TCM Prescription: Shen Qi Er Xian Tablets



Prescription Description
Prescription IDTCMF3368
Pinyin NameShen Qi Er Xian Pian
Chinese Name参芪二仙片
English NameShen Qi Er Xian Tablets
Function Description阳痿, 早泄, 遗精, 绝经前后诸症
IndicationsPremature ejaculation disorder, Involuntary ejaculation disorder, Impotence disorder, Menopausal disorder, Menopausal and perimenopausal disorder, Sexual dysfunction, Premature ejaculation
Disease ICD-11 Category SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1) ];
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SB95 [Menopausal disorder (TM1), 绝经前后诸症 (TM1) ];
GA30 [Menopausal or certain specified perimenopausal disorders, 绝经期或某些特指的围绝经期疾患 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
HA03.0Z [Male early ejaculation, unspecified, 男性早泄，未特指的 ];
Human Tissues Associated with IndicationKidney
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH877 Radix ginseng rubra 红参 TCMH877 GBVE1679-11
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2256 Curculigo orchioides 仙茅 TCMH2256 GENG778-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH949 Phellodendron amurense 黄柏 TCMH949 ITSAM1586-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 14.4797
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.4223
[BP] GO:0044281 small molecule metabolic process AKR1B1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, PDE5A, PPARA, XDH 9.50242
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 9.17067
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, FABP3, PPARA 7.87558
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, HSD17B1, PPARA 6.75522
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.3671
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.29851
[BP] GO:0009056 catabolic process ACHE, ADORA1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MAOB, MMP1, MMP2, MMP9, PDE5A, XDH 5.31035
[BP] GO:0008202 steroid metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, HSD17B1 4.9728
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, HCAR2, HSD17B1 4.83158
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD1, DRD2, MAOB 4.69556
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 4.61038
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 4.55447
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1 4.55164
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.52065
[BP] GO:0044255 cellular lipid metabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD2, FABP3, FABP4, PPARA 4.26425
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 4.23143
[BP] GO:0010035 response to inorganic substance AKR1B1, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, MAOB, MMP9 4.16471
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.96929
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.96929
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, HSD17B1, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, XDH 3.91838
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, HCAR2, HSD17B1, MAOB, PPARA, XDH 3.91838
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, MAOB, MMP2, MMP9, PPARA 3.9098
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.80523
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 3.78762
[BP] GO:0055114 oxidation-reduction process AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, MAOB, XDH 3.71469
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 3.60559
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, MMP9, PDE5A, XDH 3.55458
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, MMP9, PDE5A, XDH 3.54065
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.53687
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, MAOB 3.52264
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.42056
[BP] GO:0097164 None ACHE, AKR1B1, CSNK2A1, DRD1, DRD2, MAOB 3.41359
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.39493
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.37784
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, FABP3, PPARA 3.37678
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, MAOB 3.37165
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, MAOB 3.37165
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 3.34286
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.32919
[BP] GO:1901361 None CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, MAOB, PDE5A, XDH 3.29605
[BP] GO:0010038 response to metal ion CA2, CYP1A1, CYP1A2, DRD2, FABP4, MAOB, MMP9 3.24208
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP3A4, MAOB 3.16505
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 3.16505
[BP] GO:1901575 None ACHE, ADORA1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MAOB, PDE5A, XDH 3.13868
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD1, DRD2 3.05005
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.82782
[BP] GO:0014070 response to organic cyclic compound CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, MAOB 2.7893
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, FABP3, FABP4, HSD17B1, MAOB, MMP1, MMP2, PDE5A, PPARA, XDH 2.77544
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2 2.76179
[BP] GO:0010033 response to organic substance AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, MAOB, MMP2, PPARA 2.72934
[BP] GO:0009719 response to endogenous stimulus AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, MAOB, MMP2, PPARA 2.61134
[BP] GO:1901568 fatty acid derivative metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.57104
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.55996
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.55928
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.50717
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 2.50495
[BP] GO:0044248 cellular catabolic process ACHE, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, MAOB, PDE5A, XDH 2.47327
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, MAOB 2.47299
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.4202
[BP] GO:0042221 response to chemical AKR1B1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP3, FABP4, MAOB, MMP2, MMP9, PPARA 2.39179
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD1, DRD2 2.35857
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD1, DRD2 2.35857
[BP] GO:0042417 None DRD1, DRD2, MAOB 2.34069
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, PPARA 2.33552
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.33408
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.33408
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, MAOB, PPARA 2.28115
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, MAOB 2.28115
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CSNK2A1, CYP1B1, DRD2, F3, FABP3, MMP2, MMP9, PDE5A, XDH 2.26972
[BP] GO:0032787 None CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.26494
[BP] GO:0001659 None ADORA1, DRD1, DRD2 2.25073
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, F3, HCAR2, MAOB, MMP9, PPARA 2.1562
[BP] GO:0021853 None DRD1, DRD2 2.1562
[BP] GO:1904936 None DRD1, DRD2 2.1562
[BP] GO:0042321 None ADORA1, DRD2 2.1562
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, MAOB 2.10859
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2 2.09325
[BP] GO:0006721 terpenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.03523
[BP] GO:0021843 None DRD1, DRD2 2.01817
[BP] GO:0021830 None DRD1, DRD2 2.01817
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01817
[BP] GO:0021826 None DRD1, DRD2 2.01817
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01817
[BP] GO:0042493 response to drug AKR1B1, CA9, CYP1A1, CYP1B1, DRD1, DRD2, FABP3, MAOB 2.01817
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1 1.49485
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2 1.45577
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9 1.35494
[CC] GO:0031233 None CA4, F3 1.20236
[CC] GO:0097730 None DRD1, DRD2 0.894186
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 20.0804
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 13.5903
[MF] GO:0046914 transition metal ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PPARA, XDH 13.4223
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.4495
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 10.0769
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.66783
[MF] GO:0043167 ion binding ACHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, F3, FABP3, FABP4, HSD17B1, MAOB, MMP1, MMP2, MMP9, PDE5A, PPARA, XDH 8.52223
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 8.31526
[MF] GO:0043169 cation binding ACHE, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD1, DRD2, MMP1, MMP2, MMP9, PDE5A, PPARA, XDH 6.66791
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.54614
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 6.30121
[MF] GO:0005506 iron ion binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 6.29851
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, F3, HSD17B1, MAOB, MMP1, MMP2, MMP9, PDE5A, XDH 6.02254
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA 5.95786
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.49438
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 5.38852
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.31035
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, MAOB, XDH 5.00154
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 5.00062
[MF] GO:0046872 metal ion binding CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, MMP1, MMP2, MMP9, PDE5A, PPARA, XDH 4.55447
[MF] GO:0016491 oxidoreductase activity AKR1B1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HSD17B1, MAOB, XDH 4.50788
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.65713
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, XDH 3.26155
[MF] GO:0008389 None CYP2A13, CYP2A6 2.98474
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.55996
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.33408
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.33408
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.1562
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01817


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 21.8959
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 7.5186
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 7.0792
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.8959
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 5.0276
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, CYP1A1, CYP1B1, CYP19A1 4.6988
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, CYP3A4 4.2967
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2, CYP3A4 4.2897
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, DRD1, DRD2, PPARA 3.7433
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 4.2897
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, MAOB, HSD17B1, CYP1A2, CYP1A1, AKR1B1, CYP3A4, CYP19A1, XDH 2.8851
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 3.4796
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 3.3636
Cocaine addiction_Homo sapiens_hsa05030 MAOB, DRD1, DRD2 3.3133
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1, DRD1, DRD2 2.2169
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB, DRD1, DRD2 2.2107
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 6.1079
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, PDE5A 1.9147
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.8514
Amphetamine addiction_Homo sapiens_hsa05031 MAOB, DRD1 1.6874
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.8199
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, F3 1.4307
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9 1.4314
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.4847
Gap junction_Homo sapiens_hsa04540 DRD1, DRD2 1.4955
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.6572
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 2.2735
Pathways in cancer_Homo sapiens_hsa05200 MMP1, MMP2, MMP9 1.1214
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.3195
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.3195
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 1.1976
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.4496
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9 0.9952
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 1.0672
MicroRNAs in cancer_Homo sapiens_hsa05206 CYP1B1, MMP9 0.7857
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.7298
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2 0.6906
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.6906
Adherens junction_Homo sapiens_hsa04520 CSNK2A1 0.7298
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.6661
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.7345
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.678
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.6661
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.6661
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.6906
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.7617
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.7122
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.6906
Measles_Homo sapiens_hsa05162 CSNK2A1 0.6045
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.6906
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.6062
Peroxisome_Homo sapiens_hsa04146 XDH 0.7007
Hepatitis B_Homo sapiens_hsa05161 MMP9 0.5972
Serotonergic synapse_Homo sapiens_hsa04726 MAOB 0.6661
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.7857
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.6014
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.6906
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.5909
Calcium signaling pathway_Homo sapiens_hsa04020 DRD1 0.5378
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.6028
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.5078
Rap1 signaling pathway_Homo sapiens_hsa04015 DRD2 0.4981
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 MMP9 0.5378
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.5337
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.8345
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.9172
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.9952
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.9523
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.9512
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.9792
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 1.0162
Histidine metabolism_Homo sapiens_hsa00340 MAOB 1.054
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.1622


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)