization activity | ACHE, BCL2, FLT3, HMGCR, MCL1, NQO2, PTGS2, SMAD3, TERT, TOP2A, TYR, XDH | 2.13135 |
[MF] GO:0019903 | protein phosphatase binding | BCL2, EGFR, HMGCR, MET, PTPN1 | 2.10478 |
[MF] GO:0005518 | collagen binding | ACHE, MMP12, MMP9, SMAD3 | 2.10434 |
[MF] GO:0030284 | estrogen receptor activity | ESR1, ESR2 | 2.05003 |
[MF] GO:0043559 | insulin binding | IGF1R, INSR | 2.05003 |
[MF] GO:0051434 | BH3 domain binding | BCL2, MCL1 | 2.05003 |
[MF] GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | EGFR, MET, PIK3CA, PIK3CB | 2.04165 |
[MF] GO:0035639 | purine ribonucleoside triphosphate binding | ABCB1, AURKB, AXL, CSNK2A1, DYRK1A, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A | 2.01897 |
KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
---|---|---|
Nitrogen metabolism_Homo sapiens_hsa00910 | CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 | 17.5674 |
Ovarian steroidogenesis_Homo sapiens_hsa04913 | ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R | 10.376 |
Estrogen signaling pathway_Homo sapiens_hsa04915 | PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A | 7.7838 |
Proteoglycans in cancer_Homo sapiens_hsa05205 | PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, HIF1A, EGFR, IGF1R | 7.5974 |
Adherens junction_Homo sapiens_hsa04520 | PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R | 7.5974 |
Metabolic pathways_Homo sapiens_hsa01100 | CBR1, MGAM, DNMT1, GAA, GBA, AKR1B1, HMGCR, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, DAO, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH | 7.0837 |
Pathways in cancer_Homo sapiens_hsa05200 | SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, HIF1A, EGFR, IGF1R, PIK3CA, BCL2, MET | 6.7731 |
MicroRNAs in cancer_Homo sapiens_hsa05206 | DNMT1, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B, MCL1 | 7.0851 |
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 | 7.0851 |
HIF-1 signaling pathway_Homo sapiens_hsa04066 | PIK3CA, INSR, BCL2, TEK, PIK3CB, HIF1A, EGFR, IGF1R | 6.7503 |
Rap1 signaling pathway_Homo sapiens_hsa04015 | PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 5.5378 |
Chemical carcinogenesis_Homo sapiens_hsa05204 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 | 6.1385 |
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, MCL1, IGF1R | 4.8706 |
Central carbon metabolism in cancer_Homo sapiens_hsa05230 | PIK3CA, FLT3, PIK3CB, MET, HIF1A, EGFR | 5.3887 |
Steroid hormone biosynthesis_Homo sapiens_hsa00140 | HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 | 5.7007 |
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 | 5.1954 |
Focal adhesion_Homo sapiens_hsa04510 | PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R | 4.7726 |
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 4.4885 |
Ras signaling pathway_Homo sapiens_hsa04014 | PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R | 4.4401 |
Bladder cancer_Homo sapiens_hsa05219 | SRC, MMP1, MMP2, MMP9, EGFR | 5.1519 |
VEGF signaling pathway_Homo sapiens_hsa04370 | PIK3CA, SRC, KDR, PIK3CB, PTGS2 | 4.3924 |
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A | 4.3201 |
Melanoma_Homo sapiens_hsa05218 | PIK3CA, PIK3CB, MET, EGFR, IGF1R | 4.1219 |
Hepatitis B_Homo sapiens_hsa05161 | SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 | 3.7183 |
Prolactin signaling pathway_Homo sapiens_hsa04917 | PIK3CA, SRC, PIK3CB, ESR1, ESR2 | 4.109 |
FoxO signaling pathway_Homo sapiens_hsa04068 | SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R | 3.9314 |
Prostate cancer_Homo sapiens_hsa05215 | PIK3CA, BCL2, PIK3CB, EGFR, IGF1R | 3.7082 |
Endocytosis_Homo sapiens_hsa04144 | SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A | 3.2827 |
Insulin resistance_Homo sapiens_hsa04931 | PTPN1, PIK3CA, INSR, PIK3CB, PPARA | 3.3094 |
Toxoplasmosis_Homo sapiens_hsa05145 | PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A | 3.218 |
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | PIK3CA, SRC, PIK3CB, ESR1, HIF1A | 3.218 |
Sphingolipid signaling pathway_Homo sapiens_hsa04071 | PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB | 3.1956 |
Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.3094 |
AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, INSR, PIK3CB, HMGCR, IGF1R | 3.1734 |
Colorectal cancer_Homo sapiens_hsa05210 | SMAD3, PIK3CA, BCL2, PIK3CB | 3.218 |
Glioma_Homo sapiens_hsa05214 | PIK3CA, PIK3CB, EGFR, IGF1R | 3.1748 |
Jak-STAT signaling pathway_Homo sapiens_hsa04630 | PIK3CA, BCL2, PIM1, PIK3CB, MCL1 | 2.7467 |
Arachidonic acid metabolism_Homo sapiens_hsa00590 | CBR1, ALOX5, PTGS2, PTGS1 | 3.218 |
Oxytocin signaling pathway_Homo sapiens_hsa04921 | PIK3CA, SRC, PIK3CB, PTGS2, EGFR | 2.7467 |
Pancreatic cancer_Homo sapiens_hsa05212 | SMAD3, PIK3CA, PIK3CB, EGFR | 3.1734 |
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | PIK3CA, ADORA3, INSR, ADORA1, PIK3CB | 2.6728 |
Renal cell carcinoma_Homo sapiens_hsa05211 | PIK3CA, PIK3CB, MET, HIF1A | 3.1734 |
ErbB signaling pathway_Homo sapiens_hsa04012 | PIK3CA, SRC, PIK3CB, EGFR | 2.7615 |
Small cell lung cancer_Homo sapiens_hsa05222 | PIK3CA, BCL2, PIK3CB, PTGS2 | 2.7708 |
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | PIK3CA, SRC, PIK3CB, MET | 2.9226 |
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | PIK3CA, PIK3CB, CDC25B, IGF1R | 2.6289 |
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | PIK3CA, INSR, PIK3CB, IGF1R | 2.6801 |
Galactose metabolism_Homo sapiens_hsa00052 | MGAM, AKR1B10, GAA, AKR1B1 | 4.3201 |
Choline metabolism in cancer_Homo sapiens_hsa05231 | PIK3CA, PIK3CB, HIF1A, EGFR | 2.588 |
Cholinergic synapse_Homo sapiens_hsa04725 | ACHE, PIK3CA, BCL2, PIK3CB | 2.4669 |
TNF signaling pathway_Homo sapiens_hsa04668 | PIK3CA, PIK3CB, PTGS2, MMP9 | 2.4738 |
Epstein-Barr virus infection_Homo sapiens_hsa05169 | CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A | 2.3889 |
PPAR signaling pathway_Homo sapiens_hsa03320 | FABP3, FABP4, MMP1, PPARA | 3.1176 |
cAMP signaling pathway_Homo sapiens_hsa04024 | HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA | 2.4033 |
Serotonergic synapse_Homo sapiens_hsa04726 | APP, ALOX5, PTGS2, PTGS1 | 2.46 |
Platelet activation_Homo sapiens_hsa04611 | PIK3CA, SRC, PIK3CB, PTGS1 | 2.3659 |
Leukocyte transendothelial migration_Homo sapiens_hsa04670 | PIK3CA, MMP2, PIK3CB, MMP9 | 2.3983 |
Measles_Homo sapiens_hsa05162 | CSNK2A1, PIK3CA, PIK3CB, HSPA1A | 2.2232 |
Hepatitis C_Homo sapiens_hsa05160 | PIK3CA, PIK3CB, PPARA, EGFR | 2.2425 |
Apoptosis_Homo sapiens_hsa04210 | PIK3CA, BCL2, PIK3CB, MCL1 | 2.1935 |
Insulin signaling pathway_Homo sapiens_hsa04910 | PTPN1, PIK3CA, INSR, PIK3CB | 2.1986 |
Phospholipase D signaling pathway_Homo sapiens_hsa04072 | PIK3CA, INSR, PIK3CB, EGFR | 2.1675 |
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | SMAD3, PIK3CA, PIK3CB, IGF1R | 2.1834 |
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | PIK3CA, INSR, PIK3CB, PPARA | 2.1109 |
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | FLT3, MMP9, MET, IGF1R | 1.8589 |
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | PIK3CA, SRC, PIK3CB, EGFR | 1.633 |
MAPK signaling pathway_Homo sapiens_hsa04010 | DUSP3, EGFR, CDC25B, HSPA1A | 1.4013 |
HTLV-I infection_Homo sapiens_hsa05166 | SMAD3, PIK3CA, TERT, PIK3CB | 1.3908 |
Herpes simplex infection_Homo sapiens_hsa05168 | CSNK2A1 | 0.269 |
Purine metabolism_Homo sapiens_hsa00230 | XDH | 0.2782 |
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | FLT3, KDR, MET, EGFR | 1.3664 |
Calcium signaling pathway_Homo sapiens_hsa04020 | EGFR | 0.2743 |
Hippo signaling pathway_Homo sapiens_hsa04390 | SMAD3 | 0.318 |
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.3758 |
Neurotrophin signaling pathway_Homo sapiens_hsa04722 | PIK3CA, BCL2, PIK3CB | 1.5864 |
Lysosome_Homo sapiens_hsa04142 | FUCA1, GAA, GBA | 1.5627 |
GnRH signaling pathway_Homo sapiens_hsa04912 | SRC, MMP2, EGFR | 1.8713 |
Spliceosome_Homo sapiens_hsa03040 | HSPA1A | 0.3576 |
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | PIK3CA, SRC, PIK3CB | 1.8041 |
Viral carcinogenesis_Homo sapiens_hsa05203 | PIK3CA, SRC, PIK3CB | 1.0763 |
Influenza A_Homo sapiens_hsa05164 | PIK3CA, PIK3CB, HSPA1A | 1.2218 |
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | SMAD3, PIK3CA, PIK3CB | 1.7387 |
Axon guidance_Homo sapiens_hsa04360 | MET | 0.3725 |
Oocyte meiosis_Homo sapiens_hsa04114 | IGF1R | 0.3804 |
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | GPR35, ADORA3, ADORA1 | 0.8274 |
Chemokine signaling pathway_Homo sapiens_hsa04062 | PIK3CA, SRC, PIK3CB | 1.1588 |
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | BCL2, HSPA1A | 0.7111 |
Osteoclast differentiation_Homo sapiens_hsa04380 | PIK3CA, PIK3CB | 0.8289 |
NF-kappa B signaling pathway_Homo sapiens_hsa04064 | CSNK2A1, BCL2, PTGS2 | 1.856 |
Tight junction_Homo sapiens_hsa04530 | CSNK2A1, SRC | 0.813 |
Tuberculosis_Homo sapiens_hsa05152 | SRC, BCL2 | 0.6824 |
Glucagon signaling pathway_Homo sapiens_hsa04922 | PPARA | 0.445 |
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | PIK3CA, PIK3CB | 0.8274 |
Melanogenesis_Homo sapiens_hsa04916 | TYR | 0.445 |
Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.7118 |
Cell cycle_Homo sapiens_hsa04110 | SMAD3, CDC25B | 0.8668 |
Wnt signaling pathway_Homo sapiens_hsa04310 | SMAD3, CSNK2A1 | 0.8055 |
Glycerophospholipid metabolism_Homo sapiens_hsa00564 | ACHE | 0.4554 |
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | PTGS2 | 0.445 |
Pancreatic secretion_Homo sapiens_hsa04972 | CA2 | 0.4546 |
mTOR signaling pathway_Homo sapiens_hsa04150 | PIK3CA, PIK3CB, HIF1A | 2.2969 |
Chronic myeloid leukemia_Homo sapiens_hsa05220 | SMAD3, PIK3CA, PIK3CB | 2.1221 |
Morphine addiction_Homo sapiens_hsa05032 | ADORA1 | 0.468 |
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | PIK3CA, PIK3CB | 0.9755 |
Hematopoietic cell lineage_Homo sapiens_hsa04640 | FLT3 | 0.4743 |
T cell receptor signaling pathway_Homo sapiens_hsa04660 | PIK3CA, PIK3CB | 0.9859 |
GABAergic synapse_Homo sapiens_hsa04727 | SRC | 0.4743 |
TGF-beta signaling pathway_Homo sapiens_hsa04350 | SMAD3 | 0.4853 |
Endometrial cancer_Homo sapiens_hsa05213 | PIK3CA, PIK3CB, EGFR | 2.4343 |
Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.0118 |
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | CSNK2A1 | 0.4731 |
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | PIK3CA, PIK3CB | 1.0232 |
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | PIK3CA, PIK3CB | 1.0592 |
Non-small cell lung cancer_Homo sapiens_hsa05223 | PIK3CA, PIK3CB, EGFR | 2.3696 |
Rheumatoid arthritis_Homo sapiens_hsa05323 | MMP1, TEK | 1.0763 |
Gap junction_Homo sapiens_hsa04540 | SRC, EGFR | 1.0854 |
Antigen processing and presentation_Homo sapiens_hsa04612 | HSPA1A | 0.5143 |
Leishmaniasis_Homo sapiens_hsa05140 | PTGS2 | 0.5281 |
Retinol metabolism_Homo sapiens_hsa00830 | CYP2A6, CYP1A2, CYP1A1 | 2.2232 |
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | SRC, MET, EGFR | 2.1859 |
Gastric acid secretion_Homo sapiens_hsa04971 | CA2 | 0.5261 |
Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5409 |
Bile secretion_Homo sapiens_hsa04976 | ABCB1, CA2, HMGCR | 2.1504 |
Type II diabetes mellitus_Homo sapiens_hsa04930 | PIK3CA, INSR, PIK3CB | 2.5051 |
Peroxisome_Homo sapiens_hsa04146 | DAO, XDH | 1.1266 |
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | PIK3CA, INSR, PIK3CB | 2.7113 |
B cell receptor signaling pathway_Homo sapiens_hsa04662 | PIK3CA, PIK3CB | 1.2188 |
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | PIK3CA, PIK3CB | 1.2576 |
Shigellosis_Homo sapiens_hsa05131 | SRC | 0.5658 |
Renin secretion_Homo sapiens_hsa04924 | ADORA1 | 0.5686 |
Inositol phosphate metabolism_Homo sapiens_hsa00562 | PIK3CA, PIK3CB | 1.2322 |
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | MGAM, PIK3CA, PIK3CB | 2.5792 |
Long-term depression_Homo sapiens_hsa04730 | IGF1R | 0.5902 |
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | CYP2A6, CYP1A2 | 1.2504 |
Tryptophan metabolism_Homo sapiens_hsa00380 | CYP1A2, CYP1A1, CYP1B1 | 2.6878 |
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | SMAD3, RORC | 1.2891 |
Legionellosis_Homo sapiens_hsa05134 | HSPA1A | 0.6207 |
Glycerolipid metabolism_Homo sapiens_hsa00561 | AKR1B10, AKR1B1 | 1.3625 |
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | BCL2 | 0.6469 |
Arginine and proline metabolism_Homo sapiens_hsa00330 | DAO | 0.6515 |
Malaria_Homo sapiens_hsa05144 | MET | 0.6562 |
Starch and sucrose metabolism_Homo sapiens_hsa00500 | MGAM, GAA | 1.3908 |
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | ESR1 | 0.6696 |
Sphingolipid metabolism_Homo sapiens_hsa00600 | GBA | 0.6696 |
ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6826 |
Cysteine and methionine metabolism_Homo sapiens_hsa00270 | DNMT1 | 0.6803 |
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | DAO | 0.7118 |
Drug metabolism - other enzymes_Homo sapiens_hsa00983 | CYP2A6, XDH | 1.5375 |
Prion diseases_Homo sapiens_hsa05020 | HSPA1A | 0.7577 |
Pyruvate metabolism_Homo sapiens_hsa00620 | GLO1 | 0.7118 |
Dorso-ventral axis formation_Homo sapiens_hsa04320 | EGFR | 0.828 |
Tyrosine metabolism_Homo sapiens_hsa00350 | TYR | 0.7577 |
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | FUT7 | 0.7964 |
Base excision repair_Homo sapiens_hsa03410 | APEX1 | 0.7744 |
Linoleic acid metabolism_Homo sapiens_hsa00591 | CYP1A2 | 0.813 |
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | FUT7 | 0.8324 |
Circadian rhythm_Homo sapiens_hsa04710 | RORC | 0.8055 |
Fructose and mannose metabolism_Homo sapiens_hsa00051 | AKR1B10, AKR1B1 | 1.8049 |
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | AKR1B10, AKR1B1 | 1.7215 |
Collecting duct acid secretion_Homo sapiens_hsa04966 | CA2 | 0.828 |
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | HMGCR | 0.8938 |
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | CA2, CA4 | 2.0652 |
Caffeine metabolism_Homo sapiens_hsa00232 | CYP2A6, CYP1A2, XDH | 5.1519 |
Folate biosynthesis_Homo sapiens_hsa00790 | ALPL | 1.0593 |
Other glycan degradation_Homo sapiens_hsa00511 | FUCA1, GBA | 2.2232 |