TCM-ID Prescription

Prescription Description

Prescription ID	TCMF3668
Pinyin Name	Cui Ru Wan
Chinese Name	催乳丸
English Name	Cui Ru Pills
Function Description	缺乳
Indications	Hypogalactia disorder
Disease ICD-11 Category	SC12 [Hypogalactia disorder (TM1), 缺乳 (TM1) ];
Human Tissues Associated with Indication
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH421	Angelica sinensis	当归	TCMH421	ITSAF173-14
TCMH2119	Tetrapanax papyriferus	通草	TCMH2119
TCMH1430	Hordeum vulgare	麦芽	TCMH1430	ITSAI3101-14
TCMH305	Cnidium officinale	川芎	TCMH305	ITSAP4207-14
TCMH293	Manis pentadactyla	穿山甲	TCMH293	GBMA15413-17
TCMH1331	Rhaponticum uniflorum	漏芦	TCMH1331	ITSAJ4341-14
TCMH451	Rehmannia glutinosa	地黄	TCMH451	ITSAH4578-14
TCMH981	Astragalus membranaceus	黄芪	TCMH981	ITSAK2981-14
TCMH1346	Cornu cervi degelatinatum	鹿角霜	TCMH1346
TCMH104	Paeonia lactiflora	白芍	TCMH104	ITSAH2416-14
TCMH1533	Saussurea lappa	木香	TCMH1533
TCMH2161	Vaccaria segetalis	王不留行	TCMH2161

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT102	ACP1	Low molecular weight phosphotyrosine protein phosphatase	Hydrolase	P24666
TCMT103	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	Hydrolase	P10586
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT139	CA6	Carbonic anhydrase VI	Lyase	P23280
TCMT140	CA5B	Carbonic anhydrase VB	Lyase	Q9Y2D0
TCMT141	CA5A	Carbonic anhydrase VA	Lyase	P35218
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT150	RORC	Nuclear receptor ROR-gamma	Nuclear receptor	P51449
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT161	HCAR2	Hydroxycarboxylic acid receptor 2	GPCR	Q8TDS4
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT315	HTR6	Serotonin 6 (5-HT6) receptor	GPCR	P50406
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT332	AOC3	Amine oxidase, copper containing	Oxidoreductase	Q16853
TCMT335	MPO	Myeloperoxidase	Oxidoreductase	P05164
TCMT336	IDO1	Indoleamine 2,3-dioxygenase	Oxidoreductase	P14902
TCMT560	F10	Coagulation factor X	Unclassified	P00742
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT690	HDAC3	Histone deacetylase 3	Hydrolase	O15379
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT907	FDPS	Farnesyl diphosphate synthase	Lyase	P14324

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1178	Actinomyces viscosus
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1218	Staphylococcus aureus
TCMT1219	Enterococcus
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1226	Klebsiella pneumoniae
TCMT1227	Streptococcus
TCMT1229	Enterococcus faecalis
TCMT1232	Pseudomonas aeruginosa
TCMT1243	Aspergillus flavus
TCMT1245	Phytophthora cactorum
TCMT1246	Escherichia coli
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1284	Penicillium expansum
TCMT1286	Bacillus cereus
TCMT1294	Human parainfluenza virus 3
TCMT1321	Staphylococcus hominis
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1353	Plasmodium yoelii
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408	Colletotrichum gloeosporioides
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value
[BP] GO:0015701	bicarbonate transport	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	14.0837
[BP] GO:0006730	one-carbon metabolic process	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	13.1331
[BP] GO:0044281	small molecule metabolic process	AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, IDO1, MPO, PPARA, PTGS2, XDH	13.1331
[BP] GO:0006629	lipid metabolic process	ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, HSD17B1, PPARA, PTGS2	8.12944
[BP] GO:0015711	organic anion transport	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA	7.54818
[BP] GO:0006820	anion transport	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA	6.29655
[BP] GO:0019373	epoxygenase P450 pathway	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6	6.25467
[BP] GO:0019748	secondary metabolic process	AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6	6.10168
[BP] GO:0033559	unsaturated fatty acid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	6.08456
[BP] GO:0019369	arachidonic acid metabolic process	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	6.03977
[BP] GO:0006690	icosanoid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	5.93892
[BP] GO:0044255	cellular lipid metabolic process	ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, PPARA, PTGS2	5.7029
[BP] GO:0006631	fatty acid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGS2	5.3724
[BP] GO:0055114	oxidation-reduction process	AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, MPO, PTGS2, XDH	5.09425
[BP] GO:1901568	fatty acid derivative metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	4.81531
[BP] GO:0009056	catabolic process	ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, MMP1, MMP2, MMP9, MPO, XDH	4.77938
[BP] GO:0032787	None	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGS2	4.77938
[BP] GO:0008202	steroid metabolic process	AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FDPS, HSD17B1	4.77291
[BP] GO:0001676	long-chain fatty acid metabolic process	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	4.58096
[BP] GO:1901700	response to oxygen-containing compound	AKR1B1, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, IDO1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC	4.28322
[BP] GO:1903409	reactive oxygen species biosynthetic process	CYP1A1, CYP1A2, CYP1B1, MPO	4.10924
[BP] GO:0009698	phenylpropanoid metabolic process	CYP1A1, CYP2A13, CYP2A6	3.87251
[BP] GO:0009804	coumarin metabolic process	CYP1A1, CYP2A13, CYP2A6	3.87251
[BP] GO:0008152	metabolic process	ACHE, ADORA1, AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FDPS, FUT7, HSD17B1, IDO1, MMP1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, XDH	3.75782
[BP] GO:0019216	regulation of lipid metabolic process	ADORA1, CYP1A1, FABP3, FDPS, HCAR2, PPARA, PTGS2, RORC	3.58869
[BP] GO:0097267	omega-hydroxylase P450 pathway	CYP1A1, CYP1A2, CYP1B1	3.37785
[BP] GO:0044237	cellular metabolic process	ACHE, AKR1B1, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FDPS, FUT7, HSD17B1, IDO1, MMP1, MMP2, MPO, PPARA, PTGS2, RORC, XDH	3.36271
[BP] GO:0033993	response to lipid	CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, IDO1, MPO, PTGS2, RORC	3.27687
[BP] GO:0042445	hormone metabolic process	ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1	3.10925
[BP] GO:0043436	oxoacid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, MPO, PPARA, PTGS2	3.10737
[BP] GO:0006082	organic acid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, MPO, PPARA, PTGS2	3.04107
[BP] GO:0044283	None	AKR1B1, ALOX5, CYP19A1, CYP1A1, FDPS, IDO1, MPO, PTGS2	3.04107
[BP] GO:0034754	cellular hormone metabolic process	AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1	3.01088
[BP] GO:0006805	xenobiotic metabolic process	CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC	2.90829
[BP] GO:0010035	response to inorganic substance	AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, MMP9, PTGS2	2.90829
[BP] GO:0010033	response to organic substance	AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, IDO1, MMP2, MPO, PPARA, PTGS2, RORC	2.87045
[BP] GO:0019752	carboxylic acid metabolic process	ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, IDO1, PPARA, PTGS2	2.68055
[BP] GO:0006811	None	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA	2.66055
[BP] GO:0010817	regulation of hormone levels	ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1	2.63528
[BP] GO:0017144	drug metabolic process	ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, IDO1, MPO	2.52599
[BP] GO:0042221	response to chemical	AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, IDO1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC	2.43608
[BP] GO:0071248	cellular response to metal ion	CYP1A1, CYP1A2, FABP4, MMP9, PTGS2	2.41361
[BP] GO:0032849	positive regulation of cellular pH reduction	CA2, CA7	2.41311
[BP] GO:0010647	positive regulation of cell communication	ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, HTR6, MMP9, PTGS2, XDH	2.41311
[BP] GO:0008610	lipid biosynthetic process	ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, FDPS, HSD17B1, PTGS2	2.41311
[BP] GO:0023056	positive regulation of signaling	ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, HTR6, MMP9, PTGS2, XDH	2.40075
[BP] GO:0009404	toxin metabolic process	CYP1A1, CYP1A2, CYP1B1	2.3897
[BP] GO:0008210	estrogen metabolic process	CYP19A1, CYP1B1, HSD17B1	2.33848
[BP] GO:0016042	lipid catabolic process	ADORA1, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4	2.32546
[BP] GO:0048661	positive regulation of smooth muscle cell proliferation	AKR1B1, MMP2, MMP9, PTGS2	2.31067
[BP] GO:0022900	electron transport chain	AKR1B1, CYP19A1, CYP1A2, IDO1, XDH	2.28001
[BP] GO:0032847	regulation of cellular pH reduction	CA2, CA7	2.18312
[BP] GO:0018894	dibenzo-p-dioxin metabolic process	CYP1A1, CYP1A2	2.18312
[BP] GO:0071241	cellular response to inorganic substance	CYP1A1, CYP1A2, FABP4, MMP9, PTGS2	2.18312
[BP] GO:0042743	hydrogen peroxide metabolic process	CYP1A1, CYP1A2, MPO	2.09163
[BP] GO:0032228	regulation of synaptic transmission, GABAergic	ADORA1, CA2, CA7	2.0156
[BP] GO:1901575	None	ACHE, ADORA1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, IDO1, XDH	2.0156
[CC] GO:0016323	basolateral plasma membrane	ADORA1, CA2, CA4, CA9	1.08391
[CC] GO:0031233	None	CA4, F10	0.984563
[CC] GO:0044444	cytoplasmic part	ACHE, ADORA1, AKR1B1, ALOX5, CA1, CA2, CA4, CA5A, CA5B, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FDPS, FUT7, HSD17B1, IDO1, MMP2, MMP9, MPO, PTGS2, XDH	0.756568
[CC] GO:0005789	endoplasmic reticulum membrane	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	0.722351
[CC] GO:0032991	None	CSNK2A1, PTGS2	0.790689
[MF] GO:0004089	carbonate dehydratase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	19.6826
[MF] GO:0046914	transition metal ion binding	ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PPARA, RORC, XDH	13.5494
[MF] GO:0016836	hydro-lyase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	13.3198
[MF] GO:0016835	carbon-oxygen lyase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	12.1224
[MF] GO:0016829	lyase activity	CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9	8.18351
[MF] GO:0020037	heme binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2	8.12944
[MF] GO:0043169	cation binding	ACHE, ALOX5, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FDPS, IDO1, MMP1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, XDH	8.12944
[MF] GO:0046906	tetrapyrrole binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, IDO1, MPO, PTGS2	7.92286
[MF] GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6	7.77082
[MF] GO:0043167	ion binding	ACHE, ALOX5, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FABP3, FABP4, FDPS, HSD17B1, IDO1, MMP1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, XDH	7.70191
[MF] GO:0046872	metal ion binding	ALOX5, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FDPS, IDO1, MMP1, MMP2, MMP9, MPO, PPARA, PTGS2, RORC, XDH	7.54818
[MF] GO:0003824	catalytic activity	ACHE, ADORA1, AKR1B1, ALOX5, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F10, FDPS, FUT7, HSD17B1, IDO1, MMP1, MMP2, MMP9, MPO, PTGS2, XDH	7.21262
[MF] GO:0008270	zinc ion binding	CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, RORC	6.47426
[MF] GO:0070330	aromatase activity	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13	6.08456
[MF] GO:0005506	iron ion binding	ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH	6.08456
[MF] GO:0016491	oxidoreductase activity	AKR1B1, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, MPO, PTGS2, XDH	6.08456
[MF] GO:0048037	cofactor binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, IDO1, MPO, PTGS2, XDH	5.83036
[MF] GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS2	4.81531
[MF] GO:0019825	oxygen binding	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13	4.75871
[MF] GO:0004497	monooxygenase activity	CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6	4.70371
[MF] GO:0008395	steroid hydroxylase activity	CYP19A1, CYP1A1, CYP2A13, CYP2A6	3.52559
[MF] GO:0009055	electron transfer activity	AKR1B1, CYP19A1, CYP1A2, IDO1, XDH	3.01088
[MF] GO:0008389	None	CYP2A13, CYP2A6	2.83386
[MF] GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOX5, IDO1, PTGS2	2.25473
[MF] GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOX5, IDO1, PTGS2	2.20994

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910	CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14	21.475
Ovarian steroidogenesis_Homo sapiens_hsa04913	ALOX5, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1	7.6755
Chemical carcinogenesis_Homo sapiens_hsa05204	CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2	6.5281
Steroid hormone biosynthesis_Homo sapiens_hsa00140	HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP19A1	5.8496
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1	5.4224
Metabolic pathways_Homo sapiens_hsa01100	FDPS, CYP2A6, FUT7, ALOX5, HSD17B1, CYP1A2, CYP1A1, AKR1B1, PTGS2, CYP19A1, XDH, IDO1	4.6225
Tryptophan metabolism_Homo sapiens_hsa00380	CYP1A2, CYP1A1, CYP1B1, IDO1	4.9281
PPAR signaling pathway_Homo sapiens_hsa03320	FABP3, FABP4, MMP1, PPARA	4.0791
Bladder cancer_Homo sapiens_hsa05219	MMP1, MMP2, MMP9	3.272
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	FABP4, ADORA1, PTGS2	2.9073
cAMP signaling pathway_Homo sapiens_hsa04024	HCAR2, HTR6, ADORA1, PPARA	2.4525
Retinol metabolism_Homo sapiens_hsa00830	CYP2A6, CYP1A2, CYP1A1	2.7528
Caffeine metabolism_Homo sapiens_hsa00232	CYP2A6, CYP1A2, XDH	5.8807
Serotonergic synapse_Homo sapiens_hsa04726	HTR6, ALOX5, PTGS2	2.1596
Pathways in cancer_Homo sapiens_hsa05200	MMP1, MMP2, PTGS2, MMP9	1.5072
Arachidonic acid metabolism_Homo sapiens_hsa00590	ALOX5, PTGS2	1.5305
Drug metabolism - other enzymes_Homo sapiens_hsa00983	CYP2A6, XDH	1.7575
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	CYP2A6, CYP1A2	1.4889
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	HTR6, ADORA3, ADORA1	1.2349
Estrogen signaling pathway_Homo sapiens_hsa04915	MMP2, MMP9	1.2349
MicroRNAs in cancer_Homo sapiens_hsa05206	CYP1B1, PTGS2, MMP9	1.1931
NF-kappa B signaling pathway_Homo sapiens_hsa04064	CSNK2A1, PTGS2	1.263
TNF signaling pathway_Homo sapiens_hsa04668	PTGS2, MMP9	1.1931
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	CA2, CA4	2.299
Sphingolipid signaling pathway_Homo sapiens_hsa04071	ADORA3, ADORA1	1.1688
Leukocyte transendothelial migration_Homo sapiens_hsa04670	MMP2, MMP9	1.1688
cGMP-PKG signaling pathway_Homo sapiens_hsa04022	ADORA3, ADORA1	0.9367
Transcriptional misregulation in cancer_Homo sapiens_hsa05202	MMP9, MPO	0.8993
Proteoglycans in cancer_Homo sapiens_hsa05205	MMP2, MMP9	0.8993
VEGF signaling pathway_Homo sapiens_hsa04370	PTGS2	0.6755
Gastric acid secretion_Homo sapiens_hsa04971	CA2	0.6653
Renin secretion_Homo sapiens_hsa04924	ADORA1	0.6702
Glycerolipid metabolism_Homo sapiens_hsa00561	AKR1B1	0.6784
Leishmaniasis_Homo sapiens_hsa05140	PTGS2	0.6653
Adipocytokine signaling pathway_Homo sapiens_hsa04920	PPARA	0.6653
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	MMP2	0.6381
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	RORC	0.6702
GnRH signaling pathway_Homo sapiens_hsa04912	MMP2	0.6415
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	CSNK2A1	0.6415
Adherens junction_Homo sapiens_hsa04520	CSNK2A1	0.6653
Small cell lung cancer_Homo sapiens_hsa05222	PTGS2	0.6415
Bile secretion_Homo sapiens_hsa04976	CA2	0.6653
Morphine addiction_Homo sapiens_hsa05032	ADORA1	0.6415
Cholinergic synapse_Homo sapiens_hsa04725	ACHE	0.6153
Rheumatoid arthritis_Homo sapiens_hsa05323	MMP1	0.6415
Complement and coagulation cascades_Homo sapiens_hsa04610	F10	0.6478
Glucagon signaling pathway_Homo sapiens_hsa04922	PPARA	0.6381
Insulin resistance_Homo sapiens_hsa04931	PPARA	0.6153
Peroxisome_Homo sapiens_hsa04146	XDH	0.6415
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	PTGS2	0.6381
Glycerophospholipid metabolism_Homo sapiens_hsa00564	ACHE	0.6381
Measles_Homo sapiens_hsa05162	CSNK2A1	0.5575
Hepatitis C_Homo sapiens_hsa05160	PPARA	0.5592
Pancreatic secretion_Homo sapiens_hsa04972	CA2	0.6381
Toxoplasmosis_Homo sapiens_hsa05145	ALOX5	0.5984
Hepatitis B_Homo sapiens_hsa05161	MMP9	0.5502
Wnt signaling pathway_Homo sapiens_hsa04310	CSNK2A1	0.5542
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	PPARA	0.5439
Tight junction_Homo sapiens_hsa04530	CSNK2A1	0.5558
Oxytocin signaling pathway_Homo sapiens_hsa04921	PTGS2	0.5394
Influenza A_Homo sapiens_hsa05164	FDPS	0.5117
Calcium signaling pathway_Homo sapiens_hsa04020	HTR6	0.5095
Epstein-Barr virus infection_Homo sapiens_hsa05169	CSNK2A1	0.4795
Purine metabolism_Homo sapiens_hsa00230	XDH	0.5117
Phagosome_Homo sapiens_hsa04145	MPO	0.5429
HTLV-I infection_Homo sapiens_hsa05166	FDPS	0.4006
Herpes simplex infection_Homo sapiens_hsa05168	CSNK2A1	0.5053
African trypanosomiasis_Homo sapiens_hsa05143	IDO1	0.8732
Galactose metabolism_Homo sapiens_hsa00052	AKR1B1	0.8993
Linoleic acid metabolism_Homo sapiens_hsa00591	CYP1A2	0.8993
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	FUT7	0.8993
Circadian rhythm_Homo sapiens_hsa04710	RORC	0.8993
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	FUT7	0.8993
Pentose and glucuronate interconversions_Homo sapiens_hsa00040	AKR1B1	0.8726
Fructose and mannose metabolism_Homo sapiens_hsa00051	AKR1B1	0.8993
Collecting duct acid secretion_Homo sapiens_hsa04966	CA2	0.8993
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	FDPS	0.9367

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway
5. Targets Expression Levels in Healthy Donor (mRNA Level)
6. Targets Expression Levels in Healthy Donor (Protein Level)

TCM Prescription: Cui Ru Pills