TCM Prescription: Gu Chang Zhi Xie Pills



Prescription Description
Prescription IDTCMF3619
Pinyin NameGu Chang Zhi Xie Wan
Chinese Name固肠止泻丸
English NameGu Chang Zhi Xie Pills
Function Description痢疾, 腹泻
IndicationsDysentery disorder, Diarrhea, Dysentery
Disease ICD-11 Category SA56 [Dysentery disorder (TM1), 痢疾 (TM1) ];
ME05.1 [Diarrhoea, 腹泻 ];
1A40.Z [Infectious gastroenteritis or colitis without specification of infectious agent, 未特指感染性病原体的感染性胃肠炎或结肠炎 ];
Human Tissues Associated with IndicationIntestine, Stomach
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH2515 Papaver somniferum 罂粟壳 TCMH2515 ITSAD207-14
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT113 OPRD1 Delta opioid receptor GPCR P41143
TCMT116 OPRM1 Mu opioid receptor GPCR P35372
TCMT117 OPRK1 Kappa opioid receptor GPCR P41145
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT617 SENP6 Sentrin-specific protease 6 Protease Q9GZR1
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT789 PDE3A Phosphodiesterase 3A Hydrolase Q14432
TCMT790 PDE3B Phosphodiesterase 3B Hydrolase Q13370
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT792 PDE10A Phosphodiesterase 10A Hydrolase Q9Y233
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.867
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1759
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 8.93876
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7, OPRD1, OPRK1, OPRM1 8.46006
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP4, FLT3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 8.46006
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7, OPRD1, OPRK1, OPRM1 8.46006
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, AXL, CA2, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FABP4, FLT3, HTR5A, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 8.36996
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA3, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, HTR5A, IGF1R, MMP2, MMP9, OPRK1, OPRM1, PDE3A, PDE3B, SRC 8.27146
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, DRD1, DRD2, DRD3, ESR1, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, SIGMAR1, SRC 8.23741
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, HTR2A, HTR2B, OPRD1, OPRK1, OPRM1 8.02974
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, FLT3, HTR5A, OPRK1, OPRM1, PDE3A, SRC 8.02974
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 7.84683
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 7.84019
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 7.79308
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HTR2B, PDE10A, PDE3A, PDE3B, PIM1, XDH 7.56761
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, SRC, XDH 7.52026
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 7.3782
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, OPRM1, PIM1, SRC, XDH 7.2363
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.19127
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.19127
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, OPRK1, OPRM1, PDE3A, SRC 7.18648
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FLT3, HTR5A, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC 7.07875
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 6.82755
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 6.69534
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, OPRD1, OPRK1, SRC 6.68739
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, SIGMAR1, SRC 6.58447
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3 6.50652
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CYP1B1, DRD2, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, OPRK1, OPRM1, SRC, XDH 6.30097
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, XDH 6.16604
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PDE3A, SRC 6.16604
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.9886
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRB, F2, F3, FABP4, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC 5.97253
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, OPRK1, SRC 5.9118
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A, OPRK1 5.79056
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP9, OPRK1, OPRM1, SRC, XDH 5.67973
[BP] GO:0038003 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.63559
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, ESR1, HSD17B1, HTR1A, HTR2A, OPRK1 5.59292
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.48387
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESRRA, F2, F3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.33098
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CSNK2A1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1 5.30923
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3 5.28927
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A, OPRM1, PDE3A 5.28866
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FLT3, HTR5A, OPRK1, PDE3B, SRC 5.24449
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, PDE3A, SRC 5.24449
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PIM1, SRC, XDH 5.15351
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.15351
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, ESRRA, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP2, MMP9, OPRK1, OPRM1, SRC, XDH 5.0886
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.04022
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A, OPRM1, PDE3A 5.04022
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 5.00653
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.8252
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.82328
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.82108
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FLT3, HTR5A, OPRK1, OPRM1, SRC 4.81417
[BP] GO:0043269 regulation of ion transport ADORA1, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, MMP9, OPRD1, OPRK1, OPRM1 4.79746
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR, OPRM1, PDE3A 4.79506
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, HSD17B1 4.61973
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, HTR2A, HTR2B, OPRM1 4.60124
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.51934
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.46737
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.46134
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.46134
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, F2, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP2, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 4.42671
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A, OPRK1 4.42502
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SRC, XDH 4.40441
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, ESR1, FABP4, HSD17B1, MET, PDE3A 4.36576
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 4.36222
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 4.36179
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.30957
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 4.30366
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.29531
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 4.28237
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F2, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC 4.26775
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, AXL, CA2, CYP1B1, DRD2, DRD3, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, HTR2B, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 4.19386
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, ESR1, HTR7, OPRK1, OPRM1, SRC 4.19386
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, DRD1, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 4.19386
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, DRD1, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 4.19386
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, OPRD1, OPRK1, OPRM1 4.1746
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, FLT3, HSD17B1, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SRC, XDH 4.17372
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, OPRK1, OPRM1, PDE10A, PDE3B, SRC, XDH 4.1681
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 4.1194
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 4.1194
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET, OPRK1 4.1011
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, SRC, XDH 4.06372
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, DRD2, ESRRB, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 4.06305
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR1, ESR2, HTR2A, IGF1R, MET, MMP9, OPRK1, OPRM1, PDE3B, SRC, XDH 4.05426
[BP] GO:0099536 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 4.05426
[BP] GO:0099537 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 4.05426
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.03683
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 4.03683
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, OPRD1, OPRK1, OPRM1, SRC 4.00637
[BP] GO:0072523 None AOX1, PDE10A, PDE3A, PDE3B, XDH 4.00547
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.97158
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.97158
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 3.96702
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, HTR2A, HTR2B, KDR, OPRK1, OPRM1, SRC, XDH 3.94522
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 3.93952
[BP] GO:0009056 catabolic process ACHE, ADORA1, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP4, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, SRC, XDH 3.89573
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, OPRK1, SRC 3.88618
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, DRD1, DRD2, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.84902
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HTR2B, IGF1R, KDR, MMP9, PDE3A, PIM1, SIGMAR1, SRC, XDH 3.84792
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3 3.82462
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PDE3A, PDE3B, PIM1, SIGMAR1, SRC 3.81703
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.76101
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, CA2, CYP1B1, DRD2, DRD3, ESRRB, F2, F3, HTR2A, HTR2B, KDR, MET, MMP9, OPRM1, PDE3A, PIM1, SRC 3.74013
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 3.70612
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.70602
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.62564
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, FABP4, HTR2A, HTR2B, MET 3.61433
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.60645
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESRRB, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.58706
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.58706
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.58706
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, OPRM1, PDE3A, SRC 3.56345
[BP] GO:0014059 None DRD2, DRD3, HTR2A, OPRK1 3.55775
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.54319
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 3.54211
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.54168
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 3.51358
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.49983
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, F2, FLT3, HTR2A, HTR2B, PDE3B, SRC 3.46296
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.44195
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SIGMAR1, SRC, XDH 3.44195
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, OPRK1, OPRM1, SRC, XDH 3.40392
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.40392
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, PDE3A 3.37265
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.36295
[BP] GO:0043278 None DRD2, DRD3, OPRK1, OPRM1 3.36232
[BP] GO:0014072 None DRD2, DRD3, OPRK1, OPRM1 3.36232
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, OPRM1, SRC 3.35839
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3, OPRM1 3.3399
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, PIM1, SRC, XDH 3.3399
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR2, HTR2A, HTR6, HTR7, OPRD1, OPRK1, OPRM1 3.3399
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 3.3399
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, ESR1, FABP4, IGF1R, MET, MMP9, OPRM1, PIM1, SRC 3.33167
[BP] GO:0007191 None DRD1, DRD3, OPRM1 3.33167
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.33167
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.33167
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SRC 3.28777
[BP] GO:0051930 None ADORA1, OPRD1, OPRK1, OPRM1 3.28777
[BP] GO:0051931 None ADORA1, OPRD1, OPRK1, OPRM1 3.28777
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 3.27126
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, DRD1, ESR1, IGF1R, MMP2, MMP9, OPRK1, PDE3A, PDE3B, SRC 3.24303
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.24303
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.21431
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD1, DRD2, DRD3, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC 3.20794
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A 3.20676
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 3.20676
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, ESR1, HTR2A, HTR2B 3.20422
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, ESR1, IGF1R, MET, MMP9, PDE3B, SRC, XDH 3.16495
[BP] GO:0007212 None DRD1, DRD2, DRD3, OPRM1 3.16222
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.1545
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 3.14932
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, OPRD1, OPRK1, OPRM1, PDE3A, SRC 3.13052
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 3.11685
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, OPRD1, OPRM1, PIM1, SRC, XDH 3.10711
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, KDR, MET, OPRM1 3.10528
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HTR1A 3.10431
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, F2 3.04187
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.02071
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.02071
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, SRC, XDH 3.0099
[BP] GO:0050801 ion homeostasis ADRA1A, CA12, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 3.00817
[BP] GO:0060359 None DRD1, DRD2, DRD3, OPRK1, OPRM1 2.99296
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PDE3A, PIM1, SRC 2.99168
[BP] GO:0031635 None OPRK1, OPRM1 2.98257
[BP] GO:0009115 None AOX1, XDH 2.98257
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, ESR1, ESRRA, ESRRB, F2, FLT3, HTR5A, KDR, MMP9, PIM1, SIGMAR1, SRC 2.95819
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, OPRK1, OPRM1, SRC 2.95819
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, CSNK2A1, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.95819
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.95819
[BP] GO:0006195 None PDE10A, PDE3A, PDE3B, XDH 2.95819
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.95819
[BP] GO:1903727 positive regulation of phospholipid metabolic process FLT3, HTR2A, HTR2B, SRC 2.95819
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.95819
[BP] GO:0006198 None PDE10A, PDE3A, PDE3B 2.95819
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.95819
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.95819
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD1, DRD2, DRD3, FLT3, IGF1R, MMP2, OPRK1, OPRM1, PDE3A, PDE3B, SRC 2.95412
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 2.94542
[BP] GO:0030003 cellular cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.89405
[BP] GO:0007631 None DRD1, DRD2, OPRD1, OPRK1, OPRM1 2.8752
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.8752
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, AURKB, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.87203
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP3A4, PDE10A, PDE3A, PDE3B, XDH 2.85273
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B 2.84587
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.84174
[BP] GO:0050433 None DRD2, DRD3, HTR2A, OPRK1 2.83208
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A, OPRK1 2.82365
[BP] GO:0006873 cellular ion homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.82137
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, F2, HTR1A, HTR2A, HTR2B, MMP9, OPRD1, OPRK1, OPRM1, SRC 2.80872
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PDE3A, PIM1, SRC 2.80759
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.80731
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.80731
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CA3, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PDE10A, PDE3A, PDE3B, PIM1, SRC, XDH 2.80004
[BP] GO:0010959 None ADORA1, DRD1, DRD2, DRD3, F2, HTR2A, OPRD1, OPRK1 2.78028
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.78028
[BP] GO:0009214 None PDE10A, PDE3A, PDE3B 2.73595
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, SRC 2.72429
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.72429
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, OPRK1, OPRM1, SRC 2.72219
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, KDR, SRC 2.72219
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, OPRM1, PDE3A, SRC 2.72125
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.71055
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, DRD2, ESR1, F2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.71055
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SRC, XDH 2.69922
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.69783
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, OPRM1, SRC, XDH 2.68625
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, F2, OPRM1 2.68625
[BP] GO:0007626 None DRD1, DRD2, DRD3, OPRD1, OPRK1, OPRM1 2.68625
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.67913
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.66628
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 2.65981
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, DRD2, F2, FLT3, HTR2A, HTR2B, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.65646
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.64587
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, DRD2, HTR2A, HTR2B, KDR, OPRM1, SRC 2.62817
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.6238
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.6238
[BP] GO:0009187 None HTR2B, PDE10A, PDE3A, PDE3B 2.6238
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.6238
[BP] GO:0046110 None AOX1, XDH 2.6238
[BP] GO:0060160 None DRD2, DRD3 2.6238
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.6238
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.62061
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.618
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.61636
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, OPRK1, SRC 2.61291
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, MMP9, OPRD1, OPRM1, SIGMAR1, SRC, XDH 2.61095
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B 2.6036
[BP] GO:0055080 cation homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.6036
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.59207
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.58834
[BP] GO:0072347 None DRD2, DRD3, OPRK1, OPRM1 2.58275
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, OPRM1, SRC 2.58009
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.58009
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, DRD1, DRD2, F2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, OPRD1, OPRK1, OPRM1, SRC, XDH 2.57883
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, HTR2A, HTR2B 2.55674
[BP] GO:0055074 calcium ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.54452
[BP] GO:1904062 None DRD1, DRD2, DRD3, F2, MMP9, OPRK1, OPRM1 2.54055
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.54055
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.54055
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.54055
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.53742
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.53118
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.53118
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.5184
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, HTR2A, OPRD1, OPRK1, OPRM1 2.51205
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B, MMP9, OPRD1, OPRM1, SIGMAR1, SRC, XDH 2.51174
[BP] GO:0097237 cellular response to toxic substance AKR1B1, AXL, CYP1B1, KDR, OPRD1 2.5099
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, DRD2, F2, F3, MET, OPRK1, XDH 2.50856
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.49611
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.49611
[BP] GO:0042698 ovulation cycle AXL, OPRK1, OPRM1 2.48223
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.48223
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, OPRK1, OPRM1, SRC 2.48031
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.47593
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FLT3, HTR2A, HTR2B, SRC 2.47083
[BP] GO:0009166 None PDE10A, PDE3A, PDE3B, XDH 2.45117
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.43056
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.43056
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.42818
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, F2, HTR2B, OPRK1, SRC 2.42098
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD2, FABP4, MET, PDE3A 2.41796
[BP] GO:0007610 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, OPRD1, OPRK1, OPRM1 2.40323
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.39728
[BP] GO:0006145 None AOX1, XDH 2.39728
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.39728
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.39728
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.39426
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.39426
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.39426
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, SRC 2.38222
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CYP19A1, DRD1, DRD2, DRD3, ESR1, ESR2, F2, IGF1R, MET, MMP9, PDE3B, SRC, XDH 2.37208
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SIGMAR1, SRC, XDH 2.37085
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, DRD1, ESR1, FLT3, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.37085
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.36471
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, DRD1, IGF1R, MMP2, OPRM1, PDE3A, PDE3B, SRC 2.34669
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, F2, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.339
[BP] GO:1901292 None PDE10A, PDE3A, PDE3B, XDH 2.33032
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, MMP9, OPRD1, OPRM1, SIGMAR1, SRC, XDH 2.31289
[BP] GO:0031644 None ADORA1, OPRD1, OPRK1, OPRM1 2.30827
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.30485
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.30485
[BP] GO:0008306 None DRD1, DRD2, DRD3, OPRK1 2.28902
[BP] GO:0034762 None CA2, DRD1, DRD2, DRD3, F2, MMP9, OPRK1, OPRM1 2.28097
[BP] GO:1903725 regulation of phospholipid metabolic process FLT3, HTR2A, HTR2B, SRC 2.26766
[BP] GO:0045745 None DRD2, DRD3, F2 2.25953
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.23718
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, MMP2, MMP9, OPRK1, OPRM1, PDE3A, SRC 2.2329
[BP] GO:0044248 cellular catabolic process ACHE, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP4, PDE10A, PDE3A, PDE3B, SRC, XDH 2.2329
[BP] GO:0042755 None OPRD1, OPRK1, OPRM1 2.22236
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.22236
[BP] GO:0008209 androgen metabolic process CYP19A1, CYP3A4, ESR1 2.22236
[BP] GO:0051302 None AURKB, DRD2, DRD3, ESRRB, HTR2B 2.22236
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, F2, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC 2.22236
[BP] GO:0021853 None DRD1, DRD2 2.22236
[BP] GO:0010641 None F3, SRC 2.22236
[BP] GO:0090325 None DRD2, DRD3 2.22236
[BP] GO:1904936 None DRD1, DRD2 2.22236
[BP] GO:0042321 None ADORA1, DRD2 2.22236
[BP] GO:0010513 None HTR2A, HTR2B 2.22236
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC 2.2128
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.19828
[BP] GO:1901575 None ACHE, ADORA1, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, FABP4, PDE10A, PDE3A, PDE3B, XDH 2.19482
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, HTR2A, OPRM1 2.19044
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, AURKB, DRD2, ESR1, ESR2, F2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, OPRD1, SRC, XDH 2.19028
[BP] GO:0009410 None DRD1, DRD2, DRD3, OPRK1, OPRM1 2.19028
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, CA1, CA2, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SIGMAR1, SRC, XDH 2.18929
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, F2, FLT3, IGF1R, KDR, MET, SENP6, SRC 2.18555
[BP] GO:0046427 positive regulation of JAK-STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.1841
[BP] GO:0035265 organ growth ADRA1A, CYP19A1, ESR1 2.15252
[BP] GO:0009154 None PDE10A, PDE3A, PDE3B 2.15252
[BP] GO:1904894 positive regulation of STAT cascade AKR1B1, CYP1B1, F2, FLT3 2.14525
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, HTR2A, OPRM1 2.13171
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, XDH 2.11923
[BP] GO:0042220 None DRD2, DRD3, OPRM1 2.11923
[BP] GO:0009261 None PDE10A, PDE3A, PDE3B 2.11923
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.11923
[BP] GO:0045744 None DRD2, DRD3, MET 2.11923
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.0861
[BP] GO:0007194 None DRD2, DRD3, OPRM1 2.08247
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.08247
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.08247
[BP] GO:0021843 None DRD1, DRD2 2.08247
[BP] GO:0046113 None AOX1, XDH 2.08247
[BP] GO:0021830 None DRD1, DRD2 2.08247
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.08247
[BP] GO:0021826 None DRD1, DRD2 2.08247
[BP] GO:0051781 None AURKB, DRD2, DRD3, HTR2B 2.06357
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC 2.05208
[BP] GO:0046058 None PDE10A, PDE3A, PDE3B 2.05208
[BP] GO:0060191 regulation of lipase activity ADRA1A, ESR1, HTR2A, HTR2B 2.04745
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, F2, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.04745
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, DRD1, DRD2, DRD3, ESR1, F2, HTR2A, HTR2B 2.04578
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, OPRD1, SIGMAR1 2.04526
[BP] GO:0040017 positive regulation of locomotion DRD1, F3, IGF1R, KDR, MET, MMP9, OPRK1, SRC 2.0296
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A 2.02735
[BP] GO:0031280 None DRD2, DRD3, OPRM1 2.02027
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.01876
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 2.0007
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 7.31757
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 6.19299
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 5.29519
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PIM1, SRC 4.74471
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1, SRC 3.36367
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, OPRD1, OPRK1, OPRM1, PDE10A, PDE3B, PIM1, SIGMAR1, SRC 3.3589
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, OPRD1, OPRM1, SRC 3.06781
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, HTR2A, MET, OPRD1, OPRM1, SIGMAR1, SRC 2.90092
[CC] GO:0043204 None DRD2, HTR5A, OPRK1, OPRM1, PDE10A 2.57883
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD1, DRD2, DRD3, ESR1, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, PDE3A, PDE3B, SIGMAR1 2.30642
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, HTR6, OPRD1, OPRK1, OPRM1, SRC 2.16564
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.11923
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, DRD1, DRD2, HTR2A, OPRD1, OPRK1, OPRM1, SIGMAR1, SRC 2.11923
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 20.2845
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, XDH 13.3382
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, SRC, XDH 13.2164
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 13.1628
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.6391
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 11.0537
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, XDH 11.0537
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 9.847
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 9.55642
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 8.93876
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.52966
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, OPRM1 8.5078
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.97126
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 7.84019
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 7.73355
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, OPRD1, OPRK1, OPRM1, SIGMAR1 7.73355
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, OPRM1 7.64213
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 7.25863
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.19127
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.19127
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.15068
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.15068
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 7.01031
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9 6.60679
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, F2, F3, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SRC, XDH 6.38986
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PDE10A, PIM1, SIGMAR1, SRC 6.15158
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH 6.05914
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 5.63559
[MF] GO:0004985 None OPRD1, OPRK1, OPRM1, SIGMAR1 5.63559
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, OPRD1, OPRK1, OPRM1, SIGMAR1 5.38806
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, MMP1, MMP2, MMP9, PDE10A, PDE3A, PDE3B, PIM1, XDH 5.38543
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.2988
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 4.38423
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, SRC 4.19797
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1 4.17372
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 3.97158
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.59533
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.44195
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, SRC, XDH 3.36295
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6, CYP3A4 3.28777
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.18514
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.11685
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.02071
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.98257
[MF] GO:0004119 None PDE3A, PDE3B 2.98257
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 2.95819
[MF] GO:0047555 None PDE10A, PDE3A, PDE3B 2.95819
[MF] GO:0004115 None PDE10A, PDE3A, PDE3B 2.8752
[MF] GO:0005488 binding ACHE, ADORA1, ADRA1A, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, OPRD1, OPRK1, OPRM1, PDE10A, PDE3A, PDE3B, PIM1, SENP6, SIGMAR1, SRC, XDH 2.82137
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB 2.78028
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB 2.78028
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, HSD17B1, XDH 2.7427
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.66628
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.66547
[MF] GO:0001965 None HTR2A, HTR2B, OPRM1 2.6238
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.6238
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.58009
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB 2.54055
[MF] GO:0042923 None OPRD1, OPRK1, OPRM1 2.48223
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, HSD17B1 2.39728
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.39728
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.39728
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.39728
[MF] GO:0004114 None PDE10A, PDE3A, PDE3B 2.39426
[MF] GO:0004112 None PDE10A, PDE3A, PDE3B 2.34727
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.22236
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.22236
[MF] GO:0004064 arylesterase activity CA1, CA2 2.08247
[MF] GO:0043546 None AOX1, XDH 2.08247


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.7688
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 OPRD1, HTR2B, HTR1A, OPRK1, OPRM1, HTR2A, F2, HTR5A, ADRA1A, HTR6, HTR7, ADORA3, ADORA1, DRD1, DRD2, DRD3 13.8511
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, HTR5A 7.0603
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, CYP1A1, CYP1B1, CYP19A1, IGF1R 6.4996
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 6.1989
Morphine addiction_Homo sapiens_hsa05032 PDE10A, PDE3B, ADORA1, PDE3A, OPRM1, DRD1 5.0965
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, OPRM1, MMP9, ESR1, ESR2 4.9465
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 4.6513
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, PDE3B, ADORA1, PDE3A, HTR1A, DRD1, DRD2 4.4426
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 4.4426
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.4426
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 OPRD1, ADORA3, PDE3B, ADORA1, PDE3A, ADRA1A 3.9594
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 4.1547
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1547
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1547
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 3.4203
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1, CYP3A4 3.3446
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.2503
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.5311
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP1A2, CYP1A1, CYP1B1, CYP3A4 3.1224
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.1455
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PDE3B, ADORA1 2.4129
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.1455
Renin secretion_Homo sapiens_hsa04924 PDE3B, ADORA1, PDE3A 2.263
Purine metabolism_Homo sapiens_hsa00230 PDE10A, PDE3B, PDE3A, XDH 1.9927
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.8496
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9846
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.8496
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.8401
Metabolic pathways_Homo sapiens_hsa01100 ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, AKR1B1, CYP3A4, CYP19A1, XDH 1.7471
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.7106
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5494
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.5967
Sphingolipid signaling pathway_Homo sapiens_hsa04071 OPRD1, ADORA3, ADORA1 1.6708
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.393
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3932
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3584
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9594
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PDE3B, IGF1R 1.0688
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1191
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3018
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2923
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2995
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9562
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2251
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8318
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.9259
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9562
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8453
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8453
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.7886
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8468
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.2923
Complement and coagulation cascades_Homo sapiens_hsa04610 F2, F3 1.2237
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.794
PPAR signaling pathway_Homo sapiens_hsa03320 FABP4, MMP1 1.2971
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5078
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7421
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2 0.6402
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.5494
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3214
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3206
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.342
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3502
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.342
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3856
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.4038
Measles_Homo sapiens_hsa05162 CSNK2A1 0.421
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4141
Platelet activation_Homo sapiens_hsa04611 SRC 0.4442
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4641
Insulin signaling pathway_Homo sapiens_hsa04910 PDE3B 0.4175
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5054
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4248
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4641
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5054
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4442
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4827
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5054
Axon guidance_Homo sapiens_hsa04360 MET 0.4369
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4462
Glucagon signaling pathway_Homo sapiens_hsa04922 PDE3B 0.4855
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4445
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.8496
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5054
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4998
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5054
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4998
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5054
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4998
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5054
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5054
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4998
Peroxisome_Homo sapiens_hsa04146 XDH 0.5054
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5354
Glioma_Homo sapiens_hsa05214 IGF1R 0.5699
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5699
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5693
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5688
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5791
Shigellosis_Homo sapiens_hsa05131 SRC 0.5699
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.58
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5719
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9927
Malaria_Homo sapiens_hsa05144 MET 0.6423
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.647
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6445
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.7924
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1 0.7484
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7433
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.7788
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.794
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8156
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0241
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2272
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3018


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)